Q & A for ASSASS1NATE

Page 30 of 30 First ... 282930

  1. Quote Originally Posted by NoAddedHmones View Post
    It will metabolise alcohol faster if you consume just prior to, or during drinking.
    Ok thanks. & in term of damage control, still beneficial or better saved for meals with no alcohol?

  2. Q & A for ASSASS1NATE


    Quote Originally Posted by NoAddedHmones View Post
    It will metabolise alcohol faster if you consume just prior to, or during drinking.
    does this mean you have to drink more to get the same effect as without AS?

    what if you take one dose after drinking and before bed, will it help with a hangover?
    •   
       


  3. Quote Originally Posted by dbenj7 View Post
    Ok thanks. & in term of damage control, still beneficial or better saved for meals with no alcohol?
    Absolutely. Alcohol need not be the bad guy, ultimately if you waaaay overdo it, clearly you will need to deal with the ramifications the next day. Body comp wise its going to come down to how over you go on total cals, id sure as hell prefer to have liver and neuroprotective actives in Assassinate in my system while drinking though.
    OLYMPUS LABS R&D
    Any OL questions? DM me on IG: Skinnybozz (Check more frequently than AM PMs)

  4. Quote Originally Posted by iamyourfather View Post
    does this mean you have to drink more to get the same effect as without AS?

    what if you take one dose after drinking and before bed, will it help with a hangover?
    Lol good question, i donít usually follow a controlled testing environment when on the sauce..usually to caught up making regrettable decisions and enjoying myself 🤷🏿*♂️🤷🏿*♂️
    OLYMPUS LABS R&D
    Any OL questions? DM me on IG: Skinnybozz (Check more frequently than AM PMs)

  5. Quote Originally Posted by NoAddedHmones View Post
    Absolutely. Alcohol need not be the bad guy, ultimately if you waaaay overdo it, clearly you will need to deal with the ramifications the next day. Body comp wise its going to come down to how over you go on total cals, id sure as hell prefer to have liver and neuroprotective actives in Assassinate in my system while drinking though.
    Ok cool thanks. Ramifications I’m not worried about, it will be fine, but wasn’t sure if I was wasting it by dosing pre session tonight. Wasn’t aware of hepatic and neuroprotective properties!
    •   
       


  6. For your delight...

    Dihydromyricetin Attenuates Dexamethasone-Induced Muscle Atrophy by Improving Mitochondrial Function via the PGC-1α Pathway.
    Huang Y, Chen K, Ren Q, Yi L, Zhu J, Zhang Q, Mi M.
    Abstract
    BACKGROUND/AIMS:
    Skeletal muscle atrophy is an important health issue and can impose tremendous economic burdens on healthcare systems. Glucocorticoids (GCs) are well-known factors that result in muscle atrophy observed in numerous pathological conditions. Therefore, the development of effective and safe therapeutic strategies for GC-induced muscle atrophy has significant clinical implications. Some natural compounds have been shown to effectively prevent muscle atrophy under several wasting conditions. Dihydromyricetin (DM), the most abundant flavonoid in Ampelopsis grossedentata, has a broad range of health benefits, but its effects on muscle atrophy are unclear. The purpose of this study was to evaluate the effects and underlying mechanisms of DM on muscle atrophy induced by the synthetic GC dexamethasone (Dex).

    METHODS:
    The effects of DM on Dex-induced muscle atrophy were assessed in Sprague-Dawley rats and L6 myotubes. Muscle mass and myofiber cross-sectional areas were analyzed in gastrocnemius muscles. Muscle function was evaluated by a grip strength test. Myosin heavy chain (MHC) content and myotube diameter were measured in myotubes. Mitochondrial morphology was observed by transmission electron microscopy and confocal laser scanning microscopy. Mitochondrial DNA (mtDNA) was quantified by real-time PCR. Mitochondrial respiratory chain complex activities were examined using the MitoProfile Rapid Microplate Assay Kit, and mitochondrial membrane potential was assessed by JC-1 staining. Protein levels of mitochondrial biogenesis and dynamics markers were detected by western blotting. Myotubes were transfected with siRNAs targeting peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), mitochondrial transcription factor A (TFAM) and mitofusin-2 (mfn2) to determine the underlying mechanisms.

    RESULTS:
    In vivo, DM preserved muscles from weight and average fiber cross-sectional area losses and improved grip strength. In vitro, DM prevented the decrease in MHC content and myotube diameter. Moreover, DM stimulated mitochondrial biogenesis and promoted mitochondrial fusion, rescued the reduced mtDNA content, improved mitochondrial morphology, prevented the collapse in mitochondrial membrane potential and enhanced mitochondrial respiratory chain complex activities; these changes restored mitochondrial function and improved protein metabolism, contributing to the prevention of Dex-induced muscle atrophy. Furthermore, the protective effects of DM on mitochondrial function and muscle atrophy were alleviated by PGC-1α siRNA, TFAM siRNA and mfn2 siRNA transfection in vitro.

    CONCLUSION:
    DM attenuated Dex-induced muscle atrophy by reversing mitochondrial dysfunction, which was partially mediated by the PGC-1α/TFAM and PGC-1α/mfn2 signaling pathways. Our findings may open new avenues for identifying natural compounds that improve mitochondrial function as promising candidates for the management of muscle atrophy.

    © 2018 The Author(s). Published by S. Karger AG, Basel.
    Olympus Labs Forum Rep, R&D Team
    Olympus Labs. Innovation. Value. Results.

  7. Iím thinking of adding in GW50156 for cholesterol benefits. Is there any danger adding this to 4 caps Assas1nate a day?

  8. Bump.

    Also would the leptin boost negate the ghrelin hunger from mk677?
  •   

      
     

Similar Forum Threads

  1. Replies: 0
    Last Post: 05-27-2010, 12:13 AM
  2. Replies: 0
    Last Post: 03-03-2008, 01:53 PM
  3. For Sale: SDNG & Advanced PCT (Testosterone Boosters)
    By aztec127 in forum Supplement Auction
    Replies: 0
    Last Post: 02-19-2008, 08:09 PM
  4. Ergopharm AMP for weight loss
    By Syr in forum Supplements
    Replies: 19
    Last Post: 08-01-2005, 01:58 PM
Log in
Log in