[csunkramer]

what are the recommended dosages on this thing? i have no idea when and how many to take

[EasyEJL]

you could dose 2x a day, preferably at least 5 hrs before bed for the last one, and i'd start at 1 cap each time, work upwards. If you aren't taking other stims, you might be ok at 2 or even 3. If you do take other stims, likely 1 is enough. leviathan reloaded has 11mg between yohimbine hcl + 11-hydroxy yohimbine per dose. so 5mg is pretty realistic. I have taken 3 caps with other stims, I've heard people taking 4.

[B5150]

Dosage--->

The dosage of .2 mg/kg (approximately 1 mg per 10 lbs.) per day is relatively free of side effects and effective for weight loss (2, 3), while .1 mg/kg is more commonly used for sexual stimulant effects. For fat loss, yohimbine is generally taken twice daily, in the morning and afternoon. It is best taken on an empty stomach, as taking it with a meal can reduce its lipolytic effects (3). The half-life of yohimbine is short (1-2 hours), but the half-life of a metabolite with similar activity, 11-hydroxy-yohimbine, is 6-8 hours (18), so it is not necessary to take it every 2 hours. It is best to start with half the dose or less to see how sensitive you are to yohimbine, as inter-individual bioavailability and tolerance can vary greatly.

In addition to what Easy shared it is very benefitial when taken on an empty stomach before cardio

Safety--->

Anxiety is the most common side effect seen with yohimbine, especially higher doses, and for this reason it should not be used by individuals prone to panic attacks or with stress-related disorders (14, 15). Other common side effects are increased heart rate and blood pressure, although these do not appear to be a problem at the doses used for weight loss (2, 3). Other side effects associated with elevated levels of NE, such as insomnia, can also be expected. All of these side effects disappear after termination of use (11).

Stacking (caution)--->

As covered above, arginine and other NO enhancers may operate synergistically with yohimbine as a sexual stimulant. It is also probably synergistic with caffeine for fat loss through PDE inhibition.

A possible synergism between yohimbine and ephedrine hasn't been thoroughly explored, and the information that exists is somewhat contradictory. In theory, they should work well together as yohimbine blocks one of the negative feedback mechanisms that would normally make ephedrine less effective. Cell culture studies confirm that yohimbine increases the lipolytic effects of beta(3) agonists (19). However, a study using rats indicated that yohimbine blocked the effects of the same beta(3) agonist, indicating that the two may antagonize each other (19). Additionally, a study on cardiovascular variables found that ephedrine and caffeine together were safe, but the addition of yohimbine may produce undesirable effects (20). So it is still unknown whether the combination of yohimbine and ephedrine produces any additional benefit, and whether it is justified by the potential dangers.

Additionally, caffeine and green tea extract are very effective stacked with Yohimbine

[EasyEJL]

well, I may jack up my dose now given the 1mg/10lbs a day. that would be 10mg bid for me

[B5150]

I split mine up at about 7-8mg x 3

[frizzlerock]

it is good to use with the Anabolic Diet right?

[saludable24]

How long should one wait after dosing before eating a meal when taking this?

[dsade]

Originally Posted by saludable24

How long should one wait after dosing before eating a meal when taking this?

20-25 minutes should be fine.

[nat]

I heard yhcl is not effective orally. Any thoughts!

I know alot of people are using a transdermal or injections of the stuff.

[dsade]

Originally Posted by nat

I heard yhcl is not effective orally. Any thoughts!

I know alot of people are using a transdermal or injections of the stuff.

Where did you hear that?

It works differently when taken orally, but it is still VERY effective.

[Aggravated]

Yohimbine is ok, I am not sure I like it as much as caffeine, but I don't get the crash I get from caffeine either.

[nat]

Originally Posted by dsade

Where did you hear that?

It works differently when taken orally, but it is still VERY effective.

Dan Duchaine talks about it in his book. He sees great potential with the compound as a stubborn fat burner but states that yhcl is not effective taken orally. Plus I heard this around other forums that the bioavaibility is really pore.

[frizzlerock]

for $8 im not gonna complain too much.

[VolcomX311]

My four orders just came in right now. They came in bags instead of bottles, so it looks like I ordered something illegal, haha. I thought that was funny. Great deal though!!!!

[B5150]

Originally Posted by nat

Dan Duchaine talks about it in his book. He sees great potential with the compound as a stubborn fat burner but states that yhcl is not effective taken orally. Plus I heard this around other forums that the bioavaibility is really pore.

I would suggest that you get some research under your belt.

Alpha 2-antagonist compounds and lipid mobilization: evidence for a lipid mobilizing effect of oral yohimbine in healthy male volunteers.
Galitzky J, Taouis M, Berlan M, Rivière D, Garrigues M, Lafontan M.

Laboratoire de Pharmacologie Clinique et Médicale, Université Paul Sabatier, Toulouse, France.

Investigations were carried out to analyse the interactions of alpha 2-antagonists (yohimbine, idazoxan, SK & F-86,466) with human fat cell alpha 2-adrenoceptors. All the alpha 2-antagonists enhanced the lipolytic potencies of epinephrine with an order of potency: yohimbine greater than idazoxan greater than SK & F-86,466; the same order was also found in 3H-yohimbine competition studies on human fat cell membranes. The most potent agent, yohimbine, was administered orally in humans to define the conditions of appearance and the time-course of a putative lipid-mobilizing action. Oral yohimbine administration (0.2 mg kg-1) elevated plasma glycerol and non-esterified fatty acids in fasting healthy subjects without significant action on heart rate or blood pressure during the time-course of the experiment. The lipid-mobilizing action of yohimbine was reinforced during physical exercise, completely suppressed after a meal and partially blocked by administration of propranolol (0.5 mg kg-1; 60 min before yohimbine). Plasma norepinephrine concentrations were increased (40-50%) after oral yohimbine administration. The rise in plasma catecholamine concentration elicited by yohimbine was not modified by propranolol treatment. The lipid-mobilizing effect of yohimbine could be attributable to: (i) the increase in synaptic norepinephrine with a resultant increment in lipolysis by beta-adrenergic agonism; (ii) a decrease in alpha 2-adrenoceptor stimulation of human fat cell alpha 2-adrenoceptors; (iii) a blockade of presynaptic alpha 2-adrenoceptors. The use of highly selective alpha 2-antagonists will allow investigations into alpha 2-adrenoceptors, which may represent a novel locus for pharmacological intervention in lipid-mobilization strategies.(ABSTRACT TRUNCATED AT 250 WORDS)

PMID: 2906290 [PubMed - indexed for MEDLINE]

Please notice that the doses on this study are the doses being recommended here. Additionally, the timing of the dose (empty stomach), pre exercise, especially pre cardio has also been emphasized here, by myself, as well.