EvoMuse Presents: GÜT HEALTH Ultimate

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  1. EvoMuse Presents: GÜT HEALTH Ultimate




    Probably just going to keep it as Gut Health, but this formula keeps Gut Health on top of the Probiotic Wars.

    Glad to see everyone catch up. However beware, more species is not necessarily better, and carries a good chance of killing each other off leaving your immune system more compromised than before supplementation.

    2006 - Gut Health - the ORIGINAL Probitioc for phenotype enhancemnt, improvement of physique, nutrient optimization, and a kickass immune system so you don't lose any training days (ok works days, too, but let's get out priorities straight.)

    https://www.ncbi.nlm.nih.gov/pubmed/23899653

    Ann Nutr Metab. 2013;63(1-2):1-9. doi: 10.1159/000349922. Epub 2013 Jul 5.
    Effect of multispecies probiotic supplements on metabolic profiles, hs-CRP, and oxidative stress in patients with type 2 diabetes.
    Asemi Z1, Zare Z, Shakeri H, Sabihi SS, Esmaillzadeh A.
    Author information
    Abstract
    BACKGROUND:

    We are aware of no study that has indicated the effects of daily consumption of multispecies probiotic supplements on metabolic profiles, high-sensitivity C-reactive protein (hs-CRP), and oxidative stress in diabetic patients.
    OBJECTIVE:

    This study was designed to determine the effects of multispecies probiotic supplements on metabolic profiles, hs-CRP, and oxidative stress in diabetic patients.
    METHODS:

    This randomized double-blind placebo-controlled clinical trial was performed on 54 diabetic patients aged 35-70 years. Subjects were randomly assigned to take either a multispecies probiotic supplement (n = 27) or placebo (n = 27) for 8 weeks. The multispecies probiotic supplement consisted of 7 viable and freeze-dried strains: Lactobacillus acidophilus (2 × 10(9) CFU), L. casei (7 × 10(9) CFU), L. rhamnosus (1.5 × 10(9) CFU), L. bulgaricus (2 × 10(8) CFU), Bifidobacterium breve (2 × 10(10) CFU), B. longum (7 × 10(9) CFU), Streptococcus thermophilus (1.5 × 10(9) CFU), and 100 mg fructo-oligosaccharide. Fasting blood samples were taken at baseline and after intervention to measure metabolic profiles, hs-CRP, and biomarkers of oxidative stress including plasma total antioxidant capacity and total glutathione (GSH).
    RESULTS:

    Between-group comparisons of fasting plasma glucose (FPG) revealed that consumption of probiotic supplements prevented a rise in FPG (+28.8 ± 8.5 for placebo vs. +1.6 ± 6 mg/dl for probiotic group, p = 0.01). Although a significant within-group increase in serum insulin and low-density lipoprotein cholesterol levels was found in both the probiotic group and the placebo group, the changes were similar between the two groups. We observed a significant increase in HOMA-IR (homeostasis model of assessment-insulin resistance) in both the probiotic group (p = 0.02) and the placebo group (p = 0.001); however, the increase in the placebo group was significantly higher than that in the probiotic group (+2.38 vs. +0.78, p = 0.03). Mean changes in serum hs-CRP were significantly different between the two groups (-777.57 for the probiotic group vs. +878.72 ng/ml for the placebo group, p = 0.02). Probiotic supplementation led to a significant increase in plasma GSH levels compared to placebo (240.63 vs. -33.46 µmol/l, p = 0.03).
    CONCLUSION:

    In conclusion, multispecies probiotic supplementation, compared with placebo, for 8 weeks in diabetic patients prevented a rise in FPG and resulted in a decrease in serum hs-CRP and an increase in plasma total GSH.

    Copyright © 2013 S. Karger AG, Basel.

    PMID:
    23899653


    So, what did I change in the formula? Nope, I haven't added any new strains because my original work was spot on the the strains working in an unbelievably potent complement. So what then? Well, after finding a production company that specializes in probiotic manufacturing for private labels, they are bored crapless with the same old ****. They have gotten me a double density CFU material for only a little more money, Each capsule will now contain a full 12 billion CFU (2 billion per strain.)

    The inulin/prebiotic will stay the same at 100mg
    The next two depend on how much flow agent/anti-caking agent the need to use, but I have added:

    Apple Polyphenols 150mg. These magical compounds show some amazing anti-inflammatory properties, especially in the gut, as well as killing off pathogenic bacteria and encouraging the growth of benefiial strains.

    Zinc-L-Carnosine 150mg - probably best to post the wiki sections, as it's VERY well done. -

    Gastrointestinal

    Its mechanism of action is believed to oxygen radical scavenging, anti-oxidation, and acceleration of gastrointestinal wound healing.[3] It exhibits ROS-quenching activities.[4] It can remain in the stomach without rapid dissociation and adhere specifically to ulcerous lesions, after which L-carnosine and zinc are released to heal the ulcer.[6] It has been shown to stimulate mucus production and to maintain the integrity of the gastric mucosal barrier.[5] In summary, it maintains homeostasis of the gastric mucosa by prostaglandin-independent cytoprotective effects due to anti-oxidative membrane stabilizing actions, and it promotes the repair of damaged tissues by wound healing action.[6]

    It has a potential to stimulate Hsp70 expression, with overexpression of Hsp70 being found to prevent the development of inflammatory process in the large intestinal mucosa provoked by various damaging factors.[8]

    It exhibits an inhibitory effect on H. pylori.[6]
    Comparisons

    Its healing efficacy against ulceration is significantly greater than that of other zinc complexes, free L-carnosine, and zinc D-carnosine.[6] Its pharmacological activity seems attributable mainly to zinc ion, presumably transported effectively into the ulcer by means of L-carnosine together with the action of L-carnosine itself.[6] In contrast, a simple mixture of L-carnosine and zinc had a lesser effect, presumably due to rapid diffusion of L-carnosine and zinc ion in the entire stomach.[6]
    Other

    It has a stimulatory effect on bone formation and a restorative effect on bone loss under various pathophysiologic conditions.[9]

    For those that want extra points, tell me why I included that last sentence, since it doesn't at first seem relevant to a probiotic.

    Anyway, the price will be going up a bit, but not a ridiculous amount. I'm still trying to keeo the 75 capsule bottles under $40 (50 cents per day).
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless


  2. Quote Originally Posted by dsade View Post
    Probably just going to keep it as Gut Health, but this formula keeps Gut Health on top of the Probiotic Wars.

    Glad to see everyone catch up. However beware, more species is not necessarily better, and carries a good chance of killing each other off leaving your immune system more compromised than before supplementation.

    2006 - Gut Health - the ORIGINAL Probitioc for phenotype enhancemnt, improvement of physique, nutrient optimization, and a kickass immune system so you don't lose any training days (ok works days, too, but let's get out priorities straight.)

    https://www.ncbi.nlm.nih.gov/pubmed/23899653

    Ann Nutr Metab. 2013;63(1-2):1-9. doi: 10.1159/000349922. Epub 2013 Jul 5.
    Effect of multispecies probiotic supplements on metabolic profiles, hs-CRP, and oxidative stress in patients with type 2 diabetes.
    Asemi Z1, Zare Z, Shakeri H, Sabihi SS, Esmaillzadeh A.
    Author information
    Abstract
    BACKGROUND:

    We are aware of no study that has indicated the effects of daily consumption of multispecies probiotic supplements on metabolic profiles, high-sensitivity C-reactive protein (hs-CRP), and oxidative stress in diabetic patients.
    OBJECTIVE:

    This study was designed to determine the effects of multispecies probiotic supplements on metabolic profiles, hs-CRP, and oxidative stress in diabetic patients.
    METHODS:

    This randomized double-blind placebo-controlled clinical trial was performed on 54 diabetic patients aged 35-70 years. Subjects were randomly assigned to take either a multispecies probiotic supplement (n = 27) or placebo (n = 27) for 8 weeks. The multispecies probiotic supplement consisted of 7 viable and freeze-dried strains: Lactobacillus acidophilus (2 × 10(9) CFU), L. casei (7 × 10(9) CFU), L. rhamnosus (1.5 × 10(9) CFU), L. bulgaricus (2 × 10(8) CFU), Bifidobacterium breve (2 × 10(10) CFU), B. longum (7 × 10(9) CFU), Streptococcus thermophilus (1.5 × 10(9) CFU), and 100 mg fructo-oligosaccharide. Fasting blood samples were taken at baseline and after intervention to measure metabolic profiles, hs-CRP, and biomarkers of oxidative stress including plasma total antioxidant capacity and total glutathione (GSH).
    RESULTS:

    Between-group comparisons of fasting plasma glucose (FPG) revealed that consumption of probiotic supplements prevented a rise in FPG (+28.8 ± 8.5 for placebo vs. +1.6 ± 6 mg/dl for probiotic group, p = 0.01). Although a significant within-group increase in serum insulin and low-density lipoprotein cholesterol levels was found in both the probiotic group and the placebo group, the changes were similar between the two groups. We observed a significant increase in HOMA-IR (homeostasis model of assessment-insulin resistance) in both the probiotic group (p = 0.02) and the placebo group (p = 0.001); however, the increase in the placebo group was significantly higher than that in the probiotic group (+2.38 vs. +0.78, p = 0.03). Mean changes in serum hs-CRP were significantly different between the two groups (-777.57 for the probiotic group vs. +878.72 ng/ml for the placebo group, p = 0.02). Probiotic supplementation led to a significant increase in plasma GSH levels compared to placebo (240.63 vs. -33.46 µmol/l, p = 0.03).
    CONCLUSION:

    In conclusion, multispecies probiotic supplementation, compared with placebo, for 8 weeks in diabetic patients prevented a rise in FPG and resulted in a decrease in serum hs-CRP and an increase in plasma total GSH.

    Copyright © 2013 S. Karger AG, Basel.

    PMID:
    23899653


    So, what did I change in the formula? Nope, I haven't added any new strains because my original work was spot on the the strains working in an unbelievably potent complement. So what then? Well, after finding a production company that specializes in probiotic manufacturing for private labels, they are bored crapless with the same old ****. They have gotten me a double density CFU material for only a little more money, Each capsule will now contain a full 12 billion CFU (2 billion per strain.)

    The inulin/prebiotic will stay the same at 100mg
    The next two depend on how much flow agent/anti-caking agent the need to use, but I have added:

    Apple Polyphenols 150mg. These magical compounds show some amazing anti-inflammatory properties, especially in the gut, as well as killing off pathogenic bacteria and encouraging the growth of benefiial strains.

    Zinc-L-Carnosine 150mg - probably best to post the wiki sections, as it's VERY well done. -

    Gastrointestinal

    Its mechanism of action is believed to oxygen radical scavenging, anti-oxidation, and acceleration of gastrointestinal wound healing.[3] It exhibits ROS-quenching activities.[4] It can remain in the stomach without rapid dissociation and adhere specifically to ulcerous lesions, after which L-carnosine and zinc are released to heal the ulcer.[6] It has been shown to stimulate mucus production and to maintain the integrity of the gastric mucosal barrier.[5] In summary, it maintains homeostasis of the gastric mucosa by prostaglandin-independent cytoprotective effects due to anti-oxidative membrane stabilizing actions, and it promotes the repair of damaged tissues by wound healing action.[6]

    It has a potential to stimulate Hsp70 expression, with overexpression of Hsp70 being found to prevent the development of inflammatory process in the large intestinal mucosa provoked by various damaging factors.[8]

    It exhibits an inhibitory effect on H. pylori.[6]
    Comparisons

    Its healing efficacy against ulceration is significantly greater than that of other zinc complexes, free L-carnosine, and zinc D-carnosine.[6] Its pharmacological activity seems attributable mainly to zinc ion, presumably transported effectively into the ulcer by means of L-carnosine together with the action of L-carnosine itself.[6] In contrast, a simple mixture of L-carnosine and zinc had a lesser effect, presumably due to rapid diffusion of L-carnosine and zinc ion in the entire stomach.[6]
    Other

    It has a stimulatory effect on bone formation and a restorative effect on bone loss under various pathophysiologic conditions.[9]

    For those that want extra points, tell me why I included that last sentence, since it doesn't at first seem relevant to a probiotic.

    Anyway, the price will be going up a bit, but not a ridiculous amount. I'm still trying to keeo the 75 capsule bottles under $40 (50 cents per day).
    Hell yes! Count me in for a years worth hands down. I've missed my gut health and basically been waiting for this to restock
    •   
       


  3. Quote Originally Posted by dsade View Post

    It has a stimulatory effect on bone formation and a restorative effect on bone loss under various pathophysiologic conditions.[9]

    For those that want extra points, tell me why I included that last sentence, since it doesn't at first seem relevant to a probiotic.
    Curiousity piqued.

  4. Interested in the immune system boost. My family and I have been hit harder than I can ever remember, these last 2 months. I'm currently on 2nd round of Antibiotics, and still can't stop coughing and having sore throat.
    Performax Labs Product Specialist
    Like Us On Facebook:
    https://www.facebook.com/PmaxLabs
    Visit our site at www.performaxlabs.com

  5. When will this be released?
    Serious Nutrition Solutions Representative
    [email protected] ons.com
    •   
       


  6. The last sentence seems to be included because of it's effect on bone formation which sounds a lot like BMP's MoA - making zinc-L-carnosine it linked to muscle formation just like BMP.

    Is that worth the extra points?

  7. Quote Originally Posted by KevinConn View Post
    The last sentence seems to be included because of it's effect on bone formation which sounds a lot like BMP's MoA - making zinc-L-carnosine it linked to muscle formation just like BMP.

    Is that worth the extra points?
    It's worth a $10 gift card for being spot on.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  8. Woohoo! PM'd

  9. Looks amazing. I will definitely be ordering some!

    I managed to snag a bottle of the original gut health a few weeks back. I'm impressed to say the least. I hate to sound like a commercial, but Ive suffered from IBS and its accompanying issues for over a decade, about 10 days in, taking this has all but alleviated most of my symptoms.

  10. Quote Originally Posted by Myrmidon View Post
    Looks amazing. I will definitely be ordering some!

    I managed to snag a bottle of the original gut health a few weeks back. I'm impressed to say the least. I hate to sound like a commercial, but Ive suffered from IBS and its accompanying issues for over a decade, about 10 days in, taking this has all but alleviated most of my symptoms.
    Thank you....about 6 weeks after releasing the first version (back in 2006) I got my first "thank you" email from an IBS sufferer telling me that Gut Health had changed his life (he still buys from me to this day). Since then, I've literally gotten hundreds of messages from IBS sufferers asking me to NEVER stop making Gut Health. I made a promise then that I plan to keep.

    It might not be the most profitable product out there, but I'm also going to make sure it keeps getting better while keeping it affordable.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  11. What's the ETA on this? I'm guessing the extra point question is related to BMP MOA and your research in the area? Does this mean this would enhance BMP (your product) effects?
    Olympus Labs Demigod
    PM me with any Olympus Labs questions
    Use Code WOODY30 for 30% off your order at www.Olympus-Labs.com

  12. Quote Originally Posted by dsade View Post
    Thank you....about 6 weeks after releasing the first version (back in 2006) I got my first "thank you" email from an IBS sufferer telling me that Gut Health had changed his life (he still buys from me to this day). Since then, I've literally gotten hundreds of messages from IBS sufferers asking me to NEVER stop making Gut Health. I made a promise then that I plan to keep.

    It might not be the most profitable product out there, but I'm also going to make sure it keeps getting better while keeping it affordable.
    Well you have another lifer here. Ive tried everything, all that ever worked was grinning and bearing it, and your product. Kudos!

  13. I guess now is as good of time as any to finally try out some Gut Health. Lol maybe my life long stomach issues can be changed as well.

  14. I'll give it a try as well.

  15. Quote Originally Posted by Woody View Post
    What's the ETA on this? I'm guessing the extra point question is related to BMP MOA and your research in the area? Does this mean this would enhance BMP (your product) effects?
    Curious as well, I'll definitely be stocking up. Do you recommend refrigerating it for long term storage?

  16. Will this help with inflammatory bowel disease? @dsade
    Olympus Labs Demigod
    PM me with any Olympus Labs questions
    Use Code WOODY30 for 30% off your order at www.Olympus-Labs.com

  17. Quote Originally Posted by Woody View Post
    Will this help with inflammatory bowel disease? @dsade
    Official answer:

    You will have to discuss it with your physician. Nutritional supplements do not claim to treat, diagnose, etc any diseases.

    Any other answe I give you is illegal and will get my put into prison.

    Please speak with your physician.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  18. Quote Originally Posted by dsade View Post
    Official answer:

    You will have to discuss it with your physician. Nutritional supplements do not claim to treat, diagnose, etc any diseases.

    Any other answe I give you is illegal and will get my put into prison.

    Please speak with your physician.
    Anecdotally have people commented on it helping their IBD like people with IBS have?
    Olympus Labs Demigod
    PM me with any Olympus Labs questions
    Use Code WOODY30 for 30% off your order at www.Olympus-Labs.com

  19. Quote Originally Posted by dsade View Post
    Thank you....about 6 weeks after releasing the first version (back in 2006) I got my first "thank you" email from an IBS sufferer telling me that Gut Health had changed his life (he still buys from me to this day). Since then, I've literally gotten hundreds of messages from IBS sufferers asking me to NEVER stop making Gut Health. I made a promise then that I plan to keep.

    It might not be the most profitable product out there, but I'm also going to make sure it keeps getting better while keeping it affordable.
    See above
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  20. What's the eta on it ?

  21. can't wait for this... held off on picking up more probiotics for this.

  22. @dsade showing as sold out on your store front. Any pre-sale options coming? I wanted to put an order in for a couple of bottles + a couple clear edge (they can all ship at the same time when gut health is in stock. I am in no rush.. well, not terribly so ).
    http://anabolicminds.com/forum/workout-logs/281831-sparkss-journey-recovery.html

  23. we need this ASAP!

  24. Well, let's just say I ended up selling my car and I've made them an offer to move us up to the "next" spot. Will have solid date tomorrow.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  25. Quote Originally Posted by dsade View Post
    Well, let's just say I ended up selling my car and I've made them an offer to move us up to the "next" spot. Will have solid date tomorrow.
    Wow bold move best of luck as I love your stuff
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