Mk-677: The liver & the bloat

  1. Mk-677: The liver & the bloat


    So, it had occurred to me after realizing that mk-677, for all its use; is a bit toxic on the liver. More than a bit, if seems.

    Then I realized the bloating people are experiencing with it & I put 2+2 together.

    I think pretty much anyone running this needs to take extra care of their livers, but what I'm presupposing here is that the bloating can be alleviated by cleansing the liver.

    Will post any results I experience. Have been on the stuff a couple of weeks now & for the most part; I'm impressed.

    Raging hunger, insomnia if I take it before bed...that's about it for sides, but I'm starting to sense liver issues (anyone ive seen get blood work can confirm this + apparently it's methylated so...)

    Liver congestion leads to fat and what have you. Bring the liver back to stasis & I bet this compound shines.

    Will see if can be managed.


  2. What doses are you running it at? I couldn't get past the insomnia personally. Never did cause any bloat or weight gain in the time I ran it. What do you mean you're sensing liver issues?
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  3. Curious about this as well, I've been running it for a month now, and definitely experience bloating, and appetite. How can you tell about the liver issues without bloods? I dose about an hour before bed and sleep like a rock.
  4. See.


    I really like this product. I see alot of potential in it - - but it's kinda of a tricky one for the long-term, I gather.

    Gh/igf1 levels ONLY improve with consisten use up to a year or more - - but liver sides I'd say kick in in a few weeks, if not sooner.

    I feel like there's got to be a reason for the insta-bloat & MEGA hunger, which IS out of hand. Initially i handled it with green tea all day & adderall as needed - - but even with that protocol, I would eat like a viking in the night. still gaining weight.

    Haven't get my fat percentage checked, I do feel FULLER to a crazy degree sometimes, but i'm afraid i'm getting puffy as well.

    Looking into this.

    Sauana, REAL celtic grey sea salt with water (sole') for water balance.

    prolactic sides - i'm taking quality vitamin E and Zinc as needed.



    Liver issues...let's just say i have a feel for. I've run my liver through the gamut of detox/retox/detox ad infinitum over the years, from just about everything. My staunch believe in natural healing, tcm and ayurvedic methods has given me a slew of options, as well as symptoms and signs to watch out for.

    Or more simply put...after a while, my liver starts to feel like i've just taken tynenol...probably the most toxic thing to your liver on the otc market. The stuff gives me a verifyable tylenol feeling.

    I know my body. I know my liver.

    I've even cured my friend of HEP C - using only herbal and dietary means. No pharma. just took what i advised and BOOM. one summer later, the man is healed.

    I got a handle on this liver stuff and I'm starting to think it's more prevailent than we realize...

    nothing to scoff at...more than clean the body out - - the liver is where alot of the body's chemical reactions occur...this gets turned into that...this gets sopped up in the liver, but you really didn't want it anyways..


    ultimately - - you keep yo **** clean, youre gonna get better results & usually at lower doses, so it might just save you money in the long run.

    Guru yo.

    Medicine man.

    With a modern twist - - is kinda my style, but i've proven RESULTS as well.


    *unlicensed psuedo-science, any advice implied is on these grounds. ordained subgenius minister, reiki healer & yoga teacher. I know what I know...but IAM NOT the american medical association. Not by a long shot.

    What i say is what i say - - take it with a grain of salt, do your research, listen to your body...find your own answers to what is in front of you.

    Peace

    C

  5. Quote Originally Posted by ericos_bob View Post
    What doses are you running it at? I couldn't get past the insomnia personally. Never did cause any bloat or weight gain in the time I ran it. What do you mean you're sensing liver issues?
    Started taking it in the morning and then gettn by on green tea like a pro. IT has helped with the intial insomnia, but it almost seems to switch over after a few weeks...

    To where it make syou super tired and ready for a nap, like an hour after you take it...an hour or two...so i'm considering moving my dose to the early evening time.

    i find 12.5 is most sensible, with least side-effects. 25 makes me feel like superman, but i eat like the incredible hulk...and that's not the kind of super i am looking for at the moment! : ) still powerful stuff.

    i just came across some people that good bloods done and consistently - between the lot of em on that site, they all ran pretty high....not like deadly high up in the thousands, but definitely in the 200's - which was of concern to me personally....perhpas my hopes for long term use are ill fated, still gonna try and see if i can over come this through various liver cleansing actions - will post findings..
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  6. It seems like alot of these new sarms - serms - whateverms have a learning curve.

    Both for the body to adjust to find statis, but also to the mind to wrap around it.

    These are all novel compounds, as far as i can tell; but with great powers come great responsibility, lest you be left loosing your hair, libido, drive etc....

    sad town.
    Do it right! * i think the skies the limit.

    Leave no stone unturned.

    LOVE your Liver, always.

    pay attention to the research

    It's all golden.

    don't take everything at face value.

    These are still a gift, but there's much further study required as far as optimization goes.

    Om

    Rev. C

  7. Quote Originally Posted by ironyogi View Post
    I really like this product. I see alot of potential in it - - but it's kinda of a tricky one for the long-term, I gather.

    Gh/igf1 levels ONLY improve with consisten use up to a year or more - - but liver sides I'd say kick in in a few weeks, if not sooner.

    I feel like there's got to be a reason for the insta-bloat & MEGA hunger, which IS out of hand. Initially i handled it with green tea all day & adderall as needed - - but even with that protocol, I would eat like a viking in the night. still gaining weight.

    Haven't get my fat percentage checked, I do feel FULLER to a crazy degree sometimes, but i'm afraid i'm getting puffy as well.

    Looking into this.

    Sauana, REAL celtic grey sea salt with water (sole') for water balance.

    prolactic sides - i'm taking quality vitamin E and Zinc as needed.



    Liver issues...let's just say i have a feel for. I've run my liver through the gamut of detox/retox/detox ad infinitum over the years, from just about everything. My staunch believe in natural healing, tcm and ayurvedic methods has given me a slew of options, as well as symptoms and signs to watch out for.

    Or more simply put...after a while, my liver starts to feel like i've just taken tynenol...probably the most toxic thing to your liver on the otc market. The stuff gives me a verifyable tylenol feeling.

    I know my body. I know my liver.

    I've even cured my friend of HEP C - using only herbal and dietary means. No pharma. just took what i advised and BOOM. one summer later, the man is healed.

    I got a handle on this liver stuff and I'm starting to think it's more prevailent than we realize...

    nothing to scoff at...more than clean the body out - - the liver is where alot of the body's chemical reactions occur...this gets turned into that...this gets sopped up in the liver, but you really didn't want it anyways..


    ultimately - - you keep yo **** clean, youre gonna get better results & usually at lower doses, so it might just save you money in the long run.

    Guru yo.

    Medicine man.

    With a modern twist - - is kinda my style, but i've proven RESULTS as well.


    *unlicensed psuedo-science, any advice implied is on these grounds. ordained subgenius minister, reiki healer & yoga teacher. I know what I know...but IAM NOT the american medical association. Not by a long shot.

    What i say is what i say - - take it with a grain of salt, do your research, listen to your body...find your own answers to what is in front of you.

    Peace

    C
    interesting theory...

    I looked back at my bloodwork while on this, and my AST and ALT went down, so I'd presume that this is not hard on the liver.

  8. My ast and alt went up double time.

  9. subbed to see other people's results. My liver values were on the upper 20s after a month of conservative usage (10mg/day bumped up to 20mg/day, taking breaks over the weekend). Pretty healthy if you ask me, but then again I take a lot of health supplements including a detox greens supplement. Might be something to look into if you wanna keep using this.

  10. what brand are you taking?......you sure you aren't taking a PH? insomnia, liver stress, libido shut down, i hardly see anyone mentions these symptoms for MK677 on this board, and when they do they are taking some random brand of MK677 they got of e bay

  11. I know this is a little off topic but after about a month on 20mg MK I accumulated cold like symptoms, the worst being extremely swollen glands in my neck. Once I stopped use I was able to get rid of the symptoms within a week or so.

    About 2 weeks later I started back up 10MG MK and 2 days in the swollen glands returned! Anyone ever experienced or heard of similar sides to this?

    My Mk seemed legit, gained a lot of water weight, slept great, felt lethargic, huge appetite and had semi numb hands.

  12. Can anyone site studies where this is mentioned? Could this possibly be contaminated raws because none of the studies I have read mention this.

    MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism.
    https://www.ncbi.nlm.nih.gov/pubmed/9467534
    Neither the serum cortisol nor the PRL response was significantly greater after 7 days of MK-677 dosing compared with 7 days of placebo. MK-677 (25 mg) was generally well tolerated and without clinically significant adverse experiences. In conclusion, MK-677 reverses diet-induced nitrogen wasting, suggesting that if these short-term anabolic effects are maintained in patients who are catabolic because of certain acute or chronic disease states, it may be useful in treating catabolic conditions.

    Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man.
    https://www.ncbi.nlm.nih.gov/pubmed/9349662
    In young subjects, high-dose MK-677 treatment resulted in an approximately 50% increase in the duration of stage IV and in a more than 20% increase in REM sleep as compared to placebo (p < 0.05). The frequency of deviations from normal sleep decreased from 42% under placebo to 8% under high-dose MK-677 (p < 0.03). In older adults, treatment with MK-677 was associated with a nearly 50% increase in REM sleep (p < 0.05) and a decrease in REM latency (p < 0.02). The frequency of deviations from normal sleep also decreased (p < 0.02). The present findings suggest that MK-677 may simultaneously improve sleep quality and correct the relative hyposomatotropism of senescence.

    Discrepancy between serum leptin values and total body fat in response to MK-677.
    https://www.ncbi.nlm.nih.gov/pubmed/10468903
    Abstract
    OBJECTIVE:

    Growth hormone (GH) treatment decreases total body fat while this effect has not yet been documented for the oral GH secretagogue MK-677. In the present study, the effects of MK-677 treatment on serum levels of leptin, thyroid hormones and testosterone were determined.

    DESIGN:
    This was a randomized, double-blind, and parallel study. Twenty-four healthy obese males, 19-49 years of age, with body mass index (BMI) > 30 kg/m2 and a waist:hip ratio > 0.95, were treated with MK-677 (25 mg/day; n = 12) or placebo (n = 12) for 8 weeks.

    RESULTS:
    MK-677 treatment increased serum leptin levels and leptin/body fat ratio at 2 weeks of treatment (P < 0.05 vs. placebo) but no significant change was observed at 8 weeks. An increase in serum free 3, 5, 3'-triiodothyronine (free T3) was not detected until 8 weeks of MK-677 treatment (P < 0.05 vs. placebo). Peak serum thyroid stimulating hormone (TSH) concentration after MK-677 administration was similar to that after placebo administration at initiation of treatment and at 2 weeks. At 8 weeks of MK-677 treatment, mean peak serum TSH concentration was increased (P < 0.05 vs. placebo) although it remained within the normal range. Serum peak values of luteinizing hormone (LH) and follicle stimulating hormone (FSH) were similar after MK-677 and placebo administration. MK-677 treatment reduced serum total testosterone (P < 0.05 vs. placebo) although total testosterone/sex hormone-binding globulin (SHBG) ratio (an index of free testosterone) was not changed.

    CONCLUSION:
    Treatment with the oral GH secretagogue MK-677 transiently increased serum leptin levels and leptin/body fat ratio at 2 weeks of treatment, and increased serum free T3 after 8 weeks. These results indicate that MK-677 treatment is able to affect circulating factors of importance for adipose tissue mass and fuel metabolism.
    VEIN NUTRITION - PREMIUM BODYBUILDING SUPPLEMENTS
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  13. Mk677 has never raised my liver values. If it raised yours then you either were running other aas or had a terrible diet due to hunger increase.

  14. Quote Originally Posted by JahCure View Post
    I know this is a little off topic but after about a month on 20mg MK I accumulated cold like symptoms, the worst being extremely swollen glands in my neck. Once I stopped use I was able to get rid of the symptoms within a week or so.

    About 2 weeks later I started back up 10MG MK and 2 days in the swollen glands returned! Anyone ever experienced or heard of similar sides to this?

    My Mk seemed legit, gained a lot of water weight, slept great, felt lethargic, huge appetite and had semi numb hands.
    I experienced the exact same thing last year on 2 separate cycles, though in my case, i had severe cold symptoms without noticing swollen glands. It was disappointing because I definitely felt stronger during the first cycle.

  15. Quote Originally Posted by texastea View Post
    I experienced the exact same thing last year on 2 separate cycles, though in my case, i had severe cold symptoms without noticing swollen glands. It was disappointing because I definitely felt stronger during the first cycle.
    Interesting. I wonder if we were using the same source. I'll PM you. Major bummer because I love this supplement.

  16. I've had nothing but good experiences with MK. The insta-bloat came from the amount/type of carbs I ate. I can't really speak on the liver toxicity, but I take Himilaya Livercare and TUDCA. They've become some staples for me. I remember initially starting MK, I blew my weight up quickly in a month (20 pounds of which i'm sure you can is MAINLY water and fat). As far as sleep goes, I usually dose my MK (30mg) before bed and I sleep less, but wake up feeling like a brand new person.

    My two cents about the bloat has to come from the carbs reacting with insulin. The pump is always too much if I dose pre workout/early morning with heavy carb load.

  17. My latest tests came back with perfect liver values and all round excellent health markers despite having run mk677 at 25mg ED for 4 months to that point. I never did experience any bloat on MK mind you. Liver toxicity was never mentioned in any of the numerous human trials with MK unless I've missed something?

  18. Quote Originally Posted by ericos_bob View Post
    My latest tests came back with perfect liver values and all round excellent health markers despite having run mk677 at 25mg ED for 4 months to that point. I never did experience any bloat on MK mind you. Liver toxicity was never mentioned in any of the numerous human trials with MK unless I've missed something?
    No your not missing anything, it should have no effect on liver values.

  19. Quote Originally Posted by ericos_bob View Post
    My latest tests came back with perfect liver values and all round excellent health markers despite having run mk677 at 25mg ED for 4 months to that point. I never did experience any bloat on MK mind you. Liver toxicity was never mentioned in any of the numerous human trials with MK unless I've missed something?
    Quote Originally Posted by JahCure View Post
    No your not missing anything, it should have no effect on liver values.
    All of my blood work pointed to no liver impact from long term running of MK. Including a test just a couple of weeks ago. I am at about 5 months at 20 mg per night.
    http://anabolicminds.com/forum/workout-logs/281831-sparkss-journey-recovery.html
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