Undermethylation and Autoimmune issues

[Duhhbeach]

Hi everyone, I fairly new to this forum. Lots of very knowledgeble posters here.
To the Matrix or anyone else who can help:
I was recently diagnosed with Hashimoto's thyroiditis (TPO ab at 1022)...and put on Levoxothyrine 50mcg, advised to be gluten and dairy free and supplementing with Vitamin D with K2, Pregnenalone, Vitamin C, Zinc, selenium taken with Vitamin A...I have installed shower filter changed deodorant to aluminum free and fluoride free toothpaste, and trying to get all the chemicals out of my house any way I can..
I eat clean and I am also currently trying to clear my methylation pathway so I can start to take methylated B12 etc. and I am on a low sulphur/thiol diet...I have an appointment with ENdo next week but I have no clue if he is versed in MTHFR issues...I sent my 23andme results ahead of my visit and Im hoping he has a clue...I have been researching a lot online and I have learned a lot but I am hoping to hear from Matrix regarding my DNA test results I am posting below.


Thanks!

ALLERGY
Gene rsID Minor Allele Genotype Phenotype
1 HLA rs2155219 G GG +/+
2 HLA rs7775228 C TT -/-
CLOTTING FACTORS
Gene rsID Minor Allele Genotype Phenotype
1 CETP rs1800775 C AC +/-
2 CYP4V2 rs13146272 C AA -/-
3 F10 rs3211719 G AA -/-
4 F11 rs2036914 T CT +/-
5 F11 rs2289252 T CT +/-
6 F12 rs1801020 A GG -/-
7 F3 rs1324214 A GG -/-
8 F5 rs6025 T CC -/-
9 F7 rs6046 T GG -/-
10 F9 rs6048 G AA -/-
11 GP6 rs1613662 G AG +/-
12 HRG rs9898 T CC -/-
13 ITGB3 rs5918 C CC +/+
14 KNGI598T rs2731672 T CC -/-
15 NR1I2 rs1523127 C CC +/+
16 SERPINC1 rs2227589 T CC -/-
DETOX
Gene rsID Minor Allele Genotype Phenotype
1 CTH rs1021737 T GG -/-
2 CYP1A1 rs1799814 T GG -/-
3 CYP1A1 rs4986883 C TT -/-
4 CYP1A1 rs1048943 G TT -/-
5 CYP1A2 rs762551 C AA -/-Gene rsID Minor Allele Genotype Phenotype
6 CYP1B1 L432V rs1056836 G CC -/-
7 CYP1B1 N453S rs1800440 C TT -/-
8 CYP1B1 R48G rs10012 G GG +/+
9 CYP2A6*2 A1799T rs1801272 A AA +/+
10 CYP2C19 rs12248560 T CT +/-
11 CYP2C9 rs1057910 C AA -/-
12 CYP2C9*2 C430T rs1799853 T CT +/-
13 CYP2D6 rs1065852 A GG -/-
14 CYP2D6 rs1135840 G CG +/-
15 CYP2D6 T2850C rs16947 A AG +/-
16 CYP2E1 rs55897648 A GG -/-
17 CYP2E1*1B G9896C rs2070676 G CG +/-
18 CYP2E1*4 A4768G rs6413419 A GG -/-
19 CYP3A4 rs12721627 G GG +/+
20 CYP3A4 rs4986910 G AG +/-
21 CYP3A4 rs2740574 C TT -/-
22 CYP3A4*2 S222P rs55785340 G AA -/-
23 GPX3 rs8177412 C TT -/-
24 GSTM1 rs1056806 T CC -/-
25 GSTM1 rs4147567 G AA -/-
26 GSTM1 rs4147565 A GG -/-
27 GSTM1 rs2239892 G AA -/-
28 GSTP1 rs1138272 T CC -/-
29 GSTP1 rs1695 G AA -/-
30 NAT1 rs4986782 A GG -/-
31 NAT2 rs1208 G AG +/-
32 NAT2 rs1801279 A GG -/-
33 NAT2 rs1799930 A GG -/-
34 NAT2 rs1799931 A GG -/-
35 NAT2 rs1801280 C CT +/-
GLUTEN INTOLERANCE
Gene rsID Minor Allele Genotype Phenotype
1 HLA rs2858331 G AG +/-
2 HLA-DQA1 rs2187668 T CC -/-IGA
Gene rsID Minor Allele Genotype Phenotype
1 CFH rs6677604 A GG -/-
2 HLA rs9271366 G AG +/-
3 HLA-DPB2 / COL11A2P rs1883414 A GG -/-
4 HLA-DQA2 rs9275224 A AG +/-
5 HORMAD2 rs2412971 A AA +/+
6 IFIH1 rs1990760 T TT +/+
7 IGF1R rs2229765 A GG -/-
8 IRF5 rs4728142 A AA +/+
9 MTC03P1 rs2856717 A AG +/-
10 MTC03P1 rs9275596 C CT +/-
11 PSMB8 rs9357155 A GG -/-
12 TRAF1 rs3761847 G AA -/-
IGE
Gene rsID Minor Allele Genotype Phenotype
1 C3 rs366510 G GT +/-
2 C3 rs10402876 C CG +/-
3 CD14 rs2569191 C CT +/-
4 DARC rs2814778 C TT -/-
5 FCER1A rs2427837 A AA +/+
6 FCER1A rs2427824 T CC -/-
7 FCER1A rs2494262 A AA +/+
8 FCER1A rs2427827 T CC -/-
9 FCER1A rs2251746 C CC +/+
10 FCER1A / OR10J2P rs10489854 T CC -/-
11 IL13 rs1800925 T CT +/-
12 IL13 rs1295685 A AA +/+
13 IL5 rs2069812 G GG +/+
14 RAD50 rs17772583 G AA -/-
15 RAD50 rs17772565 T CC -/-
16 RAD50 rs2040704 G AG +/-Gene rsID Minor Allele Genotype Phenotype
17 RAD50 rs2240032 T CT +/-
18 RAD50 rs6884762 T CC -/-
19 RAG1 rs3740955 A AA +/+
20 SOCS1 rs33977706 A AC +/-
IGG
Gene rsID Minor Allele Genotype Phenotype
1 FCGR2A rs1801274 G AG +/-
2 GSTM3 rs7483 T CC -/-
3 Intergenetic rs2013111 C CC +/+
4 MUC21 rs1634731 G AA -/-
5 TBC1D27 rs3751987 A AG +/-
6 TNFRSF13B rs4792800 G AA -/-
METHYLATION
Gene rsID Minor Allele Genotype Phenotype
1 ACAT1 rs3741049 A GG -/-
2 ACE Del16 rs4343 G AG +/-
3 AGT M235T/C4072T rs699 A AA +/+
4 AHCY-01 rs819147 C TT -/-
5 AHCY-02 rs819134 G AA -/-
6 AHCY-19 rs819171 C TT -/-
7 ATG9B (NOS3 G10T) rs7830 T GT +/-
8 BHMT R239Q rs3733890 A GG -/-
9 BHMT-02 rs567754 T CC -/-
10 BHMT-04 rs617219 C AA -/-
11 BHMT-08 rs651852 T CC -/-
12 C18orf56 (TYMS) rs502396 T TT +/+
13 CBS A13637G rs2851391 T CT +/-
14 CBS A360A rs1801181 A AG +/-
15 CBS C19150T rs4920037 A GG -/-
16 CBS C699T rs234706 A GG -/-
17 CBS N212N rs2298758 A GG -/-Gene rsID Minor Allele Genotype Phenotype
18 CLCN6 rs13306560 T CT +/-
19 CLCN6 rs13306561 G AG +/-
20 CLCN6 rs3737964 T CC -/-
21 DAO rs2070586 A AG +/-
22 DAO rs3741775 C AC +/-
23 DAO rs2111902 G GT +/-
24 DHFR rs1643649 C CT +/-
25 FOLR1 rs2071010 A GG -/-
26 FOLR2 rs651933 G GG +/+
27 FOLR3 rs7926875 A CC -/-
28 FOLR3 rs7925545 G AA -/-
29 FUT2 rs601338 A AG +/-
30 FUT2 rs602662 A AA +/+
31 FUT2 rs492602 G AG +/-
32 G6PD rs1050829 C TT -/-
33 G6PD rs1050828 T CC -/-
34 GAD1 rs769395 G GG +/+
35 GAD1 rs10432420 A AG +/-
36 GAD1 rs3749034 A GG -/-
37 GAD1 rs2241165 C TT -/-
38 GAD1 rs701492 T TT +/+
39 GAD1 rs3791878 T TT +/+
40 GAD1 rs3791850 A GG -/-
41 GAD1 rs769407 C CC +/+
42 GAD1 rs12185692 A CC -/-
43 GAD1 rs3791851 C CC +/+
44 GAD1 rs2058725 C TT -/-
45 GAD1 rs3828275 T CC -/-
46 GAD2 rs1805398 T GG -/-
47 GAMT rs55776826 T CC -/-
48 GAMT rs17851582 A GG -/-
49 GIF rs558660 A GG -/-
50 MAO A R297R rs6323 G TT -/-
51 MAOB rs1799836 C CT +/-
52 MIR4761 (COMT -61 P199P) rs769224 A GG -/-
53 MIR4761 (COMT H62H) rs4633 T CC -/-
54 MIR4761 (COMT V158M) rs4680 A GG -/-Gene rsID Minor Allele Genotype Phenotype
55 MIR4761 (COMT) rs6269 G GG +/+
56 MTHFD1 C105T rs1076991 T TT +/+
57 MTHFD1 G1958A rs2236225 A AA +/+
58 MTHFD1L rs6922269 A AG +/-
59 MTHFD1L rs11754661 A AG +/-
60 MTHFD1L rs17349743 C CT +/-
61 MTHFD1L rs803422 A AG +/-
62 MTHFR rs4846049 T GT +/-
63 MTHFR rs17037396 T CC -/-
64 MTHFR rs12121543 A CC -/-
65 MTHFR rs1476413 T CC -/-
66 MTHFR rs17037390 A AG +/-
67 MTHFR (LOC100506310) rs4846048 G AG +/-
68 MTHFR 03 P39P rs2066470 A GG -/-
69 MTHFR A1298C rs1801131 G GT +/-
70 MTHFR A1572G rs17367504 G AG +/-
71 MTHFR C677T rs1801133 A GG -/-
72 MTHFR G1793A (R594Q) rs2274976 T CC -/-
73 MTHFS rs6495446 T CT +/-
74 MTR A2756G rs1805087 G AG +/-
75 MTRR A66G rs1801394 G AG +/-
76 MTRR H595Y rs10380 T CC -/-
77 MTRR K350A rs162036 G AA -/-
78 MTRR R415T rs2287780 T CC -/-
79 MTRR-11 A664A rs1802059 A GG -/-
80 NOS1 rs3782206 T CC -/-
81 NOS2 rs2297518 A GG -/-
82 NOS2 rs2274894 T GT +/-
83 NOS2 rs2248814 A AG +/-
84 NOS3 rs1800783 A AT +/-
85 NOS3 rs3918188 A AC +/-
86 NOS3 rs1800779 G AG +/-
87 NOS3 T786C rs2070744 C CT +/-
88 PEMT rs4646406 T TT +/+
89 PEMT rs4244593 T TT +/+
90 SHMT1 C1420T rs1979277 A GG -/-
91 SLC19A1 rs1888530 C CT +/-Gene rsID Minor Allele Genotype Phenotype
92 SLC19A1 rs3788200 A AG +/-
93 SOD2 rs4880 G AA -/-
94 SOD2 rs2758331 A CC -/-
95 SOD3 rs2855262 C CT +/-
96 TCN1 rs526934 G AA -/-
97 TCN2 C766G rs1801198 G CG +/-
98 VDR Bsm rs1544410 T CC -/-
MITOCHONDRIAL FUNCTION
Gene rsID Minor Allele Genotype Phenotype
1 ATP5C1 rs2778475 A AG +/-
2 ATP5C1 rs12770829 T CT +/-
3 ATP5C1 rs1244422 T CT +/-
4 ATP5C1 rs4655 C CT +/-
5 ATP5C1 rs1244414 T CC -/-
6 ATP5G3 rs36089250 C TT -/-
7 ATP5G3 rs185584 G AA -/-
8 CCL2 rs1024611 G AA -/-
9 COX5A rs8042694 G AA -/-
10 COX6C rs4510829 A AG +/-
11 COX6C rs4626565 C CT +/-
12 COX6C rs7828241 C AC +/-
13 COX6C rs12544943 G AG +/-
14 COX6C rs1135382 A AG +/-
15 COX6C rs7844439 A AC +/-
16 NDUFS3 rs4147731 A GG -/-
17 NDUFS3 rs4147730 A GG -/-
18 NDUFS3 (KBTBD4) rs2233354 C TT -/-
19 NDUFS7 rs1142530 T CC -/-
20 NDUFS7 rs2332496 A GG -/-
21 NDUFS7 rs7258846 T GG -/-
22 NDUFS7 rs11666067 A CC -/-
23 NDUFS7 rs2074895 A CC -/-
24 NDUFS7 rs7254913 G GG +/+
25 NDUFS7 rs809359 G AG +/-Gene rsID Minor Allele Genotype Phenotype
26 NDUFS8 rs4147776 C AA -/-
27 NDUFS8 rs1051806 T CC -/-
28 NDUFS8 rs1104739 C AC +/-
29 NDUFS8 rs3115546 G TT -/-
30 NDUFS8 rs999571 A AG +/-
31 NDUFS8 rs2075626 C CT +/-
32 NDUFS8 rs1122731 A AG +/-
33 SLC19A1 rs1051266 C CT +/-
34 UQCRC2 rs11648723 T GG -/-
35 UQCRC2 rs6497563 C TT -/-
36 UQCRC2 rs4850 A GG -/-
OTHER IMMUNE FACTORS
Gene rsID Minor Allele Genotype Phenotype
1 4q27 Region rs6822844 T GG -/-
2 ADD1 G460W rs4961 T GG -/-
3 APOE rs429358 C TT -/-
4 ATG16L1 rs10210302 T CC -/-
5 HLA-DRB1 rs660895 G AA -/-
6 IL13 rs20541 A AA +/+
7 IL4R rs1801275 G AG +/-
8 MEFV rs3743930 C CC +/+
9 MEFV rs11466023 A GG -/-
10 STAT4 rs10181656 G CG +/-
11 TNF rs1800629 A GG -/-
12 TNF rs361525 A GG -/-
13 TYR rs28940879 C GG -/-
SULFOTRANSFERASE
Gene rsID Minor Allele Genotype Phenotype
1 SULT1A1 rs7193599 C AA -/-
2 SULT1A1 rs7192559 T CC -/-
3 SULT1A1 rs1801030 C TT -/-Gene rsID Minor Allele Genotype Phenotype
4 SULT1A1 rs9282862 C TT -/-
5 SULT1A1 rs4149381 G TT -/-
6 SULT1A1 rs6498090 A GG -/-
7 SULT1A1 rs1042157 A -- NC
8 SULT1A1 rs8057055 A CC -/-
9 SULT2A1 rs296366 T CC -/-
10 SULT2A1 rs11569679 T CC -/-
11 SULT2A1 rs2910393 T CC -/-
12 SULT2A1 rs11083907 A GG -/-
13 SULT2A1 rs4149448 G AA -/-
14 SULT2A1 rs4149452 T CC -/-
15 SULT2A1 rs2547231 C AA -/-
16 SULT2A1 rs296365 G GG +/+
17 SULT2A1 rs8113396 G AA -/-
18 SULT2A1 rs2547242 C TT -/-
19 SULT2A1 rs4149449 T CC -/-
THYROID
Gene rsID Minor Allele Genotype Phenotype
1 CTLA4 rs231775 G AA -/-
2 FOXE1 rs1867277 A AG +/-
3 FOXE1 rs7043516 C AA -/-
4 FOXE1 rs10984009 A GG -/-
TONGUE TIE
Gene rsID Minor Allele Genotype Phenotype
1 IRF6 rs987525 A AC +/-
2 IRF6 rs861020 A GG -/-
3 RARA rs7217852 G AG +/-
4 RARA rs9904270 T CT +/-
5 TBX22 rs41307258 A AT +/-Report generated by Livewello 23andMe App

 

[Mr.TT]

I would post this on

http://forums.phoenixrising.me/index.php?forums/detox-methylation-b12-glutathione-chelation.6/

 

[Duhhbeach]

Thanks Mr. TT I will take your advice

 

[Duhhbeach]

I am still hoping to hear From Matrix and a few others ...:newbie:

 

[The Matrix]

With out case history, family history and proper supplementation. Actually I can probably pull the family history from hear tell you more about your self then you want to know. LOL I done close to 1000 of these reports already. Unfortunately I am not going to strain my eyes looking at this thing. Put it in the proper PDF form would be helpful. BTW I am one of the ones who is doing a lot of the research in these genes. probably about 15% of the chart from my research.. This report is missing a lot of the major ones COMT and a few others which are crucial to the case. Why I use Mthfrsupport.com application..

 

[Duhhbeach]

View attachment Livewelloresults.pdf

Hi Matrix,
I have attached PDF of my Livewello report.
My mother and my sister both have thyroid issues, and most likely my deceased grandmother. Mother has undiagnosed Hashimotos, sister has Graves disease.
Mother and sister have Mitral valvle prolapse. I Have have LGL syndrome which is outdated Diagnosis...causes palpitations..
Stated having extreme fatigue in my early thirties and depression , meds never helped. I have gained and lost the same 20 lbs but most recently my weight is stable but my muscle tone is not what it should be, skin is saggy and crepe like.
Thanks!

 

[The Matrix]

Bro you got a lot of stuff going on...it would take me close to a damn hour to even start to explain this stuff along to type it all out. The history you provided was only 10% of what I normally require. I do about 20 of these things a week.

HAve you ever taken cipro or levaquin in the past?
Does you family have history of addictions (drug, alcohol, or other addictive behaviors)
I can could sit here and ask you numerous questions which I can see the answers already present with in the information presented.

 

[Duhhbeach]

Hi Matrix,
I took Cipro for travelers diarrhea back in 2002. That is the last time I can remember taking it.
No, Not a lot of addicton problems in my family...I have a half sister with drug issues that's all.
Can you please tell me What other things can you see that I should look further into or address?
I want to get back into good physical shape, it is really bugging me...that and my non existent libido and hair loss are symptoms that bother me the most.

Thanks Again.