Best write up I've seen:
I have seen misinformation on Clomid too often - Men on TRT taking Clomid thinking that it will keep their testes producing testosterone (T) while on TRT. WRONG. Let me try to clear up this mess.
T production is controlled by the hypothalamus-pituitary-testicular axis (HTPA). I like to analogize the HPTA regulation of androgens and estrogens to a room thermostat.
Thermostat clicks ON = When the hypothalamus (H) senses that estrogen (E) is too low, it releases Gonadotropin-releasing hormone (GnRH), which tells the pituitary (P) to release luteinizing hormone (LH), which in turn tells the balls to make T. Some of this T will be aromatized into E.
Thermostat clicks OFF = When E levels are adequate, the H stops releasing GnRH. This means that nothing is telling the P to release LH. That in turn, means nothing is telling the testes to make T.
How does Clomid raise T levels? It tricks the H such that it doesn’t see as much E as is there. So relative to my thermostat analogy, Clomid causes the thermostat to GET STUCK IN THE ON POSITION for longer than it would normally. Thus, more GnRH--->more LH--->more--->T production.
What happens when you take Clomid while on an APPROPRIATE AMOUNT of TRT? Well, I left something very important out in my thermostat analogy. You see, the H senses androgens as well as E. So when you are on TRT, the exogenous T shut the HTPA. So, properly-dosed TRT causes the thermostat to be stuck in the OFF position. Take all the Clomid you want, the HTPA will not respond b/c it is suppressed by the exogenous T. Sure Clomid will still blind the H to your Estrogen. However, in this case It won’t matter. The HTPA is shut.
Justin Saya Rand McClain Nelson Vergel Gene Devine