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pregolone cream

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    sidnee's Avatar
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    pregolone cream


    where can I buy a compounded cream?

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    Quote Originally Posted by sidnee View Post
    where can I buy a compounded cream?
    You would have to get a compounded cream from a compounding pharmacy.

    But even though it's OTC, I still think you need a doctor to call it in.

    I take 1 ml of a 10% cream or 100 mg transdermally a day.
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    Ttttttt
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    Quote Originally Posted by rick055 View Post
    You would have to get a compounded cream from a compounding pharmacy.

    But even though it's OTC, I still think you need a doctor to call it in.

    I take 1 ml of a 10% cream or 100 mg transdermally a day.
    Yes to the above, but I want to make some guessing here.

    I just heard, I think it was here:

    PROLibraries.com - Online Professional Education
    --------------
    GS02m - Estrogen Metabolism: Modifying Risk in Clinical Practice
    Conference: A4M Orlando 2006
    Speaker: Patrick Hanaway, MD
    April 9, 2006 5:00 pm - 5:40 pm
    ---------------
    that women on TRT that use either oral (pills) or cream Progesterone,
    have a problem with clearing estrogen metabolites.
    They produce lots of them.

    So the solution is to use progesterone in gel.
    ============================== =========

    I know, you are talking pregnenolone, but it may also apply.

    I will dig some more, plus in few days I should have my Estroessence results.
    There is when one see mess if not properly treated.
    If I see something out of line there or even with out, next time I am ordering my pregnenolone as a gel.
    Right now I just started new jar, 2 months supply.

    Wonder if there are different gells?

    I suggest buyng this $20 lecture, I am sure I am missing at least half of very good information.
    Possibly we could have more inteligent discussion if couple of guys would read this.
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    Quote Originally Posted by JanSz View Post
    Yes to the above, but I want to make some guessing here.

    I just heard, I think it was here:

    PROLibraries.com - Online Professional Education
    --------------
    GS02m - Estrogen Metabolism: Modifying Risk in Clinical Practice
    Conference: A4M Orlando 2006
    Speaker: Patrick Hanaway, MD
    April 9, 2006 5:00 pm - 5:40 pm
    ---------------
    that women on TRT that use either oral (pills) or cream Progesterone,
    have a problem with clearing estrogen metabolites.
    They produce lots of them.

    So the solution is to use progesterone in gel.
    ============================== =========

    I know, you are talking pregnenolone, but it may also apply.

    I will dig some more, plus in few days I should have my Estroessence results.
    There is when one see mess if not properly treated.
    If I see something out of line there or even with out, next time I am ordering my pregnenolone as a gel.
    Right now I just started new jar, 2 months supply.

    Wonder if there are different gells?

    I suggest buyng this $20 lecture, I am sure I am missing at least half of very good information.
    Possibly we could have more inteligent discussion if couple of guys would read this.

    Pregenolone IMO topical actually helps keep e2 in check due to helping it control DHT as well as converting to progesterone through the skin unlike orals do (or have not been determined yet )
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    Quote Originally Posted by hardasnails1973 View Post
    Pregenolone IMO topical actually helps keep e2 in check due to helping it control DHT as well as converting to progesterone through the skin unlike orals do (or have not been determined yet )
    HAN
    I am taking about way of getting the pregnenolone into our bodies.
    I am not questioning if we need it or not (not yet, due to lack of knowledge).
    ----------------------------------------
    Apparently (with women using progesterone) form of delivery makes big difference in their estrogene clearing.

    pills
    cream
    gel

    looks like only gel is ok.
    ----------------------------------------

    I am just making wild guess, that possibly it is similar situation with pregnenolone.

    Remember when I was using Androgel I was responding beatifully (average by the book).

    When I changed to Tcream I went down hill.
    ============================== ==========
    Estrogene clearing means, that they produce tonns of first and second Phase

    2-Hydroxyestrone
    4-Hydroxyestrone
    16α-Hydroxyestrone

    2-Methoxyestrone
    4-Methoxyestrone
    Quinones

    and do not have enough (chemicals, vitamins what not)
    to process it and get rid of it.
    ============================== =========
    Some of this are in not big enoug quantity or quality:

    Metabolism of Estrogen
    Phase I
    + Major path (450)
    + Hydroxylation (C2, C4, C16)

    Phase II
    + Glucoronidation
    +Sulfation
    +Methylation

    Genomic diferences are reson for different speed reaction, %% of reactions and speed of

    elimination of different metabolites.
    Different genes = different outcome

    Phase I
    CYP450 1A1 --> 2OH
    CYP450 1B1 --> 4-OH ---> (Quinones Phase II) (cancer)
    CYP450 3A4/5 --> 16OH (cancer)

    Phase II
    COMT
    GST
    ===================
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    Quote Originally Posted by JanSz View Post
    HAN
    I am taking about way of getting the pregnenolone into our bodies.
    I am not questioning if we need it or not (not yet, due to lack of knowledge).
    ----------------------------------------
    Apparently (with women using progesterone) form of delivery makes big difference in their estrogene clearing.

    pills
    cream
    gel

    looks like only gel is ok.
    ----------------------------------------

    I am just making wild guess, that possibly it is similar situation with pregnenolone.

    Remember when I was using Androgel I was responding beatifully (average by the book).

    When I changed to Tcream I went down hill.
    ============================== ==========
    Estrogene clearing means, that they produce tonns of first and second Phase

    2-Hydroxyestrone
    4-Hydroxyestrone
    16α-Hydroxyestrone

    2-Methoxyestrone
    4-Methoxyestrone
    Quinones

    and do not have enough (chemicals, vitamins what not)
    to process it and get rid of it.
    ============================== =========
    Some of this are in not big enoug quantity or quality:

    Metabolism of Estrogen
    Phase I
    + Major path (450)
    + Hydroxylation (C2, C4, C16)

    Phase II
    + Glucoronidation
    +Sulfation
    +Methylation

    Genomic diferences are reson for different speed reaction, %% of reactions and speed of

    elimination of different metabolites.
    Different genes = different outcome

    Phase I
    CYP450 1A1 --> 2OH
    CYP450 1B1 --> 4-OH ---> (Quinones Phase II) (cancer)
    CYP450 3A4/5 --> 16OH (cancer)

    Phase II
    COMT
    GST
    ===================

    If a person is low in cholesterol (under 160) I would recomended pregenolone. Taking 50 mgs topical pregenlone a day i beleived help to keep my e2 in check with out armidex as well other varaibles where consitant. I stopped the preg and my e2 went sky high. With my cholestrtol at 120 I NEED IT FOR SURE other people may not..
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