Glycine Propionyl-L-Carnitine Hydrochloride?

  1. Glycine Propionyl-L-Carnitine Hydrochloride?


    Any idea if NP might be picking this one up? Pleeaseee


  2. Quote Originally Posted by donny;
    Any idea if NP might be picking this one up? Pleeaseee
    Probably. It is patented as GlycoCarn™ (the propionyl-carnitine ester attached to a glycine bond) by Sigma-Tau, though, making the whole thing a tad complex. Straight PLC is a different matter. Let's see, if someone from NutraPlanet chimes in.
    Product Educator | USPowders
    Statements made by this online persona are the sole property of the owner, and do not necessarily reflect USPowders’ opinion as a whole.

  3. They could always pick up the Jarrow products if they wanted to, they are the cheapest that I have seen.
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  4. Quote Originally Posted by machinehead;
    They could always pick up the Jarrow products if they wanted to, they are the cheapest that I have seen.
    That's right! Still Sigma-Tau, though.
    Product Educator | USPowders
    Statements made by this online persona are the sole property of the owner, and do not necessarily reflect USPowders’ opinion as a whole.

  5. If there is enough demand, I am sure we could work with Sigma-Tau to bring some in.

  6. Don't know if it elicits the same response but I'd luuuuuv to see some bulk plcar/nutracaps in the very near future!

  7. Quote Originally Posted by Bionic View Post
    Don't know if it elicits the same response but I'd luuuuuv to see some bulk plcar/nutracaps in the very near future!
    i've received a few requests for the bulk plcar restock, but prices are still more than double what they used to be for all forms of carnitine out of china.
    i believe we are patiently awaiting a price reduction before we restock.
    i agree, caps would be nice.

  8. More-than-double?! That's INSANE! I know the Olympics had something to do with it, although I'm not sure of the reason. Do you have any insight on why the price went up?

  9. Quote Originally Posted by Bionic View Post
    More-than-double?! That's INSANE! I know the Olympics had something to do with it, although I'm not sure of the reason. Do you have any insight on why the price went up?
    yeah, you guessed it. things should hopefully get back to normal soon though.
    Quote Originally Posted by dsade View Post
    During the Olympics, the TWO factories in China that manufacture PLCAR completely shut down for months.

  10. Interrupted/no supply, lots of demand... Not price friendly as you can imagine

  11. Thanks for the info, guys. It makes sense now. Cheers to things getting back to normal!

  12. I got quoted $300 (plus a bank fee of $20) for 1kg, plus shipping, from Bepharm in China.

  13. Quote Originally Posted by Steveoph View Post
    so what the different between this product and Incarnate ?and can they be used together ?

  14. Quote Originally Posted by Bionic View Post
    More-than-double?! That's INSANE! I know the Olympics had something to do with it, although I'm not sure of the reason. Do you have any insight on why the price went up?
    there are two main Factories in China that produce the majority of the carnitines. They BOTH completely closed up shop during the entire Olympic season (I believe one of them moved to a larger facility), which kicked in the laws of supply and demand with a vengeance.

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  15. Is the a difference as far as effectiveness with the Glycine Propionyl-L-Carnitine and just regular Propionyl-L-Carnitine? Does the glycine make that big of a difference.

  16. Quote Originally Posted by chainsaw View Post
    Is the a difference as far as effectiveness with the Glycine Propionyl-L-Carnitine and just regular Propionyl-L-Carnitine? Does the glycine make that big of a difference.
    Depends on your goals. If it's just mitochondrial function and strength, any would do, although l-carnitine-l-tartrate is claimed to be 'better'

  17. the glycine form is designed to increase bioavailibility of PLC.
    depending on cost increase of this form it may not be worthwhile given the fact that carnitine has a fairly ok absorption rate already.

  18. Bump for any new info on PLCAR and LCLT supplies/stock!

  19. NP is still waiting for the price to come down to a reasonable level before considering a re-stock.
    i want some myself!

  20. Quote Originally Posted by Hank Vangut View Post
    NP is still waiting for the price to come down to a reasonable level before considering a re-stock.
    i want some myself!
    You can always go with NOW for LCLT:

    http://www.nowfoods.com/Products/Pro...tegory/M097150

  21. yeah, we have some liquid l-carnitine available http://www.nutraplanet.com/product/n....html?sel=1973

    the out of stock np bulk powders are such a good value though.
    that's really what's holding up the restock, because right now given the prices from our china sources it wouldn't be such a tremendous savings over brands like NOW.

  22. Quote Originally Posted by machinehead View Post
    You can always go with NOW for LCLT:

    http://www.nowfoods.com/Products/Pro...tegory/M097150
    I hope this is not a silly question but are L-carnitine l-tartrate and l-carnitine tartrate the same thing?

  23. Quote Originally Posted by Bionic View Post
    I hope this is not a silly question but are L-carnitine l-tartrate and l-carnitine tartrate the same thing?
    in that NOW product, it is all referring to L-Carnitine-L-Tartrate - LCLT (a specific form of carnitine)

    here is a quick summary of the different forms....

    Carnitines: Dissimilar Members of the Same Family

    One of the best known amino acid is actually not an amino acid. L-Carnitine (also known as carnitine) is not an amino acid in the strict definition as it is not a component of proteins and more closely resembles a B-vitamin. Many readers are familiar with the general benefits of carnitine, such as its effect on improving cardiovascular health. The main biological effect of carnitine is to shuttle long chain fatty acids into the mitochondria, which is the energy manufacturing organelle inside our cells. Systemically, the overwhelming amount of carnitine (approximately 95%) is found in our skeletal muscle and heart tissue cells.

    Nutritional scientists use the phrase “conditionally essential” to describe carnitine because under certain conditions of physical stress, disease, or trauma, it may be imperative to consume carnitine. We only produce about 20 milligrams of carnitine internally (de-novo synthesis) on a daily basis. The amounts we get from our diet vary tremendously according to dietary practices. The estimates of carnitine consumption are 72 mg/person/day in Japan, 225 mg /person/day in the U.S., and 290 mg/person/day in New Zealand.

    While dietary supplement consumers have favorably embraced carnitines, the array of different carnitine forms available in the market has resulted in consumer confusion. Choices include Carnitine Tartrate, Carnitine Fumarate, Acetyl-L-Carnitine, Acetyl-L-Carnitine Arginate, Propionyl- L-Carnitine, to name a few. Which is the best form and what are the differences? To answer these questions requires a slight investigation to uncover the differences in forms and effects of these various carnitines.

    One of the main reasons for the different commercial forms of carnitine is because the carnitine molecule is inherently unstable. It has a powerful ability to attract moisture (hygroscopicity), thus resulting in difficulties of formulating in a finished dosage format. This led the two primary pioneers of carnitine manufacturing, Sigma Tau and Lonza, to employ the use of stabilizing salts to eliminate the hygroscopic effect and stabilize carnitine. The addition of the salts tartrate or fumarate results in a stable carnitine for a finished dosage format. These forms of carnitine are called salts of carnitine, as they are not molecular bonds per se, but rather weak ionic interaction. In other words, when you consume a carnitine tartrate or a carnitine fumarate, it results in a release of free of carnitine and the stabilizing salt. Sure, there are differences in the effects of the salt themselves, but in my opinion the differences are minor as the real active compound is the carnitine.

    Some forms of carnitine are not stabilized salts but completely different molecules with differences in biological effects. These are not carnitine salts but rather molecular analogs of carnitine. Some examples of these analogs are Acetylcarnitine (also known as Alcar or ALC), Propionylcarnitine (PLC), Carnitine Creatinate, Carnitine Taurinate, and Carnitine Arginate. As a result of the additional compounds bonded to the carnitine molecule, these carnitine analogs offer different biological effects. Unfortunately, for most of these products, there have not been comparative clinical trials conducted to determine if these biological effects are specific to the carnitine analog or to carnitines in general. But, the following can provide some understanding of the carnitine analogs:
    “Carnitine Plus” molecules

    This is a group of carnitine-based molecules whereby an additional nutrient is bonded to the carnitine. The additional molecule can be Arginine, Creatine, Taurine, Lysine, or other nutrient. These carnitine analogs are likely cleaved into free carnitine plus the accompanying nutrient prior to absorption into the body. Sure, taking a carnitine creatinate is superior to taking ordinary carnitine, but it’s not a fair comparison. A more interesting comparison would be to investigate if there’s any difference after oral administration of a carnitine-plus-nutrient molecule versus a carnitine-and-nutrient mixture - - the latter being a simple mixture of two powders, not a molecular bond, and a lot less costly. So, in general, the “carnitine plus” molecules are still in a phase of proving their worth. Two carnitine analogs, though, are deserving of a special mention because of their difference from ordinary carnitines as well as the amount of clinical data substantiating their use: Propionylcarnitine and Acetylcarnitine.
    Propionylcarnitine

    Propionylcarnitine (PLC) is available commercially in the form of glycine-propionylcarnitine (esterified carnitine) and this is a superb form of carnitine very specific for muscle tissue and cardiovascular protection. In an experimental rodent study, ordinary carnitine and acetylcarnitine had no protective effect on vascular inflammation, but PLC offered significant protection. Although ordinary carnitine and acetylcarnitine have proven cardiovascular benefit, there are some effects of PLC that are superior for particular cardiovascular conditions.
    Acetylcarnitine

    This is one of my favorite forms of carnitine because of its versatility in affecting a variety of tissues including the brain, nerve, and muscle tissue. Ordinary carnitine cannot cross the blood brain barrier (BBB), however acetylcarnitine crosses the BBB and has been proven clinically to benefit the brain. Acetylcarnitine is also a better stimulator of the mitochondria for energy synthesis than ordinary carnitine. The surprising twist is that no pharmacokinetic study has been done with acetylcarnitine to determine if it is absorbed intact. However, it has been determined in a study that consuming acetylcarnitine raises acetylcarnitine levels in the blood, and therefore yielding the desired result. If I had to simplify my life and choose one form of carnitine, based on versatility, price, and proven efficacy, I would choose acetylcarnitine.

    A few other points should also be considered in order to best utilize carnitine. First, carnitine is not caffeine, so don’t expect a result in one hour. Carnitine’s effects are really felt after about four weeks of supplementation. Second, use carnitine in conjunction with synergestic nutrients such as D-Ribose (an ATP stimulator), CoQ10, and Magnesium. As to the form of carnitine, remember that there are significant differences in the members of the carnitine family. Use the above as a guide to maximize your results from the benefits of carnitines. In the final analysis, the type of carnitine you choose should be based on your specific health condition and budget.

  24. Great posting! Thanks for the info.

  25. I am trying to verify quality of some PLCAR and LCLT

    For the PLCAR

    Jarrow Formulas

    Glycine Propionyl-L-Carnitine HCl 758 Milligrams *

    Propionyl-L-Carnitine (PLC) 500 Milligrams

    Glycine 174 Milligrams


    Is says 758mgs of the Glycine and 500mg of the PLC why two seperate ingredients.


    I am also looking into LCLT

    Pure Gels Carnisol TM

    Can anyone verify if this is legit or not.

  26. GPLC is a propionyl ester of carnitine (PLC) that includes an additional glycine
    component. Compared with other forms of carnitine, PLC executes its powerful effects on
    muscle tissues, including the heart.GPLC maximizes muscle function by compensating
    for reduced oxygen availability duringsupport for arterial blood flow. Under reduced oxygen conditions, GPLC also supports
    normal carbohydrate metabolism and minimizes lactic acid buildup. times of physical exertion and it offers powerful

  27. GPLC is a propionyl ester of carnitine (PLC) that includes an additional glycine
    component. Compared with other forms of carnitine, PLC executes its powerful effects on
    muscle tissues, including the heart.GPLC maximizes muscle function by compensating
    for reduced oxygen availability during times of physical exertion and it offers powerful support for arterial blood flow. Under reduced oxygen conditions, GPLC also supports
    normal carbohydrate metabolism and minimizes lactic acid buildup.

  28. Quote Originally Posted by NutraMan View Post
    If there is enough demand, I am sure we could work with Sigma-Tau to bring some in.
    YESS MAKE ME HAPPY!!!!!!
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    Maxximal @ seriousnutritionsolutions.com

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  29. Quote Originally Posted by chainsaw View Post
    I am trying to verify quality of some PLCAR and LCLT

    For the PLCAR

    Jarrow Formulas

    Glycine Propionyl-L-Carnitine HCl 758 Milligrams *

    Propionyl-L-Carnitine (PLC) 500 Milligrams

    Glycine 174 Milligrams


    Is says 758mgs of the Glycine and 500mg of the PLC why two seperate ingredients.


    I am also looking into LCLT

    Pure Gels Carnisol TM

    Can anyone verify if this is legit or not.

    Anything from Jarrow is indeed legit.

  30. Primordial Performance now has Glycine PLCAR in bulk, if anyone wants it as GlycoCarn.
    Personally, I find PLCAR work the best! none of that GlycoCarn hype....
  

  
 

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