Influence of DHEA administration on 24-hr cortisol concentration

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    Influence of DHEA administration on 24-hr cortisol concentration


    Kroboth PD, Amico JA, Stone RA, Folan M, Frye RF, Kroboth FJ, Bigos KL, Fabian TJ, Linares AM, Pollock BG, Hakala C.
    SourcePharmacodynamic Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA. krobothpd@msx.upmc.edu



    Abstract


    DHEA is marketed and readily available as a daily nutritional supplement to counteract the effects of aging. The effect of DHEA administration on 24-hour plasma cortisol profiles has not been investigated. In this single-blind placebo-controlled crossover study, the effect of DHEA administration on cortisol concentrations was evaluated in healthy older women and men. Once each morning, subjects took either placebo (Days 1 to 7, and 23 to 29) or oral DHEA 200 mg (Days 8 to 22: doses 1 to 15). Twenty-four hour DHEA and cortisol concentrations were measured on Day 1 (placebo), Day 8 (DHEA dose 1), Day 15 (DHEA dose 8), Day 22 (DHEA dose 15), and Day 29 (placebo washout dose 7). DHEA administration resulted in a decrease in plasma cortisol concentrations (mean, peak, and/or AUC) in healthy older women and men. The cortisol-lowering effect of DHEA was more pronounced in women than in men in our study; pairwise differences in concentrations between days showed that relative to Day 1, cortisol was lower on Days 15, 22, and 29 in women (p = 0.0001) and on Day 15 in men (p = 0.002). The mechanism by which DHEA lowers plasma cortisol concentrations merits further investigation.
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    High Cortisol = Big Love Handles
    Low Cortisol = Little/No Love Handles

    I can attest to this when I cycle DHEA.
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    Quote Originally Posted by Cordeen View Post
    High Cortisol = Big Love Handles
    Low Cortisol = Little/No Love Handles

    I can attest to this when I cycle DHEA.
    Yes but

    High cortisol : less joint pain
    Low cortisol : ouch that set of squats really hurt.

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