Nice find phaeton66!
The article was weak but it references a new study where elderly were given MK-677 for one year.
I'm tired of reading DatBtrue's tired refrain so lets take a look at the Nov. 4th study in Annals of Internal Medicine and see if there is anything cool in it.
Okay they gave them 25mgs of MK-677 per day.
The "them" were 65 healthy adults (men, women receiving hormone replacement therapy, and women not receiving hormone replacement therapy) ranging from 60 to 81 years of age.
The results were "daily administration of MK-677 significantly increased growth hormone and insulin-like growth factor I levels to those of healthy young adults without serious adverse effects."
A graph tells the story:
Figure 2. Growth hormone (GH) and insulin-like growth factor I (IGF-I) levels at baseline and at 6 and 12 months, and a representative GH profile.
Growth hormone and IGF-I data were not normally distributed and were analyzed on the natural logarithmic scale. Line graphs show geometric means and 95% CIs.
A. Mean 24-hour GH levels. The dashed line indicates 24-hour mean GH level for young men and women combined (~1.3 µg/L). *P < 0.001 for MK-677 versus placebo.
B. Serum IGF-I levels. The lower dotted line indicates the lower limit of the IGF-I normal range for older adults (59 to 225 µg/L), and the upper dashed line indicates the lower limit in adults age 21 to 25 years (116 to 358 µg/L).
C. Representative 24-hour GH profile in a 70-year-old man with a body mass index of 23.2 kg/m2 who received MK-677 for 1 year. His 24-hour mean GH levels were 0.37, 1.0, and 0.86 µg/L at baseline, 6 months, and 12 months, respectively. The pulsatile pattern of GH secretion at baseline is maintained and enhanced at 6 and 12 months, primarily because of increased secretion per peak rather than peak frequency.
There is something new and really cool in that study! It took six months to build up but in the end GH & IGF-1 were elevated and remained so for the remainder of the year of continued use. As expected one month after discontinuing levels declined.
There was no demonstrated desensitization in this study.
The study: Effects of an Oral Ghrelin Mimetic on Body Composition and Clinical Outcomes in Healthy Older Adults, Ralf Nass, MD et al., Annals of Internal Medicine 4 November 2008 | Volume 149 Issue 9 | Pages 601-611