The Complete Vitamin D Thread

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    The Complete Vitamin D Thread


    I've decided to put together a resourceful Vitamin D thread for you all. I've had a thread on this in the past (as well as some documented information in some of my logs), but I wanted to put together a more broad spectrum wealth of resources for everyone to read and enjoy. I will continue to update the information over time, as well as help to answer any questions that you all may have.


    Scientific evidence is mounting with the myriad of factors/processes Vitamin D not only influences (at the cellular level and gene expression), but also regulates (both up and down regulation).

    This thread is a work in progress, and I still have much information to add.




    Vitamin D: An Overview:



    Overview of general physiologic features and functions of vitamin D

    The vitamin D story: a collaborative effort of basic science and clinical medicine

    Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety

    1,25(OH)2-vitamin D3 receptors: gene regulation and genetic circuitry -- Minghetti and Norman 2 (15): 3043 -- The FASEB Journal

    Vitamin D2 Is Much Less Effective than Vitamin D3 in Humans -- Armas et al. 89 (11): 5387 -- Journal of Clinical Endocrinology & Metabolism

    http://www.direct-ms.org/pdf/VitDGen...k%20review.pdf

    http://www.thinkorbeeaten.com/thekno...20Practice.pdf

    http://www.mayoclinicproceedings.com.../81/3/353.full

    Linus Pauling Institute at Oregon State University

    Vitamin D in dermatology

    Vitamin D

    The Nuclear Vitamin D Receptor: Biological and Molecular Regulatory Properties Revealed

    Newly Identified Actions of the Vitamin D Endocrine System

    Vitamins and Hormones

    Vitamin D2 Is as Effective as Vitamin D3 in Maintaining Circulating Concentrations of 25-Hydroxyvitamin D -- Holick et al. 93 (3): 677 -- Journal of Clinical Endocrinology & Metabolism

    http://www.direct-ms.org/pdf/VitDVie...APTER%2061.pdf

    http://www.uku.fi/biokem/research/ca...ons/2003-2.pdf




    Vitamin D and Cancer:


    The Role of Vitamin D in Cancer Prevention

    Vitamin D and prostate cancer: 1,25 dihydroxyvitamin D3 receptors and actions in human prostate cancer cell lines

    http://cebp.aacrjournals.org/content/2/5/467.full.pdf

    Expression Profiling in Squamous Carcinoma Cells Reveals Pleiotropic Effects of Vitamin D3 Analog EB1089 Signaling on Cell Proliferation, Differentiation, and Immune System Regulation

    Vitamin D: molecular biology

    Association of Prostate Cancer with Vitamin D Receptor Gene Polymorphism -- Taylor et al. 56 (18): 4108 -- Cancer Research

    Prospective Study of Serum Vitamin D and Cancer Mortality in the United States -- Freedman et al. 99 (21): 1594 -- JNCI Journal of the National Cancer Institute

    IngentaConnect Vitamin D and systemic cancer: is this relevant to malignant mela...

    Vitamin D3 promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of {beta}-catenin signaling -- Plmer et al. 154 (2): 369 -- The Journal of Cell Biology

    Vitamin D, Calcium and Prevention of Breast Cancer: A Review -- Lipkin and Newmark 18 (Supplement 5): -- Journal of the American College of Nutrition

    Calcium and Calpain as Key Mediators of Apoptosis-like Death Induced by Vitamin D Compounds in Breast Cancer Cells ? JBC




    Vitamin D and the Immune System:


    Vitamin D: its role and uses in immunology

    http://www.direct-ms.org/pdf/VitDImmunology/Hayes.pdf

    Vitamin D and Autoimmunity: Is Vitamin D Status an Environmental Factor Affecting Autoimmune Disease Prevalence?

    Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity

    The vitamin D pathway: a new target for control of the skin?s immune response?

    Vitamin D Signaling, Infectious Diseases, and Regulation of Innate Immunity -- White 76 (9): 3837 -- Infection and Immunity

    Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D–dependent mechanism

    Cutting Edge: Vitamin D-Mediated Human Antimicrobial Activity against Mycobacterium tuberculosis Is Dependent on the Induction of Cathelicidin




    Antimicrobial Peptides that Vitamin D upregulates:


    Cutting Edge: Mast Cell Antimicrobial Activity Is Mediated by Expression of Cathelicidin Antimicrobial Peptide





    Vitamin D in Preventative Medicine:


    Randomised controlled trial of calcium and supplementation with cholecalciferol (vitamin D3) for prevention of fractures in primary care -- Porthouse et al. 330 (7498): 1003 -- BMJ

    Effects of a Short-Term Vitamin D3 and Calcium Supplementation on Blood Pressure and Parathyroid Hormone Levels in Elderly Women -- Pfeifer et al. 86 (4): 1633 -- Journal of Clinical Endocrinology & Metabolism

    Vitamin D supplementation to prevent infections: a sub-study of a randomised placebo-controlled trial in older people (RECORD trial, ISRCTN 51647438) -- Avenell et al. 36 (5): 574 -- Age and Ageing

    Mounting Evidence for Vitamin D as an Environmental Factor Affecting Autoimmune Disease Prevalence -- Cantorna and Mahon 229 (11): 1136 -- Experimental Biology and Medicine

    http://www.direct-ms.org/pdf/VitDOth...taminDIDDM.pdf

    Cutting Edge: 1,25-Dihydroxyvitamin D3 Is a Direct Inducer of Antimicrobial Peptide Gene Expression -- Wang et al. 173 (5): 2909 -- The Journal of Immunology

    http://www.biochem.wisc.edu/courses/...sloff_2006.pdf

    Vitamin D Supplementation and Total Mortality: A Meta-analysis of Randomized Controlled Trials -- Autier and Gandini 167 (16): 1730 -- Archives of Internal Medicine

    Circulating 25-Hydroxyvitamin D Levels Indicative of Vitamin D Sufficiency: Implications for Establishing a New Effective Dietary Intake Recommendation for Vitamin D -- Hollis 135 (2): 317 -- Journal of Nutrition

    http://cdn3.libsyn.com/yourhealthwiz...72ee5bbd2760b4

    http://www.direct-ms.org/pdf/VitDMS/...tDMSreview.pdf

    The Role of Vitamin D and Calcium in Type 2 Diabetes. A Systematic Review and Meta-Analysis -- Pittas et al. 92 (6): 2017 -- Journal of Clinical Endocrinology & Metabolism

    Association Between Serum 25-Hydroxyvitamin D Level and Upper Respiratory Tract Infection in the Third National Health and Nutrition Examination Survey




    Vitamin D and Influenza:



    CJO - Abstract - Epidemic influenza and vitamin D




    Vitamin D and its role in the treatment of disease processes:


    Vitamin D3, gamma interferon, and control of proliferation of Mycobacterium tuberculosis by human monocytes.

    http://www.springerlink.com/content/...7/fulltext.pdf

    A Single Dose of Vitamin D Enhances Immunity to Mycobacteria -- Martineau et al. 176 (2): 208 -- American Journal of Respiratory and Critical Care Medicine

    BioMed Central | Full text | Vitamin D and the vitamin D receptor are critical for control of the innate immune response to colonic injury




    Various info on Vitamin D:


    http://www.rsc.org/delivery/_Article...JournalCode=PP

    Vitamin D Receptor Expression in Human Muscle Tissue Decreases With Age

    Sunscreens Suppress Cutaneous Vitamin D3 Synthesis -- MATSUOKA et al. 64 (6): 1165 -- Journal of Clinical Endocrinology & Metabolism

    Wiley InterScience :: Session Cookies

    http://www.springerlink.com/content/...2/fulltext.pdf

    http://www.nature.com/jid/journal/v1...f/5602822a.pdf

    Low Vitamin D Status despite Abundant Sun Exposure -- Binkley et al. 92 (6): 2130 -- Journal of Clinical Endocrinology & Metabolism

    http://www.pnas.org/content/92/13/6112.full.pdf

    The Vitamin D Epidemic and its Health Consequences -- Holick 135 (11): 2739S -- Journal of Nutrition

    http://www.ncbi.nlm.nih.gov/pmc/arti...00173-0036.pdf




    Youtube Vids on Vitamin D:





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    This jogged my memory of an article that t-nation ran awhile ago by Chris Shugart. Usually their supplement related articles are just exaggerated pimping to push Biotest, but this one had a pretty good, no bs approach.

    Link below. There are also a few links to studies that you might not have included.

    http://www.tmuscle.com/free_online_a..._is_for_doping
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    props for the log.
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    Mate this is a fantastic collection of articles, thanks very much!
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    Quote Originally Posted by UKStrength View Post
    Mate this is a fantastic collection of articles, thanks very much!
    I have a bunch more to add this coming week. I really hope to make this a great thread for you all with various degrees of information. Glad you're enjoying it.

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    so from these articles I concluded that a good amount to supplement is about 4000 IU. Do you guys get it liquid,powder, pill. I like to do all my vitamins liquid, I wonder if Vshopp got any liquid D.

    hahaha i thought vitamin D should only be given to girls, in massive amounts
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    Quote Originally Posted by AntonG42O View Post
    so from these articles I concluded that a good amount to supplement is about 4000 IU. Do you guys get it liquid,powder, pill. I like to do all my vitamins liquid, I wonder if Vshopp got any liquid D.

    hahaha i thought vitamin D should only be given to girls, in massive amounts
    Yeah it's very indicated in females especially those with a poor bone health status, since vitamin D is needed for adequate calcium absorption.
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    Quote Originally Posted by UKStrength View Post
    Yeah it's very indicated in females especially those with a poor bone health status, since vitamin D is needed for adequate calcium absorption.
    lol u missed the joke. giving girls vitamin D(ick)
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    lol u missed the joke. giving girls vitamin D(ick)
    High vitamin *D* is just another reason why baby gravy is natures most perfect meal for women.
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    I wrote up a post/stickie liek this over on PHF as well. I have done presentations on the use of Vitamin D and populations.

    The FDA is about to change the recommendations and they NEVER change things so even they believe there is enough evidence for increased Vitamin D supplementation and sun exposure.

    I take in 4,000 IU a day, nice and cheap tiny gel caps from NOW.

    In a research paper done on the toxicity of Vitamin D it too patients a couple of months to get to toxic levels/effects using IV vitamin D at 100,000iu.
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    Updated.

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    Quote Originally Posted by Trauma1 View Post
    Updated.
    Looks like too much too read..... I will take your word for it
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    Quote Originally Posted by Grambo View Post
    Looks like too much too read..... I will take your word for it
    Tons of good reading.

    I'll be further defining some of these research articles when I have more time so you can have a general idea what each individual article entails.

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    I will be picking up some Vitamin D3 for sure. Thanx for the readings, gotta make this a staple

    //CC
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    Questions or concerns? → conny[@]seriousnutritionsolutions.com
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    Toco-D.....maybe in a future?
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    Any chance we could get a summary of the benifits of D?? Thats a ton of reading...
    Thanks!
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    Quote Originally Posted by drivehard View Post
    Any chance we could get a summary of the benifits of D?? Thats a ton of reading...
    Thanks!
    Absolutely. This thread shall continue to evolve. I'll have a FAQ done on it eventually with all the basic info.

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    Bumping this. I still have quite a bit to add when I have time, but this is a pretty good resource for you guys in regard to Vitamin D.

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    Quote Originally Posted by Trauma1 View Post
    Bumping this. I still have quite a bit to add when I have time, but this is a pretty good resource for you guys in regard to Vitamin D.
    High vitamin D level = high testosterone level

    like this too: http://www.ergo-log.com/vitamindtestosterone.html

    http://www.rgo-log.com/vitdperformance.html

    http://www.ergo-log.com/vitamindmuscle.html

    http://www.ergo-log.com/vitdaging.html

    http://www.ergo-log.com/vitdlong.html

    http://www.vitamindcouncil.org/
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    Really informative thread. Thanks!
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    People should also be looking at their Vitamin E intake too, such an important Vitamin with a myriad of uses in the body. Toco 8 is my supplement of choice.
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    Quote Originally Posted by UKStrength View Post
    People should also be looking at their Vitamin E intake too, such an important Vitamin with a myriad of uses in the body. Toco 8 is my supplement of choice.
    No doubt, Rick. Vitamin E is next on my list for a thread like this.

    -John

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    Quote Originally Posted by Trauma1 View Post
    No doubt, Rick. Vitamin E is next on my list for a thread like this.

    -John
    Vitamin A, D, E and are the essential vitamins men need to be looking at when it comes to increasing and maintaining a healthy level of testosterone.

    So perhaps my good friend you could do a Vitamin A thread as well as a Vitamin E thread. . In general, as I have said before...vitamins and minerals are overlooked...they do a hell of a lot more than they are given credit for.

    Cheers to John!

    -Sean-
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    I take it NOW Foods would be a good brand to look at if starting to supplement with more Vitamin D than whats already in my multivit.
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    Quote Originally Posted by Chub View Post
    I take it NOW Foods would be a good brand to look at if starting to supplement with more Vitamin D than whats already in my multivit.
    They are who I use for my extra supplementation. Cheap and good to go.
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    Quote Originally Posted by Grambo View Post
    They are who I use for my extra supplementation. Cheap and good to go.
    This thread should be stickied IMO. Great info T1!
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    Bought me a bottle of Vitamin D3, can't hurt
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    Quote Originally Posted by SamBoz19 View Post
    Vitamin A, D, E and are the essential vitamins men need to be looking at when it comes to increasing and maintaining a healthy level of testosterone.

    So perhaps my good friend you could do a Vitamin A thread as well as a Vitamin E thread. . In general, as I have said before...vitamins and minerals are overlooked...they do a hell of a lot more than they are given credit for.

    Cheers to John!

    -Sean-
    Indeed my friend. I'm going to do all the fat soluble vitamins (A,D,E,K). It will take some time because I have a full plate right now, but it will be done. I have a lot of good information on all of them to display for you all for reference.

    BTW: I got your text the other day; I'm responding shortly. The family just got into town, so it's been crazy the last week, haha.

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