I'm quoting this out of my bio book. I typed it fast so may have some errors:
"Today, the mutation of existing viruses is a major source of new viral diseases. The RNA viruses tend to have an unusually high rate of mutation because the replication of their nucleic acid does not involve proofreading steps, as does DNA replication. Some mutations may enable existing viruses to evolve into new genetic varieties that can cause disease in individuals who had developed immunity to the ancestral virus. Flu epidemics are caused by viruses that are genetically different enough from earlier years' viruses that people have little immunity to them.
Another source of new viral deiseases is the spread of existing viruses to a new host species. For example, hantavirus is common in rodents, especially deer mice. The population of deer mice in the southwestern United States exploded in 1993 after unusually wet weather increased the rodents' food supply. Humans acquired hantavirus when they inhaled sut containing traces of urine and feces from infected mice.
Finally, a viral disease may start out in a small, isolated population and then rather suddenly become widespread. AIDS, for example, went unnamed and virtually unnoticed for decades before starting to spread around the world. In this case, technological and social factors, including affordable international travel, blood transfusion technology, sexual promiscuity, and the abuse of intravenous drugs, allowed a previously rare human disease to become a global epidemic. It is likely that when we do find the means to control HIV and other deadly viruses, genetic research--in particular, molecular biology--will be responsible for the discovery."
Campbell, Neil, Jane Reece, and Eric Simon. Essential Biology with Physiology. San Francisco: Pearson Education, Inc., 2004. 192-193.