A New Drug on the Horizon Fispemifene. - AnabolicMinds.com

A New Drug on the Horizon Fispemifene.

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    A New Drug on the Horizon Fispemifene.


    Fispemifene is a new, selective estrogen receptor antagonist that is being developed as an oral treatment for testosterone deficiency and associated disorders in men. Symptoms of low testosterone include sexual dysfunction, muscle wasting, reduced bone density, lowered energy levels and glucose intolerance. Unlike testosterone replacement therapies, fispemifene utilizes the body's normal feedback mechanism to increase testosterone levels into, but not beyond, the normal range. By blocking estrogen feedback to the pituitary with a drug like fispemifene, the pituitary increases LH and FSH secretion which increases testosterone secretion. As these rising testosterone levels feedback on the pituitary, LH and FSH secretion return toward normal and testosterone reaches a new, albeit higher, steady state level. Based on this mechanism of action, fispemifene is being studied for the treatment of androgen deficiency and associated symptoms. We believe that increased production of testosterone may treat many of the symptoms of low testosterone. In a Phase II study we conducted in hypogonadal men, fispemifene increased total testosterone levels by 78% over 28 days of treatment.

    QuatRx : Fispemifene

    Clinical Trial: Efficacy and Safety Evaluating Fispemifene in the Treatment of Hypogonadal Men With Erectile Dysfunction Unresponsive to PDE5 Inhibitors.

    This could mean for me no more shots or high E2 problems.
    Phil

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    Quote Originally Posted by pmgamer18 View Post
    Fispemifene is a new, selective estrogen receptor antagonist that is being developed as an oral treatment for testosterone deficiency and associated disorders in men. Symptoms of low testosterone include sexual dysfunction, muscle wasting, reduced bone density, lowered energy levels and glucose intolerance. Unlike testosterone replacement therapies, fispemifene utilizes the body's normal feedback mechanism to increase testosterone levels into, but not beyond, the normal range. By blocking estrogen feedback to the pituitary with a drug like fispemifene, the pituitary increases LH and FSH secretion which increases testosterone secretion. As these rising testosterone levels feedback on the pituitary, LH and FSH secretion return toward normal and testosterone reaches a new, albeit higher, steady state level. Based on this mechanism of action, fispemifene is being studied for the treatment of androgen deficiency and associated symptoms. We believe that increased production of testosterone may treat many of the symptoms of low testosterone. In a Phase II study we conducted in hypogonadal men, fispemifene increased total testosterone levels by 78% over 28 days of treatment.

    QuatRx : Fispemifene

    Clinical Trial: Efficacy and Safety Evaluating Fispemifene in the Treatment of Hypogonadal Men With Erectile Dysfunction Unresponsive to PDE5 Inhibitors.


    This could mean for me no more shots or high E2 problems.
    Phil
    Thats awesome news !!
    Progrrmer if I was taking testocreme in plo base and already had problems with estrogen conversion to begin with (zinc deficncy) is it possible for taking the 10% creame that it was converting straight to estrogen rather then tesosterone resulting in elevated shbg and even lowering serum testosterone?
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    Quote Originally Posted by pmgamer18 View Post
    Fispemifene is a new, selective estrogen receptor antagonist that is being developed as an oral treatment for testosterone deficiency and associated disorders in men. Symptoms of low testosterone include sexual dysfunction, muscle wasting, reduced bone density, lowered energy levels and glucose intolerance. Unlike testosterone replacement therapies, fispemifene utilizes the body's normal feedback mechanism to increase testosterone levels into, but not beyond, the normal range. By blocking estrogen feedback to the pituitary with a drug like fispemifene, the pituitary increases LH and FSH secretion which increases testosterone secretion. As these rising testosterone levels feedback on the pituitary, LH and FSH secretion return toward normal and testosterone reaches a new, albeit higher, steady state level. Based on this mechanism of action, fispemifene is being studied for the treatment of androgen deficiency and associated symptoms. We believe that increased production of testosterone may treat many of the symptoms of low testosterone. In a Phase II study we conducted in hypogonadal men, fispemifene increased total testosterone levels by 78% over 28 days of treatment.

    QuatRx : Fispemifene

    Clinical Trial: Efficacy and Safety Evaluating Fispemifene in the Treatment of Hypogonadal Men With Erectile Dysfunction Unresponsive to PDE5 Inhibitors.

    This could mean for me no more shots or high E2 problems.
    Phil
    =====================
    Very nice find, good work Phil.
    This new medicine may work for me too and many others.
    ======================
    The same company have drug QRX-431.
    QuatRx : QRX-431
    Here I learned about T3 :
    "The naturally occurring thyroid hormone, T3, has been shown to lower LDL cholesterol and Lp(a) through its effects on the thyroid beta receptor, but T3 also stimulates the thyroid alpha receptor which produces potentially harmful increases in heart rate. "

    It look like it pays to take maximum dose of Armour,
    dose that would still not increase heart rate.
    Among other things the pay off is lower LDL and Lp(a).
    My LDL=143(0-99)mg/dL (high)
    Lipoprotein(a)=13mg/dL(0-30)
    ============================== ====
    I am currently at 2grains of Armour and 10mg of Cortef.
    Never had any problems while increasing dose.
    Heart rate or blood pressure did not changed.
    Temperature is higher then on beginning (36.0C= 96.8F)
    now36.4C=97.88F),
    but it still fluctuates quite a bit (36C=96.8F to 37C=98.6)
    most of the time it is at 36.4C=97.88F
    my blood test is still two months away,
    what do you say, should I increase slowly to
    3grains of Armour???

    I started with
    Free (T3) --2.9pg/mL(2.3-4.2)
    •   
       

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    Quote Originally Posted by hardasnails1973 View Post
    Thats awesome news !!
    Progrrmer if I was taking testocreme in plo base and already had problems with estrogen conversion to begin with (zinc deficncy) is it possible for taking the 10% creame that it was converting straight to estrogen rather then tesosterone resulting in elevated shbg and even lowering serum testosterone?
    All I can tell you is find out what is low and why fix it keep everything normal as possable. If your low on Zinc and can't find any reason for this get some Zinc/Copper and take it. Don't just take something because someone said it worked for them you will be on a ton of ****. Just find what is wong and fix it. In my case I have low T, low cortisol, low Thyroid, High Estradiol and low DHEA. My reasion for this is a Pituitary so I keep this undre control. I don't use gels because the cause me joint and muscle pain and my levels don't go high enough because my skin does not let it though. I do best on shots every 3 days and HCG. You need to get to a Dr. that knows how to look for this and fix it. Like Dr. John.
    Phil
    Phil
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    Is one of the reason you are concerned about estrogen antagonism in the brain is because it might create a serotonin deficiency?

    Also isn't it a MAOI inhibitor in the brain as well?

    I am just trying to understand all this hormone stuff and am testing myself.
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    Well, i will do some more digging but as always i am looking forward to your future findings.
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    Quote Originally Posted by Dr. John View Post
    Mark my words: time will prove estrogen antagonism is a terrible way to treat testosterone deficiency.

    We NEED the actions of estrogens in our bodies. I am particularly concerned about the brain.
    But what exactly is an ideal estradoil number?

    Mine is 43 (10 - 50, quest diagnostics). Dr John, would you consider this high

    Ive heard that higher end estradoil levels do help with some things, such as HDL(mine is high) and youthfull appearance of skin(me again)
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    Quote Originally Posted by plymouth city View Post
    But what exactly is an ideal estradoil number?

    Mine is 43 (10 - 50, quest diagnostics). Dr John, would you consider this high

    Ive heard that higher end estradoil levels do help with some things, such as HDL(mine is high) and youthfull appearance of skin(me again)
    I guess it is all about how you feel if my E2 was this high I would be having panic attacks, breaking out in rashs, have bad ED, not able to reach an orgasm, have hard and sore nipples, look like I have a sunburn on the upper part of my body, feel hot and sweat allday, have slow voiding and a low pain in my prostate. Bad brain fog and feel like flying off the handle a lot.
    Phil
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    Quote Originally Posted by pmgamer18 View Post
    I guess it is all about how you feel if my E2 was this high I would be having panic attacks, breaking out in rashs, have bad ED, not able to reach an orgasm, have hard and sore nipples, look like I have a sunburn on the upper part of my body, feel hot and sweat allday, have slow voiding and a low pain in my prostate. Bad brain fog and feel like flying off the handle a lot.
    Phil
    I suffer from anxiety from time to time, and emotional at times as well. And I also suffer from BAD BAD brain fog. My forgetfullness is on par with an old mans.

    The ED and other side effects though is difficult to say though. Im only 27 with at near 500 TT level and a very low BF%. Basically Im young and physically healthy. So, meaning Ive got a very healthy cardiovascular system and all other things connected, and this may be TEMPORARILY offesetting alot of the side effects you have noted. If I was older and not in such top physical shape, I wouldn't bet against not having alot the other things youve noticed.
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    Quote Originally Posted by plymouth city View Post
    But what exactly is an ideal estradoil number?

    Mine is 43 (10 - 50, quest diagnostics). Dr John, would you consider this high

    Ive heard that higher end estradoil levels do help with some things, such as HDL(mine is high) and youthfull appearance of skin(me again)
    LEF desired (good) ranges, their values are per LabCorp tests

    Estradiol 10–30 pg/mL
    Estriol <2.0 mg/dL
    Estrogens Total 40–115 pg/mL
    Estrone 12–72 pg/mL

    Print Friendly
    Blood Testing Protocols
    Updated: 07/18/2006
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    Quote Originally Posted by JanSz View Post
    LEF desired (good) ranges, their values are per LabCorp tests

    Estradiol 1030 pg/mL
    Estriol <2.0 mg/dL
    Estrogens Total 40115 pg/mL
    Estrone 1272 pg/mL

    Print Friendly
    Blood Testing Protocols
    Updated: 07/18/2006

    Cool, thanks. I only had estradoil measured. Im not sure these other numbers, weren't checked.
    Estriol <2.0 mg/dL
    Estrogens Total 40115 pg/mL
    Estrone 1272 pg/mL)

    Im intested in taking as few drugs as possible, and if its something my MD thinks as an issue not messing with, thats fine with me.
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    bump to see if this ever came out... and how effective it is (im aware its from 07)
    Quote Originally Posted by alwaysgaining View Post
    I've also done fasting and doseing and felt grealt anabolicness , deffint hunger but I'm stronger than that keep full and vascular and strength gose up
    http://anabolicminds.com/forum/cycle-info/177245-swollen87s-training-log.html
  

  
 

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