Hi all --
I'm a 30 year-old guy and this is my first post here. I'm a patient of Dr. Crisler's and one of those ex-finasteride users. I took the drug for five years (started at 23, stopped at 28) without noticeable sides and prior to quitting cold turkey, I took dutasteride for a number of months without noticeable sides on either drug. After cessation, I didn't experience sexual sides right away; it was a gradual process over the period of several months in which it became not only more difficult for me to achieve erection, but also nearly impossible for me to get fully hard and stay hard. Along with erectile dysfunction, I have a loss in libido and in general very rarely feel horny unless I'm with my girl.
My andrologist/endocrinologist ordered blood work on me several times over the course of about two years and initially prescribed Cialis for me, which worked great for a few months and then gradually lost efficacy. Two months ago I was prescribed Clomiphene Citrate (25mg every other day, which I downsized to 12.5mg every other day) by my endo and then approximately a month ago I had my first consult with Dr. Crisler, where a urine analysis and blood analysis were ordered. As you can see, my serum testosterone levels did not increase with the Clomiphene and otherwise I felt no mental or physical effects from the drug.
Looking back, it seems the only time I have experienced any real "relief" from what is commonly referred to as post-finasteride syndrome, is when I recklessly decided to take finasteride for approximately 2 weeks. I did this several months ago without the advice of anyone in the medical field and felt a boost in libido and sex drive. During this period, I noticed an ability to get hard again immediately after having sex/ejaculating -- a skill that had vanished previously. After cessation, I almost immediately had horrible ED and a general feeling of malaise.
Today, I'm pretty consistent in my symptoms. ED, low libido, low energy levels, occasional anxiety. Physically, my penis changes shape often -- sometimes taking an hourglass shape and other times shrinking up with a feeling of hardness/fibrosis.
Here's some blood work results prior to meeting with Dr. Crisler:
Result - 422 ng/dL, Flag Reference Range - 249-836
Result - 40 ng/dL, Reference Range - 30-85
Result - 82 ng/dL, Flag Reference Range - 249-836
Result - 60 ng/dL, Reference Range - 30-85
And now the urine analysis and bloods ordered by Dr. Crisler
TEST, UNITS, ABN, RESULTS, REFERENCE RANGE
Estrone (E1) ug/24hrs 3.5 3 - 12 2-Hydroxyestrone ug/24hrs 6.1 --- 16-a-Hydroxyestrone ug/24hrs 0.7 --- 2OH/16OH Estrone ratio 8.7 --- 4-Hydroxyestrone ug/24hrs 0.4 --- Estradiol (E2) ug/24hrs 1.9 0 - 7 Estriol (E3) ug/24hrs 2.7 1 - 16 Total Estrogens ug/24hrs 8.0 4 - 22 Testosterone ug/24hrs HIGH 121 45 - 85 Dihydrotestosterone (DHT) ug/24hrs 11 0 - 13 Androstanediol ug/24hrs 172 48 - 578 Androstanedione ug/24hrs 9.6 Not established DHEA ug/24hrs 453 5 - 1476 Androstenetriol (5-AT) ug/24hrs 271 42 - 710 Androsterone (AN) ug/24hrs HIGH 4953 798 - 4705 11b-OH-Androsterone ug/24hrs 1090 461 - 1692 Etiocholanolone (ET) ug/24hrs 1742 689 - 3252 11b-OH-Etiocholanolone ug/24hrs 741 134 - 1186 Progesterone NONE DETECTED Pregnanediol (PD) ug/24hrs 147 32 - 501 5-Pregnenetriol (5-PT) ug/24hrs 305 28 - 1062 Pregnenolone ug/24hrs 1.6 Not established Cortisone (E) ug/24hrs 180 92 - 366 THE ug/24hrs 3865 1365 - 5788 THB ug/24hrs 86 32 - 238 5a-THB ug/24hrs 314 135 - 588 THA ug/24hrs 91 52 - 277 Cortisol (F) ug/24hrs 93 35 - 168 THF ug/24hrs 1803 942 - 2800 5a-THF ug/24hrs HIGH 3185 796 - 2456
TESTS, RESULT, FLAG, UNITS, REFERENCE INTERVAL
LH mIU/mL 3.3 1.7 - 8.6 FSH mIU/mL LOW 1.3 1.5 - 12.4 Testosterone, Serum ng/dL 412 348 - 1197 Vitamin D, 25-Hydroxy ng/dL 33.5 30.0 - 100.0 SHBG, Serum nmol/L 22.7 16.5 - 55.9
Dr. Crisler is having me stop the Clomiphene and go with testosterone injections on account of the high testosterone in my urine compared to the much lower amount in my blood. I'm at a little bit of a loss on what to think as my primary endo classifies me as "in range" and does not feel that TRT is appropriate for me.
At any rate, I thought I would just post up my numbers and see what this community thinks.