E-CONTROL Rx™ - ANTI-ESTROGEN & TESTOSTERONE BOOSTER
- 05-11-2011, 02:46 PM
E-CONTROL Rx™ - ANTI-ESTROGEN & TESTOSTERONE BOOSTER
E-CONTROL Rx™ - ANTI-ESTROGEN & TESTOSTERONE BOOSTER
NEW FORMULA WITH 6-OXO - COMING VERY SOON!
- Pharmaceutical Grade 1,4,6-Androstatriene-3,17-dione (aka 6-OXO)
- Increases Testosterone Levels Up To 226%
- Decreases & Helps Control Estrogen Levels
- Effective for PCT (Post Cycle Therapy)
E-Control Rx™ contains 4-Androstene-3,6,17-trione (aka "6-OXO") a dietary supplement that increases the testosterone-estrogen ratio. E-Control Rx™ is a potent irreversible aromatase inhibitor that inhibits estrogen biosynthesis by permanently binding and inactivating aromatase in adipose and peripheral tissue. Aromatase is responsible for the conversion of testosterone to estradiol. Blocking aromatase causes the body to decrease in levels of estradiol, which then results in increase of LH and consequently, testosterone. Since testosterone has myotropic activity and estradiol does not, elevated testosterone levels increase muscle mass.
E-Control Rx™™ is also used by steroid or prohormone users to counteract estrogen level increases caused by aromatization during their steroid cycle. This helps minimize side effects such as gynecomastia but can lead to acne. Also, after a steroid cycle, the compound may be used to shorten the recovery from the testicular suppression that can be the result of the use of steroids. A recent United States patent application claims an 88% increase in plasma testosterone levels in men, while decreasing estrogen levels by 11%. The subjects took 300mg orally twice a day for four weeks without taking any other drugs or supplements.
Baylor University conducted an eight-week study to determine the effects of 300 mg or 600 mg of 6-OXO in resistance-trained males. Compared to baseline, free testosterone increased by 90% for 300mg group and 84% for 600mg group, respectively. Also dihydrotestosterone and the ratio of free testosterone to estradiol increased significantly.
THE STRONGEST LEGAL AROMATASE INHIBITOR ON THE MARKET!
The science of IronMagLabs E-Control Rx™ with 6-OXO
It's The Scientific Results That Go Beyond the high Expectations of Every Serious Bodybuilder...
When advanced bodybuilders think of IronMagLabs, they think of state-of-the-art prohormones--like the revolutionary product Super-DMZ Rx. Most recently, IronMagLabs developed E-Control Rx™ with 6-OXO - a unique compound that has been shown in scientific literature to be a "suicide" inhibitor of the estrogen producing enzyme aromatase. In addition, it was believed that 6-OXO would also increase testosterone levels through manipulation of the body's natural hormonal feedback system. This was great news for bodybuilders who desired in-cycle and post-cycle estrogen management as well as a boost in testosterone.
However, research has revealed that the power of 6-OXO is even greater than had been anticipated, and therefore has even more to offer the competitive or serious bodybuilder. With the advent of 6-OXO, ErgoPharm founder, Patrick Arnold, has once again delivered a compound to the sport that is destined to become a staple in every bodybuilder's arsenal. In fact, no matter what level of development you've attained, it just might be the most effective supplement for maximizing your anabolic environment. IronMagLabs recognizes the power of 6-OXO and has made it the main ingredient of E-Control Rx™.
Science Serious Bodybuilders Can Use
A study on 6-OXO was completed by a prestigious clinical research organization. This study examined the blood hormone responses over a 3-week cycle of 600mg per day of 6-OXO. The study used 6 normal men aged 32-40, and in addition to tracking changes in sex hormone levels it also looked at common indicators of toxicity.
The results were very impressive. Total testosterone levels rose an average of 188%, while free testosterone levels rose an average of 226% over the course of the three weeks! The variability among the 6 subjects was quite low, and majority of the testosterone increase was acheived after only the first week. Not only that, but there was NO indication of acute toxicity and in some areas (cholesterol, liver function) health and function even improved!! Results from two of the six subjects are demonstrated below:
An Advanced Look At The Estrogen/Testosterone Connection
A decrease in estradiol (the bioactive form of estrogen) was seen, but unlike testosterone the change was not drastic--levels still remained within the low end of normal. The explanation for this is simple; 6-OXO acts to inhibit the aromatase enzyme and block the conversion of testosterone to estradiol. A consequence of this is a signal from the brain to increase production of testosterone to compensate for the blocked estradiol production. As testosterone levels increase, so do estradiol levels since more substrate has now become available for the aromatase enzyme. Basically, what has occurred is the establishment of a new baseline level of testosterone to maintain the body's normal levels of estradiol. This sort of hormonal response is in fact very desirable, as decreasing estradiol levels below normal can be detrimental. E-Control Rx™ with 6-OXO will CONTROL estrogen but not CRUSH it.
The Clinically Proven Supplement For Serious Results
Finally, E-Control Rx™ with 6-OXO is the only product that is both an effective estrogen inhibitor AND a non-hormonal testosterone trigger. It's the product with the science every serious bodybuilder has been waiting for.
* What: E-Control Rx™ with 6-OXO contains a natural compound that helps trigger the release of Luteinizing Hormone (LH). Recent data by a prestigious clinical research organization has shown that after 3 weeks of 600mg/day, test subjects averaged a 226% increase in free testosterone! 6-OXO also combats estrogen formation by inhibiting aromatase.
* Why: Having increased testosterone is a no-brainer--train harder and recover faster. But estrogen contributes to a host of unwanted side effects--water retention, gyno (bitch tits), moodiness, and an overall smooth, soft look.
* Who: Any athlete interested in achieving a hard, lean physique. E-control with 6-OXO is for those that have been predictably disappointed by the hype promised by cheap Tribulus and other non-hormonal testosterone boosters.
Go here for E-Control Rx
- 05-11-2011, 02:46 PM
6-OXO - The First Effective All-Natural Aromatase Inhibitor
by Patrick Arnold
Pat is responsible for launching several major product and innovation in the prohormone industry through LPJ Research and Ergopharm, including the first to release androstenedione, 1-AD, 6-OXO, 4-androstenediol, and 19-norandrostenediol. In addition, he is responsible for bringing innovative delivery systems to the prohormone market including HPB cyclodextrin, bioadhesive technology for sustained release, and sustained release sprays.
For athletes familiar with prohormones and steroids, the female hormone estrogen is undoubtedly a familiar enemy. While most of us understand that estrogen is not necessarily always a harmful and worthless substance to men (in the right amounts it is necessary and beneficial), we still are aware that it must be kept under control or some pretty undesirable conditions may arise in the body.
The Evils of Estrogen
In males, higher than normal estrogen levels (or estrogen levels that are out of balance with androgen levels) can lead to several physiological disturbances. The most well known estrogen induced malady is, of course, gynecomastia (aka gyno or bitch tits). Gyno, simply put, is the growth of breast tissue in men. Usually gyno is a benign growth that is little more than a cosmetic nuisance, however it occasionally (rarely) can become malignant and lead to male breast cancer. Either way, it is something than definitely is anathema to any guy that takes pride in his physical appearance and musculature. Rock hard pecs topped off with puffy cone shaped girlie lumps are simply not for showing off - at least not in my neighborhood.
High estrogen can also promote excessive water and sodium retention, resulting in a bloated, puffy, and smooth appearance. Steroids that aromatize heavily (such as testosterone and Anadrol®) are renowned for putting on lots of bodyweight. However, that body weight usually is in large part estrogen induced water retention, and certainly not all muscle.
If all this is not enough then there is the potent inhibitory effect of estrogen on the hypothalamus, resulting in a shutdown of testicular testosterone production. Science has demonstrated that perhaps the most important regulator of testosterone production in males is estrogen - produced by the conversion of testosterone (and other androgens) to estrogen in the body and the brain. Estrogen sends a signal to the hypothalamus to shut down production of a substance known as GnRH. GnRH is a hormone that stimulates the pituitary to produce luteinizing hormone (LH) which is the signal that tells the testicles to produce testosterone. Therefore, men with elevated estrogen levels will have suppressed testosterone levels and perhaps even atrophied testes. Not a pretty picture, eh?
Controlling estrogen in males
Bodybuilders who use steroids caught on years ago to drugs that control estrogen in the body. The first drugs to be utilized were estrogen receptor antagonists such as tamoxifen and clomiphene. These drugs worked by binding to the estrogen receptor like estrogens do, but unlike estrogens they are unable to translocate to the nucleus and activate estrogen responsive genes. While these drugs are somewhat effective in countering gynecomastia and testicular shut down, they still retain some estrogenic activity in certain tissues such as the liver. The result of this residual estrogenic activity can be a reduction in IGF-1 production and an increase in sex hormone binding globulin (SHBG) production. These are both undesirable side effects.
Later on, bodybuilders discovered aromatase inhibitors. These drugs work by blocking the production of estrogens in the body through binding to the enzyme aromatase. Aromatase catalyzes the transformation of aromatizable androgens (i.e. androstenedione, testosterone) into estrogens such as estrone and estradiol. By actually blocking the production of estrogens altogether, aromatase inhibitors do not share the undesirable estrogen agonist activity of estrogen receptor blockers. Instead they function as true anti-estrogens, and because of this have arisen as the most preferred compounds for combating estrogen.
6-OXO™, the first effective all natural aromatase inhibitor
Before I go into detail about 6-OXO™, I would like to give a very brief review and commentary on the current variety of estrogen blocking supplements.
The first estrogen blocking supplement to be introduced, and perhaps the most popular one to date is the isoflavone chrysin. Yes, chrysin has some good in-vitro ("test tube") research on it that demonstrates it blocks aromatase. However, for years many experts including myself have contended that it suffers from very poor bioavailability, and therefore is ineffective in-vivo. Recently, an article has been published in a very reputable journal that substantiates this suspicion. So chrysin, as promising as it once seemed, unfortunately appears to be a total bust.
After chrysin there was Indole-3-carbinol and Di-indoylmethane. These related compounsds work by shifting the metabolism of estrogens away from strong estrogen compounds (16-hydroxylated) and towards weaker estrogens (2-hydroxylated). This can have benefits for women prone to breast cancer as 16-hydroxylated estrogens are quite notorious for promoting estrogen dependent breast cancer. However, there has never been any benefit demonstrated in men for reducing estrogen related effects or for increasing androgen levels. In fact, these compounds may actually REDUCE androgen levels. So for males looking to reduce estrogen and raise testosterone, I-3-C and DIM are poor choices.
In addition to these aforementioned compounds there have been a slew of other compounds sold for estrogen control purposes. These include bioflavonoids such as quercitin, herbs such as Vitex Agnus Castus, and phytochemicals such as resveratrol (3,5,4'-trihydroxystilbene). None of these has ever been substantiated by any research to reduce estrogen levels or to increase testosterone levels.
After years of research into natural estrogen blockers I finally discovered a compound that really truly works, in males, to both reduce estrogen and increase testosterone. Its called 6-OXO™.
6-OXO™ is what is known as a suicide inhibitor of aromatase. This means that 6-OXO™ binds to the aromatase enzyme in a permanent and irreversible manner, rendering it inactive. The result of this is an eventual diminishment of aromatase enzyme in the body and a concomitant reduction in estrogen levels. A corresponding increase in testosterone production is usually experienced as well.
It is important to note here that this deactivation of aromatase enzymes by 6-OXO™ does not mean that your body becomes permanently deficient in the ability to synthesize estrogen. Your body will react to the deficiency of enzyme by producing more enzyme to replace that which has been deactivated. Therefore, when you stop taking 6-OXO™ your aromatase enzyme level will quickly catch up to normal and full estrogen production will resume.
When and how you should use 6-OXO™
There are two main situations where 6-OXO™ can come in useful. The first situation is in combating estrogen elevation while taking aromatizable prohormones or steroids. Aromatizable prohormones/ steroids include testosterone, testosterone precursors (4-androstenedione, 4-androstenediol), nortestosterone, nortestosterone precursors (19-nor-4-androstenedione, 19-nor-4-androstenediol), and synthetic anabolic steroids such as oxymetholone (Anadrol®) and methandrostenolone (Dianabol).
The second situation where 6-OXO™ stands very useful is in restoring full endogenous testosterone production after a cycle of prohormones or steroids. Prohormones and steroids act as replacements for natural testosterone, and as a consequence, prolonged usage of these substances results in the body resetting the level of its own natural testosterone production. Your body does this by adjusting the activity of the hypothalamic pituitary testicular axis, or HPTA. The HPTA acts like a thermostat that constantly adjusts the body's production of testosterone to maintain a certain level in the blood. The hypothalamus is the primary sensor in this system, and it responds to both androgens (i.e. testosterone, DHT) and estrogens (derived from aromatization of androgens). The hypothalamus is so sensitive to estrogens in fact that administration of an estrogen blocker can often result in a very substantial surge in testosterone production. This is why steroid using bodybuilders take products such as Clomiphene (an estrogen receptor antagonist) and Anastrazole (an aromatase inhibitor) after cycles to jump-start their suppressed testicular testosterone production. Now, with the introduction of 6-OXO™, there is a natural - over the counter alternative available to these prescription only drugs.
Okay, am I saying that one has to be a prohormone or steroid user to find 6-OXO™ useful? Certainly not! Even if you never touch prohormones/steroids you can obtain a very substantial and beneficial increase in natural testosterone production by taking nothing but 6-OXO™. For those that are wary of hormonal supplements and their effects on the bodies endocrine balance, yet still want to obtain the benefits of increased testosterone levels, 6-OXO™ offers a very safe and effective alternative.
So how does one use 6-OXO™? If you are using it to combat estrogen during a cycle of aromatizable steroids then you can take it every day of your cycle, once a day (preferably with your evening meal) at a dosage of 200-600 mg. If you are using it to jump-start your testosterone production after a cycle of prohormones (or just to increase your own natural production in a clean state) then you would also take 200-600mg of 6-OXO™ once a day, for a period of 3-6 weeks.
1 Saarinen N et.al., .No evidence for the in vivo activity of aromatase-inhibiting flavonoids.. J Steroid Biochem Mol Biol. 2001 Sep;78(3):231-9.
2 Wilson, V.S., et al., .Alteration in sexually dimorphic testosterone biotransformation profiles as a biomarker of chemically induced androgen disruption in mice.” Environ Health Perspect, 1999. 107(5):377-384.
3 Covey DF, Hood WF, “Enzyme-generated intermediates derived from 4-androstene-3,6, 17-trione and 1,4,6-androstatriene-3,17-dione cause a time-dependent decrease in human placental aromatase activity” Endocrinology. 1981 Apr;108(4):1597-9.
4 Numazawa M, Mutsumi A, Tachibana M, “Mechanism for aromatase inactivation by a suicide substrate, androst-4-ene-3,6,17-trione. The 4 beta, 5 beta-epoxy-19-oxo derivative as a reactive electrophile irreversibly binding to the active site” Biochem Pharmacol. 1996 Oct 25;52(8): 1253-9.
5 Numazawa M, Midzuhashi K, Nagaoka M, “Metabolic aspects of the 1 beta-proton and the 19-methyl group of androst-4-ene-3,6,17-trione during aromatization by placental microsomes and inactivation of aromatase” Biochem Pharmacol. 1994 Feb 11;47(4):717-26.
6 Numazawa M, Tsuji M, Mutsumi A, “Studies on aromatase inhibition with 4-androstene-3,6, 17-trione: its 3 beta-reduction and time-dependent irreversible binding to aromatase with human placental microsomes”.J Steroid Biochem. 1987 Sep;28(3):337-44.
7 Marsh DA, Brodie HJ, Garrett W, Tsai-Morris CH, Brodie AM, “Aromatase inhibitors. Synthesis and biological activity of androstenedione derivatives” J Med Chem. 1985 Jun;28(6): 788-95.
8 Booth JE “Effects of the aromatization inhibitor androst-4-ene-3,6,17-trione on sexual differentiation induced by testosterone in the neonatally castrated rat” J Endocrinol. 1978 Oct;79 (1):69-76.
9 Levy H et.al, “The inhibition by metopirone of 11beta and 19-hydroxylations of androst-4-ene-3,17-dione in bovine adrenal perfusion” Steroids. 1965; 5:479-493.
10 Tan L et al., “De novo biosynthesis of 6 beta-hydroperoxyandrostenedione in human placental microsomes.” Biochem Biophys Res Commun. 1984 Feb 14;118(3):805-13.
Read more from this MESO-Rx article at: 6-OXO - The First Effective All-Natural Aromatase Inhibitor by Patrick Arnold
- 05-11-2011, 02:47 PM
Journal of the International Society of Sports Nutrition
Research article Open Access
Effects of eight weeks of an alleged aromatase inhibiting nutritional
supplement 6-OXO (androst-4-ene-3,6,17-trione) on serum
hormone profiles and clinical safety markers in resistance-trained,
Dan Rohle1, Colin Wilborn2, Lem Taylor3, Chris Mulligan4, Richard Kreider5
and Darryn Willoughby*5,6
Address: 1Pharmacology Department, Weill Cornell Graduate School of Medical Sciences, 445 East 69th Street, Room 412, New York, NY 10021,
USA, 2Department of Exercise and Sport Science, University of Mary Hardin-Baylor, UMHB Station, 900 College Box 8010, Belton, Texas 76513,
USA, 3Department of Health, Leisure, and Exercise Science, University of West Florida, 11000 University Parkway, # 72-219, Pensacola, FL 32514, USA, 4Department of Nutrition and Food Science, Colorado State University, Fort Collins, CO 80523, USA, 5Department of Health, Human
Performance, and Recreation, Baylor University, Box 97313, Waco, TX 76798, USA and 6Institute for Biomedical Studies, Baylor University, Waco,
TX 76798, USA
Email: Dan Rohle - [email protected]; Colin Wilborn - [email protected]; Lem Taylor - [email protected];
Chris Mulligan - [email protected]; Richard Kreider - [email protected]; Darryn Willoughby* - [email protected]
* Corresponding author
The purpose of this study was to determine the effects of 6-OXO, a purported nutritional
aromatase inhibitor, in a dose dependent manner on body composition, serum hormone levels, and
clinical safety markers in resistance trained males. Sixteen males were supplemented with either
300 mg or 600 mg of 6-OXO in a double-blind manner for eight weeks. Blood and urine samples
were obtained at weeks 0, 1, 3, 8, and 11 (after a 3-week washout period). Blood samples were
analyzed for total testosterone (TT), free testosterone (FT), dihydrotestosterone (DHT),
estradiol, estriol, estrone, SHBG, leutinizing hormone (LH), follicle stimulating hormone (FSH),
growth hormone (GH), cortisol, FT/estradiol (T/E). Blood and urine were also analyzed for clinical
chemistry markers. Data were analyzed with two-way MANOVA. For all of the serum hormones,
there were no significant differences between groups (p > 0.05). Compared to baseline, free
testosterone underwent overall increases of 90% for 300 mg 6-OXO and 84% for 600 mg,
respectively (p < 0.05). DHT underwent significant overall increases (p < 0.05) of 192% and 265%
with 300 mg and 600 mg, respectively. T/E increased 53% and 67% for 300 mg and 600 mg 6-OXO,
respectively. For estrone, 300 mg produced an overall increase of 22%, whereas 600 mg caused a
52% increase (p < 0.05). Body composition did not change with supplementation (p > 0.05) and
clinical safety markers were not adversely affected with ingestion of either supplement dose (p >
0.05). While neither of the 6-OXO dosages appears to have any negative effects on clinical
chemistry markers, supplementation at a daily dosage of 300 mg and 600 mg for eight weeks did
not completely inhibit aromatase activity, yet significantly increased FT, DHT, and T/E.
Published: 19 October 2007
Journal of the International Society of Sports Nutrition 2007, 4:13 doi:10.1186/1550-2783-4-
13 Received: 25 September 2007 Accepted: 19 October 2007
This article is available from: Journal of the International Society of Sports Nutrition | Full text | Effects of eight weeks of an alleged aromatase inhibiting nutritional supplement 6-OXO (androst-4-ene-3,6,17-trione) on serum hormone profiles and clinical safety markers in resis
© 2007 Rohle et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (Creative Commons — Attribution 2.0 Generic — CC BY 2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly
FULL STUDY HERE: http://www.jissn.com/content/pdf/1550-2783-4-13.pdf
05-12-2011, 08:25 AM
05-12-2011, 06:32 PM
05-16-2011, 12:43 PM
05-16-2011, 01:26 PM
05-17-2011, 03:12 PM
05-17-2011, 04:46 PM
05-17-2011, 06:03 PM
05-31-2011, 08:23 PM
Just got mine today, am running a 600/600/600/800/800/800 of 1-andro rx...when should I start the e-control rx, and how much per day?
06-01-2011, 09:31 AM
06-01-2011, 12:53 PM
07-12-2011, 04:26 PM
07-12-2011, 04:31 PM
06-04-2012, 05:07 PM
06-04-2012, 05:23 PM
06-04-2012, 05:37 PM
06-04-2012, 06:18 PM
06-05-2012, 12:13 PM
06-15-2012, 03:09 PM
06-22-2012, 01:32 AM
07-06-2012, 05:08 PM
07-06-2012, 05:20 PM
07-07-2012, 03:18 AM
tha question is not that of price but of advantages of 6-oxo compared to other test boosters/AI. if it would be superior in effects i would even pay the double price
07-07-2012, 02:17 PM
07-08-2012, 01:12 PM
How does one release something thats not suppose to be around, but the company that brought it to market doesn't want anything to do with it anymore?
07-08-2012, 04:46 PM
07-08-2012, 05:51 PM
Interesting after the phila baseball crap I thought the reason why it was dropped from ergopharm because it was going to be banned and plus they did not want the bad publicity. Wonder why other companies wouldn't just pick up were they left off. How long has it been? 3 yrs?Originally Posted by IronMagLabs
07-09-2012, 03:35 PM
i would be more interested in real world results of people who took it and who are able to compare it to other test boosters or AI's like triazole or erase. the study looks fine though
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