What M1D is and isn't...the science behind it

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  1. What M1D is and isn't...the science behind it


    Ok, Methyl 1-D is always being questioned, so I thought I would write a quick explanation on the science behind it and why the knock off products are no where near as good. You can get an idea of the time spent on the product.

    Methyl 1-D isn't just DHEA, we use a DHEA Ethanoate Ester. Ethanoate Esters help improve functional absorbtion while (my theory) blocking some of the effects of Sulfotransferase. Sufation is the main way Androsterones get inactivated in the body and the Ethanoate Ester occupies the same spot as the Sufate, so in theory it should increase the bioavailability of the molecule. Sulfation is the main reason you need to take a thousand milligrams of a diol to make it effective. Blocking Sulfation was started in this industry by US!

    Ingredient # 1 - ATD
    ATD blocks aromatase and keeps more of the conversion process in check, so more DHEA is available to convert into Testosterone.

    Ingredient # 2 - Ellagic Acid
    A natural SERM derivied from raspberries. Ellagic Acid would serve to block any intrinsic estrogenic effects of the 5-ENE molecule.

    Ingredient # 3 - Milk Thistle
    Milk Thistle isn't just for livers, it blocks the second big route of excretion, Glucoronidation. The standardized Milk Thistle we use, inhibits Glucoronidase.

    Ingredient # 4 - Luteolin
    Luteolin is a Sulfotransferase competitive inhibitor. Meaning it soaks up the Sulfotransferase enzyme so it can't act on the hormone. A HUGE percent of 3b-ol steroids get sulfated, which makes them inactive. Luteolin is a strong binder to Sulfotransferase, much stronger than a prohormone.

    Ingredient # 5 - Stinging Nettle Extract
    We all know that this blocks SHBG, freeing up more testosterone, but the full plant extract is also a 5aReductase inhibitor, which means less converstion to DHT and much higher androgen levels.

    Ingredient # 6 - Coleus Forskolin
    CF upregulates 3bHSD, the enzyme responsible for converting the 3b-ol to the active. Since the gut contains a boat load of 17bHSD much of the oral hormone is turned into 5-AD, which if you block the estrogenic effects (which we have) is pretty potent.

    Ingredient # 7 - Caprylic Acid
    This is one half of Receptor, which makes the cells more sensitive to androgens.

    Ingredient # 8 - Zinc Aspertate
    The Z in ZMA is what does all the work. Zinc increases the effeciency of the Androgen receptor fingers.

    Ingredient # 9 - Piperine
    Piperine increases absorbtion by blocking Glucoronidase as well as increasing intestinal permeability.

    So, when someone says "M1D is ****, it's just DHEA" post them this write up please...

    Honestly, all hormones (except the 17aMethyl) could benefit from our delivery methods (patent pending). Making the stuff you have work better is what we are all about. We are not perfect, but as you can see I am quite proud of Methyl 1-D!


  2. Great Post! You know i learned a ton about this the other night and was very excited once i was informed!
    E-Pharm Rep... PM me with any questions or concerns
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  3. Does sound better than I first thought.

  4. Quote Originally Posted by jasonschaffin View Post
    Does sound better than I first thought.
    It really is a great and well-thought out product. Just like all of our products seem to be when you look a little bit closer then just the label. I look forward to trying it.
    E-Pharm Rep... PM me with any questions or concerns

  5. Quote Originally Posted by 3clipseGT View Post
    It really is a great and well-thought out product. Just like all of our products seem to be when you look a little bit closer then just the label. I look forward to trying it.
    So do I!

  6. Does "making the stuff you have work better" mean to stack this with something else, like H-Dol or M-Drol perhaps? Making that compound more effective?

  7. Quote Originally Posted by Big Dane View Post
    Does "making the stuff you have work better" mean to stack this with something else, like H-Dol or M-Drol perhaps? Making that compound more effective?

    Not at all. It just means we are making sure you are getting what you paid for in the sense that were trying to make sure what you ingest is bein fully used in the body. Im sure though if you stacked it with something like h-drol or m-drol ( altho those are methyl and dont get much better then that ) it may help increase absorbtion a tad. Its really used for non-methyl compounds.
    E-Pharm Rep... PM me with any questions or concerns

  8. I liked my gains while on Methyl 1-D, use it and try it out.
    AZZA

  9. Quote Originally Posted by 3clipseGT View Post
    Not at all. It just means we are making sure you are getting what you paid for in the sense that were trying to make sure what you ingest is bein fully used in the body. Im sure though if you stacked it with something like h-drol or m-drol ( altho those are methyl and dont get much better then that ) it may help increase absorbtion a tad. Its really used for non-methyl compounds.
    This is true. It is not uncommon to see non methylated compounds stacked with a methylated compound to increase potential gains.

  10. Just bought some methyl 1 d. i have used the old massdrol and trenadrol before and hoping i can get good gains on the m1d since i have used prohormones n the past. just tryin to c if i should stack it . thanx
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  11. Quote Originally Posted by steezy69 View Post
    Just bought some methyl 1 d. i have used the old massdrol and trenadrol before and hoping i can get good gains on the m1d since i have used prohormones n the past. just tryin to c if i should stack it . thanx
    What you looking to stack it with man?

  12. e****lent post, will be using this info in the future when I try to explain it to friends!

  13. Terrific thread. M1D has been far and away my favorite LG supplement. PH like gains without the PH like sides is what Ive experienced bottle after bottle.
    Molecular Nutrition - Unlevel The Field
    X-Factor: THE Most Scientifically Valid Muscle Builder, Ever!
    Sign up for INSANE deals via our newsletter: www.mninsider.com

  14. " Ingredient # 8 - Zinc Aspertate
    The Z in ZMA is what does all the work. Zinc increases the effeciency of the Androgen receptor fingers. "

    Interesting, but it is unfortunate that zinc aspartate has been chosen. Aspartates causes excitotoxicity. So, I will not use this product given the harmful effects of the present formula.

  15. Zinc Aspartate is simple zinc chelated, or bound to, L-aspartic acid. I hope you realize that protein contains L-aspartic acid. Including whey, casein, pea, chicken, beef, eggs well all of them. Some of the functions of L-aspartic acid include:Aspartic Acid
    Helps convert carbohydrates into muscle energy
    Builds immune system immunoglobulins and antibodies
    Reduces ammonia levels after exercises

    So ya way to play it safe just make sure to avoid all sources of protein.
    LG Sciences/Legal Gear Rep
    Nothing I state is medical advice and is for informational purposes only.

  16. Play it safe, and do some simple research on excitotoxins.

    Aspartates cause excitotoxicity. Not L-aspartic acid. There is a difference between the two.

    Or for more in depth reading: " Excitotoxins: The Taste That Kills "

  17. I know what you are referring to but zinc aspartate is simply zinc bound to L-aspartic acid, the same L-aspartic acid that you find in protein.
    LG Sciences/Legal Gear Rep
    Nothing I state is medical advice and is for informational purposes only.

  18. Correct: " Zinc aspartate is simply zinc bound to L-aspartic acid, "

    Incorrect: " the same L-aspartic acid that you find in protein. "

    Correct: Aspartates cause excitotoxicity.

  19. Quote Originally Posted by Fresprt View Post
    Play it safe, and do some simple research on excitotoxins.

    Aspartates cause excitotoxicity. Not L-aspartic acid. There is a difference between the two.

    Or for more in depth reading: " Excitotoxins: The Taste That Kills "
    Quote Originally Posted by Fresprt View Post
    Correct: " Zinc aspartate is simply zinc bound to L-aspartic acid, "

    Incorrect: " the same L-aspartic acid that you find in protein. "

    Correct: Aspartates cause excitotoxicity.
    You contradicted yourself? You just said L-Aspartic does not cause excitotoxicity. So how does this formula's zinc aspartate cause harm if the zinc is bonded to L-Aspartic acid, which you just said does not cause excitotoxicity

  20. Please explain how the L-aspartic acid that is in protein is different from the L-aspartic acid in zinc aspartate. Zinc aspartate is NOT aspartame. If you do not feel comfortable taking zinc aspartate, while I feel it is safe, I respect your right to choose what you do or do not ingest.

    Here is a link to some more info on ZA:
    http://www.mineralsinc.com/WriteUp/ZincAspartate_w.htm
    LG Sciences/Legal Gear Rep
    Nothing I state is medical advice and is for informational purposes only.

  21. Think big picture. The amount of zinc aspartate involved here is negligible.
  22. How Aspartate (and Glutamate) Cause Damage


    Please explain how the L-aspartic acid that is in protein is different from the L-aspartic acid in zinc aspartate.
    Dr. Joseph Mercola:

    Aspartate and glutamate act as neurotransmitters in the brain by facilitating the transmission of information from neuron to neuron. Too much aspartate or glutamate in the brain kills certain neurons by allowing the influx of too much calcium into the cells. This influx triggers excessive amounts of free radicals, which kill the cells. The neural cell damage that can be caused by excessive aspartate and glutamate is why they are referred to as "excitotoxins." They "excite" or stimulate the neural cells to death.

    The excess glutamate and aspartate slowly begin to destroy neurons. The large majority (75 percent or more) of neural cells in a particular area of the brain are killed before any clinical symptoms of a chronic illness are noticed. A few of the many chronic illnesses that have been shown to be contributed to by long-term exposure to excitatory amino acid damage include:

    Multiple sclerosis (MS)
    Parkinson's disease
    ALS
    Hypoglycemia
    Memory loss
    AIDS
    Hormonal problems
    Dementia
    Epilepsy
    Brain lesions
    Alzheimer's disease
    Neuroendocrine disorders

    A few of the many experts who have spoken out against the damage being caused by aspartate and glutamate include Adrienne Samuels, Ph.D., an experimental psychologist specializing in research design. Another is Olney, a professor in the department of psychiatry, School of Medicine, Washington University, a neuroscientist and researcher, and one of the world's foremost authorities on excitotoxins. (He informed G.D. Searle, [the manufacturer of aspartame] in 1971 that aspartic acid caused holes in the brains of mice.)

    Dr. Joseph Mercola is an osteopathic physician and a prolific author including two New York Times Bestsellers, The Great Bird Flu Hoax and The No-Grain Diet. He has been interviewed on national and local news, including:
    Today Show, CNN, ABC's World News Tonight, The Dr. Oz Show, The Doctors, CBS, NBC and ABC local news shows, Time Magazine, Forbes Magazine, Dozens of Nationally Broadcast Radio Shows

    mercola.com/forms/background.htm


    Note: Regarding "holes in the brains of mice" referenced above. Humans are 5X more sensitive to excitotoxins than a mouse.

    Source - Video lecture by Dr. Russell Blaylock: Excitotoxins - The Taste That Kills (Posted July 11, 2011)
    youtube.com/watch?v=tTSvlGniHok

    Russell L. Baylock board certified neurosurgeon, author, lecturer and educator
    russellblaylockmd.com

    Zinc aspartate is NOT aspartame.
    Using a modest amount of 15 mg. zinc aspartate for comparison

    Zinc aspartate is formed with 85% L-aspartic acid
    85 mg. L-aspartic acid is reacted to
    15 mg. elemental zinc

    versus

    12 oz. diet coke

    Aspartame is formed with 40% L-aspartic acid
    90 mg. L-phenylalanine is reacted with
    72 mg. L-aspartic acid and
    18 mg. methanol

  23. Think big picture. The amount of zinc aspartate involved here is negligible.
    Hmm, okay please tell us the exact "amount of zinc aspartate involved here," what amount of excitotoxins you consider "negligible" and why.

    “Think big picture.”

    Yes, it is call science. Neurology and toxicology.

    Aspartates are dangerous toxins that cause brain damage and disease. One example is Alzheimer’s Disease.

    “The most common thought of the ideology [for the cause of Alzheimer’s Disease] is excessive excitotoxicity in the brain”

    Source - Video lecture by Dr. Russell Blaylock: Excitotoxins - The Taste That Kills (Posted July 11, 2011)
    youtube.com/watch?v=tTSvlGniHok

    Russell L. Baylock board certified neurosurgeon, author, lecturer and educator
    russellblaylockmd.com

  24. Whey protein has about 12.5g of aspartic acid per 100 grams. 12.5g is 12500mg of aspartic acid, that is far far far more than the amount you receive from zinc aspartate. I already stated that I respect your right to choose not to ingest this supplement so please take your l-aspartic crusade elsewhere. Thank you.
    LG Sciences/Legal Gear Rep
    Nothing I state is medical advice and is for informational purposes only.

  25. God seriously why goes it even matter? If you don't like the supplement don't take it. There are worse things for you in the air and food you probably consume everyday

  26. Thank you. As I have pointed out there is a TON more l-aspartic acid in every protein source we consume that worrying about mg quantities in a zinc chelate is not worth the stress. To each there own I suppose.
    LG Sciences/Legal Gear Rep
    Nothing I state is medical advice and is for informational purposes only.

  27. Whey protein has about 12.5g of aspartic acid per 100 grams. 12.5g is 12500mg of aspartic acid, that is far far far more than the amount you receive from zinc aspartate. I already stated that I respect your right to choose not to ingest this supplement so please take your l-aspartic crusade elsewhere. Thank you.
    In responding to your previous comments I have merely presented the statements by eminent physicians on the established scientific fact that aspartates are dangerous neurotoxins such as the zinc aspartate contained in M1D.

    Your position appears to deviate and focus on aspartic acid instead of aspartate. The two are not the same and zinc aspartate is an ingredient of in M1D as stated on the product label.

    Dr. Joseph Mercola, a prominent osteopathic physician and author

    “Aspartate and glutamate act as neurotransmitters in the brain”

    “Too much aspartate or glutamate in the brain kills certain neurons by allowing the influx of too much calcium into the cells.”

    Therefore, it is a relevant discussion.

  28. Quote Originally Posted by Fresprt View Post

    In responding to your previous comments I have merely presented the statements by eminent physicians on the established scientific facts that aspartates are dangerous neurotoxins such as the zinc aspartate contained in M1D.

    Your position seems to focus on aspartic acid instead of aspartate. The two are not the same and zinc aspartate is an ingredient of in M1D as stated on the product label.

    "Aspartate and glutamate act as neurotransmitters in the brain"

    "Too much aspartate or glutamate in the brain kills certain neurons by allowing the influx of too much calcium into the cells."

    Therefore it is a relevant discussion.
    You do know Aspartic Acid and Aspartate are the same exact compound, just different chemical nomenclature

  29. Quote Originally Posted by Rarchib View Post
    You do know Aspartic Acid and Aspartate are the same exact compound, just different chemical nomenclature
    I have tried to be patient with this but he just does not get it. Fresprt I get it you are not in favor of this ingredient, so just don't take it and please stop posting in this thread.
    LG Sciences/Legal Gear Rep
    Nothing I state is medical advice and is for informational purposes only.

  30. Quote Originally Posted by bigflex0 View Post
    I have tried to be patient with this but he just does not get it. Fresprt I get it you are not in favor of this ingredient, so just don't take it and please stop posting in this thread.
    Lol I can't believe this debate is still going on
  

  
 

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