I have had a major problem with HCG and its ability to output so much estrogen in my body. I took a larger than normal dose on Monday (1500 IU) due to missing a couple shots due to work and I felt terrible. My estrogen had to skyrocket: felt bloated, crabby as hell, itchy nipples, had little to no energy. Been taking a lot of anti-estrogen over the past few days and starting to feel better. I seem to have this issue worsen when I'm not taking a liver care supplement like NAC, TUDCA, or thistle. Does the liver have something to do with HCG's high aromatization rate? I'm on TRT (200mg/week) as well with the doctor prescribing 3000 IU HCG/week. I'm going to the doctor tomorrow and telling her I need to be on potent anti-estrogen if we are going to continue the HCG that high. Arimidex won't cut it.