I can't speak directly to your issue, b/c I have always been blessed with friendly hormones. I've never even had PMS. But I will say that if you do try an appetite suppressant, SlimX by Anabolic Xtreme is phenomenally great for mood boost. I'm not taking it for weight loss. I've had some of my best workouts ever since starting it. Focus is unreal. Max energy level. Even detailing my car earlier, I noticed myself paying more attention to the smallest things and taking extra pains with the task. It's also enhanced my creativity. I hope the effect doesn't dissipate. I love it. It can't hurt to give it a try.