Just wondering how efficient calcium d glucarate is in keeping e2 low? Is it worth taking while on TRT if e2 is a little high? What else will it lower besides e2? At 50mg twice a week I'm not getting any signs of high e2, but at 100mg twice a week I do get sides (nothing major). I might try 100mg twice a week again, and see if the calcium d glucarate keeps sides under control. I'll let you guys know.