SLIN-SANE ~ Product Write-Up and FAQ

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    SLIN-SANE ~ Product Write-Up and FAQ


    Slin-Sane







    Physique athletes have long since realized the profound benefits of the anabolic hormone insulin, whether it be through maximizing endogenous timing and release or simply by injecting the exogenous compound. Insulin release is stimulated in the body simply by the ingestion of carbohydrates, certain amino acids, or the combination of both. However, many people have inherent dysfunction in the complex insulin signaling cascade, which can result in limited nutrient uptake by the muscle cells, excessive uptake by the fat cells, too much insulin released, or too little insulin released. Even those with proper nutrient signaling can still greatly benefit their quest for increased muscle gain and accelerated fat loss by optimizing the body’s nutrient storage capabilities.

    Slin-Sane was designed to be just that nutrient storage optimization tool, by working to maximize uptake of glucose and amino acids at the muscle cell through multiple angles similar to and in conjunction with insulin, while delivering increased vascularity and muscle fullness.

    Overview of ingredients and function


    Lagerstroemia Speciosa

    A small to medium sized tree grown throughout parts of southern Asia, the leaves of Lagerstroemia Speciosa (LS) yield a novel compound called Banaba. Commonly used in Phillipine folk medicine to treat symptoms of diabetes, this compound shows great promise for its multi-faceted beneficial interaction with glucose and insulin.

    Initially, researchers thought banaba’s positive effects to be solely related to its content of corosolic acid, but studies have since shown there may be multiple other compounds in the leaf that contribute to its numerous benefits.

    Multiple studies have shown LS to have the ability to increase translocation of the GLUT4 receptor at the muscle cell, therefore allowing increased nutrient uptake (1,9). This cellular receptor is the main gatekeeper for nutrient influx, and optimal expression can greatly enhance cellular storage capabilities, increasing muscle fullness.

    A recent study out of Japan found a significant reduction in blood glucose response after feeding sugar to subjects pretreated with LS versus subjects who didn’t take the supplement (2). A similar study published in Diabetes Research and Clinical Practice also showed a potent glucose lowering effect over control from ingestion of 75g of glucose after administration of LS (6). In addition to reduction in glucose response to food intake, LS has been shown in multiple studies to lower fasting glucose and insulin levels, a key marker in overall health and cell responsiveness to nutrient sensing (3,8,10,13).

    Aside from Lagerstroemia’s basic glucose stabilizing effects, it touts numerous other capabilities related to health and longevity including elevating insulin sensitivity (8), lowering free fatty acids, blood pressure, CRP, and oxidative stress (7), suppression of adipocyte differentiation similar to AICAR (5), reducing triglycerides and A1C levels (8), and significantly lowering hepatic lipid content (11).

    Looking at things purely from a body composition angle, LS can help promote the anabolic effects of insulin by mimicking the hormone and working through an independent mechanism of insulin itself (12), act anti-catabolically to prevent muscle breakdown (4), lower fasting glucose/insulin levels, and increase insulin sensitivity to aid in fat loss and muscle gain.

    Lagerstroemia Review

    * Enhances glucose uptake at muscle cell
    * Reduces fat gain from a high fat diet
    * Lowers blood glucose response to feeding
    * Reduces fasting glucose, insulin, triglycerides, FFA’s, CRP and A1C
    * Increases insulin sensitivity and GLUT4 translocation
    * Increases adiponectin

    Gymnema Sylvestre

    Used as a natural treatment for diabetic symptoms in parts of India for thousands of years, this tropical herb has many promising attributes for the modern day physique enthusiast. Much of the research on this compound has focused on diabetic conditions, with some pretty incredible results.

    Studies have shown Gymnema to reverse elevated cholesterol and triglycerides (15,17,26), decrease serum blood glucose in a fasted and fed state (16,20,22,24,26), and improve the time it takes to clear glucose from the bloodstream post-prandially (24). A long term study out of India looked at diabetics who had been given Gymnema daily for up to a year, and found that fasting glucose levels had dropped from an average of 232 mg/dL to a remarkable 152 mg/dL, with no change in the control group. The Gymnema group was able to halve their required insulin dosages over the course of the study, and they also showed a significant drop in A1C levels (22), which was later confirmed by a 2009 study in the journal Phytomedicine (26).

    Gymnema has a profound effect on the insulin secreting cells of the pancreas, known as the beta cells located inside the islets of Langerhans. The herb has the unique ability to stimulate insulin release, even without the presence of carbs (18), and can actually regenerate the beta cells that often become damaged and dysfunctioning over time (22). One study published in the Journal of Ethnopharmacology even found Gymnema to double the number of beta and islet cells in diabetic rats (23).

    Aside from the profound effects on pancreatic function, Gymnema also acts at nutrient destination cells by increasing permeability of cell walls, which assists in the process of nutrient uptake (18). Damaged cell walls become less permeable over time, due to excess insulin in the bloodstream and dietary deficiencies, among other things. Gymnema acts as sort of a cellular repair kit, restoring optimal function.

    The addition of Gymnema alongside Lagerstroemia to Slin-Sane allows for a two-pronged attack for optimization of glucose and insulin. By increasing the enzymes responsible for glucose utilization (25), enhancing the action of endogenous insulin (22), stimulating insulin release and repairing beta cells, increasing cell permeability and repairing insulin induced damage to the liver, kidney and muscle cells (25), Gymnema will aid in driving nutrients into the muscles for a full, pumped feeling and increased performance.

    Gymnema Review

    * Stimulates insulin release and mimics insulin
    * Increases nutrient uptake
    * Increases cell permeability
    * Reduces serum glucose, cholesterol, triglycerides, and A1C
    * Elevates HDL levels
    * Regenerates pancreatic cells

    L-Norvaline

    An analogue of the branched chain amino acid L-Valine, this compound was chosen due to its vasodilating properties for an increase vascularity, muscle pump, and nutrient delivery.

    L-Norvaline works by inhibiting the arginase enzyme, which is responsible for the breakdown of L-Arginine into L-Ornithine and urea (28-30). An animal study published in the American Journal of Heart and Circulatory Physiology found that L-Norvaline increased Nitric Oxide production by 55% (28).

    L-Norvaline Review

    * Increases Nitric Oxide production
    * Causes vasodilation and muscle pump

    Slin-Sane Overview

    * Enhances vasodilation and muscle pumps
    * Elevates nitric oxide
    * Drives nutrients into cells
    * Stimulates insulin release, mimics insulin and enhances insulin’s endogenous effect
    * Reduces fasting glucose and insulin
    * Reduces glucose response to meals
    * Reduces fat gain and speeds up fat loss
    * Regenerates pancreatic beta cells
    * Supports healthy blood lipids
    * Lowers liver lipid content (major factor in cardiovascular disease)
    * Increases plasma adiponectin


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    References


    1. Shi L, Zhang W, Zhou YY, Zhang YN, Li JY, Hu LH, Li J. 2008. Corosolic acid stimulates glucose uptake via enhancing insulin receptor phosphorylation. Eur J Pharmaco. 584(1):21-9.

    2. Takagi S, Miura T, Ishibashi C, Kawata T, Ishihara E, Gu Y, Ishida T. 2008. Effect of corosolic acid on the hydrolysis of disaccharides. J Nutr Sci Vitaminol (Tokyo). 54(3):266-8.

    3. Yamada K, Hosokawa M, Yamada C, Watanabe R, Fujimoto S, Fujiwara H, Kunitomo M, Miura T, Kaneko T, Tsuda K, Seino Y, Inagaki N. 2008. Dietary corosolic acid ameliorates obesity and hepatic steatosis in KK-Ay mice. Biol Pharm Bull. 31(4):651-5.

    4. Yamada K, Hosokawa M, Fujimoto S, Fujiwara H, Fujita Y, Harada N, Yamada C, Fukushima M, Ueda N, Kaneko T, Matsuyama F, Yamada Y, Seino Y, Inagaki N. 2008. Effect of corosolic acid on gluconeogenesis in rat liver. Diabetes Res Clin Pract. 80(1):48-55.

    5. Zong W, Zhao G. 2007. Corosolic acid isolation from the leaves of Eriobotrta japonica showing the effects on carbohydrate metabolism and differentiation of 3T3-L1 adipocytes. Asia Pac J Clin Nutr. 16 Suppl 1:346-52.

    6. Fukushima M, Matsuyama F, Ueda N, Egawa K, Takemoto J, Kajimoto Y, Yonaha N, Miura T, Kaneko T, Nishi Y, Mitsui R, Fujita Y, Yamada Y, Seino Y. 2006. Effect of corosolic acid on postchallenge plasma glucose levels. Diabetes Res Clin Pract. 73(2):174-7.

    7. Yamaguchi Y, Yamada K, Yoshikawa N, Nakamura K, Haginaka J, Kunitomo M. 2006. Corosolic acid prevents oxidative stress, inflammation and hypertension in SHR/NDmcr-cp rats, a model of metabolic syndrome. Life Sci. 79(26):2474-9.

    8. Park MY, Lee KS, Sung MK. 2005. Effects of dietary mulberry, Korean red ginseng, and banaba on glucose homeostasis in relation to PPAR-alpha, PPAR-gamma, and LPL mRNA expressions. Life Sci. 77(26):3344-54.

    9. Miura T, Itoh Y, Kaneko T, Ueda N, Ishida T, Fukushima M, Matsuyama F, Seino Y. 2004. Corosolic acid induces GLUT4 translocation in genetically type 2 diabetic mice. Biol Pharm Bull. 27(7):1103-5.

    10. Judy WV, Hari SP, Stogsdill WW, Judy JS, Naguib YM, Passwater R. 2003. Antidiabetic activity of a standardized extract (Glucosol) from Lagerstroemia speciosa leaves in Type II diabetics. A dose-dependence study. J Ethnopharmacol. 87(1):115-7.

    11. Suzuki Y, Unno T, Ushitani M, Hayashi K, Kakuda T. 1999. Antiobesity activity of extracts from Lagerstroemia speciosa L. leaves on female KK-Ay mice. J Nutr Sci Vitaminol (Tokyo). 45(6):791-5.

    12. Hattori K, Sukenobu N, Sasaki T, Takasuga S, Hayashi T, Kasai R, Yamasaki K, Hazeki O. Activation of insulin receptors by lagerstroemin. J Pharmacol Sci. 2003 Sep;93(1):69-73.

    13. Liu F, Kim J, Li Y, Liu X, Li J, Chen X. An extract of Lagerstroemia speciosa L. has insulin-like glucose uptake-stimulatory and adipocyte differentiation-inhibitory activities in 3T3-L1 cells. J Nutr. 2001 Sep;131(9):2242-7.

    14. Ramkumar KM, Manjula C, Sankar L, Suriyanarayanan S, Rajaguru P. 2009. Potential in vitro antioxidant and protective effects of Gymnema montanum H. on alloxan-induced oxidative damage in pancreatic beta-cells, HIT-T15. Food Chem Toxicol. 47(9):2246-56.

    15. Ramkumar KM, Vijayakumar RS, Ponmanickam P, Velayuthaprabhu S, Archunan G, Rajaguru P. 2008. Antihyperlipidaemic effect of Gymnema montanum: a study on lipid profile and fatty acid composition in experimental diabetes. Basic Clin Pharmacol Toxicol. 103(6):538-45.

    16. Gholap S, Kar A. 2003. Effects of Inula racemosa root and Gymnema sylvestre leaf extracts in the regulation of corticosteroid induced diabetes mellitus: involvement of thyroid hormones. Pharmazie. 58(6):413-5.

    17. Shigematsu N, Asano R, Shimosaka M, Okazaki M. 2001. Effect of administration with the extract of Gymnema sylvestre R. Br leaves on lipid metabolism in rats. Biol Pharm Bull. 24(6):713-7.

    18. Persaud SJ, Al-Majed H, Raman A, Jones PM. 1999. Gymnema sylvestre stimulates insulin release in vitro by increased membrane permeability. J Endocrinol. 163(2):207-12.

    19. Chattopadhyay RR. 1998. Possible mechanism of antihyperglycemic effect of Gymnema sylvestre leaf extract, part I. Gen Pharmacol. 31(3):495-6.

    20. Shimizu K, Iino A, Nakajima J, Tanaka K, Nakajyo S, Urakawa N, Atsuchi M, Wada T, Yamashita C. 1997. Suppression of glucose absorption by some fractions extracted from Gymnema sylvestre leaves. J Vet Med Sci. 59(4):245-51.

    21. Imoto T, Miyasaka A, Ishima R, Akasaka K. 1991. A novel peptide isolated from the leaves of Gymnema sylvestre--I. Characterization and its suppressive effect on the neural responses to sweet taste stimuli in the rat. Comp Biochem Physiol A Comp Physiol. 100(2):309-14.

    22. Shanmugasundaram ER, Rajeswari G, Baskaran K, Rajesh Kumar BR, Radha Shanmugasundaram K, Kizar Ahmath B. 1990. Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus. J Ethnopharmacol. 30(3):281-94.

    23. Shanmugasundaram ER, Gopinath KL, Radha Shanmugasundaram K, Rajendran VM. 1990. Possible regeneration of the islets of Langerhans in streptozotocin-diabetic rats given Gymnema sylvestre leaf extracts. J Ethnopharmacol. 30(3):265-79.

    24. Okabayashi Y, Tani S, Fujisawa T, Koide M, Hasegawa H, Nakamura T, Fujii M, Otsuki M. 1990. Effect of Gymnema sylvestre, R.Br. on glucose homeostasis in rats. Diabetes Res Clin Pract. 9(2):143-8.

    25. Shanmugasundaram KR, Panneerselvam C, Samudram P, Shanmugasundaram ER. 1983. Enzyme changes and glucose utilisation in diabetic rabbits: the effect of Gymnema sylvestre, R.Br. J Ethnopharmacol. 7(2):205-34.

    26. Daisy P, Eliza J, Mohamed Farook KA. 2009. Hypoglycemic and hypolipidemic effect of a novel Gymnemic triacetate on STZ-induced diabetic rats. Phytomedicine. Sep 10.

    27. Ming XF, Rajapakse AG, Carvas JM, Ruffieux J, Yang Z. 2009. Inhibition of S6K1 accounts partially for the anti-inflammatory effects of the arginase inhibitor L-norvaline. BMC Cardiovasc Disord. 9:12.

    28. Chiung-I Chang1, James C. Liao2, and Lih Kuo1 . 1998. Arginase modulates nitric oxide production in activated macrophages. Am J Physiol Heart Circ Physiol. 274: H342-H348.

    29. Bachetti T, Comini L, Francolini G, Bastianon D, Valetti B, Cadei M, Grigolato P, Suzuki H, Finazzi D, Albertini A, Curello S, Ferrari R. 2004. Arginase pathway in human endothelial cells in pathophysiological conditions. J Mol Cell Cardiol. Aug;37(2):515-23.

    30. Wheatley DN, Philip R, Campbell E. 2003. Arginine deprivation and tumour cell death: arginase and its inhibition. Mol Cell Biochem. Feb;244(1-2):177-85.
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    Additional functionality of SlinSane:

    J Biomed Sci. 2006 Jul;13(4):535-48. Epub 2006 Mar 10.
    Gypenoside XLIX isolated from Gynostemma pentaphyllum inhibits nuclear factor-kappaB activation via a PPAR-alpha-dependent pathway.
    Huang TH, Li Y, Razmovski-Naumovski V, Tran VH, Li GQ, Duke CC, Roufogalis BD.
    Pharmaceutical Chemistry Discipline and Herbal Medicines Research and Education Centre, Faculty of Pharmacy, University of Sydney, A15 S322, Sydney, NSW 2006, Australia.
    Abstract
    Nuclear factor (NF)-kappaB is important in the generation of inflammation. Besides regulating lipid metabolism, peroxisome proliferator-activated receptor (PPAR)-alpha activators also reduce NF-kappaB activation to terminate activation of inflammatory pathways. Gynostemma pentaphyllum (GP) has been used to treat various inflammatory diseases and hyperlipidemia. Here, we demonstrate that GP extract and one of its main components, Gypenoside XLIX (Gyp-XLIX) inhibited LPS-induced NF-kappaB activation in murine macro****es. Furthermore, Gyp-XLIX restored the LPS- and TNF-alpha-induced decrease in cytosolic I-kappaBalpha protein expression and inhibited the translocation of NF-kappaB(p65) to the nucleus in THP-1 monocyte and HUVEC cells. The inhibition of LPS- and TNF-alpha-induced NF-kappaB luciferase activity in macro****es was abolished by MK-886, a selective PPAR-alpha antagonist. GP extract and Gyp-XLIX (EC(50): 10.1 microM) enhanced PPAR-alpha luciferase activity in HEK293 cells transfected with the tK-PPREx3-Luc reporter plasmid and expression vectors for PPAR-alpha. Additionally, Gyp-XLIX specifically enhanced PPAR-alpha mRNA and protein expression in THP-1-derived macro****e cells. The selectivity of Gyp-XLIX for PPAR-alpha was demonstrated by the activation of only PPAR-alpha in HEK293 cells transfected with expression vectors for PPAR-alpha, PPAR-beta/delta or PPAR-gamma1 plasmids and in THP-1-derived macro****e naturally expressing all three PPAR isoforms. The present study demonstrates that Gyp-XLIX, a naturally occurring gynosaponin, inhibits NF-kappaB activation via a PPAR-alpha-dependent pathway.
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    Thanks Smitty. Pretty good study Matt.
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    That's one long winded scientific intricate and elegant way of saying... Slin Sane is (sl)INSANE!

    I haven't found the bottom of the barrel for uses of this supplement yet! Pre bed for GH spikes and glucose clearing waking up to a more full physique, pre training to induce an even more acute inhibition of arginase and muscle-saturation of any intra-workout drink carbohydrates, and pre post-post workout meal to prolong the anabolic window of opportunity to ingest and divert more nutrients toward muscle recuperation and proliferation!
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    Quote Originally Posted by Outstanding View Post
    That's one long winded scientific intricate and elegant way of saying... Slin Sane is (sl)INSANE!

    I haven't found the bottom of the barrel for uses of this supplement yet! Pre bed for GH spikes and glucose clearing waking up to a more full physique, pre training to induce an even more acute inhibition of arginase and muscle-saturation of any intra-workout drink carbohydrates, and pre post-post workout meal to prolong the anabolic window of opportunity to ingest and divert more nutrients toward muscle recuperation and proliferation!
    love the versatility... not even specific to SS, either, but protocol as well.

    just started employing SS in a post-training capacity.
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    Awesome Product!
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    Quote Originally Posted by Smitty77 View Post
    love the versatility... not even specific to SS, either, but protocol as well.

    just started employing SS in a post-training capacity.
    Absolutely! Slin Sane isn't a one-trick pony - even if it was though it is effective enough to make it worthy - but it can be implemented in a myriad of performance enhancing ways.

    Quote Originally Posted by fmoncas View Post
    Awesome Product!
    Oh yeah - didn't take my long to realize this... one of the great blessings in diguise, was when I ran out of my Slin Sane stock, and for that week I truly notice a dramatic difference overall, and knew it was obvious Slin Sane has been filling that void.
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