I had trouble dosing this stuff. I thought I was a non responder for a long time. Then one day I really decided to take high amounts. All the sudden I'm walking around in my room and everything starts to slow down. I start giggling like a little school girl for no reasons. I didn't even attempt to drive. It almost felt similar to marijuana. I ended up taking a long nap. When I woke up I felt like a million bucks. Haven't taken it again since. I usually use phenibut. A whole different feeling for sure. Picamilon targets more the gaba-a receptors vs phenibut targeting more the gaba-b's.