Time frame to reduce SHBG & feel normal again?

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    Time frame to reduce SHBG & feel normal again?


    Hello everyone. New person here. Did a search and read many threads. Pardon my long thread but I am concerned.

    Has anyone been able to retrieve their energy and libido pre-high SHBG?
    I was 47 years of age, 5'11 and weighed 170lbs. Have always been healthy, sharp minded and with never ending energy.(I mean I had the energy of a 20year old through my 30s and early 40s.) Noticed a decline late last year in the attributes mentioned above. I thought it was due to my wife and I being separated and presumed I would snap out of it. I started a cardio routine in January 2012 and started going 4x per week with good results for overall energy but I will still had afternoon mental fogginess.
    I was feeling tired every now and then and still had loss of libido and visited a Dr for full bloodwork and had the following results:

    June 07,2012 Labcorp Tampa

    Serum T 970, 348-1197 ng/dl scale
    Free T 12.7, 6.8-21.5 pg/ml scale
    Pregnenolone 14ng/dl scale not listed
    Reverse T3 26.3, 30-100 ng/ml scale
    DHEA 208.2, 44.3-331 ug/dl scale
    SHBG 87.5, 16.5 -55.9nmol/l scale
    Vitamin D 26.3, 30-100ng/ml

    Otherwise all was in normal range. Estradiol was 16.1 on a scale of 7.6-42.6pg/ml

    Dr. Started me on Pregnenolone,100mg, and Vitamin D and I started a serious strength training progam instead of cardio.(I have insomnia from the cardio due to be revved up at night after a workout) I have gained much strength and definition since the first week of June when starting lifting. Mental fogginess went away. Energy is usually quite good. Libido is low but then my wife and I are still separated and I presume it is because of that situation.

    I recently, Sept 18.2012, went for a blood retest and had the following results:

    Serum T 755, 348-1197ng/dl scale
    Free T 9.8, 6.8-21.5pg/ml scale
    Pregnenolone 32ng/dl no scale
    Reverse T3 26.1, 13.5-34.2ng/ml
    DHEA 243.1, 44.3-331ug/dl scale
    SHBG 73.9, 16.5-55.9nmol/l scale
    Vitamin D 38.5, 30-100 ng/ml scale

    I was rather disappointed at the reduction in T levels and still high SHBG. I still have to continuing supplementing with Vitamin D and Preg. Dr. believes I have an inflamed liver or G.I. track and gave me a detox power to take every day until the next retest in 90days. Again, I truly worked hard at physical activity +zinc supplements, horny goat weed,food selection,etc. I was happy until the results were revealed. Now, I wonder how much progression can actually be done and what time frame I am looking at?
    Anyone have input on these questions?

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    Quote Originally Posted by UCSMiami View Post
    I was rather disappointed at the reduction in T levels and still high SHBG. I still have to continuing supplementing with Vitamin D and Preg. Dr. believes I have an inflamed liver or G.I. track and gave me a detox power to take every day until the next retest in 90days. Again, I truly worked hard at physical activity with zinc supplements, horny goat weed. I was happy until the results. Now, I wonder how much progression can actually be done and what time frame I am looking at?
    Anyone have input on these questions?
    Incase it works, will you share with us the name of this "DETOX POWDER"????? PLEASE...
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    If you want a short term shbg inhibitor u can stack something like exemestane and stinging nettle. Will drop your shbg significantly in a short time span but you can't run it long term with the same effects. But at least you can be certain shbg is the cause
    CELTIC LABS REP
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    ^^Yes of course. I return for the results the first week of January.

    ^I purchase some stinging nettle yesterday. I note exemestane is a drug and would rather be all natural. Have never used a prescription drug. I have been that healthy all these years. I know I have to find the root cause of the high SHBG. Strange, I have been feeling wonderful the previous several weeks as I got into my stride with the workouts and the Vit. D and Preg. eliminated the mental fogginess. Not quite pre-2011 levels but a considerable improvement over earlier this year.
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    Do you feel sad and depressed?
    I think is because of the separation too, and although it has not much to do with test production since yours is almost 1000, I believe is the mental aspect that is the culprit. There are many chemical reactions taking place in your head and when our bodies are stressed mentally and physically other organs inside go array. Some ppl get very attached to their mates and when that bond gets broken the brain goes crazy.
    I've been there and done that. It's quite annoying to say the least. Work on geting your head in the right place and get your spouse out of the picture and begin the mental healing first. How long has it been since separation if you dont mind me asking?

    BTW, your test is lower because you prob traininig too hard. Back off it wont help you but end up overtraining. Do the same type training when your test was close to 1000.
    I had same bouts with separation issues where my sex drive would plumed for 6-12 months then would come back on its own. It was all mental because it happened every time I would break up with a girl.
    I mean in your case could be the liver anything is possible but I bet on the mental issue much more.
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    Do you feel sad and depressed?
    I think is because of the separation too, and although it has not much to do with test production since yours is almost 1000, I believe is the mental aspect that is the culprit. There are many chemical reactions taking place in your head and when our bodies are stressed mentally and physically other organs inside go array. Some ppl get very attached to their mates and when that bond gets broken the brain goes crazy.
    I've been there and done that. It's quite annoying to say the least. Work on geting your head in the right place and get your spouse out of the picture and begin the mental healing first. How long has it been since separation if you dont mind me asking?

    BTW, your test is lower because you prob traininig too hard. Back off it wont help you but end up overtraining. Do the same type training when your test was close to 1000.
    I had same bouts with separation issues where my sex drive would plumed for 6-12 months then would come back on its own. It was all mental because it happened every time I would break up with a girl.
    I mean in your case could be the liver anything is possible but I bet on the mental issue much more.
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    Quote Originally Posted by vassille View Post
    Do you feel sad and depressed?I think is because of the separation too, and although it has not much to do with test production since yours is almost 1000, I believe is the mental aspect that is the culprit. There are many chemical reactions taking place in your head and when our bodies are stressed mentally and physically other organs inside go array. Some ppl get very attached to their mates and when that bond gets broken the brain goes crazy. I've been there and done that. It's quite annoying to say the least. Work on geting your head in the right place and get your spouse out of the picture and begin the mental healing first. How long has it been since separation if you dont mind me asking?BTW, your test is lower because you prob traininig too hard. Back off it wont help you but end up overtraining. Do the same type training when your test was close to 1000. I had same bouts with separation issues where my sex drive would plumed for 6-12 months then would come back on its own. It was all mental because it happened every time I would break up with a girl. I mean in your case could be the liver anything is possible but I bet on the mental issue much more.
    Need to find the underlying cause which is driving it up. There is a possibility this may be linked back to a specific gene I am finding in people which have a higher probability of having higher SHBG. I need to do further research in evaluate this. Also need to look at medications currently taking. Coming down to conclusion it has to due with blockage in detoxification pathways. This trend has just been coming about in last 5-7 years which tells me its more environmentally related.
    I am not a medical Dr, please keep in mind that this answer is for information purposes only, and is not intended to diagnose, treat or replace sound medical advice from your physician or health care provider.
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    Quote Originally Posted by vassille View Post
    Do you feel sad and depressed?
    I think is because of the separation too, and although it has not much to do with test production since yours is almost 1000, I believe is the mental aspect that is the culprit. There are many chemical reactions taking place in your head and when our bodies are stressed mentally and physically other organs inside go array. Some ppl get very attached to their mates and when that bond gets broken the brain goes crazy.
    I've been there and done that. It's quite annoying to say the least. Work on geting your head in the right place and get your spouse out of the picture and begin the mental healing first. How long has it been since separation if you dont mind me asking?

    BTW, your test is lower because you prob traininig too hard. Back off it wont help you but end up overtraining. Do the same type training when your test was close to 1000.
    I had same bouts with separation issues where my sex drive would plumed for 6-12 months then would come back on its own. It was all mental because it happened every time I would break up with a girl.
    I mean in your case could be the liver anything is possible but I bet on the mental issue much more.
    I did feel considerable and intense sadness and depression at the commencement of the separation-August 2011. I only do so now if I dwell on the subject which I try mightily not to. We do communicate regularly and there is a sadness following our discussions. Otherwise, all is good and pleasant with life other than the reasons for visiting a Dr. and posting here.

    Regarding overtraining-agreed. I compared my routine and schedule with a few regulars and I am exceeding recommended reps and weights. Scaled back and added cardio into the routine as of yesterday.

    I will report back in January and advise what the results are from following the Dr's recommendation + own mental and physical exercise. I was wondering what type of time frame to plan for. Have never been ill,(other than a cold), and so find this experience unusual.
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    Probably over training causing depletion of.glutathione which can start a whole cascade of issues.
    I am not a medical Dr, please keep in mind that this answer is for information purposes only, and is not intended to diagnose, treat or replace sound medical advice from your physician or health care provider.
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    Quote Originally Posted by UCSMiami View Post
    I did feel considerable and intense sadness and depression at the commencement of the separation-August 2011. I only do so now if I dwell on the subject which I try mightily not to. We do communicate regularly and there is a sadness following our discussions. Otherwise, all is good and pleasant with life other than the reasons for visiting a Dr. and posting here.

    Regarding overtraining-agreed. I compared my routine and schedule with a few regulars and I am exceeding recommended reps and weights. Scaled back and added cardio into the routine as of yesterday.

    I will report back in January and advise what the results are from following the Dr's recommendation + own mental and physical exercise. I was wondering what type of time frame to plan for. Have never been ill,(other than a cold), and so find this experience unusual.
    Since it's has been a year so far I would say 3-6 more months if not better then is time to dig deeper.
    Good thing is that your body is making a load of test which is a good thing.
    One thing I would suggest and not to get too personal is to start dating around without being too worried of this issue. Just talk to other women and enjoy the new life. Time will heal the sadness and the stress you have been through. Love can be a powerful thing sometimes
    Wish you the best and keep us posted.
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    I appreciate the courtesy but I am fully functional in my public life.Fortunately, I have a postive and cheerful disposition. I do not wallow in sadness.(Well, not now) I realize there are connections between emotional and physical injuries. I asked the Q.s above so to be able to forecast and plan around and after this predicament.

    NB: I get your point and have passed it on many times to disconsolate acquaintainces in similar situations...Time Heals All Wounds.

    Thanks Again.
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    Can you please elaborate on the detox powder you mentioned above?

    Thanks
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    I do not know if I am allowed to mention a non-sponsor source.(I just started here and do not wish to fall under the ban hammer) I noticed the ingredients are a mixture of vitamins, amino acids, herbal extracts and some others which I have not yet researched.
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    Would you mind PM-ing me?
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    Was Ornithine in you detox powder? Lipoic Acid? Milk Thistle(silymarin)?

    Do you know your ALT and AST levels and ranges?
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    AST 20 IU/L scale 0-40
    AKT 32 IU/L scale 0-55

    Milk thistle yes

    Lipoic Acid no.

    Hurt my stomach terribly the first two days. No negative effects now.
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    Quote Originally Posted by UCSMiami View Post
    AST 20 IU/L scale 0-40
    AKT 32 IU/L scale 0-55

    Milk thistle yes

    Lipoic Acid no.

    Hurt my stomach terribly the first two days. No negative effects now.
    Liver values are not accurate reading of how the liver is truly functioning. Dr had a case of 2nd stage cirhorrsis with normal values.
    I am not a medical Dr, please keep in mind that this answer is for information purposes only, and is not intended to diagnose, treat or replace sound medical advice from your physician or health care provider.
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    Quote Originally Posted by The Matrix View Post
    Liver values are not accurate reading of how the liver is truly functioning. Dr had a case of 2nd stage cirhorrsis with normal values.
    I agree. Good point
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    Hello Folks, back as promised. Just returned from the Dr.

    Blood drawn on 12-27-2012. Work done by LabCorp Tampa

    Serum T 820, 348-1197ng/dl scale
    Free T 11.5, 6.8-21.5pg/ml scale
    DHEA 218.4, 44.3-331ug/dl scale
    SHBG 64.1 16.5-55.9nmol/l scale

    AST 19 IU/L scale 0-40
    AKT 21 IU/L scale 0-55

    I feel wonderful and have been for the previous few months. Almost back to the pre2011 Jack Russell-like energy levels. I attribute the improvement to the continued weight training and Pregnenolone. Maybe the detox powder the Dr. insisted on. Maybe the Stinging Nettles helped. I do not consume the latter every day-on/off. Libido has improved.

    Return in six months to see how the values above are. Also my Vit. D and Pregnelolone are within normal values now. Every other facet tested just plain shows good health.

    Still trying to work things out with my wife. I am not a quitter. Stresses me when I think about it which is daily. Otherwise life is great.

    I should mention I have been pushing/pulling/lifting every bit as hard as when I started. No letup. Still at it. Part of life like eating/sleeping. I stopped for one week prior to the blood draw date.

    I would like to lower the SHBG to at least within the 55.9 nmol/L of the scale being used.

    I will check back in at the next blood draw results.
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    Quote Originally Posted by UCSMiami View Post
    Hello Folks, back as promised. Just returned from the Dr.

    Blood drawn on 12-27-2012. Work done by LabCorp Tampa

    Serum T 820, 348-1197ng/dl scale
    Free T 11.5, 6.8-21.5pg/ml scale
    DHEA 218.4, 44.3-331ug/dl scale
    SHBG 64.1 16.5-55.9nmol/l scale

    AST 19 IU/L scale 0-40
    AKT 21 IU/L scale 0-55

    I feel wonderful and have been for the previous few months. Almost back to the pre2011 Jack Russell-like energy levels. I attribute the improvement to the continued weight training and Pregnenolone. Maybe the detox powder the Dr. insisted on. Maybe the Stinging Nettles helped. I do not consume them every day-on/off. Libido has improved.

    Return in six months to see how the values above are. Also my Vit. D and Pregnelolone are within normal values now. Every other facet tested just plain shows good health.

    Still trying to work things out with my wife. I am not a quitter. Stresses me when I think about it which is daily. Otherwise life is great.

    I should mention I have been pushing/pulling/lifting every bit as hard as when I started. No letup. Still at it. Part of life like eating/sleeping. I stopped for one week prior to the blood draw date.

    I would like to lower the SHBG to at least within the 55.9 nmol/L of the scale being used.

    I will check back in at the next blood draw results.
    What I have been mentioning all along. SHBG is a sign of inflammation which can indicated hidden liver imbalances resulting in altered detoxfication pathways. It may take another 6 months for it to come down completely. Kudos to your DR. Your Dr may want to get in contact with me about genetic SNPS in relationship to detoxification pathways. I have been using them very successful in Doctor's patients for a number of health related issues. PM me
    I am not a medical Dr, please keep in mind that this answer is for information purposes only, and is not intended to diagnose, treat or replace sound medical advice from your physician or health care provider.
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    Hello Everyone,

    I am 30 days away from my next bloodwork. Thought to ask a few questions:

    Q.1 How many days prior to the blood test should I discontinue weightlifting so as to achieve accurate results? I do not take any stimulants or supplements.

    Q.2 Aside from those listed below what other values should I ask the Dr. to test for?
    They currently consist of the: CBC With Differential/Platelet, Comp. Metabolic Panel (14), Urinalysis, Routine, Lipid Panel With LDL/HDL Ratio, FSH and LH and the various values as below

    Serum T
    Free T
    Reverse T3
    DHEA
    SHBG
    Estradiol

    Should I request a test for thyroid? Other hormones not mentioned above?

    I admit I feel wonderful. Do not wish to leave anything overlooked.
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    Good to see you are feeling well! Keep on the right/good path!

    Best of luck!
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    Hello Everyone,

    Updating this thread. Blood draw on 4-21-2014. Labwork by LabCorp Tampa

    Serum T 810, 348-1197ng/dl scale
    Free T not enough blood for result, 6.8-21.5pg/ml scale
    DHEA 240, 44.3-331ug/dl scale
    SHBG 55, 16.5-55.9nmol/l scale

    AST 40, IU/L scale 0-40
    ALT 115, IU/L scale 0-55 I wrote AKT in earlier tests. I meant ALT

    Full panel test. All other values within normal range. Dr. took me off 100mg pregnenolone as of 4-21-2014. I was consuming a 100mg capsule every two days.(I did not know it was a steroid!)

    I was working out strenuously for 10 days prior to the blood draw. Dr. thinks that is why the liver values are high-due to the weight training. Took two weeks off weight training, only cardio and blood draw with results in today to see if there is a change. I use creatine as well but do not know if that will affect those values. I should have stopped but you know how it is.

    Feel wonderful otherwise.

    Will update thread as soon as I hear about the latest result.
    Last edited by UCSMiami; 05-14-2014 at 08:25 AM. Reason: punctuation
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    Quote Originally Posted by UCSMiami View Post
    Hello Everyone,

    Updating this thread. Blood draw on 4-21-2014. Labwork by LabCorp Tampa

    Serum T 810, 348-1197ng/dl scale
    Free T not enough blood for result, 6.8-21.5pg/ml scale
    DHEA 240, 44.3-331ug/dl scale
    SHBG 55, 16.5-55.9nmol/l scale

    AST 40, IU/L scale 0-40
    ALT 115, IU/L scale 0-55 I wrote AKT in earlier tests. I meant ALT

    Full panel test. All other values within normal range. Dr. took me off 100mg pregnenolone as of 4-21-2014. I was consuming a 100mg capsule every two days.(I did not know it was a steroid!)

    I was working out strenuously for 10 days prior to the blood draw. Dr. thinks it is due to the weight training. Took two weeks off weight training, only cardio and blood draw with results in today to see if there is a change. I use creatine as well but do not know if that will affect those values. I should have stopped but you know how it is.

    Feel wonderful otherwise.

    Will update thread as soon as I hear about the latest result.
    Thank you for the update.

    Keep up the good work.
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    Bit of a downer. Dr. did not redo liver ALT/AST but rather various Hepatitits, IGF-1,etc.

    Everything negative(Hep) or normal except
    My IGF-1 is 262nl/ml on a scale of 67-205.

    I am rescheduled for a full panel on May 23. No lifting until then. I requested he do a GGT.

    Should I be concerned at the high IGF-1? IGFBP-3 was well within normal range
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    what is the liver detox powder? what does it contain?
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    Quote Originally Posted by mrmagoo2010 View Post
    what is the liver detox powder? what does it contain?
    Complementary Prescriptions Detox Complex CP5600. Dr. provided only.
    Ingredients here http://www.cpmedical.net/detox-complex-4.html
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    Quote Originally Posted by UCSMiami View Post
    Bit of a downer. Dr. did not redo liver ALT/AST but rather various Hepatitits, IGF-1,etc.

    Everything negative(Hep) or normal except
    My IGF-1 is 262nl/ml on a scale of 67-205.

    I am rescheduled for a full panel on May 23. No lifting until then. I requested he do a GGT.

    Should I be concerned at the high IGF-1? IGFBP-3 was well within normal range
    Liver values back to normal after one week off weight lifting.

    GGT was low as well.

    IGF-1 still high and Dr. says that is good.
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