GHRP-6 cause gyno to grow?

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    GHRP-6 cause gyno to grow?


    Hey guys i ahve a very very small case of gyno, lump smaller then a dime. I have been using GHRP-6 for some time now and im not sure if it is just me but it seems like the lump gets bigger when i am using this peptide...... again this is probably just me. I am using no more then the saturation dose (100 mcg) and use it no more then 3 times daily. I understand the prolactin/cortisol risk, i am taking 500mg of b-6 daily, and .25 mg of letro daily. Any thoughts?

    Height: 5' 11"
    Weight: 208
    Age:21

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    don't take B6, B6 only if your gyno is prolactin. Letro is SOOO strong that you don't need B6

    No
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    500mg of b6 could cause nerve damage and B6 is toxic at high doses too so I wouldn't run that dose very long. If you can't get cabergoline try vitex and run it high but i'd try to get Rx strength stuff just in case that doesn't work for ya.

    Hopefully someone else will have a answer for your gyno question.
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    try Anti-P or Cabaser, dostinex and see how it goes ! letro is for estrogen gyno

    ur gyno is mostly progesterone
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    Why the hell are you using GH peptides at 21?
    M.Ed. Ex Phys
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    Quote Originally Posted by Rodja View Post
    Why the hell are you using GH peptides at 21?
    To get huge
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    Im using GH peptides at 21 to get swole. The gyno existed before i started the GHRP-6 so how is it for sure progesterone related? i had my blood work done before i started using the GHRP-6 and everything seemed fine except LH was a bit high, i am really confused here, what should i be taking to keep this problem at bay, thanks for all the help so far guys, just trying to get to the bottom of this
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    Quote Originally Posted by bcmjra1 View Post
    Im using GH peptides at 21 to get swole. The gyno existed before i started the GHRP-6 so how is it for sure progesterone related? i had my blood work done before i started using the GHRP-6 and everything seemed fine except LH was a bit high, i am really confused here, what should i be taking to keep this problem at bay, thanks for all the help so far guys, just trying to get to the bottom of this
    You can'r really know for sure without a blood test...

    I was just trying to bring to your attention that mega dosing B6 is not a very effective way to lower prolactin (not that we know if its causing your gyno to grow).

    Are you on a bulking diet with your peptides? Without any pain/sensitivity in the nip itself, I'd say it might just be that you're putting on some fat making it feel like your gyno is growing. Could just be putting on chest fat?

    21 is a bit young for using peptides recreationally. just saying
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    Ghrp-6 causes prolactin gyno. Throw away your peptides. Buy some test boosters, Divanex and a sh!tload of frozen grilled chicken breasts. Lift hard, eat hard, screw hard. You'll get the most out of your physique long term if you'll leave drugs alone for now. Age will creep on you before you know it.
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    Yeah it's related to the prolactin. What else are you using that you are taking letro for? I would lower the dose and see if that helps. The gains from ghrp aren't going to get you "swole"... at best you'll get some glycogen retention and joint repair. DOn't get me wrong, it's good stuff, but not worth jumping on dopamine agonists and **** for
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    Hahaha, I know GHRP isn't going to make me" swole" I was mainly just using it to help out a rotator cuff injury,if I were to purchase sellegeline would this prevent thos problem from happening or would you guys just suggest using ipapromelan (sorry speeling is wrong, on my phone and too lazy to find the right spelling) but isn't that peptide the same as GHRP 6 except no hunger and no cort/prolactin?
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    Quote Originally Posted by bcmjra1 View Post
    Hey guys i ahve a very very small case of gyno, lump smaller then a dime. I have been using GHRP-6 for some time now and im not sure if it is just me but it seems like the lump gets bigger when i am using this peptide...... again this is probably just me. I am using no more then the saturation dose (100 mcg) and use it no more then 3 times daily. I understand the prolactin/cortisol risk, i am taking 500mg of b-6 daily, and .25 mg of letro daily. Any thoughts?

    Height: 5' 11"
    Weight: 208
    Age:21
    B6 for prog compounds like deca or tren but even then its pritty mild in helping out./
    letro 0.6mg - 0.25mg eod to e3d is a good spot.
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    These statements have not been evaluated by the FDA, do not constitute medical advice, and are not official or authorized comments by LG Sciences, LLC.
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    Quote Originally Posted by monstermash View Post
    500mg of b6 could cause nerve damage and B6 is toxic at high doses too so I wouldn't run that dose very long. If you can't get cabergoline try vitex and run it high but i'd try to get Rx strength stuff just in case that doesn't work for ya.

    Hopefully someone else will have a answer for your gyno question.
    yes sadly alot dotn knwo that soem vitamiens can KILL YOU or cause damage if run at high doses and then soem you wtake take as much as you want and be fine or at very most have diariaa liek say vitC 8g is safe but 8g of b6 would REALLY **** you up.
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    Quote Originally Posted by stankyleg View Post
    Ghrp-6 causes prolactin gyno. Throw away your peptides. Buy some test boosters, Divanex and a sh!tload of frozen grilled chicken breasts. Lift hard, eat hard, screw hard. You'll get the most out of your physique long term if you'll leave drugs alone for now. Age will creep on you before you know it.
    im pritty sure its Ghrp-2 that can cause this. NOT Ghrp-6.
    here is info:
    Growth Hormone Releasing Peptide - 2 (GHRP2)
    Is a synthetic six amino acid peptide that has robustly potent properties.
    GHRPs are a small family of peptides acting at the pituitary and the hypothalamus to release Growth hormone (GH) through the activation of a specific, G protein-coupled receptor.
    ______________________________ __________
    They were discovered 20 years ago as synthetic metenkephalin- derived oligopeptides (Synthetic tissue derived amino acids). Although it has no structural homology with Growth Hormone Releasing Hormone (GHRH), in clinical studies GHRP-2 demonstrated action on the pituitary to release Human Growth Hormone (HGH). Similar results were effective when GHRP-2 was administered sublingual. Clinical studies showed the most potent GHRP being the hexapeptide GHRP-2.
    ______________________________ __________
    Growth Hormone Releasing Peptide 2(GHRP2) substantially stimulates the pituitary gland's increased natural production of the body's own endogenous human growth hormone (HGH). This therapy consists of daily periodic sub-lingual dosing. Growth Hormone releasing peptide 2, GHRP2 has shown on it's own to robustly increase IGF-1 levels, and even greater results occurred when used with Growth Hormone Releasing Hormone (GHRH) to which also stimulates the pituitary gland to produce increased natural secretion of human growth hormone. This also boosts the hypothalamus function as well.
    ______________________________ __________
    The results of the clinical studies published in the Journal of Endocrinology and Metabolism in 1997 for GHRP2 - showed that a medically supervised, prescribed and administered therapy increased growth hormone levels in adults and children, who have growth hormone deficiency.
    ______________________________ __________
    The increase in the body's growth hormone via elevated IGF-1 levels produced by the pituitary gland in response to GHRP2 therapy -- has an anabolic effect on the tissues of the body and other benefits identified below.
    Synergy of GHRH + GHRP

    It is well documented and established that the concurrent administration of Growth Hormone Releasing Hormone (GHRH) and a Growth Hormone Releasing Peptide (GHRP-6, GHRP-2 or Hexarelin) results in synergistic release of GH from pituitary stores. In other words if GHRH contributes a GH amount quantified as the number 2 and GHRPs contributed a GH amount quantified as the number 4 the total GH release is not additive (i.e. 2 + 4 = 6). Rather the whole is greater than the sum of the parts such that 2 + 4 = 10.

    While the GHRPs (GHRP-6, GHRP-2 and Hexarelin) come in only one half-life form and are capable of generating a GH pulse that lasts a couple of hours re-administration of a GHRP is required to effect additional pulses.

    Growth Hormone Releasing Hormone (GHRH) however is currently available in several forms which vary only by their half-lives. Naturally occurring GHRH is either a 40 or 44 amino acid peptide with the bioactive portion residing in the first 29 amino acids. This shortened peptide identical in behavior and half-life to that of GHRH is called Growth Hormone Releasing Factor and is abbreviated as GRF(1-29).

    GRF(1-29) is produced and sold as a drug called Sermorelin. It has a short-half life measured in minutes. If you prefer analogies think of this as a Testosterone Suspension (i.e. unestered).

    To increase the stability and half-life of GRF(1-29) four amino acid changes where made to its structure. These changes increase the half-life beyond 30 minutes which is more than sufficient to exert a sustained effect which will maximize a GH pulse. This form is often called tetrasubstituted GRF(1-29) (or modified) and unfortunately & confusingly mislabeled as CJC-1295. If you prefer analogies think of this as a Testosterone Propionate (i.e. short-estered).

    Note that some may also refer to this as CJC-1295 without the DAC (Drug Affinity Complex).

    Frequent dosing of either the aforementioned modified GRF(1-29) or regular GRF(1-29) is required and as previously indicated works synergistically with a GHRP.

    In an attempt to create a more convenient long-lasting GHRH, a compound known as CJC-1295 was created. This compound is identical to the aforementioned modified GRF(1-29) with the addition of the amino acid Lysine which links to a non-peptide molecule known as a "Drug Affinity Complex (DAC)". This complex allows GRF(1-29) to bind to albumin post-injection in plasma and extends its half-life to that of days. If you prefer analogies think of this as a Testosterone Cypionate (i.e. long-estered). However this is not accurate. CJC-1295 results in continual GH bleed. Although natural pulsation still occurs CJC-1295 does nothing to increase those pulses. Instead it raises base levels of GH and creates a more feminized pattern of release. This not desirable.

    Modified GRF(1-29)however when combined with a GHRP brings about a substantial pulse which has desirable effects.

    A Brief Summary of Dosing and Administration

    Dosing GHRPs

    The saturation dose in most studies on the GHRPs (GHRP-6, GHRP-2, Ipamorelin & Hexarelin) is defined as either 100mcg or 1mcg/kg.

    What that means is that 100mcg will saturate the receptors fully, but if you add another 100mcg to that dose only 50% of that portion will be effective. If you add an additional 100mcg to that dose only about 25% will be effective. Perhaps a final 100mcg might add a little something to GH release but that is it.

    So 100mcg is the saturation dose and you could add more up to 300 to 400mcg and get a little more effect.

    A 500mcg dose will not be more effective then a 400mcg, perhaps not even more effective then 300mcg.

    The additional problems are desensitization & cortisol/prolactin side-effects.

    --------------------------------------------------

    INFO: GHRP-6 (Growth Hormone Releasing Peptide – 6)
    ______________________________ __________
    GHRP-6: GHRP-6 (Growth Hormone Releasing Peptide – 6) is a hexapeptide with a chain comprised of 6 amino acids. This special sequence is considered to provide a signal to the body to begin secreting Growth Hormone(GH) release while also blocking Somatostatin, a hormone that inhibits Growth Hormone release. Growth Hormone has host of beneficial effects such as decreased body fat, increased muscle, and increased strength and stamina so maximizing the production and secretion can be a great addition to improved animal physical shape. Increased amounts of Growth Hormone then can cause the Liver to secrete the hormone IGF-1 which has also been implicated in improving the animal body’s ability to burn fat and build muscle. Clinical cases have shown that the use of GHRP-6 was associated with increased muscle mass and a reduction of body fat.

    Dosage - 250-500mcg daily


    Growth hormone releasing hexapeptide
    From Wikipedia, the free encyclopedia
    Growth hormone releasing hexapeptide

    IUPAC name[hide]
    L-histidyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-Lysinamide
    Other names[hide]
    GHRP-6
    Identifiers
    CAS number
    87616-84-0

    PubChem
    5486806

    MeSH
    Growth+hormone+releasing+hexap eptide

    Jmol-3D images Image 1

    SMILES
    [show]

    Properties
    Molecular formula
    C46H56N12O6
    Molar mass
    873.014
    Except where noted otherwise, data are given for materials in their standard state (at 25 C, 100 kPa)

    Infobox references

    Growth hormone releasing hexapeptide (GHRP6) is one of several synthetic met-enkephalin analogs that include unnatural D-amino acids, were developed for their growth hormone (GH) releasing activity and are called GH secretagogues. They lack opioid activity but are potent stimulators of GH release. These secretagogues are distinct from growth hormone releasing hormone (GHRH) in that they share no sequence relation and derive their function through action at a completely different receptor. This receptor was originally called the GH secretagogue receptor, the hormone ghrelin is now considered the receptor's natural endogenous ligand. Therefore, these GH secretagouges act as synthetic ghrelinmimetics.
    The major side effect accompanied by the use of GHRP-6 or other GH secretagogues is a significant increase in appetite because secretagogues mimic the action of Ghrelin, a peptide which is released naturally in the lining of the stomach and increases hunger and gastric emptying.
    GHRP-6, other secretagogues and ghrelin stimulate the anterior pituitary gland causing an increase in GH release. When natural GH secretion has been inhibited by long term abuse of synthetic GH, GHRP-6 may help to re-stimulate the natural production of GH. GHRP-6 may also affect the central nervous system by protecting neurons as well as increasing strength in a way very similar to the way certain steroids in the Dihydrotestosterone family do.
    Claimed benefits of increased Growth Hormone levels through GHRP-6 stimulation include: an increase in strength, muscle mass and body fat loss, rejuvenation and strengthening of joints, connective tissue and bone mass. Enhanced GH secretion also leads to the liver secreting more IGF-1 (Insulin-Like Growth Factor 1), which is thought to be the primary anabolic mechanism of action for Growth Hormone.
    [edit] Technical data
    It has also been discovered that when GHRP-6 and insulin are used simultaneously, GH response to GHRP-6 is increased (1). A recent study in normal mice showed significant differences in body composition, muscle growth, glucose metabolism, memory and cardiac function in the mice being administered the GHRP-6 (2). There are still many questions regarding this fairly new compound, scientists are hoping to gain a better clinical understanding of the peptide through further research over the next few years.
    [edit] References
    • Korbonits M, Goldstone AP, Gueorguiev M, Grossman AB (2004). "Ghrelin--a hormone with multiple functions". Frontiers in neuroendocrinology 25 (1): 27–68. doi:10.1016/j.yfrne.2004.03.002. PMID 15183037.
    • {{Penlava, A, et. al. Effect of growth hormone (GH)-releasing hormone (GHRH), atropine, pyridostigmine, or hypoglycemia on GHRP-6-induced GH secretion in man.}}
    • Template:J Clin Endocrinol Metab. 1993 Jan;76(1):168-71. Adeghate, E. & Ponery, A.S. (2002) Ghrelin stimulates insulin secretion from the pancreas of normal and diabetic rats. Journal of Neuroendocrinology, 14, 555560.
    LG Sciences Board Rep
    These statements have not been evaluated by the FDA, do not constitute medical advice, and are not official or authorized comments by LG Sciences, LLC.
  

  
 

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