- 03-30-2013, 08:24 PM
I am looking at taking the plunge into the world of HGH. I have a few questions before making my decision though.
First some background.
29 y/o. 6'4" 250lbs bf% is approx 15%, which is the highest bf I have ever had. Which I believe is from anti-depressant/anti-anxiety meds over the last 2 years.
Have been training since the age of 16. Certified personal trainer for ****s and giggles, never used it to make money.
Training is spot on. I have always trained heavy and intense.
Diet is not spot on, but close. I could probably clean it up a bit more.
I am on TRT at 200mg/week after finding my test levels to be below range. Also arimidex 0.25mg E3D
Have used conventional cycles in the past (approx 5) over the last 10 years. Highest dosage being 800mg/week test. Last cycle approx. 2-3 years ago.
Have been battling PTSD for the last 2-2.5 years after being a paramedic for 10 years. Too many ****ed up memories sitting in the old coconut. I have been on various anti-depressants/anti-anxiety meds for 2 years and have slowly been able to come off most of them. Now the only taking Zoloft 50mg/day. Broke a nasty benzo dependency through this as well. Also have been doing intense psychotherapy for about a year now and have made great progress. And I am currently off work on disability right now due to the PTSD. Planning on going back to university for kinesiology once my brain is back to "near normal" and anxiety is very controlled (about 80% there is would say).
Now because being off work I have nothing but time to put into my training and BBing (which also seems to help greatly in my mental health progress as well). So already looking at augmenting my TRT with a blast cruise method. Nothing crazy, maybe just double the test and some dbol or drol in there at a low dose (strong MAYBEon the orals). I don't see the point in going to high now that I will always be on TRT, no worrying about the yoyo effect.
So I have always been curious about HGH but never serious enough until now (again being that I have ample time to be spot on in all aspects now). So here are the questions. What I can afford right now would be 2iu/day Monday-Friday, weekends off for 6 months. Over 6 months I would try to put away more cash for another 6 months if I like where it is heading, and repeat...
1. For anyone who has used, what did HGH do for you on a mental health aspect? Outlook/drive for life? General sense of well being? And at what dosage was that?
**Would really like to hear from users who have or had anxiety, depression, DEPERSONALIZATION (a big one for me), or any mental health issue going into HGH use and your results**
2. What would I be looking at gaining out of 2iu from an overall well being/mental aspect at 2iu/day 5/2?
3. Would the physical changes, connective tissue repair/regeneration, and anti-aging effects be noticeable to gain motivation from 2iu? (Anti-aging because I know the stress and low test levels over the past years has caused some very visible signs of aging. Commonly hear I look around 38-40 years old at 29....ouch lol)
4. As far as a BBing point of view. What kind of muscle developments would I be looking at? Is this something where is would seeing great benefits 1-2 years down the road if I can cause significant muscle hyperplasia? I do not expect crazy gains like a 800-1000mg test dosed cycle, but now I am looking more for future (1-5year), quality progress.
5. Body fat loss? If I get my diet cleaned up a bit more, with the added HGH would there be a great significance over 6 month? 1 year? Or not much difference than 'low carb it' for a few weeks then staying clean after that?
6. Side effects at 2iu/day? From your experience. I have read a lot about this and it seems less than 4iu is very low on side effects.
7. Is this whole idea a waste of time and money at 2iu? Or should I be looking at 4 iu or nothing? Again taking into account the overall well being effects are 50% of the pie here for me.
8. Anything else you wish to add to this discussion?
I would really ask that this stays more about personal experiences and results than just going by something you have read. If you do not have much/any personal experience with HGH then I would ask that would not try to push your views or opinions in this thread.
- 04-08-2013, 01:39 PM
It is in my opinion to check out peptides before you drop the cash on GH. I say this because of what you can afford at this time and i just like peptides more!
Ghrp and ghrh combo would be more cost effective for both duration and amount of hgh you will "use".
For example ghrp6 (lower cortisol and prolactin with 6) with a mod grf 1-29. A dosage of 3x a day at 250mcg ghrp6 and 100mcg would be equivalent to 5iu hgh a day. And you run it 7 days a week. Now this is natural hgh secretion over a synthetic. (Waaay safer, will not shut you down, no harm no fowl)
Search the net. Tons of info old and new. It is the new "it thing" were i am
- 10-09-2013, 09:51 PM
10-11-2013, 01:12 AM
Ghrp and cjc combo would b ur best option IMO. I can get legit peptides so easy compare to HGH which is always faked and so expensive. Peptides are cheap and usually real. I used ghrp and cjc 4-5x a day of 200 ghrp and 100cjc each time. I used different ghrps at different times like ghrp6 pre bed.
Honestly mayb it was because I was lean so I felt good but I think mentally I was like happier. Mayb increased HGH levels lead to Better balanced hormones in ur brain ?
Anyway, I hope everything goes well with you man. I'm in a similar career as u were and I can relate. Now that I think about it I prob have starting stages of PTSD.... Good luck
10-25-2013, 08:15 AM
Maybe this will help;
Copy Paste from another forum;
GREAT post imo.
A Basic Guide to HGH – by RedBaron
The intention of this guide is to give you a good basic working knowledge of HGH and how to intelligently use it. While this is not intended to cover every conceivable nuance of HGH use, it should provide you with a solid enough background to create your cycle around. I am not writing this as a scientific exposition or as an overly technical overview. I am writing this from the standpoint of a seven-year veteran of HGH use, and an athlete (yes even paid at times) that has used this as one of the tools in my arsenal. I have injected tens of thousands of IU’s of HGH into myself, and carefully monitored, tested, and experimented on myself. So with that disclaimer being made up front, lets take a look at this hormone called HGH.
Few other hormones have generated more excitement and hype in recent years than HGH. From reports of incredible fat loss to tales of increases in lean muscle to levels that defy genetics, HGH has been touted as one of the panaceas to all bodybuilding woes. Depending on which statistics you trust, reports of as many as 80% of professional athletes have experimented with, have used, or are actively using HGH as a supplement to their training program.
WHAT EXACTLY IS HGH?
Human Growth Hormone (somatotropin - also referred to as rHGH, HGH, or GH) is created by the pituitary gland, the primary form consisting of a 191 amino acid chain. When we are young, HGH is in big part responsible for the proper growth of bones, muscle, and other tissues. Too little of this hormone and we remain dwarfs … too much and we become giants and/or suffer from abnormal growth deformities. As we become adults, HGH is responsible for keeping muscles from wasting away, supports healthy immune system response, regulates aspects of our metabolic function dealing with increased fat metabolism and healthy body composition in later life, and maintains and repairs our skin and other tissues.
Our levels of HGH peak while we are adolescents and then begin to drop off sharply beginning in our 30’s. By our 60’s, our daily HGH secretion can be as little as 10% of what it was during our youth. Many of the markers of aging are affected by this decrease in HGH. Some of the results of this are:
· Increase in fat.
· Decrease in muscle and lean body structures.
· Decreased skin texture resulting in a less youthful appearance.
· Decreased bone density, onset of osteoporosis.
· Decreased brain function, loss of intellect with aging.
· Decreased sex drive.
· Decrease in overall physical and mental well being.
· Increase in sleep disorders, lower quality of sleep.
· Depression and fatigue.
The addition of supplemental HGH beginning in the latter 30’s can reverse or improve these symptoms in the majority of people attempting therapy. This is why you will often hear references with respect to HGH as “the fountain of youth” and other similar terms. It can present a better quality of life for those aging.
HOW IS HGH RELEASED IN YOUR BODY?
HGH is secreted from the pituitary in a pulsatile fashion, generally following a circadian rhythm. A number of stimuli can initiate an HGH secretion, the most powerful being short duration, high intensity exercise and sleep. During the first few hours of sleep (deep sleep stages – about 2 hours after you fall asleep), Somatostatin is turned off and GHRH is turned on, resulting in HGH pulses.
Growth Hormone Releasing Hormone (GHRH) produced by the hypothalamus stimulates HGH secretion. HGH, and igf-1 create a negative feedback loop, meaning when their levels are high; it blunts release of GHRH, which in turn blunts the release of more HGH.
Somatostatin (SS), secreted by the hypothalamus as well as other tissues inhibits the secretion of HGH Somatostatin in response to GHRH and to other stimulatory factors such as low blood glucose concentration. High levels of igf-1 also stimulate Somatostatin secretion.
Ghrelin is a peptide hormone secreted from the stomach. Ghrelin binds to receptors on somatotrophs and potently stimulates secretion of growth hormone. Ghrelin, as the stimulator for the growth hormone secretagogue receptor, potently stimulates secretion of growth hormone. The ghrelin signal is integrated with that of growth hormone releasing hormone and somatostatin to control the timing and magnitude of growth hormone secretion.
Once HGH is released, it is very short lived. It is generally metabolized and gone within a half-hour. During this half-hour, it travels to the liver and other tissues and induces them to secrete a polypeptide hormone called Insulin-like Growth Factor One (igf-1).
HOW DOES HGH DO ITS WORK?
As mentioned above, HGH is short lived, but during its short half-hour or so activity per burst from the pituitary, it exerts itself through direct and indirect effects.
Its direct effects are the result of the HGH binding its receptor on target cells. Fat cells (adipocytes) as well as myocytes (muscle cells) have HGH receptors. On fat cells, HGH stimulates them to break down triglyceride and suppresses the fat cells ability to uptake circulating lipids.
Its indirect effects are in the process we described in the section above. When HGH travels to the liver, one of the results of its pass through the liver is the livers secretion of igf-1. When this igf-1 is secreted, it stimulates proliferation of chondrocytes (cartilage cells), which result in bone growth. It also plays a part in stimulating both the proliferation and differentiation of myoblasts (the precursor to skeletal muscle fibers). igf-1 also stimulates amino acid uptake and protein synthesis in muscle and other tissues. Other tissues (muscle, etc.) are acted on by the presence of HGH, also inducing their release of igf-1.
HGH stimulates protein anabolism in many tissues. This reflects increased protein synthesis, decreased oxidation of proteins, and increased amino acid uptake. As mentioned above, HGH enhances fat utilization by stimulating triglyceride breakdown and oxidation in fat cells (adipocytes).
HGH can affect the function of other hormones. HGH can suppress the abilities of insulin to stimulate the uptake of glucose in tissues and enhance glucose synthesis in the liver, though administering HGH actually stimulates insulin secretion and can create a state of hyperinsulinemia. This combination can lead to decreased insulin sensitivity, which in turn can lead to hyperglycemia. HGH can in the right circumstances also have a slight inhibitory effect on the function of our thyroid hormones (and actually vice versa as well), though this varies greatly from individual to individual. The vast majority of users have no need to worry about this at all. Others wishing to increase their metabolism or enhance certain of HGH’s functions may wish to consider low dose thyroid to their HGH cycle. We’ll offer some strategies later in this guide.
So, we are looking at a hormone that can assist with maintenance and healing of most of the body’s systems, can create new cartilage, bone, and muscle cells, can assist with protein uptake, decrease the oxidation of proteins, and can accelerate the rate at which fat is utilized. This paints the picture of the excitement that follows HGH. How then do we utilize this to our advantage? Let’s take a look at some strategies.
HOW DO I INCREASE MY LEVELS OF HGH?
There are a few strategies for increasing your own endogenous production of HGH. For the most part these aren’t going to give us a significant enough increase that would be necessary to promote all of the benefits mentioned above in their full measure, but for some (those still young) they will prove to be sufficient.
By adding several grams of Arginine and Glutamine to our daily supplement program, we can increase our levels of HGH. If we are very young or we are only in need of a modest jump in production, this may well do the trick. Short duration, high-intensity exercise (think heavy leg day – puking and all), will trigger our bodies to secrete a significant amount of HGH
Another possibility is to inject various related hormones or peptides. There are many available, such as GHRH, GHRP (and all of its analogs), and the like. These peptides are available from research companies and when injected at doses of 100mcgs per day, sub-q it does seem to show promise in increasing levels of HGH. At this stage the game, there isn’t a significant cost advantage to this over rHGH, but if we are trying to promote some of the other forms of HGH in addition to the primary form, or have no hope of securing a prescription for HGH (or other means of access) there may be an advantage to this course of action. Aside from these strategies, what are we left with? To state it simply, we need to inject exogenous rHGH.
INJECTIBLE HGH AND ITS USE
True HGH only comes in the form of a lyophilized powder. Any other form that you see advertised or run across is NOT the real deal. The only way to administer true HGH is by sub-q or intramuscular injection. You will see studies that use IV as their method of administration, but that is certainly NOT recommended (in fact it is just outright crazy), nor necessary in any way for getting all of the benefits HGH has to offer.
HGH is somewhat fragile by nature, and it needs to be protected from light and heat. HGH should be stored between 36 and 46 degrees Fahrenheit at all times both before and after its reconstitution.
There are a couple of American brands of HGH that can survive in normal room temperature for a reasonable amount of time BEFORE reconstitution (Genotropin – 3 months, Saizen – until expiration), but for the most part it is better to err on the side of safe rather than sorry. All brands of HGH should be refrigerated after being reconstituted, and all brands should be protected from light at all times.
RECONSTITUTING AND MEASURING YOUR HGH
So you now have a vial HGH in the form of lyophilized powder. The amount of this powder should be indicated on the vial somewhere. It will either be stated in Units (IU's) or in Milligrams (mg). If it is stated in milligrams, the conversion is most commonly stated as 1mg = ~3IU's (its really more precisely 1mg=2.7IU). We will use this 1mg = 3IU's for our guide since this is the standard most commonly referenced by manufacturers.
What we need to do with this lyophilized powder is add some Bacteriostatic water (BW), Sterile Water, or even liquid vitamin B12 to reconstitute it and make it ready to inject.
What we choose to reconstitute it with should depend on how rapidly we use the GH. Bacteriostatic water is basically sterile water with 0.9% Benzyl Alcohol added, and this Alcohol keeps anything from growing in the water, thus making it safe for injection for the longest amount of time, up to three weeks. If the amount of GH in our vial is enough to last for a few weeks at our desired daily dosage, BW is the wisest choice. For the common use for bodybuilding (2-5 IU's a day) and the more commonly used vial size (10 IU's), it isn't really as critical which of the above listed dilutents are used … the vial will be used up long before bacteria or anything begins to grow in our reconstituted HGH. It is really personal preference outside of the considerations listed above.
1.) Take an alcohol swab and swab the stopper of both your HGH vial and the vial of the dilutent (BW, sterile water, B12).
2.) Take a 3cc syringe with a 23 or 25 gauge needle (1" or 1.5") and draw up and amount of your preferred dilutent. The amount isn't critical, other than making sure you know exactly how much you have used. The best rule of thumb is choose an amount that will make measuring the final product easy
example- 1ml(cc) per 10 IU vial of HGH would mean each 10 mark on a U100 slin syringe would equal 1 IU of HGH
2ml(cc) added to a 10 IU vial of HGH would mean that the 20 mark on a U100 syringe would equal 1 IU of HGH
3ml(cc) added to a 10 IU vial of HGH would mean that the 30 mark on a U100 syringe would equal 1 IU of HGH
3.) Take this syringe with the dilutent and push it into the vial of lyophilized powder, angling so that the needle touches the side of the vial, and avoiding shooting the dilutent directly on the lyophilized powder. Make it run slowly down the side of the vial (don't let it forcefully rush in).
4.) After all of the dilutent has been added to the HGH vial, gentling swirl (do NOT agitate or violently shake the vial) until the lyophilized powder has dissolved and you are left with a clear liquid. The HGH is now ready for use. Store your now reconstituted HGH in the refrigerator. If you used BW to reconstitute it will be good for three weeks. If you used sterile water, it will be good for about 5 days.
10-25-2013, 08:15 AM
After you have successfully reconstituted your HGH, now you need to know how to measure the desired amount out for injection. You will want to use a U100 insulin syringe to draw out and inject your HGH.
Here is the way to figure out how much to draw out. Since you know the amount of IU's in your HGH vial, and you also know how much water you have diluted it with, we just divide this out as follows:
You will need to know the following to be successful -
1ml = 1cc = 100 IU's
So we take our number of IU's of HGH from the label of the dry lyophilized powder (most commonly 10 IU's for all of us Jintropin users), and we divide that into the amount of dilutent we used.
example- We used 1cc(ml) of water. We have a 10 IU vial of HGH.
From our formula above we know that 1cc = 100 IU's, so we have 100 IU's of water.
We now divide the 100 IU's (the amount of our water) by 10 IU's (the amount of our HGH)
100 IU / 10 IU = 10
This 10 will perfectly correspond with the markings on a U100 insulin syringe. In our example every 10 mark on our syringe will equal 1 IU of HGH. Want to draw out 2 IU's of GH? ....draw out to the 20 mark on the syringe.
This is about all there is to it. So to recap, just keep straight:
1.) How much actual HGH you are dealing with (read from the vial)
2.) How much water (dilutent) you are using to add to the actual HGH.
3.) Divide the amount of water in units by the amount of GH in units.
4.) This result will equal the measurement on your U100 Insulin syringe per unit of GH.
5.) multiply the number you get it step 4 by how many units you want to inject. This is the number to draw to on your syringe.
Now that we have a basic understanding of what HGH is, how it does its work, and how to reconstitute and measure it, lets look at some strategies for using this hormone to our best advantage.
STRATEGIES FOR USING HGH
There are many different approaches to taking HGH. The right approach for your particular situation will depend on your goals. For many, HGH is a general supplement to help maintain low bodyfat percentages and reasonable levels of lean body mass. For others who have reached their genetic potential for growth, HGH is a supplement that can assist in continued growth beyond what your parents gave you to work with. For yet others, it is a supplement that is used for general health and healing of injuries. Let’s look at each of these uses with respect to a reasonable HGH program.
For bodybuilders, HGH (and the igf-1 that is a result of its use) is the only substance that can actually initiate hyperplasia, which in the interest of our use in bodybuilding equates to new muscle cells. While use of anabolic steroids can cause hypertrophy (the enlargement of existing muscle cells), steroids do not offer the ability to recruit and mature more muscle cells. HGH can. HGH also increases protein synthesis, which can be responsible for hypertrophy. HGH also strengthens and heals connective tissues, cartilage, and tendons. These uses are what make it so attractive to athletes in all sports, and in bodybuilding in particular.
To begin with, it should be stated that for the vast majority of HGH users, results are not rapid and earthshaking in nature. If your idea of using HGH is to get ripped in a few weeks, gaining 20 pounds of muscle in a matter of a month or two, or being miraculously healed in a matter of a few injections … you are likely in for a BIG disappointment. HGH does some pretty incredible things, but it HAS to be viewed as a long-term endeavor. A reasonable length HGH cycle would be 20-30 weeks in length. While you will always be able to find the one or two individuals who will make great strides in a short amount of time, the majority of us need to be dedicated to its use for the long haul for it to be a worthy venture.
As mentioned in our introduction to HGH, one of the major roles it plays in growth is by its acting on the liver, muscle cells, and other tissues, which in turn secretes igf-1. This process is cumulative in nature, and it will take some time for your exogenous HGH use to bring your igf-1 levels to create an environment conducive to optimal growth. While it is true that HGH begins shuttling nutrients to your muscles, and begins mobilizing fat from the first injection, these behind the scenes benefits will only be VISIBLE several weeks (up to 12) down the road.
For anti-aging, general health & healing, fat mobilization
And other purposes such as these –
A dose of 2-3 IU’s per day (~10 – 15 IU’s per week) will be sufficient. A dose of 1.5 - 2.0 IU’s is considered to be a full replacement dose for those in their middle age. Given we will get somewhere in the neighborhood of 70-80% absorption and utilization from our subQ injections, our 2-3 IU’s will for all intents and purposes equate to a full replacement measure of HGH.
For gaining lean muscle and substantially improving body composition –
For this purpose a dose of 5-10 IU’s per day (~25-50 IU’s per week) will be necessary. Most people that still have an alive and kicking pituitary will respond very well at a dose of 5 IU's per day, though advanced bodybuilders and other large strength athletes will find that dose approaching 10 IU’s per day will be in order.
For maximum benefit in this regard, the addition of Testosterone and/or other anabolic should strongly be considered. For advanced use, other supplements like Insulin, and low-dose T3 or T4 would also be considerations.
Regardless of your goal, as a general rule the best way to begin your HGH program is to start with a low dose and ease your body into the higher doses. This will allow you to avoid (or at least minimize) many of the more common (and unpleasant) sides of HGH such as bloating and joint pain & swelling. Most people can tolerate up to approximately 2 IU’s per day with few sides, so that would be a good place to start.
For many using this as a general health supplement, that is as high as you will need to go. For others this will be only the start. Above 2.5 – 3 IU’s, I would definitely suggest that your split your injections into two per day instead of one unless it is just not feasible to do so. In my experiences, I have ran doses as high as 10 IU’s per injection, but at those doses I have suffered greatly with joint pain and bloating to the point of feeling like a Goodyear blimp. Also in my experimentation it seems that at least for me, keeping my individual doses down to 3-3.5 IU’s a piece, I more effectively elevate my igf-1 levels while minimizing the need for mega-doses of HGH.
Here is what a good ramp up strategy would look like:
Weeks 1-4 = HGH 2 IU’s one injection
Week 5 = HGH 2.5 IU’s one injection
Week 6 = HGH 3.0 IU’s split into two injections of 1.5 IU’s each
Week 7 = HGH 3.5 IU’s split into two injections of 1.75 IU’s each
And so forth until you reach your desired dose.
If at any point in this progression you begin to have unbearable bloating or joint pain, drop the dose by 25% and hold it at this lower dosage for a couple of weeks. If the sides subside, begin your progression back up toward your desired level. If the sides remain, lower your dose again and hold it at the lower level for two weeks before beginning the upward progression. This method will keep your HGH experience a good one and side free for the most part.
For a normal cycle of 5-8 months in length, injecting once or twice a day, 7 days a week should be fine. While there are studies that suggest that the suppression and negative feedback from exogenous HGH is short lived (about 4 hours from time of injection), there are no large-scale studies to indicate safety of everyday injections in long-term use. There are studies by anti-aging groups demonstrating that a day or two off per week is adequate to protect the pituitary and its triggers over long cycles. If your use of HGH becomes more a lifestyle than a single cycle, I would consider running it 5 on/2 off, or 6 on/ 1 off until such time as we have reliable data demonstrating long-term safety sans any degradation of your own output or the triggers initiating that output. I have personally experimented with just about every conceivable injection strategy I could devise. What I can say about the anti-aging doctor’s supposition is that it panned out for me. I have recently come off of a 7-year run of HGH. I personally pull my own blood panels every six weeks routinely. After many months of being off of HGH, I now have the same profile I had before I began its use many years ago … high normal for my age. All levels and markers are perfectly normal.
Another option would be to run your HGH cycle everyday for the first two months to get your igf-1 levels elevated quickly and to a level to assist you in an anabolic way, then drop back to 5 days a week. If you can tolerate the sides of higher doses, running the same weekly dose divided every other day is fine as well. The list goes on and frankly is an individual proposition. What seems to be of greatest import is that your weekly supplement of HGH is respectable enough to provide the desired benefit.
As described above, the body produces HGH is a pulsatile fashion throughout the day with the heaviest pulses occurring approximately 2 hours or so after going to bed and as you fall into a deep sleep. Injectible HGH is completely absorbed and put to use within approximately 3 hours. The strategy with respect to timing depends somewhat on our age and the other elements of our cycle. As you will see below, there is no single best strategy … it depends a lot on your individual situation.
For those that are between their late 20’s and early 50’s, there is still a reasonable chance that your own endogenous production of HGH is at a reasonable level. The best time to take and injection, this being the case, would be early morning …. After your body’s own release of HGH in the night. If you get up to go to the bathroom in the early morning (3 -5am), this is probably the perfect time to take a couple of units of HGH. This will be the least disruptive time to take an injection of HGH. The second best time would be first thing in the morning when you wake up.
If you are splitting your doses, the two times of the day when your cortisol levels are at peak are when you wake up and in the early afternoon. This being the case, another good strategy is to take your HGH injections at these times. Cortisol is very catabolic by nature and a well -timed HGH injection can go a long way toward blunting this effect.
If you are in your late 50’s or beyond, or if for some reason you have a condition that has rendered your pituitary incapable of a normal release of HGH, a great time to take HGH is right before bed. This allows you to closely mimic the natural pattern that would occur if your pituitary were functioning properly. For the rest of us, taking your HGH right before bed is going to end up creating a negative feedback loop, robbing you of your body’s own nightly pulse of HGH. While the jury is still out (conflicting studies) as to the absolute nature of the negative feedback time, it is clear that the closer we push our injection to the time our body is ready to give us its biggest pulses of HGH, we are going to end up derailing our own triggers and secretion.
Yet another strategy should be considered if you are using insulin with your HGH. Insulin should be used immediately post workout. HGH and insulin do some great things together – they shuttle nutrients in a very complimentary way with each other, and the combination of HGH and Insulin create the best environment for igf-1 production from the liver. If you are using insulin immediately post workout, taking a few IU’s of HGH pre-workout will allow HGH to offer all of its fat mobilizing effects while getting your HGH and Insulin to the liver at about the right time for huge igf-1 releases.
SIDE EFFECTS – HOW TO MANAGE THEM
While HGH for the most part is well tolerated, there are some minor, mostly nuisance side effects that can occur. The biggest and most common side effect is bloating and joint pain. The chances of getting these can be minimized or even eliminated by utilizing the ramp up method discussed above in this guide.
If you are younger than your late 20’s, it would be very wise to enter an HGH cycle under the guidance of an MD, who can monitor and confirm whether your growth plates have fused. While abnormal bone growth with HGH use is not common, if used at the wrong point in your body’s development, it could cause disproportionate growth.
10-25-2013, 08:15 AM
If you have a history of cancer or other tumors (at any age), it would be wise to get a complete checkup and be monitored by an MD to make sure that there are no active tumors before your HGH cycle. While HGH (and igf-1) won’t cause cancer or tumors, they can create an environment that can allow already existing, active tumors to grow at an accelerated rate. We intentionally keep growth factor levels to a minimum in cancer patients. While tumors can create their own growth factors, we really don’t want to throw gas on the fire and allow them to grow any faster than they otherwise could.
Beyond these considerations, there really isn't anything specific that you would HAVE to take with HGH. There are supplements that you could take for specific conditions that are possible with HGH use. The way people react to HGH is a pretty individual thing. Some people get very little suppression of any kind; others don't see any gains from adding HGH because of significant enough suppression of one kind or another. Here's a general rundown of a few of the bigger ones.
For the slight thyroid support that may be desired:
conservative - take nothing
moderate - t-100x, bladderwrack, coleus forskolin, selenium, zinc, chromium, copper
aggressive - T3 at a dose of 12.5 - 25 mcgs or T4 at 100mcgs per day.
For the insulin resistance that is possible:
conservative - 300mg of Alpha Lipoic Acid and 200 - 300mcgs of Chromium Piccinolate
moderate - 15mg of Actos - a prescription med to increase insulin sensitivity, Glucophage (Metformin) to dispose of excess glucose and increase uptake in muscles.
aggressive - add a few IU's of insulin to your HGH cycle
For healthy test levels to best utilize HGH:
conservative - do nothing
moderate - use Tongkat or Tribulus
aggressive - add 200-300 milligrams (or more) of testosterone weekly to your HGH cycle
For protection against prostate growth:
conservative - do nothing
moderate - use Saw Palmetto (approx 2000mg)
aggressive - use Proscar or equivalent
For those that have a problem with breast tissue growth while on HGH:
For those that suffer from this, there is a difference of opinion as to the cause. In the presence of adequate estrogen, HGH can prompt growth of breast tissue. Also of consideration is that growth hormone, prolactin, and placental lactogen are a subfamily of a large 2-class cytokine superfamily of proteins. The amino acid sequences of HGH and hPL are similar (85% homology). In humans, each of these three proteins can bind hPRL receptors and promote a variety of physiological actions, including breast growth, lactation, and the like.
The current consensus seems to be that the best approach for those with this problem is twofold - Take 200mg of B6 (or Bromo if B6 is not sufficient) and also use 20-40mg of Tamoxifen (Nolva) to control this. If all else fails, a couple of months of letro and Bromo will most certainly (and aggressively) deal with the problem. This is a pretty rare condition, but I have talked with more than a few bros that have reported this sort of problem.
Once again, I wouldn't say that all (or any) of these are necessary for everyone. I would use these supplements as necessary to correct whatever conditions arise with your own HGH use. As stated above, reaction to HGH (and just about anything else we use) is very individual.
Hopefully this guide has given you a better understanding of HGH and what it can do for you. HGH, especially when used in conjunction with an AAS cycle, will produce some high-quality, lean mass gains. It can also be used in conjunction with igf-1 and insulin, which will be the topic of a comparative guide, that I will finish writing and get posted one of these days.
Happy growing! – RedBaron
10-25-2013, 08:16 AM
RedBaron's Guide - Putting it all together HGH + LR3 + Insulin
Putting it all together - HGH + IGF-1 + Insulin – by RedBaron
A basic peptide cycle guide for the lazy man
There are volumes of studies available regarding the use of HGH, IGF-1 (and all its variants), and Insulin, but for the most part coming up with a good cycle incorporating all of these is a tedious process and requires more of an investment in time pouring over studies and other reading than most people wish to invest. The following is put forth as a basic guide. It is meant to be a quick and simple reference as to what a cycle including all three of these components might look like and a brief description of the action of each of the components. This is in no wise intended to be a comprehensive guide, a technical document, nor is it presented as the ONLY way to run a cycle such as this. This is merely as an example of one method that will definitely yield results. Myself and several athletes and all levels of competition have used the basic cycle principles below with good success over the last few years. You will certainly want to tweak this for your particular application, but this should at least get you headed in the right direction.
Weeks 1- (20-30) – HGH – On 5/ off 2
Weeks 1-5, 11-15, (21-25)
• 2 – 3 IU’s - first thing in the morning on workout days – early afternoon on non-workout days
Weeks 6-10, 16-20, (26-30)
• 2 – 3 IU’s first thing in the morning
• 2 – 3 IU’s 1-2 p.m. or pre-workout (or IM post-workout with your insulin if preferred)
All HGH injected subQ into abdomen, obliques, fronts of the thighs, and upper triceps
Weeks 1-5, 11-15, (21-25) – Long R3 IGF-1 – Every day
80 – 100 mcg’s intramuscular
• post work out on workout days
• first thing in the morning on non-workout days
Weeks 6-10, 16-20, (26-30) – Humalog – Workout days only
• 8 – 12 IU’s immediately post workout, intramuscular
IMPORTANT / CRITICAL - Post Insulin Nutrient Routine
Immediately after Humalog injection – do the following in exacting fashion -
• Injection + 5 minutes – drink shake with 10g glutamine / 10g creatine / 7 grams of dextrose per IU of Insulin. (If you don’t wish to split the shakes, add the whey isolate described as well here for a single shake).
• Injection + 15 minutes – drink shake with 65g of whey isolate protein in water (skip if taken with above)
• Injection + 75 minutes – eat a protein / carb meal with 40-50g of protein, 40-50g of carbs, NO FATS (you may wish to add another 30g or so whey isolate protein drink with this meal if you have tore down sufficient muscle groups to utilize this without it being stored as fat)
(i.e. – two boneless, skinless chicken breasts baked or grilled, a serving of brown rice, sweet potatoes, or pasta, with green beans)
Avoid fats for 2-3 hours for Humalog IM, 3-4 hours for Humalog subQ, 4-5 hours for Humulin-R.
keep some glucose tablets or other simple carbs on hand (Orange Juice, Full sugar Coke, etc.) for the active window of your insulin. Hypo symptoms can and will hit hard and fast and you will have little time to react. This is the main danger of insulin use. . Lack of attention to detail in this area can end in a nice ambulance ride, a visit to the hospital or even a one-way trip to the morgue. Be ready and act smart. The price of stupidity is really, really high.
OPTIONAL Addition to above cycle
Weeks 1- (20-30) T3 or T4 - Every Day
one of the following –
• 12.5 mcgs - 25 mcgs T3 taken once each day
• 100 mcgs T4 taken once each day
[alternative method if additional fat loss is necessary - Only use if sufficient AAS cycle is present to protect and support lean tissue and use only during the weeks of LR3 injections to avoid any potential negative impact to our IGF levels by increased IGF binding proteins. The 13 amino acid side chain of LR3 IGF-1 has specifically been engineered to resist being impressed by or bound to IGFBP’s, so any increase in the below ramp up/down will not kill your IGF levels. A reasonable dose AAS component of the cycle will further protect lean tissue from being used for fuel. In absence of these above-mentioned components, you won’t want to run your T3 above 50mcgs per day. It will begin to elevate IGFBP’s and will dismantle and burn through hard-earned muscle proteins quicker than you could imagine.]
Weeks 1-5, 11-15, (21-25) T3 Every Day
For each of the 5 week runs of T3:
Days 1-3 25 mcgs
Days 4-6 50 mcgs
Days 7-9 75 mcgs
Days 10 - 20 100 mcgs
Days 21 - 24 75 mcgs
Days 25 - 27 50 mcgs
Days 28 - 30 25 mcgs
Days 31 - 35 12.5 mcgs
DESCRIPTION OF THE ELEMENTS OF THIS CYCLE
HGH should ideally be used for 20-30 week cycles (or longer). The dosage should be between 2-3IU per day if you are using GH primarily for fat loss, 4-8 IU’s a day for both fat loss and muscle growth, and approximately 1.0 – 2.0 IU’s a day for females. It is best to split your injections 1/2 first thing in the morning, 1/2 early afternoon if your dose is above 3.0 IU’s per day. Your pituitary will naturally produce an average of 6 or so pulses of GH per day, the mega pulse being 2 hours after we fall asleep. Each injection you take will create a negative feedback loop that as suggested by a couple of studies will suppress these pulses for an approximate 4 hours. By taking your injections first thing in the morning and early afternoon you will still allow your body to release its biggest pulse, which normally occurs shortly after going to sleep at night, as well as blunting the effects of cortisol, the two biggest peaks of which are occurring at these same times (early morning, early afternoon).
When starting out with your HGH cycle, for most people it is wise to begin you dose at 1.5 – 2.0IU per day for the first couple of weeks, and then begin increasing your dose by 0.5 unit every week or two until you reach your desired level. While it isn't an absolute necessity to do this, if you are sensitive to the type of sides HGH present you will often times avoid these sides of joint pain/swelling, CTS, and bloating/water retention by slowly acclimating to your ultimate 4-5 IU/day goal.
You should use an U100 insulin syringe for injecting HGH, and inject it subQ into your abdomen, obliques, top of thighs, triceps. Rotate injection sites. HGH can have a small-localized fat loss benefit, so keep this in mind when choosing your injection sites.
When HGH makes it pass through the liver, a release of IGF-1 is a result. IGF-1 appears to be a key player in muscle growth. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. While HGH will cause an increase in your IGF-1 level over the course of a few months, HGH has a cumulative effect, so our addition of IGF-1 will greatly speed up the time to results.
There are two types of IGF-1 that will typically be used by bodybuilders. One is bio-identical huIGF-1, a 70 amino acid string. The other is Long R3 IGF-1, which is an 83 amino acid analog of human IGF-I comprising the complete human IGF-I sequence with the substitution of an Arg for the Glu at position 3 (hence R3), and a 13 amino acid extension peptide at the N-terminus (hence the long). This 13 amino acid "side chain" helps prevent the IGF-1 from being so easily bound by binding proteins, and thus increases its active window exponentially. Which of these you use depends on your goal.
HuIGF-1 is very short lived in the body (probable half life of approximately 10 minutes). This type of IGF-1 is very useful if you are seeking local site growth. Since it is so short lived, little if any of the IGF-1 makes it to other tissues and IGF-1 receptors in other parts of the body. The way to inject this is immediately post work out into the muscle that you wish to have local site growth. Use a U100 insulin syringe, and inject 100 - 300 mcg’s (in some cases more) bilaterally into the desired muscle immediately post workout. For this type of IGF-1, I would use it workout days only.
For Long R3 IGF-1, it isn’t as critical that you inject into a local site as long R3 has a active window of many hours (if not days), and is designed specifically to resist being bound by IGF binding proteins.
Since it is common to reconstitute this type of IGF-1 with Benzyl Alcohol, Acetic Acid, or Hydrochloric Acid, I would still recommend that you inject intra-muscular. While for some purposes of nerve regrowth and other medical recovery purposes subQ is a somewhat superior injection method, it can and probably will leave a nice red irritated spot for a couple of weeks if you inject subQ, and it is not superior for our purposes of muscle growth anyway.
I still inject into a muscle just worked to take advantage of increased IGF-1 receptors present as a result of tearing down muscles with my workout, but because of the long activity window of this type of IGF-1 any muscle will work well and give you good results. I would suggest that you inject between 80 – 120 mcg’s per day everyday immediately post workout on workout days, and first thing in the morning on non-workout days.
The added bonus of using LR3 in our cycle is that fat loss will be accomplished while still eating a great number of clean calories per day. You will visibly see yourself leaning out from a couple of weeks in on while using LR3 at doses suggested here.
Use a U-100 insulin syringe with 1/2" needle to inject IGF-1 intramuscular (bilaterally for HuIGF-1, bilaterally optional for Long R3)
Working out causes our muscles to end up in a catabolic state after a good hammering. It is important to back in a positive nitrogen balance as soon as possible. When not using insulin, we drink some dextrose with our protein to cause an insulin spike immediately post workout to help shuttle the protein and sugars to the muscles.
Insulin is very good at shuttling nutrients to the muscles, and works in a very complimentary manner with GH in the types of things that they shuttle. Also, HGH can cause an amount of insulin resistance, so adding some insulin to your cycle will go a long ways toward reducing the elevated blood glucose levels caused by HGH's action of interfering with the liver's ability to uptake glucose, and thus help offset any potential resistance that might occur during your HGH cycle. Also by taking our HGH near the time of our insulin injection (immediately post workout) we are ensuring a great influx of growth factors after action on the liver. HGH + Slin passed through the liver = BIG secretion of growth factors. These growth factors will equate to muscle growth, rapid healing, etc.
For the purposes that we are using insulin, a dosage of 6-12IU’s is adequate and should be used immediately post workout. I personally prefer using Humalog intramuscular as it will cause a rapid spike and clear out of your system quickly. You can use it subQ or use Humulin-R instead, but each of these will result in a longer active window, thus a longer time to avoid eating any fats and watching your carb intake. Any fats or over abundance of carbs will end up being stored as fat during insulin's active window. The approximate windows are:
Humalog - IM - 2-3 hours
Sub-q - 3-4 hours
Humulin -R - IM - 3-4 hours
Sub-q 4-5 hours
Use a U-100 insulin syringe with 1/2" needle to inject IM immediately post workout. Alternatively, you can inject subQ if desired or if you wish a longer active window for some reason. Begin with a dose of 4IU's or so, and increase the dose each workout day until you reach your desired 8-12IU's.
If for some reason you wish to avoid insulin, I would still suggest that immediately post workout you spike you own endogenous insulin by drinking 80 grams of dextrose / 40 grams of whey isolate protein. While this certainly won't do the work of 8-12 IU's of Humalog, it will most certainly assist getting your muscle back in a nitrogen positive environment in a short amount of time.
T3 or T4
HGH can (but certainly not universally) have a slight inhibitory effect on your thyroid. For most people this is minimal and does not require any additional thyroid be taken, but if you wish to augment protein synthesis as well as give yourself a slight metabolic boost in thyroid without shutting down your own production, you can add 12.5mcg of T3 or 50mcgs of T4 daily to your HGH, IGF-1, and Insulin cycle. This will aid both in bulking and cutting.
If you add T3 or T4 to your cycle, you should also consider taking some thyroid support supplements such as t-100x, bladderwrack, and coleus forskolin. You should check and make sure your intake of trace minerals (selenium, zinc, copper) is sufficient to aid in the conversion of T4 to T3.
If you are going to take more than 12.5 mcg of T3 or 50mcgs of T4, a wise method is to cycle the dose both up and down to avoid a rebound effect when going off the T3 portion of your cycle. While many profess they don’t suffer from this rebound problem, I can personally attest to MANY that do. If you don’t have a desire to find out whether you are one of the lucky ones or not, consider the ramp up/down to minimize the rebound. It is a real bummer to lose a bunch of fat only to pack it right back on because your metabolism is in the toilet for many weeks post thyroid cycling. The other consideration is that T3 is very indiscriminant in it stoking of the metabolic fire. It will happily burn both fat and lean tissue (muscle proteins are really attractive, easy marks), so I would only recommend its use at much above 25mcgs of T3 or 100mcgs of T4 per day (and definitely if used at 50mcgs of T3 or 200mcgs of T4 or above - at which point IGFBP's will rise significantly enough to be a consideration) if you are on a reasonably healthy anabolic cycle to protect your lean tissue. For strictly our use with an HGH cycle and use in assisting with protein synthesis, 12.5mcg of T3 or 50mcgs of T4 will be sufficient and will not be problematic.
Also another consideration if cycling in higher doses, cycle your T3 in conjunction with your LR3 IGF-1 use. The thought behind this is that LR3 binds poorly to IGFBP's, so you will be able to use an elevated dose of T3 (which will likely increase IGFBP's) and still keep elevated IGF-1 levels. I would suggest that use of T3 above 25mcg's or T4 at doses above 100mcgs or so would not be advisable for too many 5 weeks segments of your complete cycle. As one of the major "anabolic" benefits of HGH use is elevated IGF-1 levels, we don't want to create an environment of radically increased IGF binding proteins. Abuse of T3 or T4 will go a long way in creating that environment hostile to IGF-1.
Well, I think that about covers the basic peptide suite …all that is needed to complete this cycle is the addition of your preferred anabolic portion of the cycle –a simple testosterone combo (cyp, e, prop, etc.) or a more complex cycle. In either event, add something along those lines and you have a great combination that can be tailored for whatever your goals may be.
I hope this guide helps get you going on the right path. Happy growing!
11-05-2013, 12:12 AM
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