Long acting Ghrelin mimetics (MK-677) = brain detrimental

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  1. Long acting Ghrelin mimetics (MK-677) = brain detrimental


    It isn't a SARM.
    It isn't exogenous GH. It is a GH Secretagogue.

    It doesn't suppress.
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  2. Could it not interfere with natural ghrelin production? It is a ghrelin mimetic after all. Taken from wikipedia...

    It is important to note that the full mechanism of ghrelin secretion and reduction has not been fully realized, e.g. "this finding appears to discount gastric distention as a mechanism for ghrelin reduction"
    •   
       


  3. So, I Don't see this thread too active anymore. But, I came back to it after reading through 180+ pages on another forum on MK. I didn't see one person report anxiety, just that they got super hungry, bloated, or eventually had elevated BG after 8+ months of being on it @ 25mg but also running tons of other peptides.

    I read through the whole post, and it makes sense. I Just find it interesting how in all official studies on on mk677 itself, nobody reported increased stress. This article makes it sound like you'll feel like you're having a bad acid trip if you use mk677 longer than 2 weeks which I don't really see as being realistic. What is fear learning anyway?

    I'm not coming down on anything or anybody, just trying to get the conversation going. I really don't feel like I know enough about mk677 despite reading a ton on it. Eager to try though!

  4. Quote Originally Posted by YamahaC76 View Post
    So, I Don't see this thread too active anymore. But, I came back to it after reading through 180+ pages on another forum on MK. I didn't see one person report anxiety, just that they got super hungry, bloated, or eventually had elevated BG after 8+ months of being on it @ 25mg but also running tons of other peptides.

    I read through the whole post, and it makes sense. I Just find it interesting how in all official studies on on mk677 itself, nobody reported increased stress. This article makes it sound like you'll feel like you're having a bad acid trip if you use mk677 longer than 2 weeks which I don't really see as being realistic. What is fear learning anyway?

    I'm not coming down on anything or anybody, just trying to get the conversation going. I really don't feel like I know enough about mk677 despite reading a ton on it. Eager to try though!
    Just use it lol
    Black Lion Representative
    I'm a Brooklyn boy I may take some gettin' use to

  5. A greater stress response is induced by contemplation of MK use.
    •   
       


  6. Gonna post this because I literally just signed up here just to read the article because of my bad side effects.

    27, dealt with regular anxiety most of my life. On my 2nd mk cycle i had a massive panic attack, had no idea what it was and thought it was a heart attack. Went to the ER twice in one week. While ive always dealt with anxiety ive never quite been the paranoid or overreact type.

    Fast forward to last night. Been on MK again for about 4 days. Had another life/reality shaking panic attack. Again. Until this year i have never had them before ever. The only thing thats changed is trying MK.

    Based on my experience i recommend avoiding mk at all costs..

    Question for OP or anyone who can understand most of that jargon...

    Have i permanently damaged my brain and will i suffer these attacks for the rest of my life? Or is there any hope to recover and normalize?..

    Thank you

  7. Quote Originally Posted by Jollygood View Post
    Gonna post this because I literally just signed up here just to read the article because of my bad side effects.

    27, dealt with regular anxiety most of my life. On my 2nd mk cycle i had a massive panic attack, had no idea what it was and thought it was a heart attack. Went to the ER twice in one week. While ive always dealt with anxiety ive never quite been the paranoid or overreact type.

    Fast forward to last night. Been on MK again for about 4 days. Had another life/reality shaking panic attack. Again. Until this year i have never had them before ever. The only thing thats changed is trying MK.

    Based on my experience i recommend avoiding mk at all costs..

    Question for OP or anyone who can understand most of that jargon...

    Have i permanently damaged my brain and will i suffer these attacks for the rest of my life? Or is there any hope to recover and normalize?..

    Thank you
    Interesting. Hard to tell if itís 100% the MK with thousands of other uncontrolled environmental variables. I personally would focus on holistic approach to life to start checking boxes towards healing and homeostasis.

    List of things to consider:
    Medical: labs from conventional physician and homeopathic
    Diet: Whole Foods and high quality meat
    Supplements: Green Vibrance 2x a day
    Activity: keep body moving. Resistance training and something outside if possible. Try not dwell on your problem.
    Environment: make sure no molds/toxins, no leds, especially 5+ hours before bed. Pitch black/cool room for sleeping 8+
    Get tons of clean water and can consider juicing and fasting.

    Best of luck
    -Thor
  8. Long acting Ghrelin mimetics (MK-677) = brain detrimental


    Quote Originally Posted by Jollygood View Post
    Gonna post this because I literally just signed up here just to read the article because of my bad side effects.

    27, dealt with regular anxiety most of my life. On my 2nd mk cycle i had a massive panic attack, had no idea what it was and thought it was a heart attack. Went to the ER twice in one week. While ive always dealt with anxiety ive never quite been the paranoid or overreact type.

    Fast forward to last night. Been on MK again for about 4 days. Had another life/reality shaking panic attack. Again. Until this year i have never had them before ever. The only thing thats changed is trying MK.

    Based on my experience i recommend avoiding mk at all costs..

    Question for OP or anyone who can understand most of that jargon...

    Have i permanently damaged my brain and will i suffer these attacks for the rest of my life? Or is there any hope to recover and normalize?..

    Thank you
    Thanks for sharing. I experienced some bad side effects from my 10 week MK run last year, including anxiety, depression, lethargy and Alzheimer's-esque symptoms. I was depressed 3 years when I was 17, 18 and 19. I'd never had clinical anxiety before the MK run. Tbf the relapse into depression could've primarily been due to the anxiety. The lethargy is to be expected whilst on MK but nonetheless I found that it inhibited my ability to deal with the anxiety, depression and surrounding stressors. Whilst there were surrounding stressors they were nothing I hadn't dealt with before and thus I attribute them to the MK. The Alzheimer's-esque symptoms id never had before. They were just booky and no doubt exacerbated the anxiety and depression.

    The way MK works necessarily stresses the body and essentially makes the body think it's pretty much constantly starving. This is a constant mental strain and thus I get the feeling that MK may not be suitable for those with pre-existing mental issues.

    My MK run ended in May last year. Upon its conclusion I found myself depressed, anxious, lethargic, mentally 'broken' and in PCT. I was worried I might be like that for the rest of my life, however long that would turn out to be. It was a *****.
    Now, I'm feeling a lot better and pretty much back to 'normal'. I'm still a little more anxious than I used to be but that may be more the aftermath of the last 9 months than a direct side-effect of the MK. Tbh it's a little hard to say when the side-effects from the MK ended but in my experience, the side-effects can snowball due to their nature, particularly the less prevalent onces. The Alzheimer's-esque symptoms didn't subside until about two months ago and those definitely had a part to play in exacerbating the problems I faced.

    Try to stay calm man, I know it's hard but it'll honestly make things better. Have you noticed anything other than the panic attacks? Keep us updated and I will you. Don't touch any MK and perhaps ask your doctor for a higher dosage of your anxiety meds temporarily. Eating at least maintenance every day for the next week could also help. Good luck man
  9. Long acting Ghrelin mimetics (MK-677) = brain detrimental


    Iíve run MK many times with no anxiety issues. I suspect that those experiencing the anxiety are younger and therefore already have a relatively high amount of IGF-1 - and adding MK (especially at dosages of 25mg/day) is bumping the level to supraphysiologocal levels. Any hormone that affects the HPTA axis in excess will cause anxiety (especially if someone is prone to it and has experienced symptoms prior to running the compound. Anxiety is a symptom of High GH/IGF-1. Thatís my theory on this. And, no - you did not cause permanent damage. Itís not possible -the HPTA will return to normal in time. My advice would be if you are still having symptoms get a full hormonal panel including Testosterone, Estradiol IGF-1 etc. if you are above the high range for IGF1 get an MRI of your pituitary to rule out any underlying issue there - but my bet is you will be good to go win 2 weeks. Also FWIW - I would not recommend this compound to guys under 40. There really is no need. You have all the IGF1 you need. Iím 50 and my IGF1 is 140 (range of 80-280) so bumping mine on MK puts me at a normal range for a guy mid-20s. When you are already in your mid-20s and run this you are likely going way out of the range.
  10. Long acting Ghrelin mimetics (MK-677) = brain detrimental


    The evidence on the impact of increased hgh on anxiety is mixed. Some suggest that increased hgh lowers or even alleviates anxiety, whilst others suggest that hgh increases anxiety. I haven't examined the exact results of the individual studies but what comes to mind is that the effect of increased hgh is highly individualistic, although more support that increased hgh reduces anxiety (and depression).

    There is nothing to suggest that increased IGF-1 worsens anxiety.

    The proposal that elevated ghrelin worsens anxiety makes sense and is supported by research. I mean, the threat of starvation used to be a greater threat and hunger more concerning, because it's a step on the path to starvation. Concern breeds anxiety. Ghrelin signals hungry. Therefore it reasons that ghrelin would lead to anxiety.

    Perhaps Jollygood does react badly to elevated hgh but I reckon the elevated ghrelin induced by MK is likely responsible, perhaps alongside the elevated hgh.


    Perhaps those with a predisposition, by nature, nurture or fate, to having psychological issues are more prone to negative side-effects.

    Stressors induce or contribute towards anxiety. Hunger, ghrelin, would be an additional stressor which may tip someone's system over the edge.

  11. Quote Originally Posted by u_e_s_i View Post
    The evidence on the impact of increased hgh on anxiety is mixed. Some suggest that increased hgh lowers or even alleviates anxiety, whilst others suggest that hgh increases anxiety. I haven't examined the exact results of the individual studies but what comes to mind is that the effect of increased hgh is highly individualistic, although more support that increased hgh reduces anxiety (and depression).

    There is nothing to suggest that increased IGF-1 worsens anxiety.

    The proposal that elevated ghrelin worsens anxiety makes sense and is supported by research. I mean, the threat of starvation used to be a greater threat and hunger more concerning, because it's a step on the path to starvation. Concern breeds anxiety. Ghrelin signals hungry. Therefore it reasons that ghrelin would lead to anxiety.

    Perhaps Jollygood does react badly to elevated hgh but I reckon the elevated ghrelin induced by MK is likely responsible, perhaps alongside the elevated hgh.


    Perhaps those with a predisposition, by nature, nurture or fate, to having psychological issues are more prone to negative side-effects.

    Stressors induce or contribute towards anxiety. Hunger, ghrelin, would be an additional stressor which may tip someone's system over the edge.
    Really? You think Mk could put one over the edge? Let's look at how likely that is to happen using actual evidence.

    First of all, NOT ONE person among 1,000's of users over the last 15 years has claimed to experience increased anxiety with ANY of the GH peptides/secretagogues! In all that time not a single person, to my knowledge (and I've been around a LOT) has EVER reported anything like that. It wasn't until THIS thread that someone reported it (one guy), but I call bull**** on that claim all day long. The guy said he experienced an increase in anxiety and fear when taking MK, but after a little bit of questioning (and his claims slightly changing every few posts) we find out that his entire life has been in shambles during this same time period! So, we have here is someone who is going through horrible life circumstances...and the first thing he thinks of is MK-677? LOL. Doesn't it seem much more likely that it was actually his horrible life circumstances that was causing the problem? I don't think we even need to address the absurdity of that claim given the circumstances. Like I said in a prior post, his claim would be akin to a life-long coal miner blaming MK-677 for his newly diagnosed lung cancer. Just LOL.

    Anyway, if GH peptides would have caused this side effect, it would have been reported in at least a small percentage of users over the last 15 years, but no one has! Furthermore, not a single clinical study, which involves literally 1,000's of people (including all GH peptides) has EVER reported a single side effect like that.

    So, what we have here is an entire generation of users without a single person reporting this side effect, as well as an entire generation of clinical research without a single report...and yet you really think that MK-677 causes this? If you don't already know, it should also be mentioned that Dat is well known to write fraudulent material for pay. Yes he is known to PURPOSELY deceive the community by writing dishonest "scientific" articles for BIG dollars...because the people who hire him (owners of supplement companies) know he will fool many people because of his fancy, scientific wording. In short, the average person isn't educated or intelligent enough to see through his bull**** without extended study.

    It's also extremely important to note that the actual study Dat referenced for his "article" does not claim what Dat is claiming. At no point do the researchers say that MK causes this side effect. They simply "speculate" that it MIGHT do so, but they also imply that the potential side effects, if they even occur at all, are mild...whereas DAT completely twists the nature of the article to make it appear as if MK not only causes this side effect, but that it is serious in nature. Anyone with a modicum of intelligence, who actually read the original article by the "researchers (not DAT's article) would realize this immediately.

    I'm sorry, but the complete lack of anecdotal evidence, the complete lack of clinical evidence, the fact that Dat completely twisted both the meaning and tone of the original article, and the fact Dat is known to write deceptive articles for money, leads me to conclusion that this is not something people need to concern themselves with. GH peptides are and always have been recognized as "generally safe" by the medical community....and to this day I don't see anyone saying MK made them afraid or anxious.
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  12. We all respond diferently and there is no blueprint how things works 100%.

    I can share a piece of an email I got from Alex W. Pastuszak, MD, PhD (professor) who was involved in:
    "The Safety and Efficacy of Growth Hormone Secretagogues"
    http://www.smr.jsexmed.org/article/S...032-X/fulltext

    "Growth Hormone Secretagogue Treatment in Hypogonadal Men Raises Serum Insulin-Like Growth Factor-1 Levels"
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675260/

    He wrote :

    "We have had good results with MK677 - they are comparable to results seen with sermorelin and the ghrps.

    There are good safety data from the initial trials before Merck shelved the medication for economic reasons - it has now been resurrected by one of its inventors and they are in early stages of clinical trials. I would expect to see the medication on the market in the years to come."

    He also said no one experienced any anxiety or other mental issues with MK677.
  13. Long acting Ghrelin mimetics (MK-677) = brain detrimental


    Quote Originally Posted by u_e_s_i View Post
    The evidence on the impact of increased hgh on anxiety is mixed. Some suggest that increased hgh lowers or even alleviates anxiety, whilst others suggest that hgh increases anxiety. I haven't examined the exact results of the individual studies but what comes to mind is that the effect of increased hgh is highly individualistic, although more support that increased hgh reduces anxiety (and depression).

    There is nothing to suggest that increased IGF-1 worsens anxiety.

    The proposal that elevated ghrelin worsens anxiety makes sense and is supported by research. I mean, the threat of starvation used to be a greater threat and hunger more concerning, because it's a step on the path to starvation. Concern breeds anxiety. Ghrelin signals hungry. Therefore it reasons that ghrelin would lead to anxiety.

    Perhaps Jollygood does react badly to elevated hgh but I reckon the elevated ghrelin induced by MK is likely responsible, perhaps alongside the elevated hgh.


    Perhaps those with a predisposition, by nature, nurture or fate, to having psychological issues are more prone to negative side-effects.

    Stressors induce or contribute towards anxiety. Hunger, ghrelin, would be an additional stressor which may tip someone's system over the edge.

    Agreed. Hence, why it should be used on a bulk and not a cut. IMO you completely cut out that ďstarvation fearĒ during a bulk. If anything this plays in your favour it makes your bulk way easier especially if you have a hard time eating.

    Although not enough to tip over the edge. Personally I think mindset is 50% of the anxiety battle. Which is why people turn to mediation and things like breathing techniques.
  14. Long acting Ghrelin mimetics (MK-677) = brain detrimental


    Quote Originally Posted by Mike Arnold View Post
    Really? You think Mk could put one over the edge? Let's look at how likely that is to happen using actual evidence.

    First of all, NOT ONE person among 1,000's of users over the last 15 years has claimed to experience increased anxiety with ANY of the GH peptides/secretagogues! In all that time not a single person, to my knowledge (and I've been around a LOT) has EVER reported anything like that. It wasn't until THIS thread that someone reported it (one guy), but I call bull**** on that claim all day long. The guy said he experienced an increase in anxiety and fear when taking MK, but after a little bit of questioning (and his claims slightly changing every few posts) we find out that his entire life has been in shambles during this same time period! So, we have here is someone who is going through horrible life circumstances...and the first thing he thinks of is MK-677? LOL. Doesn't it seem much more likely that it was actually his horrible life circumstances that was causing the problem? I don't think we even need to address the absurdity of that claim given the circumstances. Like I said in a prior post, his claim would be akin to a life-long coal miner blaming MK-677 for his newly diagnosed lung cancer. Just LOL.

    Anyway, if GH peptides would have caused this side effect, it would have been reported in at least a small percentage of users over the last 15 years, but no one has! Furthermore, not a single clinical study, which involves literally 1,000's of people (including all GH peptides) has EVER reported a single side effect like that.

    So, what we have here is an entire generation of users without a single person reporting this side effect, as well as an entire generation of clinical research without a single report...and yet you really think that MK-677 causes this? If you don't already know, it should also be mentioned that Dat is well known to write fraudulent material for pay. Yes he is known to PURPOSELY deceive the community by writing dishonest "scientific" articles for BIG dollars...because the people who hire him (owners of supplement companies) know he will fool many people because of his fancy, scientific wording. In short, the average person isn't educated or intelligent enough to see through his bull**** without extended study.

    It's also extremely important to note that the actual study Dat referenced for his "article" does not claim what Dat is claiming. At no point do the researchers say that MK causes this side effect. They simply "speculate" that it MIGHT do so, but they also imply that the potential side effects, if they even occur at all, are mild...whereas DAT completely twists the nature of the article to make it appear as if MK not only causes this side effect, but that it is serious in nature. Anyone with a modicum of intelligence, who actually read the original article by the "researchers (not DAT's article) would realize this immediately.

    I'm sorry, but the complete lack of anecdotal evidence, the complete lack of clinical evidence, the fact that Dat completely twisted both the meaning and tone of the original article, and the fact Dat is known to write deceptive articles for money, leads me to conclusion that this is not something people need to concern themselves with. GH peptides are and always have been recognized as "generally safe" by the medical community....and to this day I don't see anyone saying MK made them afraid or anxious.
    I appreciate that. Though I'm not particularly knowledgable about how ghrps work I've been told they give a strong but short lasting burst of ghrelin and hgh secretion. This contrasts with how MK works as it has a longer window in which ghrelin and hgh secretion are increased. The paper suggested that only with prolonged exposure to elevated ghrelin would the more severe side-effects be seen.
    During my run I was cutting and perhaps didn't refeed as often as I should've. I was refeeding once a month at 5-10% bf which, upon conducting further research, is unadvisable, even without being on MK.
    I'd advise users to do either use MK during a bulk or to refeed often, perhaps going for more of a recomp than a cut. Similar to what jcr said

    Although the OP may have had ulterior motives writing this thread it's still possible that additional knowledge regarding fairly novel substances such as MK are still coming to light.
    Additionally, if a single user in a 500 person samples experiences anxiety during the course of a study the researchers may simply attribute that to the individual, or the individual may not attribute it to the MK and may not speak out about it.

  15. Amazing info. How about mineral retention with mk677, possible dangerous rise in intracellular calcium which can be ACTUAL reason for lethargy, elevated heart rate in some people, etc.

  16. Quote Originally Posted by kecman96 View Post
    Amazing info. How about mineral retention with mk677, possible dangerous rise in intracellular calcium which can be ACTUAL reason for lethargy, elevated heart rate in some people, etc.
    Never looked into that... could be something that would be a cause because mk677 does increase bone mineral density.

  17. Quote Originally Posted by u_e_s_i View Post
    I appreciate that. Though I'm not particularly knowledgable about how ghrps work I've been told they give a strong but short lasting burst of ghrelin and hgh secretion. This contrasts with how MK works as it has a longer window in which ghrelin and hgh secretion are increased. The paper suggested that only with prolonged exposure to elevated ghrelin would the more severe side-effects be seen.
    During my run I was cutting and perhaps didn't refeed as often as I should've. I was refeeding once a month at 5-10% bf which, upon conducting further research, is unadvisable, even without being on MK.
    I'd advise users to do either use MK during a bulk or to refeed often, perhaps going for more of a recomp than a cut. Similar to what jcr said

    Although the OP may have had ulterior motives writing this thread it's still possible that additional knowledge regarding fairly novel substances such as MK are still coming to light.
    Additionally, if a single user in a 500 person samples experiences anxiety during the course of a study the researchers may simply attribute that to the individual, or the individual may not attribute it to the MK and may not speak out about it.
    MK brings on mega depression, anxiety for me. It works really well for me, but the side effects are terrible - PH runs (with proper test base) side effects don't even come close. Keep in mind that I do suffer from depression - so I think MK multiplies that. Great product if you can handle it. All this to say is that I support Mike Arnold and have Somatozine on hand. I take 12.5 mg 2-3 times a week prior to bed. It helps my sleep and recover greatly. Any more than that - and I am down for the count.

  18. Quote Originally Posted by bigsmall View Post
    MK brings on mega depression, anxiety for me. It works really well for me, but the side effects are terrible - PH runs (with proper test base) side effects don't even come close. Keep in mind that I do suffer from depression - so I think MK multiplies that. Great product if you can handle it. All this to say is that I support Mike Arnold and have Somatozine on hand. I take 12.5 mg 2-3 times a week prior to bed. It helps my sleep and recover greatly. Any more than that - and I am down for the count.
    Thank you, I might give somatozine a shot and try your dosing routine

  19. Quote Originally Posted by bigsmall View Post
    MK brings on mega depression, anxiety for me. It works really well for me, but the side effects are terrible - PH runs (with proper test base) side effects don't even come close. Keep in mind that I do suffer from depression - so I think MK multiplies that. Great product if you can handle it. All this to say is that I support Mike Arnold and have Somatozine on hand. I take 12.5 mg 2-3 times a week prior to bed. It helps my sleep and recover greatly. Any more than that - and I am down for the count.
    That is lethargy (which can exacerbate depression). MK can cause this in some people, but it is not related to MK-677's ghrelin mimetic effects. Exogenous GH does the same thing and it is not a ghrelin mimetic at all. Different issue. I appreciate the support, brother.
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  20. Long acting Ghrelin mimetics (MK-677) = brain detrimental


    To help combat the lethargy take mk before bed and keep a bottle of caffeine pills by your bed side table and when you wake up pop one press snooze on your alarm and bam youíre golden lethargy solved

  21. Quote Originally Posted by Danes View Post
    Ibuprofen (400mg x3) daily will also help with water retention . There is a study proving it
    No problem man. TY for sharing the info

    Hey Danes, by no means saying you are incorrect but would you mind posting that study? In the medical community ibuprofen is strongly recommended to NOT be taken by people with edema, and generally any condition that causes fluid retention due to causing fluid retention. There are a large amount of studies on this, but I was unable to find one showing ibuprofen helping with water retention.

  22. Quote Originally Posted by BigKrabbe View Post
    Hey Danes, by no means saying you are incorrect but would you mind posting that study? In the medical community ibuprofen is strongly recommended to NOT be taken by people with edema, and generally any condition that causes fluid retention due to causing fluid retention. There are a large amount of studies on this, but I was unable to find one showing ibuprofen helping with water retention.
    You are correct and I will explain you very simple why.
    Usualy NSAID drugs such as Ibuprofen decrease PGE2. (And ofcourse have other effects too).

    Less PGE2=more ADH
    More PGE2=Less ADH

    But in the study I found (some years ago), it was clearly different story. I will try to dig up.

  23. To everyone suffering from lethargy and depression. I would suggest a Monday through Friday dose. After an 8 week run I felt lethargic and no longer hungry and some mild depression(im prone to it though) Took 4 days off started back at 25 mg. Increased hunger better sleep NO lethargy. Planning on using it 5/2 from now on and will probably keep it at 10mg(12.5 cause of somatizine) from now on due to my age.

  24. You may also like to try EOD dosing. I feel great on this schedule. If I dose ED I just seem to feel a little off.

  25. Those are good tips snrub and ericos_bob. I would only be concerned that eod dosing might tend to keep cortisol slightly elevated, as every day dosing was found in studies to not elevate cortisol (sort of like when you drink coffee everyday). With everyday dosing, cortisol was only very slightly elevated for about 2 to 3 weeks in the beginning, then went completely normal after that with no elevations seen at all after that.

    I guess everyone reacts differently. I have been using 25mk677 daily for 4 months now, no lethargy, increased energy, and great sense of well-being from the 1st week even until now at 4 months. Sleep is still excellent. I would however suggest starting at 15mg and slowing working up to 25mg over a period of 2 weeks. I experienced 1 day of lethargy in the very beginning, but not any since then. No depression whatsoever even at 4 months. A friend of mine got lethargy off 15mg for several days, but then it went away he said after about a week, with some, the lethargy never goes away. I find it strange that everyone reacts so differently. However, cjc-1295 dac caused bad lethargy for me, yet most get none from it. Just goes to show how we all differ.

    Age is 48, beginning igf-1 baseline was 227. 2 weeks of mk677 brought me to 372 ng/ml. Increase of 145 points, this is huge for anti-aging and strength gains. I once tested 4iu of pharm grade chinese GH, it brought me to 380 (increase of 150 points). mk677 is the equivalent of 4iu GH for me personally, I strongly recommend having bloodwork done as it is only $69 for an igf-1 test. I have a labcore near my house which I use.

    In 4 months of 200mg a week TRT + 25mg mk677 in the morning with my coffee + 8grams of HMB daily, I've made continuous weekly strength increases, being able to add 5 lbs to all upper body lifts weekly, and well beyond that to all my lower body lifts weekly...I am astounded by the combination of TRT + mk677 + HMB...absolutely love the combo of all 3. I do take in 50g of met-rx a day so that I can meet my daily 200g protein. The addition of the mk677 really helped me to blast through previous strength plateaus as well as keeping my joints well lubricated, love the stuff. Eggs + top sirloin + chicken + 1 protein shake a day are my top 4 protein sources.

    I will keep you updated as I will continue to do bloodwork every 6 months to make sure it is keeping my igf-1 and gh way up there. 25mg mk677 daily brought me to the gh/igf-1 level of a gifted 16 year old, could not ask for more from this very inexpensive product. I will post my 4+ month bloodwork end of July after being on it over 4 months.

    I'm a big fan of datbtrue, and have copies of all his papers from back in the day, and I have read some of the speculations he made on mk677 and it's unfounded/total speculation on it's possible link to depression/stress. I'm living proof that 4 months on the stuff had no such effects on me.

    In fact, it improved my work and home life shortly after starting the stuff, I would come home in a better mood everyday. Even my spouse noticed and asked me why I was so upbeat after coming home when my usual self was always a bit gloomy and miserable. I was able to stay up later into the night after coming home from my 12 hour shift as well, when i used to fall asleep on the couch, in other words I was in a better mood (still am) and I enjoy my time better now, sort of like when I was younger, anti-aging indeed. I had just the opposite effects datbtrue had speculated, it was and still is anti-depressant/anti-aging for me as far as mental state goes.
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