most bodybuilders under stress respond good to sam-e. If methayation is a problem then idenitify it with proper testing. MY methyation problem stemmed from magneisum defiency from too much ECA and excessive calcium due to amount of protein drinks I consumed. When i figured out the ratio of CA/mg it was like 15 to 1 and never even knew it this caused excessive cortisol which further depelted magneisum, zinc levels and also caused e2 to rise, along with inuslin resistance (shbg was 10).First of all look at alkaline phospotase if it is below 60-70 then look to thyroid /adrenal, magneisum, zinc as problems. List up your complete blood work and see what we can see. Rash is histmaine response from undermethyation because it can not detoxify them and they build up. If you have reaction from wine then molybdenum will help sulfization pathways. Right now my freind you are low on gluthione and that needs to be checked via lvier detoxificaton profile from great smokies to see where liver pathways are blocked.
Focus on identify altered pathways in liver will retifcy probably 60-80 % of peoples illness and hormonal imbalnaces. With out methyation working properly your aging cellular very rapidly and detoxifcation is impaired as well as adrneals and thyroid..Check spectracell testing for minerals that found alot of my problems and pointed out alot of hidden estrogen imbalnaces later verified by estroesccence test. If you are undermethyated bank on estrogen metabolism being back logged as well in methaytion of bad estrogens