I get the best results from nutrient partitioners taking a dose immediately post workout, then in 15-30 minutes take my PWO shake. It gets me ready to eat my PWO meal an hour later, less bloat.
I also think it's good taking a dose pre-workout if you carb up. If you have a meal an hour or so before working out, take the Need2Slin 30-60 minutes before the meal and take in 50-75g carbs.
Finally you can take a dose with a higher carb meal to add to the fullness and food pump.
I think it's ideal to take it around your workout the way bodybuilders do with insulin. Get the food loaded in the muscles pre-workout, then fill them back up with nutrients post workout.
Need2Slin is my personal favorite partitioner, you should love it!