Happy New Year.
- 12-31-2011, 11:11 AM
- 12-31-2011, 01:33 PM
- 01-01-2012, 03:32 AM
2011 was a crappy year less make 2012 a better and.healthier one.I am not a medical Dr, please keep in mind that this answer is for information purposes only, and is not intended to diagnose, treat or replace sound medical advice from your physician or health care provider.
01-01-2012, 09:07 AM
Sorry I missed your call yesteday we were out I hope you had a great night out on the town with your women. I still need a lot of Arimidex about 3 to 4 pills my Co Mod. says this can take some time for the CYP3A4 emzine to clear my body like 6 months to a yr. He knows about this because his sister was on pain meds and they messed up her hormones that she was on.
I took some Tylenol Arthritis a week ago was in a lot of pain did 2 pill 2x's / day for 2 days it messed up my Arimidex from working. Like the link you gave me says " In our models, APAP appears to increase CYP3A4 activity. This increase appears to be via substrate stabilization. "
Here is part of that he said.
I was doing some more research on CYP3A4 recently - very interesting. http://en.wikipedia.org/wiki/CYP3A4 has a list of some drugs affected by this enzyme, but I wish I could find a site that lists all drugs affected. It seems that most of the info about this enzyme is pretty complicated, but there are three basic categories:
* Substrates - drugs that are metabolized by this enzyme
* Inhibitors - drugs that cause other drugs that are metabolized by this enzyme to be metabolized slower
* Inducers - drugs that cause other drugs that are metabolized by this enzyme to be metabolized faster
Of interest: Testosterone, Estradiol, hydrocortisone, caffeine, viagra/cialis, opiates, SSRIs, statins, tamoxifen, anastrazole, and many others are all listed as "substrates" - drugs that are metabolized by CYP3A4.
Some common antibiotics like Erythromycin and Cipro, some SSRIs, Ginko, and grape fruit juice are inhibitors - this means that these drugs cause the CYP3A4 enzyme to slow down metabolism so you can end up getting too high of levels of other drugs that are "substrates". I always wondered why so many drugs tell you not to drink grape fruit juice while taking those drugs...
Less common are the "inducers" - like St. John's Wort, hypoglycemics, and glucocorticoids. These drugs increase the metabolism of CYP3A4 which means that you need to take the drugs listed as substrates more often in order to keep the correct levels in your blood.
I suspect that there are more "inducers", but I haven't had enough time to do a lot of research.
Another interesting enzyme is CYP2D6. http://en.wikipedia.org/wiki/CYP2D6 I haven't had a lot of time to research this one yet, either.
Part of what interests me so much about these enzymes is (a) my sister's addiction to opiates and (b) my knowledge that I seem to metabolize opiates and laughing gas very quickly. I am allergic to Tylenol, so I can't take Vicodin or Percocet. But, when I was given oxycodone after having 3 wisdom teeth removed, I found that a standard dose only lasted about 2 hours. While having the wisdom teeth removed, I was given laughing gas and I had to keep asking for more during the procedure. At one point, I remember the doctor telling me that he wasn't sure that he could give me much more. I seem to metabolize lidocaine a bit quicker than most other people, too.
01-01-2012, 01:29 PM
01-01-2012, 01:35 PM
I am not a medical Dr, please keep in mind that this answer is for information purposes only, and is not intended to diagnose, treat or replace sound medical advice from your physician or health care provider.
01-01-2012, 03:11 PM
No can't take grape fruit juice or eat it Dr. told me a long time ago not to do them I am on a lot of meds can't remember with ones he was talking about but he said grape fruit juice will make the meds stronger.
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