dsade
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Formula just about completed for the Diabetic Foot and Hand cream. The cream/lotion will help restore nerve function and circulation to peripheral pain sufferers due to the very nasty effects of out-of-control diabetes.
I will definitely be looking for testers, which will be tricky. Generally I've found that those that allow their condition to worsen to the point of actually needing this badly aren't exactly the best at remembering/following doctor's instructions. My Aunt, for example, ignores all of her doctor's advice, then shows up every few months panicking because some new complication has popped up. The doctor finally refused to see her anymore, since she won't follow his treatment program anyway.
This is a decently pricey formula, so I need RELIABLE testers.
https://www.ncbi.nlm.nih.gov/pubmed/18930724
Eur J Pharmacol. 2008 Dec 14;600(1-3):83-6. doi: 10.1016/j.ejphar.2008.10.002. Epub 2008 Oct 9.
Preventive effect of L-carnosine on changes in the thermal nociceptive threshold in streptozotocin-induced diabetic mice.
Kamei J1, Ohsawa M, Miyata S, Tanaka S.
Author information
Abstract
Sensory abnormality is one of the serious complications in diabetes. Since the effective therapeutic regimen to ameliorate the diabetic sensory abnormality is very few, the present study was then designed to investigate the effect of zinc L-carnosine on the changes of nociceptive threshold in diabetic mice. Zinc L-carnosine (75-300 mg/kg, p.o.) was administered once daily from 1 day after streptozotocin treatment. Diabetic mice showed shorter tail-flick latency at 1-4 weeks after streptozotocin treatment and longer tail-flick latency at 6-9 weeks after its treatment. The shortened tail-flick latency in early stage of diabetic mice was ameliorated by treatment with zinc L-carnosine. Moreover, zinc L-carnosine also slowed the onset of hypoalgesia in diabetic mice. Tail-flick latency in non-diabetic mice was not affected by the zinc L-carnosine treatment, indicating that zinc L-carnosine did not affect normal nociceptive transmission. Moreover, L-carnosine, but not zinc sulfate, ameliorated the abnormal sensory perception in diabetic mice. Interestingly, the ameliorative effect of zinc l-carnosine on the abnormal sensory perception in diabetic mice is much stronger than that of L-carnosine. These results provide the evidence of the ameliorative potential of zinc L-carnosine on the progressive diabetic neuropathy. Moreover, L-carnosine combined with zinc shows more potent amelioration of abnormal sensory perception in diabetic mice than by itself.
PMID:
18930724
I will definitely be looking for testers, which will be tricky. Generally I've found that those that allow their condition to worsen to the point of actually needing this badly aren't exactly the best at remembering/following doctor's instructions. My Aunt, for example, ignores all of her doctor's advice, then shows up every few months panicking because some new complication has popped up. The doctor finally refused to see her anymore, since she won't follow his treatment program anyway.
This is a decently pricey formula, so I need RELIABLE testers.
https://www.ncbi.nlm.nih.gov/pubmed/18930724
Eur J Pharmacol. 2008 Dec 14;600(1-3):83-6. doi: 10.1016/j.ejphar.2008.10.002. Epub 2008 Oct 9.
Preventive effect of L-carnosine on changes in the thermal nociceptive threshold in streptozotocin-induced diabetic mice.
Kamei J1, Ohsawa M, Miyata S, Tanaka S.
Author information
Abstract
Sensory abnormality is one of the serious complications in diabetes. Since the effective therapeutic regimen to ameliorate the diabetic sensory abnormality is very few, the present study was then designed to investigate the effect of zinc L-carnosine on the changes of nociceptive threshold in diabetic mice. Zinc L-carnosine (75-300 mg/kg, p.o.) was administered once daily from 1 day after streptozotocin treatment. Diabetic mice showed shorter tail-flick latency at 1-4 weeks after streptozotocin treatment and longer tail-flick latency at 6-9 weeks after its treatment. The shortened tail-flick latency in early stage of diabetic mice was ameliorated by treatment with zinc L-carnosine. Moreover, zinc L-carnosine also slowed the onset of hypoalgesia in diabetic mice. Tail-flick latency in non-diabetic mice was not affected by the zinc L-carnosine treatment, indicating that zinc L-carnosine did not affect normal nociceptive transmission. Moreover, L-carnosine, but not zinc sulfate, ameliorated the abnormal sensory perception in diabetic mice. Interestingly, the ameliorative effect of zinc l-carnosine on the abnormal sensory perception in diabetic mice is much stronger than that of L-carnosine. These results provide the evidence of the ameliorative potential of zinc L-carnosine on the progressive diabetic neuropathy. Moreover, L-carnosine combined with zinc shows more potent amelioration of abnormal sensory perception in diabetic mice than by itself.
PMID:
18930724
