BRAIN FACTOR-7 /BF-7 the big brain peptide.

  1. BRAIN FACTOR-7 /BF-7 the big brain peptide.


    BF-7 (Brain factor-7)

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    The Silkworm connection.
    Silkworms are the larva of the silk moth, whose Latin name is Bombyx mori, which means “silkworm of the mulberry tree.” As you can imagine, the leaves of the mulberry tree are the preferred food of the worms.
    As obvious as the second half of the name is, the first half also tells you quite a bit about this insect, as it is a primary producer of silk.
    Cultivating silkworms for the production of raw silk has been practiced in China for more than 5,000 years.

    While in the larvae stage, the silkworms create an insoluble protein known as silk fibroin. The fibroin is the structural center of
    the raw silk the worms create to build their cocoon.

    Researchers have found that if you take the silk fibroin and filter it, purify it and hydrolyze it—or break it down into its component amino acids—it has several medicinal and therapeutic benefits, primarily related to brain health. This purified silk fibroin is called Brain Factor-7 (BF-7) for short.

    BRAIN FACTOR 7 (BF-7
    ) has been shown to=

    Increase IQ in normal healthy subjects.
    Improve Learning
    Improve Working memory
    Improve attention
    Increase reaction times
    Is antioxidant
    Reduces amyloid plaques
    Reduces ROS (reactive oxygen species)
    Prevents brain cell death
    Improves concentration
    Increases Brain circulation



    ""Previous studies indicate that BF-7 enhances learning and memory in normal and elderly individuals. Here, we evaluated whether milk containing BF-7 (BF-7 milk) could improve the brain function, with thirty normal university students (21 ± 1.2 years). Two versions of the Paced Auditory Serial Addition Test were used under double-blinded conditions to measure the efficacy of BF-7 milk on learning and memory, especially working memory and attention, and on mathematical ability. As a result, BF-7 milk improved the accuracy of the task more than 3-fold. Furthermore, BF-7 milk protected cultured neu-ronal cells from 3-hydroxykynurenine, a normal endogenous brain stress agent. These results indicate that BF-7 milk enhances memory, attention and mathematical ability in normal persons."

    "INCREASED REACTION TIME AND TEST SCORE ACCURACY=
    "Results showed that BF-7 reduced the response time by an average of 23% for the Color Trails Making Test. Moreover, BF-7 improved the accuracy of the task around twofold. The results reveal that BF-7 improves brain function for attention and cognitive flexibility"

    "BRAIN ANTIOXIDANT-
    "BF-7 play a role in the improvement of brain functions by removing oxidative stress, and provide therapeutic potential role of BF-7 to protect nervous system from oxidative damage."

    GREATLY ENHANCED MEMORY.
    "his results strongly represent that the BF-7 play effectively positive role in the improvement of brain function including learning and memory. Taken together, our results suggested that the BF-7 should be useful for developing strategies protecting nervous system and improving brain function.

    In a study published in 2004, researchers divided 98 people between the ages of 19 and 64 into three groups.6 One group received 200 mg of BF-7, the second group took 400 mg of BF-7 and the third group had a placebo every day for three weeks.

    At the end of the study period, researchers found that all subjects taking the BF-7 (regardless of dosage) saw an average improvement in the memory index from 105 to 126.6. Similarly, the memory maintenance index in both groups increased from 52 percent to 61 percent.

    The 200 mg group specifically saw an increase in memory recall efficiency from 31 percent to 59 percent, as well as a boost in the Intelligence Quotient and Memory Quotient consensus score from 53 percent to 79 percent.

    The 400 mg group was even more impressive, boasting an increase from 41.5 percent to 66.5 percent in memory recall efficiency, and increases in the Intelligence Quotient and Memory Quotient consensus score rom 52.5 percent to 91 percent.


    Circulation to Brain

    Studies have shown that Bombyx mori, as silk fibroin, can increase blood flow to critical areas of the brain involved in memory and learning. This was specifically seen in one study published in 2004, where researchers tested the effects of BF-7 on four normal, healthy students.5

    After treating the students with 400 mg of BF-7, researchers tested for improved learning and memory using the K-WAIS scale. They found BF-7 treatment raised IQs from 103 on average to 114.

    Researchers then tested blood flow to the brain, particularly those areas associated with learning and memory—the paraphippocampal gyrus and medial temporal area—using the Single Photon Emission Computed Tomography (SPECT). They found that blood flow was, in fact, increased in both areas. Additionally, blood supply also increased.

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    BLACK LION RESEARCH
    Innovation distinguishes between a leader and a follower.
    -Steve Jobs


  2. The Effect of BF-7 on the Ischemia-induced Learning and Memory Deficits
    Lee JY, Lee SH, Sung JJ, Kim ET, Cho HJ, Kim KH, Kang YK, Kim SS, Kwon OS, Lee WB.

    Korean J Anat
    2005 Apr 38(2):181-188. Korean.



    Abnormal blood supply to brain, such as ischemia induce neuronal damages, possibly leading to dementia. Such damges should be attenuated by neuroprotective materials which make neurons tolerable against limited blood supply or reinforce of blood. For the animal study, transient middle cerebral artery occlusion was operated with SD rat. To check whether BF-7 attenuated the ischemic damage, BF-7 (10 mg/kg) was oral treated for 7 days once a day. To evaluate the learning and memory of the rat, 8-arm maze test was conducted. For clinical study, Rey Complex Figure Test (RCFT) was used with control group (32 person), 200 mg treated group (33 person) and 400 mg treated group (34 person). Treatment of BF-7 greatly reduced the infarct size. Als o the neuronal damages in the hippocampus were significantly diminished. Furthermore, The memory impairment by ischemia was recovered. The clinical test showed that BF-7 greatly enhanced the brain function recognizing and memorizing complex two dimensional figures. Our results implicated that BF-7 plays a positive roles on protecting brain and enhancing brain unction clinically.

    ---------------------

    BF-7 Improved Memory Function and Protected Neuron from Oxidative Stress.

    Abstract
    Endogenously or exogenously generated oxidative stress impair organs, especially brain. Also, the oxidative stress appears to be a negative factor on normal brain function, like memory and cognition. Our result showed that BF-7, extracted from Bombyx mori, effectively diminished oxidative stress, leading to the protection of neuron from reactive oxygen species donated by FeSO4 . Clinical experiments showed that BF-7 significantly improved memory and cognitive functions of normal adults in a dose-dependent manner. Thus, our results suggest that BF-7 play a role in the improvement of brain functions by removing oxidative stress, and provide therapeutic potential role of BF-7 to protect nervous system from oxidative damage.

    --------------------



    Protective Effect of Fibroin BF-7 on Neuronal Cell Death in Alzheimer Model using Amyloid beta Peptide.

    Lee DY, Yun JY, Kim JI, Kim DH, Han IS, Lee WB.

    Department of Anatomy,College of Medicine,Chung-Ang University, Seoul, Korea. [email protected]

    Abstract
    Factors such as senescence,stress and neurodegenerative diseases,including Alzheimer's disease, contribute to the impairment of organs,especially the brain.They also negatively affect normal brain functions such as memory and cognition.In this study,the neuroprotective role of the natural product BF-7 was examined against A beta - induced neurotoxicity in SK-N-SH human neuronal cells.BF-7 significantly attenuated A beta-induced apoptosis as measured by intracellular calcium levels,accumulation of reactive oxygen species,mitochondrial dysfunction,and caspase activity.These results strongly indicate that BF-7 plays an effective and positive role in the improvement of brain functions,including learning and memory,in our model system for Alzheimer's disease.Thus,BF-7 might be useful for developing strategies to protect the nervous system and improve brain function.

    ------------------

    The Role of BF-7 on Enhancement of Memory and Cognitive Funtion.

    Abstract
    Various factors such as senescence, stress, neurodegenerative diseases including Alzheimer's disease (AD) contribute to the impairments of organs, especially brain. Also, they should be negative factors on normal brain function, like as memory and cognition. In this study, the neuroprotective role of BF-7, extracted from Bombyx mori, was examined agaist scopolamine-induced neurotoxicity in SK-N-SH cells. In order to know if the BF-7 has positive role on the cognition and memory, we examined using SD rat model and human. Scopolamine-induced memory impairments were observed, as measured by the passive avoidance and water maze tests, but treatment with BF-7 significantly improved memory and cognitive function. Moreover, the memory index and memory preservation of clinical experiments using MMSE-K tests were significantly improved memory and cognitive function. This results strongly represent that the BF-7 play effectively positive role in the improvement of brain function including learning and memory. Taken together, our results suggested that the BF-7 should be useful for developing strategies protecting nervous system and improving brain function.

    ------------------------

    The Improvement of Learning and Memory Ability of Normal Persons by BF-7.

    Abstract
    To investigate whether BF-7, extracted from Bombyx mori, improved learning and memory of ordinary people, Rey-Kim Memory Test was performed with placebo group (32 persons), 200 mg BF-7 treated group (33 persons) and 400 mg BF-7 treated group (34 persons). BF-7 enhanced significantly learning and memory function in a dose-dependent manner. To know how BF-7 plays such a positive role, we measured the concentration of acetylcholine in the brain from memory impairment animal model. Treatment of BF-7 significantly increased the concentration of acetylcholine. So, it is supposed that the protection of cholinergic neuron and/or keeping proper concentration of acetylcholine might be one of the mechanisms by which BF-7 improve brain function. So, our results suggest that the BF-7 is effective material for improving learning and memory ability.
    BLACK LION RESEARCH
    Innovation distinguishes between a leader and a follower.
    -Steve Jobs
    •   
       


  3. NOOTROL The new Nootropic from Black Lion Research has 400mg of BF7 per daily dosage. We ran a public trial on this forum. We had 5 members take a host of tests. They then took Nootrol for 2 weeks and retested. 100% of test subjects had increases on all tests with some massive IQ increases. One tester saw a 25 point IQ increase!

    Nootrol also has Centella asiatica, Salidroside, Tyrosol and 50mg caffeine.


    Results from initial test; BEFORE NOOTROL
    MemTrax test - 92% correct .865 Mean Reaction Time
    Human Benchmark tests
    1957 points in Visual Memory
    41 on Verbal Memory
    Reaction Time of 325.0ms
    11 on Number Memory
    Psychology Today Memory Test - 81
    IQ Test - 105

    Results from second test; 2 WEEKS NOOTROL
    Test results 11/08
    MemTrax test - 96% .737 Mean Reaction Time
    Human Benchmark Tests
    Visual Memory- 6687
    Verbal Memory - 47
    Reaction Time - 321.0 ms
    Number Memory - 10 digits
    Psychology Today Memory Test - 84
    IQ Test - 115

    Results from 11/21 4 WEEKS NOOTROL.
    MemTrax Test 96% .728 Mean Reaction Time
    Human Benchmark Tests
    Visual Memory - 7243
    Verbal Memory - 52
    Reaction Time - 304.0 ms
    Number Memory - 10 digits
    Psychology Today Memory Test - 97
    IQ Test - 127


    ============================== ============================== =======


    Human Benchmark
    Number memory: 10 digits, 69%
    Reaction Time: 239 ms
    Verbal Memory: 22 points
    Visual Memory: level 7, score 2698

    MemTrax: 90%, mean reaction time 0.827 seconds

    Psychology Today: 74

    Iqtest: 101

    ------------------------

    Human Benchmark
    Number memory: 10 digits, 69%
    Reaction Time: 205 ms
    Verbal Memory: 46 points!
    Visual Memory: level 7,
    score 6810!

    MemTrax: 98%, mean reaction time 0.768 seconds!

    Psychology Today: 90
    -though I honestly answered these subjective questions both times, the increased score here is likely reflective of an increased confidence in my memory.

    Iqtest: 110
    ============================== ====

    Human Benchmark-
    Number Memory-You scored 7. You're currently in the top 18 percentile for this test!
    Reaction Time-You scored 309.0. You're currently in the top 32 percentile for this test!
    Verbal Memory-You're currently in the top 17 percentile for this test!
    Visual Memory-You scored 5631. You're currently in the top 21 percentile for this test!

    Metrax- Mean Reaction Time: 0.979 seconds

    Psychology Today- I got 50

    IQ Test- 100 IQ(this was so hard in the middle)

    ------------------------------

    Human Benchmark-
    Number Memory- You scored 7. You're currently in the top 18 percentile for this test!
    Visual Memory- You scored 17723. You're currently in the top 75 percentile for this test!
    Reaction Time- You scored 300.0. You're currently in the top 36 percentile for this test!
    Verbal Memory- You scored 32. You're currently in the top 42 percentile for this test!

    Metrax- Mean Reaction Time:0.925 seconds 86% correct

    Psychology Today- 79

    IQ Test- 106

    ============================== =====================

    Pre "Treatment" Test Results:

    1. Human Benchmark Tests
    a. Number Memory: Level 9 (50%)
    b. Reaction Time: Avg - 358 ms (19%)
    c. Verbal Memory: 44 points (70%)
    d. Visual Memory: Level 8, 8799 points (41%)
    2. Mem Trax Test: 92% correct - 0.856 mean reaction time
    3. Psychology Today Memory Test: 73
    4. General IQ Test: 108 -> finished with approximately 9 minutes left (out of 40).

    -------------------------

    After two weeks on mystery BLR noot at 1 cap bid:
    1. Human Benchmark Tests:
    a. Number Memory: Level 10 (69%); +1 Level
    b. Reaction Time: Avg of 337 ms (24%); Improvement of 21 ms
    c. Verbal Memory: 129 points (98%); improvement of 85 points....
    d. Visual Memory: Level 10, Score of 12,873 (59%); +2 levels, 4074 points
    2. Memtrax: 96% correct, 0.668 second rxn time; +4% and 0.188 seconds
    3. Psychology Today Subjective Memory Questionnaire: Score of 79, 6 point improvement
    4. General IQ Test: 126; +18 points -> I forgot to look at how much time was left when I completed it. But, I would guess it was in the 10-15 minute range.
    BLACK LION RESEARCH
    Innovation distinguishes between a leader and a follower.
    -Steve Jobs

  4. I'll have to try this.

  5. The Nootrol is great stuff. Many things that increase memory, learning etc do so in part by increasing acetylcholine. This is all well and good but increased acetylcholine, over time, decreases dopamine and serotonin leaving us with a net loss and feeling terrible. Brain fog, tiredness and less cerebral function, not more. Nootrol is different. Yes Nootrol increases acetylcholine but it also has multiple ingredients that increase dopamine and serotonin which balances everything out. Keeping things in balance during the neurotransmitter elevation is crucial and is a huge part of why this Nootropic is so successful. Not only does it increase memory, learning, is, social interaction and word recall, but, it improves mood and energy all without the negatives seen with most nootropic products.
    BLACK LION RESEARCH
    Innovation distinguishes between a leader and a follower.
    -Steve Jobs
    •   
       

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