IGF-1 is good at shuttling carbs to the muscles. It can also make you hungry by rapidly lowering blood glucose levels. Get out your blood glucose monitor and measure the effect it has on blood sugar…you DO have the ability to directly observe this…in your own body.
IGF-1 is not alone in this regard…Insulin, IGF-1, R-Ala, Vanadyl Sulfate, all to some varying degree increase the shuttling of carbs to the muscles…some are more effective & selective then others. IGF-1 may have a selective advantage over Insulin.
The most outwardly observable effect of IGF-1 is that of blood glucose pumping…this is probably why so many users think IGF-1 is such a great drug. But please don’t confuse that effect with real muscle growth.
I like IGF-1…and I use it in small doses over long periods of time. I benefit from it when I diet. I benefit from it when I bulk.
I benefit from it when I am in PCT…in salmon it has been shown to increase Follicle-Stimulating Hormone…I don’t disregard animal studies…and think they have value…
And as part of an overall program that involves spot on nutrition, recovery and training IGF-1 is a tool I use to build a better body.
As for Grunt I did not mean to disparage him personally…although it is clear from the words I chose that I did…so for that I apologize.
Now having said that…do I believe that IGF-1 promotes localized growth…no (but neither do I believe test suspension (in water) does either).
Do I believe IGF-1 is directly responsible for muscular hyperplasia in humans…I should clarify...I do not believe that IGF-1 in the altered form presently being used by bodybuilders is capable…
As explained by bio-regent personnel at Gropep, once they altered IGF-1, it no longer possessed the same protein chain, and consequently muscle building properties of that of unaltered IGF-1 (rIGF-1 alternative nomenclature IGF-1 RH).
The available animal studies used rIGF-1 not the altered IGF-LR3. Gropep created the altered version LR3 for convenient lab use only. There will never be a study examining the direct effect of this altered version…and most certainly not in humans.
So for that we must rely on the cumulative reports from serious/ experienced trainers who have observed & experimented with the use of the altered version on their trainees. I have even spoken to one such trainer who used control subjects & relied on before and after hydrostatic body fat testing to conclude that there was no observable muscle mass gain from the use of IGF-1 LR3. By and large the trainers I have had communication w/ all seem to have the same low opinion of IGF-1 LR3 as a direct agent for muscle growth let alone hyperplasia.
Is any of this dispositive…NO!
It has now been several years that IGF-1 (altered version) has been used by the bodybuilding community…go ask those users who are capable of distinguishing what drug had what effect on their body composition what their thoughts are on this compound. Once you avoid those people & those board owners who had/have a tied interest (which may be as small as free product) to those that sell/sold the altered version you might be surprised…
…then again you might draw your own differing conclusion.
No big deal I still respect each of you and will consider your point of view in constantly reexaming my own…most of you are indeed more knowledgeable than I. In no way do I feel that what I have to say is anything more than just a guy posting his often inferior opinion.
I like to learn…and in fact over the years have been the beneficiary of Grunt’s research & posts across various boards. In fact I am interested in his take on IGF-II & its potential use in the bodybuilding community…because I have come to respect his mind.
Oh yes…and by-the-way…as TheSinner once pointed out to me I can be a d1ck sometimes…but it is too late for me to change my ways I’m afraid.