MA labs NEW PRODUCT is coming!! Insuligen

WesleyInman

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Insuligen Is coming

Insulin Secretagogue
800% greater insulin response
Improves Nutrient Transport
Improves Muscle Fullness
Stimulates Lypolysis/Inhibits Lipogenesis


masuppsINSULIGEN.jpg
 

Mike Arnold

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Would you use it like a gda? Or would you have to be more careful about it like actual insulin?
Use it like a GDA. You won't lower BG levels enough to be in danger (even with insulin, it requires massive dose to die), but the insulin response will be greater than anything else out there.

Unlike most GDA's that rely primarily on insulin sensitizers and mimetics to power their effects, Insuligen relies almost entirely on insulin secretagogues. This make it a very different product than other GDA's, as it supplies all the benefits of insulin without any of the detrimental effects on growth that other GDAs cause. You see, sensitizers and mimetics work primarily through activating AMPK. However, while activating AMPK may be good for fat loss, it is antagonistic to mTOR. Therefore, excessive activation of AMPK leads to lower rates of protein synthesis and reduced muscle growth.

This is why GDAs don't really cause growth. They might make you leaner while dieting, but they excessively activate AMPK. However, some degree of AMPK activation is good, as it is necessary not only for health and fat loss, but it even indirectly assists with the growth process. Problems occur when this enzyme is activated to too great of a degree and too frequently. Unfortunately, basically every GDA on the market today is LOADED with sensitizers and mimetics and as a result, AMPK is activated to an extreme degree, all day long. This is BAD for muscle growth.

Insuligen relies first an foremost on insulin secretagogues, with only moderate AMPK activation--just enough to achieve the desired effect, but without experiencing a significant degree of mTOR suppression. Therefore, insuligen was designed to be used like insulin--as a recovery and growth agent. As a secondary benefit, it will help reduce bodyfat/help prevent fat gain.

Up until this point, no one has formulated a GDA from this angle, which I find odd, but there are a LOT of things out there that no one has made yet. Unfortunately, most companies just copy what they see others doing--whatever is currently popular in the industry, without bothering to come up with something innovative or superior to the current standard.

Insuligen will absolutely be superior to ANY GDA currently on the market from a recovery and growth standpoint, as it's primary MOA (mechanism of action) is stimulating the pancreas to release insulin into the bloodstream, similar to the class of prescription drugs known as sulfonylureas (but without their side effects). In contrast, sensitizers and mimetics are only capable of performing some of the actions of insulin...and they always decrease protein synthesis at the same time. Those roadblocks are no longer an issue with insuligen.
 
Superload

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When will we see this masterpiece looking supps release???
 

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Next week. :)
 
Superload

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Next week. :)
WOOTAlso any chance your going to be doing a beast fitness podcast with Alex kiekle anytime soon?? I know he mentioned in one of his videos he wanted to and I think you two together would make a kickass video !
 

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When you mention like a GDA, would dosage follow that or would this be a touch different on how to take? Definitely in for trying this!
 
Ricky10

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I saw this on the website a few weeks ago and was interested to see what Mike would come up with to change the game.
This sounds like a definite must try!
 
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justhere4comm

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Very intrigued at this one.
 
Superload

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Can we get a hint of the expected price of this??? Or even better of the Black Friday deals??
 
Rocket3015

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Mike Arnold Any Black Friday Discounts in The Works ??
 

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WOOTAlso any chance your going to be doing a beast fitness podcast with Alex kiekle anytime soon?? I know he mentioned in one of his videos he wanted to and I think you two together would make a kickass video !
I don't know. He's never mentioned anything about it to me. I wouldn't be opposed to it, though. Sounds interesting. I really like Alex. He also promotes MA Research a lot, which is big help.
 

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When you mention like a GDA, would dosage follow that or would this be a touch different on how to take? Definitely in for trying this!
It should be taken similarly to any other GDA, but I provide specific instructions on the label . Insuligen still falls in the category of "GDA", as a GDA is technically anything which assist with glucose transport. However, there are various sub-classes within the GDA category, which include insulin sensitizers, insulin mimetics, and insulin secretagogues.

Usually, a GDA doesn't fall into just one of these categories, but has some overlap into one or more of the other categories. It may have a primary function, but many of these compounds display more than just a singular effect.

While secretagogues can also have some overlap (depending on the compound), they tend to have less overlap than the other categories and often function solely as secretagogues, without any sensitizing or mimetic effects. This is good, as it allows the developer to more finely tune his product, so that it produces the exact effect profile he is looking for. For example, it would allow the developer to ensure that his product provides a moderate degree of AMP activation, but not so much that it impairs mTOR and reduces muscle growth (which happens with basically every GDA on the market today, except Insuligen).

With Insuligen I made sure the product functions primarily as an insulin secretagogue--not a sensitizer or mimetic. It does have some sensitizing/mimetic capabilities because these things are/can be beneficial, but it is not the main driving force behind the product. First and foremost, the products functions as an insulin secretagogue, so the majority of its effects are powered by actual insulin, not compounds which only provide a portion of insulin's effects, while simultaneously compromising muscle growth. That is where Insuligen differentiates itself from the other GDA's on the market.

I dd not have top include a bunch of new compounds in order to do this, although I did include two compounds that have never been used in a bodybuilding/fitness product before. One of them, has 8X the insulin releasing power of a full gram of gymnema sylvestre. Standard gymnema is already considered to be one of the most powerful commonly utilized secretagogues, but this compound, which is derived from Gymnema itself, has 8X the insulin releasing potency. Of course, I used the full dosage found in clinical studies to produce this effect. Including just this compound alone costs me more than what it costs many companies to make their entire GDA product.

Another secretagogue in Insuligen that has never been used in a GDA before was found to have equal potency to the prescription insulin secretagogue drug, glibenclamide.

One secretagogue found in insuligen has been used in GDAs before, but always in very small dosages...because it is a very expensive compound. Unfortunately, this compound much be used in fairly large dosages in order to produce its full effects--so no one has been able to experience its true insulin releasing power yet. Insuligen contains 4-10X the dose that has been used in other companies' products. Most companies that use it only include about 1/10th the dose.

Insuligen contains only one commonly used compound. This compound provides only moderate insulin releasing effects, but it was selected because in addition to its moderate secretagogue capabilities, it also acts as an insulin sensitizer. Having some insulin sensitizing effects was important to me, so that the product would stave off any negative effects that elevated insulin levels may have on insulin sensitivity, as well as result in greater glucose disposal.

The remaining 4 ingredients all function t increase oral bioavailability, thereby further increasing the insulin releasing power of the prime movers.
 

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Can we get a hint of the expected price of this??? Or even better of the Black Friday deals??
Insuligen To Be Made Only Once​


Yes, I will have a Black Friday deal for one or more MA Labs products.

As for the price, with the 20% discount it will be comparable to the other high-end GDAs on the market. However, insuligen will never be made again after this batch sells out...because the cost is too high. Allow me to explain. After I designed the Insuligen formula I got a price quote that was at the very upper-limit of what I could spend per unit...because I needed to keep the purchase price reasonable. However, during the development process one of the ingredients increased in price by a whopping 250%, putting the product out of range (it ended up costing more to make than what most companies sold their GDAs for). When I found out about this I told my manufacturer we had to change the formula, but he had already signed a contract with another manufacturer (it was a joint project) who had already paid for the ingredients.

Basically, I told my manufacturer that I was simply was not paying an additional $12 a bottle. So, he ended up eating the loss himself (he had to because I already had a price quote) and my price stayed the same. Not only did he make no money on it, but he ended up losing many thousands of dollars. However, if I make this product again I would have to pay the full price, which would make the product way too expensive, so I will never be able to make it again. The purchase price would be too high. So, this is the ONLY run that will ever be made.
 
Superload

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Insuligen To Be Made Only Once​


Yes, I will have a Black Friday deal for one or more MA Labs products.

As for the price, with the 20% discount it will be comparable to the other high-end GDAs on the market. However, insuligen will never be made again after this batch sells out...because the cost is too high. Allow me to explain. After I designed the Insuligen formula I got a price quote that was at the very upper-limit of what I could spend per unit...because I needed to keep the purchase price reasonable. However, during the development process one of the ingredients increased in price by a whopping 250%, putting the product out of range (it ended up costing more to make than what most companies sold their GDAs for). When I found out about this I told my manufacturer we had to change the formula, but he had already signed a contract with another manufacturer (it was a joint project), who had already paid for these ingredients.

Basically, I told my manufacturer that I was imply was not paying an additional $12 a bottle. So, he ended up eating the loss himself (he had to because I already had a price quote) and my price stayed the same. Not only did he make no money on it, he ended up losing many thousands of dollars. However, if I make this product again I would have to pay the full price, which would make the product way too expensive, so I will never be able to make it again. The purchase price would be too high. So, this is the ONLY run that will ever be made.
Aka...buy in bulk because this possibly greatest GdA ever created will only be made once lol
 
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Insuligen To Be Made Only Once​


Yes, I will have a Black Friday deal for one or more MA Labs products.

As for the price, with the 20% discount it will be comparable to the other high-end GDAs on the market. However, insuligen will never be made again after this batch sells out...because the cost is too high. Allow me to explain. After I designed the Insuligen formula I got a price quote that was at the very upper-limit of what I could spend per unit...because I needed to keep the purchase price reasonable. However, during the development process one of the ingredients increased in price by a whopping 250%, putting the product out of range (it ended up costing more to make than what most companies sold their GDAs for). When I found out about this I told my manufacturer we had to change the formula, but he had already signed a contract with another manufacturer (it was a joint project), who had already paid for these ingredients.

Basically, I told my manufacturer that I was imply was not paying an additional $12 a bottle. So, he ended up eating the loss himself (he had to because I already had a price quote) and my price stayed the same. Not only did he make no money on it, he ended up losing many thousands of dollars. However, if I make this product again I would have to pay the full price, which would make the product way too expensive, so I will never be able to make it again. The purchase price would be too high. So, this is the ONLY run that will ever be made.
That sucks. When is the release date again? I need to make sure I hve money set aside for said product.
 

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ion26

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Hey all, any Black Friday discount code for this week?
 

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MA Labs Presents...



BIGGEST SALE EVER!!!!

35% off​



Discount Code: blackfriday




Those of you who are familiar with MA Labs know I don't run sales very often, usually limiting them to 3-4 times per year. Well, with basically every company having a Black Friday sale I figured I would do the same...and provide the biggest discount on Somatozine, GW and MA-PUMP ever--35% off. This brings the cost of Somatozine down to about $50 a bottle, GW to about $37 a bottle and MA-PUMP to $37 a bottle.

If there was ever a time to try the most effective MK product on the market, this is it. For those of you who are not aware, Somatozine is a combination product containing 4 optimally products in 1. It contains MK, melatonin, Vitamin D and a superior form of ZMA (I use the orotate and glycinate forms of zinc and magnesium, respectively, which are far superior to the aspartate forms of these minerals). As the most highly reviewed MK product on the market, you aren't going to beat this anywhere.








.
 
WesleyInman

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Mike Arnold Any Black Friday Discounts in The Works ??

Rocket3015

Yes the code is up and active now. "BLACKFRIDAY" at checkout for 35% off!
 

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If it works I would pay for it Mike Arnold what would be the increased price 100 dollars a bottle?
 
ion26

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Is the credit card option still available? Not seeing it?
 
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Is the credit card option still available? Not seeing it?
I could not find it either ????
I haven't had cc's in almost a year now. It is now illegal for a research company to take cc's. The FDA is now prosecuting those who do for money laundering...and research companies are being convicted. How? Because not a single bank in the country will give a research company cc's anymore. You have to LIE to the bank about what you sell in order to get one...and anytime you lie about what you are selling in order to move money, it is technically money laundering. Right now I am aware of ZERO banks which will knowingly allow a research company to take cc's.

I take e-checks. Anyone who refuses to use an e-check because they are afraid to do so just doesn't understand what they are. E-checks are just as safe as regular paper check (safer, actually). I use an actual bank, called Green Money, as my e-check provider. They are the oldest, largest, and most respected e-check provider in the U.S. Their track record is impeccable and they have performed 100's of millions of transactions.

Furthermore, e-checks are even easier to use than cc's...because you only need to enter two pieces of information--your routing and account number--instead of three like cc's. A person's routing and account numbers are found right on the bottom of every paper check they have. So, if someone doesn't know where to find their routing and account numbers, look at your paper checks. The only people who can't use e-checks are people who don't have a checking account. Just like with paper checks, you must have a checking account to use an e-check. The only difference between an e-check and a paper check is that an e-check is electronic (initially) and paper checks are, well...paper. However, e-checks become paper check part way through the process...and the method of approval is the same with e-checks as it is with paper checks (i.e. the check writer's bank has to approve the transaction).

So, use an e-check. Some people simply don't know what they are because they've never used one before. They mistakenly think they have to sign up for something...or download something...or learn something, but they don't. They just enter their routing and account numbers and that's it. The other group of people that doesn't use e-checks knows what e-checks are, but they are scared of new technology they don't understand. If they knew what they actually were and how they work, any fears would melt away. When people first started using paper checks, a LOT of people refused t use them...because they were new and people, in general, have a hard time trusting new things. then, when credit cards hit the scene, we saw the same thing happen. Tons of people refuse to use them out of fear of the unknown. These days no one is even remotely concerned with writing a check or swiping their card. Soon, it will be the same with e-checks.

A LOT of people are still unfamiliar with e-checks, but everyone who has asked me about them (after I have explained it to them and told them how to use one), has said it was super easy and convenient...because it is. For those are are unfamiliar with how to use e-checks...or how the process works, I posted a short article below that goes into more detail.





Using E-Checks

Using e-checks are a piece of cake--easier than you think. All you need in order to use an e-check is a checking account. When you go on the site and place your order, make sure you choose the payment option that says "E-check (Green Money E-check provider)". You just click the box next to the "E-check (Green Money) option".

Filling in the info to use an e-check is just as easy as using a credit card. All you need to do is fill in your basic information (name, shipping address, email, etc.) and your checking account info (routing and account numbers) and that's it. Nothing else. If you don't know what your routing and account numbers are, look on one of your paper checks. Your routing and account numbers are always located on the bottom of every paper check you have. It will look like a bunch of random numbers all in a row, with some spaces between them.

The sets of numbers will look something like this...


_ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _



Starting on the left, you will see a set of 9 numbers. This is your routing number. It is always 9 numbers long. After that there will be a small space...and then you will see another set of numbers. That is your account number. You may (or may not, depending on your bank) see another small set of numbers after that. Ignore those. That is just your check number--the same number at the top of your check.



As you can see, using an e-check uses the same info that regular paper checks do. The only difference is that it is electronic rather than paper. After you are done placing the order you don't have to do anything else. Green Money will get in contact with your bank to confirm the e-check. Within 24 hours of placing your order you will receive an email from Green Money telling you the e-check has been processed. This just means that Green Money acknowledges that your e-check has been sent and has verified your checking account as legitimate. It will take 3 days for the check to actually clear after you place the order. When that happens we will immediately ship your order and email you tracking info.


Altogether, it takes about 1 week to receive your order. Please don't hesitate to ask if you have any questions. Before I started taking e-checks for this business I had no idea what they were and was a bit intimidated. I thought I had to sign up for an account and all kinds of other stuff. You don't have to do anything like that. As long as you have a checking account you can use an e-check anywhere in the US with nothing but your basic info and your checking info.
 
ion26

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I haven't had cc's in almost a year now. It is now illegal for a research company to take cc's. The FDA is now prosecuting those who do for money laundering...and research companies are being convicted. How? Because not a single bank in the country will give a research company cc's anymore. You have to LIE to the bank about what you sell in order to get one...and anytime you lie about what you are selling in order to move money, it is technically money laundering. Right now I am aware of ZERO banks which will knowingly allow a research company to take cc's.

I take e-checks. Anyone who refuses to use an e-check because they are afraid to do so just doesn't understand what they are. E-checks are just as safe as regular paper check (safer, actually). I use an actual bank, called Green Money, as my e-check provider. They are the oldest, largest, and most respected e-check provider in the U.S. Their track record is impeccable and they have performed 100's of millions of transactions.

Furthermore, e-checks are even easier to use than cc's...because you only need to enter two pieces of information--your routing and account number--instead of three like cc's. A person's routing and account numbers are found right on the bottom of every paper check they have. So, if someone doesn't know where to find their routing and account numbers, look at your paper checks. The only people who can't use e-checks are people who don't have a checking account. Just like with paper checks, you must have a checking account to use an e-check. The only difference between an e-check and a paper check is that an e-check is electronic (initially) and paper checks are, well...paper. However, e-checks become paper check part way through the process...and the method of approval is the same with e-checks as it is with paper checks (i.e. the check writer's bank has to approve the transaction).

So, use an e-check. Some people simply don't know what they are because they've never used one before. They mistakenly think they have to sign up for something...or download something...or learn something, but they don't. They just enter their routing and account numbers and that's it. The other group of people that doesn't use e-checks knows what e-checks are, but they are scared of new technology they don't understand. If they knew what they actually were and how they work, any fears would melt away. When people first started using paper checks, a LOT of people refused t use them...because they were new and people, in general, have a hard time trusting new things. then, when credit cards hit the scene, we saw the same thing happen. Tons of people refuse to use them out of fear of the unknown. These days no one is even remotely concerned with writing a check or swiping their card. Soon, it will be the same with e-checks.

A LOT of people are still unfamiliar with e-checks, but everyone who has asked me about them (after I have explained it to them and told them how to use one), has said it was super easy and convenient...because it is. For those are are unfamiliar with how to use e-checks...or how the process works, I posted a short article below that goes into more detail.





Using E-Checks

Using e-checks are a piece of cake--easier than you think. All you need in order to use an e-check is a checking account. When you go on the site and place your order, make sure you choose the payment option that says "E-check (Green Money E-check provider)". You just click the box next to the "E-check (Green Money) option".

Filling in the info to use an e-check is just as easy as using a credit card. All you need to do is fill in your basic information (name, shipping address, email, etc.) and your checking account info (routing and account numbers) and that's it. Nothing else. If you don't know what your routing and account numbers are, look on one of your paper checks. Your routing and account numbers are always located on the bottom of every paper check you have. It will look like a bunch of random numbers all in a row, with some spaces between them.

The sets of numbers will look something like this...


_ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _



Starting on the left, you will see a set of 9 numbers. This is your routing number. It is always 9 numbers long. After that there will be a small space...and then you will see another set of numbers. That is your account number. You may (or may not, depending on your bank) see another small set of numbers after that. Ignore those. That is just your check number--the same number at the top of your check.



As you can see, using an e-check uses the same info that regular paper checks do. The only difference is that it is electronic rather than paper. After you are done placing the order you don't have to do anything else. Green Money will get in contact with your bank to confirm the e-check. Within 24 hours of placing your order you will receive an email from Green Money telling you the e-check has been processed. This just means that Green Money acknowledges that your e-check has been sent and has verified your checking account as legitimate. It will take 3 days for the check to actually clear after you place the order. When that happens we will immediately ship your order and email you tracking info.


Altogether, it takes about 1 week to receive your order. Please don't hesitate to ask if you have any questions. Before I started taking e-checks for this business I had no idea what they were and was a bit intimidated. I thought I had to sign up for an account and all kinds of other stuff. You don't have to do anything like that. As long as you have a checking account you can use an e-check anywhere in the US with nothing but your basic info and your checking info.
Appreciate the explanation. Trying this for the first time, fingers crossed everything works alright :)
 

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Ok so insuligen isn’t coming out for another 6-8 weeks. Can we at least get a look at the ingredients
 

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Insuligen

The Industry’s 1st Insulin Secretagogue”



NOW AVAILABLE!!!



Insuligen at a glance…

*The Industry’s 1st Muscle-Building GDA

* Increases Insulin Levels 800% More than the Competition

* Stimulates Muscle Tissue Specific Glucose Transport

* Improves Nutrient Absorption

* Doesn’t Suppress Protein Synthesis via Excessive AMPK Activation (like virtually every other GDA on the market today)

* Initiates Fat Loss via Increased Lipolysis

* Prevents Fat Gain via the Inhibition of Lipogenesis





GDA’s: Sensitizers, Mimetics, and Secretagogues​

Whether we’re talking about sports nutrition stores, online wholesalers, or direct to consumer companies, one thing they all have in common is that they offer a wide variety of products claiming to provide insulin-like effects. Normally referred to as glucose disposal agents, or GDA’s, these products fall into one of three categories: insulin sensitizers, insulin mimetics, and insulin secretagogues. However, for the average consumer, deciphering between this diverse class of supplementation can be difficult and even confusing. Further complicating matters is that these terms are often used interchangeably, leading one to believe that they are one in the same. While there are certainly similarities between them, there are also important differences, with each one producing its own unique effects in the body. Therefore, before we can effectively differentiate MA Labs’ Insuligen from the other GDA’s on the market, we must first possess a basic understanding of the class as a whole, as well as the underlying mechanisms of action for each category.

Keep in mind that the term GDA is somewhat ambiguous, or generic in nature, as it is an umbrella term used to describe the class as a whole. This is because the name itself refers to a singular function applicable to all categories, rather than a trait unique to a particular category. Therefore, the term "GDA” can be applied to any product claiming to provide insulin-like effects. Now that we know what the different categories of GDA’s are, let’s look at the primary differences between them:

Insulin Sensitizers: This category of GDA’s increases our cells’ responsiveness (i.e. sensitivity) to insulin, thereby enabling us to use this hormone more efficiently/effectively.

Insulin Mimetics: This category of GDA’s works by copying (or mimicking) the effects of insulin in one or more ways. For example, one way in which they might mimic insulin is by activating the translocation of Glut-4; a transporter protein utilized in the shuttling of glucose into muscle cells.

Insulin Secretagogues: This category of GDA’s differs from the previously mentioned categories, in that it actually causes the pancreas to secrete insulin into the bloodstream, resulting in greater overall insulin levels.

Although the descriptions I provided above are accurate, the reality is that none of these categories function solely within their respective category. In other words, while an insulin sensitizer may function primarily as a sensitizer, it may also possess some degree of mimetic and/or secretagogue effects, albeit to a lesser degree. The same goes for both mimetics and secretagogues.

While this can sometimes be a good thing (all categories have benefits), neither sensitizers nor mimetics are a replacement for insulin, as they are limited in terms of both functionality and potency. Unfortunately, they simply aren’t capable of replicating insulin’s full range of physiological effects, particularly in those areas responsible for regulating muscle growth. Anyone who is experienced with both insulin and GDA’s will readily attest to this fact, as GDA’s are known more for their fat loss/recomping effects than for stimulating recovery & growth. There are multiple good reasons for this, but there is one main reason. Enter AMPK.



AMPK & GDA’s​

For those of you who are unfamiliar with the term AMPK and what it means to bodybuilders, allow me to give you a brief crash course on this important, yet often misunderstood enzyme. AMPK, otherwise known as adenosine monophosphate-activated protein kinase, is an enzyme involved in regulating energy metabolism. When this enzyme is activated, such as during exercise or starvation (or in this case, when using traditional GDA’s), it can produce a number of beneficial effects, including decreased inflammation, increased fatty acid oxidation (e.g. the burning of fat for fuel) and increased glucose uptake.

Naturally, this would make AMPK activation an enticing target for supplement formulators, so it probably wouldn’t surprise you to learn that today’s GDA’s are comprised almost entirely of these substances. This is an important point to consider, as both insulin sensitizers and mimetics derive the vast majority of their insulin sensitizing effects as a direct result of AMPK activation. In fact, the terms AMPK activator and insulin sensitizer/mimetic have become so closely associated that they are almost synonymous.

Metformin and berberine would be great examples of AMPK activators. Both of these are well known to provide a moderate recomping effect (via fat loss), along with significant improvements in overall metabolic health. With such a large number of potential beneficial effects (from both a cosmetic and health standpoint), it is not unreasonable to assume that more is betterÂ…and thatÂ’s exactly where most supplement companies have erred.



AMPK Activation and Muscle Growth?​


Using a product comprised almost entirely of AMPK activators is a great idea if your primary goals are heath and fat loss oriented, but if muscle growth is at the forefront of your priority list, this is problematic. This is because AMPK activation is antagonistic to mTOR, acting as a negative feedback control to restrain muscle hypertrophy. In other words, AMPK activation directly and strongly inhibits protein synthesis, causing a decrease in muscle growth.
Now, before you start thinking that all AMPK activation is inherently bad for bodybuilders and should therefore be eliminated, think again. The truth is that some degree of AMPK activation is not only essential for our health, but is also necessary for muscle growth. However, excessive activation of this enzyme, especially during times when catabolism is at its peak (i.e. during the training window, for instance), will directly impede your ability to build muscle mass. Therefore, any product which contains copious amounts of sensitizers and/or mimetics should be avoided when muscle growth is the goal, especially at these times.

Unfortunately, nearly every GDA on the market today is loaded to the gills with insulin sensitizers/mimetics. It is no longer uncommon to see GDA’s containing 4, 5, or even more powerful AMPK activators—often at very high dosages—within a single formula. Using a product like this, especially multiple times daily, is the last thing you want to do when trying to grow. You are much better off saving these kinds of products for times when fat loss is the overriding goal, such as during contest prep or simply when trying to get in the best shape possible.



Muscle Building GDA’s vs. Fat-Loss GDA’s.​

Insuligen was formulated specifically to AVOID this modern-day pitfall by relying primarily on insulin itself (via insulin secretagogues) to power it’s unique effects, rather than AMPK activation. Unlike other GDA’s, which aren’t really insulin-like at all (how can a product claim to be “insulin-like” when it not only fails to assist with muscle growth, but actually hinders it?), Insuligen will provide the effects that bodybuilders have been seeking from these products all along—glucose transport in combination with improved recovery and growth. As a side benefit, it will even assist with fat loss/prevent fat gain.

Further improving its effect profile is that Insuligen provides just enough AMPK activation to help maintain insulin sensitivity in the face of elevated insulin levels, allowing the user to reap maximum benefit from the large increase in circulating insulin levels without experiencing the negative effects typically associated with a high insulin environment. In other words, you get the best of both worlds—elevated insulin levels when you need it, but without any of the negative side effects typically associated with a hyperinsulinemic state; all while simultaneously assisting the individual in their health and fat loss goals.

While the idea of formulating a product based solely around insulin secretagogues is a relatively simple concept, Insuligen is the first product to actually do so. Up until now, GDAs have been nothing more than a hodgepodge of randomly selected compounds, focusing solely on glucose disposal and insulin sensitivity without any regard for the detrimental effects they may have on the growth process. This all changes now.



Insuligen: Ingredients

GymnePURE®: Insuligen is the first GDA released within the bodybuilding-fitness industry to contain this novel and costly ingredient. In short, GymnePURE® is the safest, most biologically active and effective Gymnema Sylvestre extract ever developed. This is NOT your typical Gymnema product, which is nothing more than ground up leaf occasionally standardized for gymnemic acids. Rather, GymnePURE® is a unique and innovative multi-patented extract of natural Gymnema Sylvestre Leaf using a scientifically supported extraction process known as OSA™.

When looking at GymnePURE® from a biological standpoint, there are two primary characteristics which differentiate it from traditional gymnema products—potency and safety. Research performed at King’s College in London shows us just how powerful GymnePURE is. When compared directly against multiple other gymnema extracts, just a single 250 mg dose of GymnePURE® elevated insulin levels 600%-1,600% higher than a full 8 capsules (1,000-2,000 mg) of standard gymnema extract, with the average increase being 800% greater. No other Gymnema product on the market even comes close, making GymnePURE® the premier insulin secretagogue available today.

But how does GymnePURE® stack up to the competition from a safety standpoint? This rarely talked about aspect of gymnema usage may be more important than you think, particularly in individuals with compromised beta cell viability or in those who regularly use GDA products. Located in the pancreas, beta cells are the cells responsible for secreting insulin into the bloodstream. When these cells are damaged through chronic/excessive insulin secretion (Type II diabetes, for example) or improper supplementation, they can partially or even totally lose their ability to release insulin into the bloodstream.

The safety difference between GymnePURE® and other gymnema extracts lies in its mechanism of action (M.O.A). Regular gymnema extracts possess a less than ideal M.O.A, as they stimulate insulin secretion by literally breaking down the beta cell walls, causing insulin to leak into the bloodstream. This unnatural method of inducing insulin secretion leads to subsequent beta cell wall exhaustion and eventually, death. You may want to think about this the next time you reach for your gymnema containing GDA product.

In contrast, GymnePURE® works by opening and closing the cell walls in a natural manner, thus preserving their integrity and future ability to perform vital functions. But this is not GymnePURE’s only MOA. It also works through signaling pathways in the presence of Ca and even in the absence of Ca. This three-fold mechanism of action is far superior to anything encountered with normal gymnema extracts, both from an effectiveness and safety standpoint. GymnePURE® accomplishes all this without activating AMPK, so you don’t need to wonder if your muscle building efforts are being compromised.

4-Hydroxyisoleucine: 4-Hydroxyisoleucine, otherwise known as 4-HIL, is a non-protein amino acid isolated from Fenugreek seeds. Although 4-HIL has been known about for some time now, it is almost never included in GDA’s at a meaningful dose (the last time I saw a properly dosed 4-HIL product was 12-15 years ago and it was the only ingredient in the product), and when it is listed on the label, it is always part of an undisclosed (i.e. ineffective) proprietary blend. This is due to its excessive cost, as a single 200 mg dose (the dose found in Insuligen) has a higher production cost than most GDA products do in their entirety. Although highly effective, this makes 4-HIL an impractical addition to many multi-faceted GDA products, unless the company is willing to abandon conventional profit margins in the pursuit of effectiveness.

Like GymnePURE®, 4-HIL does not activate AMPK, but directly activates pancreatic islets, causing insulin to be released into the bloodstream. In addition to its insulin secreting effects, 4-HIL also possess the ability to lower plasma glucose through non-insulin dependent pathways, while simultaneously improving HDL levels and lowering total cholesterol and triglycerides.

Beta-umbelliferone: Beta-umbelliferone, also referred to as 7-hydroxycoumarin, is an interesting compound with a plethora of beneficial effects. Never before used in a GDA product, umbelliferone is the parent compound from which the prescription medication, Warfarin, is derived. However, unlike warfarin, umbelliferone does not have any significant blood thinning properties, but instead acts as an insulin secretagogue, anti-oxidant, and anti-inflammatory agent.

Impressively, umbelliferone has been shown to possess insulinotropic effects comparable to the powerful prescription insulin secretagogue, glibenclamide, but without the AMPK activation that is so prevalent among GDA's in general. That is a very significant finding, as glibenclamide is one of the most effective and long-standing secretagogues used in medicine today. Even better, Umbelliferone does this without any harmful side effects; something that cannot be said of glibenclamide, which has numerous contraindications and potentially serious negative effects on the patientÂ’s health.

As a side benefit, umbelliferone also helps prevent/reverse inflammation induced liver injury, making it a powerful and natural liver protectant. This hepatoprotective effect is largely attributable to umbelliferone’s anti-inflammatory properties, which have been repeatedly demonstrated in clinical studies. Most notably, it has been shown to reduce hepatic TNF-a, IL-1β, and IL-6 levels. These inflammatory cytokines play a critical role in the progression of liver injury by provoking hepatocellular injury and death, while TNF-α and IL-1β act as sensitizing factors, amplifying hepatocyte damage by inciting hepatic leukocyte infiltration.

Ampalaya: More commonly known as Momordica Charantia or bitter pear, Ampalaya is a routinely used oral hypoglycemic agent capable of stimulating glucose uptake through multiple pathways. Acting as an insulin secretagogue, insulin sensitizer, and insulin mimetic, Ampalaya provides a number of benefits not found with secretagogues alone. In addition to its clinical efficacy, Ampalaya was selected for this very reason, as it activates AMPK just enough to provide a potent insulin sensitizing effects, but not so much that it impairs the growth process.

Although there are dozens of hypoglycemic agents found in Ampalaya, the most powerful of these include: charantin, polypeptide-p and to a lesser extent, vicine. Charantin functions as an insulin secretagogue and has been shown in clinical studies to produce a more powerful insulinotropic effect than the prescription secretagogue, tolbutamide. Polypeptide-p functions as a potent insulin mimetic, closely resembling insulin in both structure and effect. So comparable are its physiological effects to insulin that it can even be used as an insulin replacement in Type I diabetics. There are at least a dozen additional hypoglycemic agents found within Ampalaya, all of which contribute to the overall effects of this amazing plant.



Enhanced Bioavailability

When designing an GDA formula, one could decide to include only the most powerful ingredients available, but if they are poorly absorbed due to low bioavailability, it means very little. Therefore, it would behoove any supplement company to make sure that this aspect of product development is not overlooked. In many cases, the simple addition of one or more bioavailability enhancers is all that is required to greatly improve a product’s absorption into the bloodstream, thereby enabling the product to provide the results it was intended to.

For Insuligen, I have chosen to use a combination of 4 different compounds, all of which are backed by a mountain of clinical research. These include BioPerine (a trademarked version of piperine), ginger, cumin seed, and gallic acid. Each of these possesses a different mechanism of action and/or work synergistically with the others to further improve bioavailability. Mechanisms of action include p-glycoprotein inhibition, stimulation of gut amino acid transporters, inhibition of drug metabolizing enzymes, reduced production of intestinal glucuronic acid, and increased bile production and digestive motility.

By optimizing virtually every variable associated with the absorption process, you can rest assured that you are receiving maximum benefit from the compounds within Insuligen.



***IMPORTANT***

Insuligen: Glucose Dependent

When using Insuligen, it is very important to understand that its effects are almost entirely glucose dependent. What does this mean? It means that the substances within Insuligen only stimulate insulin secretion in response to the presence of elevated blood glucose levels…and the greater the elevation, the greater the insulinogenic response. In other words, the more carbs you eat, the better the product works, while those who eat little to no carbs will notice little to no results. Yes, its lipolytic and anti-lipogenic effects will still be present, as will a portion of its insulin sensitizing effects, but without adequate carb intake insulin secretion will be minimal to non-existent. Therefore, low-carb dieters need not apply. Insuligen was designed specifically for those interested in building muscle mass.

Given the fact that Insuligen is glucose-dependent, one should not expect to experience hypoglycemia when using it, regardless of the dose employed, because as soon as Insuligen has done its job (lowered BG levels back down into a normal range), insulin secretion will cease. This self-modulatory effect is exactly what we want out of a secretagogue, as it not only prevents the occurrence of hypoglycemia, but also helps prevent insulin resistance and potential fat gain.



Conclusion

As the 1st product of its kind, Insuligen’s arrival ushers in a new class of GDA’s—the muscle-building GDA. By foregoing AMPK activation as its primary M.O.A., Insuligen takes a step away from the anti-growth approach that typifies most GDA’s and instead chooses to rely on endogenous insulin production to power its effects.

By providing a more muscle-friendly GDA, Insuligen helps fill the gap left by the current roster of GDA products, which are more suited for fat-loss and/or recomping. As always, MA Labs is proud to introduce to you it’s newest release in the MA Labs line-up—Insuligen.



 
Rocket3015

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I am looking forward to some reviews.

I would love to see a review from The Solution on this product, I know he is a fan of GDA products and is very respected in the industry!!
 

chainsaw

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I am looking forward to some reviews.

I would love to see a review from The Solution on this product, I know he is a fan of GDA products and is very respected in the industry!!
I think this is a one time only product, so I would buy before reviews
 

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I am looking forward to some reviews.

I would love to see a review from The Solution on this product, I know he is a fan of GDA products and is very respected in the industry!!
He would be one of the worst people to use this product. It wouldn't work for him because he eats almost no carbs( see below).

How does Insuligen difer from other GDA's? It differs in many ways, but from a results standpoint, one of the major differences lies in its MOA. In short, Insuligen is a glucose-dependent insulin secretagogue and unlike any other GDA on the market. It ushers in a new class of GDA known as the muscle building GDA. All other GDA's are fat-loss/recomping GDA's, not muscle builders.

Other GDA's comprised almost solely of insulin senstizers--usually at very high dosages. This is great for fat loss, but horrible for muscle growth, as excessive AMPK activation reduces protein syntheis via the suppression of mTOR. Insuligen does not do this, as it works primarily by elevating insulin levels via the stimulation of pancreatic islets, not AMPK activation.

Therefore, there are now two classes of GDA's. Fat Loss/Recomping GDA's and Muscle-bulding GDA's.

See below...




Insuligen: Glucose Dependent

When using Insuligen, it is very important to understand that its effects are almost entirely glucose dependent. What does this mean? It means that the substances within Insuligen only stimulate insulin secretion in response to the presence of elevated blood glucose levels…and the greater the elevation, the greater the insulinogenic response. In other words, the more carbs you eat, the better the product works, while those who eat little to no carbs will notice little to no results. Yes, its lipolytic and anti-lipogenic effects will still be present, as will a portion of its insulin sensitizing effects, but without adequate carb intake insulin secretion will be minimal to non-existent. Therefore, low-carb dieters need not apply. Insuligen was designed specifically for those interested in building muscle mass, which means carbs are a central part of one's diet.

Given the fact that Insuligen is glucose-dependent, one should not expect to experience hypoglycemia when using it, regardless of the dose employed, because as soon as Insuligen has done its job (lowered BG levels back down into a normal range), insulin secretion will cease. This self-modulatory effect is exactly what we want out of a secretagogue, as it not only prevents the occurrence of hypoglycemia, but also helps prevent insulin resistance and potential fat gain.
 
Rocket3015

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He would be one of the worst people to use this product. It wouldn't work for him because he eats almost no carbs.
Are we talking about the same Guy ? Donuts, Pastry, Rice, French Fries ...............
 

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Insuligen: Only A Single Run Will Be Produced​





Once this 1st batch is sold out, Insuligen will never be sold again, as the price of one of its ingredients increased by 250% during the production process, putting its production cost way out of range for a product within this product category. Even before the price of this ingedient increased by 250%, its production cost was already at the upper-limit of what is considered reasonable. If I were to make a 2nd run, I would either have to incrase the price significantly, or cut my profit margins down to almost nothing. I am not going to do that, so Insuligen will only be a single run product.

So, get it while you can...because once this batch is gone, it will not be back.
 

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Are we talking about the same Guy ? Donuts, Pastry, Rice, French Fries ...............
Last time I spoke to him he was following a low carb diet...and had been for some time. Maybe things are differnet now, but if he is someone who mostly eats low-carbs with occasional re-feeds, it is not the product for him. I clearly state in the product desription that this GDA is not for fat loss or recomping. It is designed SOLELY for those attempting to maximize muscle mass....which is why my product is called "insuligen". Other GDA's are NOTHING like insulin, as they SUPPRESS muscle growth via excessive AMPK activation. How can a product claim to be insulin-like when it not only doesn't help muscle growth, but actually hinders it? It can't. Insuligen is the first GDA that actually works primarily via insulin secretion. Insuligen requires one to eat just like if they were using exogensous insulin...if maximum results are desired (i.e. maximim increases in insulin levels).

I am only seling a single run of Insuliogen, as the price of one of its ingredients went through the roof half-way through the production process, putting its total production cost way outside of what is considered acceptable for a product in this product category. Insuligen cost more to make than most GDA's are sold for. In fact, it costs more to make than almost any other product on the market. Therefore, Insuligen is a single run product.
 

chainsaw

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Insuligen: Only A Single Run Will Be Produced​





Once this 1st batch is sold out, Insuligen will never be sold again, as the price of one of its ingredients increased by 250% during the production process, putting its production cost way out of range for a product within this product category. Even before the price of this ingedient increased by 250%, its production cost was already at the upper-limit of what is considered reasonable. If I were to make a 2nd run, I would either have to incrase the price significantly, or cut my profit margins down to almost nothing. I am not going to do that, so Insuligen will only be a single run product.

So, get it while you can...because once this batch is gone, it will not be back.
Can we get a sale and discount on your other products so I can make a total order
 
The Solution

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Last time I spoke to him he was following a low carb diet...and had been for some time. Maybe things are differnet now, but if he is someone who mostly eats low-carbs with occasional re-feeds, it is not the product for him.
I eat around 300g of carbs a day. I am the furthest guy from low carb man.









Maybe you caught me during a dieting period the "Last time" you spoke to me. But I stay high carb year round. The lowest my carbs ever got were trace during my contest prep (last few weeks) besides that My carbs are always my highest macro year round because my body thrives off them. When I try and go high fat my body rejects it. I simply just work better with carbs and therefore I keep them as high as possible regardless of my goal.

I have done countless reviews on GDA's and test each one with a Blood Glucose monitor.
For example Glcyoshield


HPScience Glycoshield

Information on GDA

Glycøshield represents a GDA for weight management & nutrient partitioning product. Glycøshield is a clinically dosed nutrient partitioner & glucose disposal agent, it also includes clinically studied and trademarked ingredients that have been shown in studies to boost metabolism, prevent excess fat gain & blood sugar spikes, prevent & reverse type 2 diabetes, lower bad cholesterol, act as an anti inflammatory & more.

Dosing





Less then 50g = 1 Cap
50-75g Carbs = 2 Caps
75-100g Carbs = 3 Caps
150+g = 4 Caps
Cheat meals = 4 Caps

Dose 20-30 Minutes Prior to a meal.

Formula


250mg Garcinia Cambogia (can block fat production)
190mg Berberine HCL (control of insulin/glucose levels and lipid parameters)
170mg Salaretin (transport/usage of fatty acids to fuel bodily processes)
150mg Banaba Leaf (lowers amounts of insulin to shuttle glucose into cells )
120mg Olive Leaf Extract (increase insulitn sensitivity)
120mg Gymnema Sylvestre (proven to lower blood glucose levels)

Monitor Readings

** All readings are 90 minutes post meal.
** 2 Caps 15 minutes prior to carb meal (Requested by Company)
** Carb meal amounts are listed

Upon Waking: (Baseline) – 85 mg/dl


90 Minutes after 25g Carb with 1 Cap – 30 mg/dl
175g Cooked Potatoes


90 minutes after 50g Carbs with 1 Caps – 61 mg/dl
7 Rice Cakes


90 Minutes after 25g Carbs with 2 Caps – 43 mg/dl
4 Rice Cakes


90 minutes after 50g Carbs with 2 Caps: - 97 mg/dl (Bad reading?)
Carb meal was 7 Rice Cakes (49g Carbs)


90 minutes after 75g Carbs with 2 Caps: - 85 mg/dl
Carb meal was 5 Rice Cakes + Honey + Banana


90 minutes after 100g Carbs with 2 Caps: - 53 mg/dl
4 Servings of Cereal


90 minutes after Cheat Meal with 2 Caps – 137 mg/dl
Thai Food → Appetizer, Entrée, and Deep Fried Cheesecake


90 Minutes after Cheat Meal with 4 Caps: - 90 mg/dl
Pint of Ice Cream


Notes

Good:
- Weight dropped on Day 1 with no dietary changes or training changes.
-BG is baselining very fast from resting in 25 – 100g Cap Meals (some readings were up and down).
- Improved digestion. Less overall bloating.

Bad:
- Hunger increase since starting Glycoshield. For those who can’t have self control they will overeat due to hunger pains.
- BG reached lows of 30-50, which is half of my resting. This could cause hypo like symptoms for some individuals.

Tracking my Weight
I will note any weight changes during my use of Glycoshield. I am making 0 dietary changes, the only thing changed is the addition of the GDA

I started Glycoshiled Wednesday Jan 10th in the afternoon
Mon Jan 8th – 172
Tue Jan 9th – 171.6
Wed Jan 10th – 170.2 (Started Glycoshield with last 2 carb meals)
Thur Jan 11th – 169.4 (took with 75g carb meals and 100g carb meals BG Dropped 30 from resting)
Friday Jan 12th- 170 (Was hungry and had extra food on top of calories still below daily average)
Saturday Jan 13th – 170.4 (Back to regular diet)
Sunday Jan 14th – 170.6 (Non Workout Day)
Monday Jan 15th - 170.4 (After Cheat Meal and 4 Cap dosing)



 

chainsaw

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I eat around 300g of carbs a day. I am the furthest guy from low carb man.









Maybe you caught me during a dieting period the "Last time" you spoke to me. But I stay high carb year round. The lowest my carbs ever got were trace during my contest prep (last few weeks) besides that My carbs are always my highest macro year round because my body thrives off them. When I try and go high fat my body rejects it. I simply just work better with carbs and therefore I keep them as high as possible regardless of my goal.

I have done countless reviews on GDA's and test each one with a Blood Glucose monitor.
For example Glcyoshield
I would like to see you run this product, but I'm afraid once your log is over the product will be done. I'd like to see how it effects you
 
Rocket3015

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Like I stated before The Solution would be the perfect guy to test this and if it works as good as advertised I could see a market for it even at a higher price. People pay for for Filet Mignon than hamburger everyday !!
 

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