EvoMuse KetoInduce Writeup.

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KetoInduce Write Up

At this point, most people understand that ketogenic diets offer numerous unique benefits over traditional diets that purely focus on calorie restriction. Problem is, they can be really hard for many people to follow. So what if you could reap some of those sweet keto benefits, without actually having to commit to a diet that only has room for 5-10% of your calories from carbs?

This is the KetoInduce concept. Using new technology and a specific combination of ingredients, you will push your body into ketosis each night while you’re sleeping, and potentially even several hours the next morning.

Will you enjoy all of the benefits of being in a constant, 24 hours per day, 7 days per week state of diet-induced keto-adaption? Nope. If only that were possible with a supplement. But, as it turns out, it should still be extremely beneficial, for many reasons to treat your body to a nightly session of intermittent ketosis.

To clarify, ketone bodies are not magical molecules that just cruise around the body melting fat off everything they come in contact with. Although KetoInduce should certainly help accelerate fat loss, it is important to be clear about what exactly ketones do, and don’t do, which we will cover.

Ketone bodies do have some unique and beneficial properties themselves, properties that are independent of being in a state of “Nutritional Ketosis” (NK).

And, being in a state of NK also offers some unique benefits, even if it is just for 1/3 of each day, triggered by KetoInduce.

Here’s a teaser of some noteworthy benefits you can expect from being in intermittent ketosis, then we’ll take a look at the individual ingredients and relevant research.

Reduced leucine oxidation while sleeping. Ketosis is anti-catabolic, so you can drop daily calories lower when dieting and still retain more LBM. Normally, when blood levels of leucine are low during a non-fed state (like while sleeping), the body liberates leucine by breaking down muscle protein. In ketosis, this process is greatly reduced as the fuel sensors in the body are now aware of ketones and fatty acids being a readily available alternate fuel.

Reduced oxidative damage in the brain and muscles, equating to faster recovery. Ketones & Free Fatty Acids (FFA’s) are a cleaner burning fuel over glucose/carbs, so you will have less oxidative damage, reduced inflammation, and quicker recovery times from workouts.

Cleaning the junk out of your brain. Ketones are like a professional maid service for your brain. You know when you’re on a trip, and you just make a total mess of the hotel room? Scattering empty mini-bar bottles everywhere, getting wasabi all over the sheets from the room-service sashimi, leaving dirty towels all over the place, etc.

Well this savaged room is kind of like what you do to your brain on a daily basis. Through various methods, you may do either a little bit of damage, or a lot.

From Michael Eades, MD: “Anti-aging scientists are now pretty sure that one of the forces behind the aging and senescence process is the junk protein matter that accumulates in the cells, hampering cellular function. If the junk builds up enough, it basically crowds out the working part of the cell, killing the cell off in the process. As this inexorable process proceeds, more and more cells function less and less well until we, as a being, cease to function. There are other processes driving the aging function besides this accumulation of cellular debris, but if we can make some headway with cleaning out the junk, then we should be able to make the cells, and by extension us, function better for longer.”

This accumulated cellular junk gets carted out to the bloodstream by lysosomes when the body is functioning optimally. But this process can go south in a hurry due to various reasons, like even just simply the ageing process itself.

Ketones have recently been shown to activate something called Chaperone-Mediated Autophagy (CMA) (1). CMA is a process in the cells that basically dictates which stuff is “junk” and which stuff is worth keeping, then it escorts all the junk to the lysosomes for removal.

Think of CMAs as super proficient maids, that have, like, doctorates in Maiding. They pop into your hotel room each time you leave, clean up and remove all of your nasty, barbaric waste, make your bed, dust the prong holes in the outlets; yet also have the sense to leave that one last piece of beef jerky, sitting in the bag on the desk, because, even though you didn’t realize it at the time, you’re gonna want that later. Ketones (BHB) clean the brain, basically.

Better sleep
Sleeping in a state of ketosis is more recuperative/regenerative for the brain. It often eliminates potential undesirable sleep stage shifts (lack of deep stage 5 sleep, too much time in R.E.M., waking up frequently, etc.) previously caused by glucose availability/glucose dependence (as well as other things). Typically sleeping in ketosis leaves people waking up feeling significantly more refreshed than they had experienced previously. This is an extremely common report from people in ketosis.

Better AM fasted workouts. In a carb-adapted state, training after an overnight fast can be tough because your body is looking for glucose, and being that you haven’t had carbs in 12-16 hours, there’s not much to spare. By taking KI at night, you are priming the body to kick the dependence on glucose, and your muscle cells and brain can use ketones and fatty acids efficiently for the morning workout. In a non-keto fasted morning workout, your RQ (a measurement of how much fat vs. carbs you’re using for fuel, a lower number means more fat usage) will still be high and the body will be looking for glucose to burn. It will still access some fatty acids as fuel, but not as efficiently, and it won’t have readily available ketones to use (which yield way more ATP/energy per unit than carbs).

Now that we have some basic concepts knocked out, lets look at the reason for including each ingredient, and how each is going to benefit you.



Betahydroxybutyrate (BHB salts)

First off, we will take a quick look at Beta-Hydroxybutyrate salts (abbreviated as BHB, you will also often see it abbreviated as BOHB).

Up until recently, the technology to take oral BHB did not exist. Oral ketone esters existed, which convert to ketones in the body, but they were completely cost prohibitive for general public consumption, apparently tasted god-awful, and unlikely to be able to be legally sold as a supplement anyway. But luckily our favorite Mad Scientist, Patrick Arnold, was able to develop a viable alternative. After a year of work, and even having to develop new advanced analytical testing methods, he created a ketone product that is stable, won’t make you gag, and is pretty cost effective.

Acectoacetate, the other primary ketone body, was not an option orally, due to it’s instability and potential to rapidly break down into acetone. So in the form of BHB salts, we now have the ability to literally drink ketones, and experience many of the benefits of being in a fully adapted state of NK.

For BHB to be a viable option, it has to be ingested with a large amount of sodium and potassium (calcium BHB is also available now), so you’ll notice a significant amount of these electrolytes in the KI formula. This is actually quite beneficial however, as being in a state of ketosis (even temporarily) causes the kidneys to upregulate water and sodium excretion, and potassium tends to drop when sodium does so that your body can maintain a proper balance. So you need to replenish this sodium dump, which makes the 842mg per serving pretty handy. Initially, the first few days of using KI, you may want to cut back on sodium in your diet slightly by reducing sodium at dinner, as this will be in close proximity to your night time dose of KI.

When ingesting BHB salts, you will typically see a peak in blood levels between 30-60 minutes, with a return to baseline at about the 3-4 hour mark. However, this doesn’t mean you’re going to be back out of ketosis halfway through the night. Because, you are in a fasted state, and due to the other ingredients in KI, you have basically kick-started your body’s own production of ketones through fatty acid conversion in the liver and acetoacetate production from the amino acids included in KI. This has been confirmed through user data with KI beta testers showing ketones well above the NK threshold in the morning.



Image credit: Patrick Arnold » Initial KetoForce (BHB mixed salts) Data


The data in the graph above came from subjects who ingested about 15g of BHB salts, which is a really high dose. Lower doses will achieve similar results in most people (personally my BHB blood levels go up around 1.1 mmol/L from a dose way less than this, the graph is showing a peak of about 0.95 mmol/L of elevation).

So why do we want to ingest BHB anyway?

Although the research on exogenous ketones is emerging and still in its infancy, we have some pretty cool data to look at already.

In one study, a group of mice replaced equicaloric amounts of carbs with a ketone ester, then were allowed to eat ad libitum (as much as they want) from protein and fat based chow (2). The control group matched the food intake of the ketone ester group, they just didn’t get the ketones. Now, keep in mind this was a ketone ester, not the same thing as the BHB salts in KI, but the ester basically converts to BHB in the body, which was measured in the study. Turns out the BHB levels ended up quite high. And now for the cool part, check out what happened to the ketone ester group, vs. control:

Voluntary food intake decreased, dose dependently with ketone ester consumption. More ketones, lower appetite.
Mitochondrial density increased. More mitochondria, more fat burning!
Electron transport chains doubled. These bad boys drive ATP synthesis.
UCP1 doubled in Brown Adipose Tissue (BAT). Yeah, BAT in mice vs. humans is tricky, but this could be a solid benefit if it is replicated in humans.
Plasma leptin levels doubled. For those that aren’t up on their leptin science, more leptin is a good thing if it is currently low, but we want optimal leptin, not too low or too high. This effect is likely a regulatory mechanism, as in, depending on current leptin levels, you may see an increase or decrease; basically an optimization effect. Other data on ketones and leptin leads me to believe this is likely the case.
Increased resting energy expenditure
Improved insulin sensitivity

More on the leptin thing, another study involving diabetic rats given BHB showed improved leptin signaling (which is really the endpoint goal with regards to leptin), as well as improved insulin signaling (3). The BHB dosed rats also had better glucose tolerance, and even lost weight.

As noted in the introduction, BHB can be considered anti-catabolic. When getting the body into endogenous NK through a keto diet, ingesting protein has been shown to cause a 40-50% greater increase in plasma BCAA levels. And when taking exogenous BHB as a supplement, urinary nitrogen excretion (a marker for how much protein you’re pissing out) has been shown to drop by 30% (4). This is one of the reasons why somebody can greatly reduce their protein intake in ketosis and still build muscle. Now even though taking a dose of KI every night is different than being in ketosis around the clock, you’re still getting this benefit for 1/3 of each 24-hour period, and you should expect to see a noticeable anti-catabolic effect.

On a ketogenic diet, ketones in the blood are typically going to be accompanied by a concurrent elevation in free fatty acids (FFAs). This consistent FFA metabolism can reduce mitochondrial NAD and CoQ10, a cascade that leads to a drop in the energy required for ATP hydrolysis. Basically your body figures out how to become super efficient at creating energy so it requires less calories to do so. Feeding ketones leads to “pure ketosis” which prevents that reduction in mitochondrial NAD and CoQ10, which basically means you would keep your body wasting extra energy (burning more calories) (5). Now if you were to do something like add MCT’s to your KI, these fats will not negate the effect, as MCT’s are absorbed and utilized differently by the body, encouraging additional ketone production, and these fatty acids have their own unique stimulatory effect on increasing energy expenditure.

Next we have another interesting ketone ester study showing a laundry list of benefits (6). Again, they used a ketone ester (which converts to BHB), and rats aren’t humans, so it’s not perfect, but we can still logically extrapolate a bit and tuck this in the “cool stuff that could possibly happen with BHB salts in humans” file. This one was a kitchen sink study that looked at tons of markers, so I’m going to save us some trouble and just bullet point the highlights. Here’s what they saw with the ketone ester fed rats:

Decreased brain L-glutamate by 15-20%. L-glutamate is an excitatory neurotransmitter that, in high levels, can damage brain cells, hence the term “excitotoxicity”.
Decreased plasma glucose
Decreased plasma insulin
Decreased voluntary food intake
Decreased plasma leptin (see what I’m saying now about “regulatory effect”?)
Increased UCP4 & UCP5, by 1.5-fold. These proteins are responsible for protecting the brain.

So as you can see, we have some cool protective effects on the brain, as well as improvement in the functions of glucose, insulin and leptin, as well as decreased food intake.

Nobody asked these rats to eat less, they just didn’t want as much food. This kind of thing is extremely important, people tend to think fat loss is all about willpower and fighting through hunger. The more powerful approach to fat loss involves optimizing the neuroendocrine signaling that can either tell your brain “eat more, now”, or “I’m full”.
Na-Rala
Na-Rala, or the sodium bound form of R-lipoic acid, is a highly stable version of the “R” isomer of alpha lipoic acid. We have included this ingredient in KI with the primary intention of helping to clear excess glucose from the blood to speed the process of inducing intermittent ketosis.

In lean, insulin-resistant, as well as obese diabetic mice, lipoic acid has been shown to significantly increase glucose uptake in numerous different types of muscle (type I fibers, type II fibers, even the diaphragm) (7). In muscle cells, lipoic acid was shown in this study to increase glucose uptake by 40-80%, comparable to a dose of insulin! A separate human study also showed subjects treated with lipoic acid before a Glucose Tolerance Test saw a decrease in glucose by about 30% over controls (8).

When you’re sleeping, your liver will typically release glucose into the bloodstream to help fuel your metabolism. We’d rather not deal with that, as we want to be burning ketones and FFA’s. Lipoic acid has been shown to reduce glucose release from the liver by up to 67% (since it’s basically telling the body to take up and store glucose, not release it, this makes perfect sense) (9).

Lipoic acid has also been shown to significantly increase a protein called IRS-1, which is responsible for taking signals from insulin and IGF-1 receptors and delivering them to the appropriate intracellular pathways, basically improving insulin signaling, even in insulin resistant muscle (10). Now, you might be thinking, what does this have to do with taking KetoInduce, when I’m specifically avoiding carbs at my last meal? Well, you may actually get a small, short-lived insulin release from the Leucine in the KI formula, so this improvement in insulin signaling may just help to more efficiently clear any excess glucose from the bloodstream right off the bat. Also, in obese, or formerly obese people, it is possible that BHB salts can cause a bit of an insulin release.

Lysine
In humans, two amino acids are exclusively ketogenic, lysine and leucine. All other amino acids are either purely glucogenic (can be used to create glucose), or a combination of gluco and ketogenic.

Lysine is broken down into Acetyl CoA and acetoacetate. Acetyl CoA can be used in the liver to make ketones. BHB is made from acetoacetate, so Lysine will give a boost to both acetoacetate and BHB production.

Additionally, acetoacetate has different, unique functions in the body over BHB. It can act to improve certain metabolic processes associated with fasting and nutritional ketosis in general.
Leucine
Leucine is included here for the same reasons as lysine, to increase ketone production (acetoacetate and then more BHB). Obviously, leucine also offers muscle sparing benefits through mTOR signaling.

Now, this isn’t to say that just taking some Lysine and Leucine under normal conditions is going to give you an acetoacetate and/or BHB boost. But when combined with the other ingredients in the KI formula, by putting yourself into a state of temporary ketosis, you should be able to get an additional ketone boost from these amino acids.
Overall benefits of ketosis and ketones
Ketones are normally only produced during starvation or high fat/very low carb ketogenic diets; however, they are quite the super fuel. As discussed before, they can readily enter the brain and can fully replace glucose as fuel, they don’t require insulin to generate ATP, unlike glucose, and they can’t be stored as body fat.

Aside from being a killer fuel source for the brain and body, ketones (whether generated endogenously or taken as a supplement), have a bunch of other impressive effects in the body.

 

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AGEs & More Brain Benefits
Advanced Glycation End Products, or AGEs, are nasty little bastards created when glucose crosslinks with protein. They can be created for several reasons, suboptimal diet being a major one. AGEs are directly linked to stiffening the arteries and making them more permeable to LDL cholesterol, and then causing oxidation of this LDL, which then triggers an immune response which is what leads to plaque build up in the arterial walls.

They also increase oxidative stress, reduce insulin sensitivity, and accelerate aging. AGEs can also be found in some foods, and created by charring or overcooking meat (just order medium rare, no excuses). Here’s a little bit of trivia that most people don’t know, you can actually test your AGEs by getting an HbA1c lab test (docs usually use this as a 3-month snapshot of glucose levels, but it also shows you if you have a high accumulation of AGEs).

It turns out that BHB inhibits the glycation (crosslinking) process, and therefore the generation of AGEs (11). This same study demonstrated that BHB prevented lipid peroxidation and was also protective for microglial cells in the brain.

Ketones resoundingly appear to be great for the brain, several more studies have shown a strong neuroprotective effect as well as reducing Reactive Oxygen Species (ROS) in the brain (12–14).

More on Appetite
One of the hardest, most frustrating parts of losing fat is controlling appetite. Our body prefers to be smarter than us by cranking up hunger signals once we start dropping weight. The neuropeptide Ghrelin plays a large role in this, acting as a “meal initiation signal”, which typically peaks about eight times per day, most strongly around regular meal times (15). During and after weight loss, Ghrelin steps its game up, which increases appetite, which is part of the reason a lot of people tend to lose weight and then put it back on, because they’re always hungry (even if they don’t actually need calories, their brains tell them they do) (16). Elevated Ghrelin has been shown to cause weight gain as well as reduce fat utilization.

Ketosis completely suppresses this weight loss induced Ghrelin upregulation, which can make it way easier to either continue losing weight, or simply keep it off without a rebound (17).

Now with KetoInduce, if you’re using it with a non-ketogenic diet, what does this really mean? I see the biggest advantage here by incorporating intermittent fasting, and being able to push your first meal out quite a bit later than usual. You should still feel good mentally and physically due to waking up in ketosis and running on FFAs and ketones for, hopefully, several hours, and by spending 1/3 or more of each 24 hours in ketosis, you will likely be able to reap at least some of the benefit of suppressing Ghrelin elevation as you lose weight. Even if you choose not to do a form of Intermittent Fasting, if Ghrelin is normalized by the induction of daily, intermittent ketosis, this could carry over to better appetite control the rest of the day.

Histone Deacetylase
Finally, one of the emerging areas of research on ketosis involves something called Histone Deacetylase Inhibitors (HDIs). When Histone Deacetylase is elevated, it creates excessive oxidative stress and can contribute to numerous problems, hence the interest in inhibitors.

Medically speaking, HDIs have been used for a long time as mood stabilizers and anti-seizure meds, like the drug Valporic acid (Depakote).

Currently, HDIs are also being looked at for things like Alzheimer’s, Depression, Huntington’s Disease, and more. One of the mechanisms of action for HDIs is the upregulation of BDNF, which regulates health and growth of neurons. Recent research shows that endogenous (from a keto diet) and/or exogenous (supplemental) BHB acts as an HDI, offering substantial protection against oxidative stress and boosting BDNF (18). Histone Deacetylase Inhibition by BHB was actually found to increase lifespan in worms by 20% (19). Sure, we’re not worms, but still pretty cool, and something to keep an eye on as more research becomes available.

Summary
KetoInduce is a special combination of ingredients, that when coupled with carb restriction before bedtime, helps the body enter into a state of ketosis overnight. This intermittent ketosis should allow you to reap many of the benefits of being in a chronic state of nutritional ketosis.
Q&A

Q: I’ve heard that ingested BHB can inhibit the body’s breakdown of its own fat stores by blocking Hormone Sensitive Lipase (HSL). Is this true, and if so, won’t this slow down fat loss instead of speeding it up?

A: I did see a study showing that HSL was reduced in adipose tissue of cows that enter ketosis, and another ex-vivo study showed that adipose cells of cows treated with BHB showed reduced HSL levels.

Conversely, in a certain type of knockout mice, HSL in adipose tissue is actually elevated, as are other fat oxidation enzymes.

I haven’t actually seen a human study that looked at the effects of HSL on subjects given BHB.

However, lets just say, for exploratory purposes, that BHB does reduce HSL in humans. I’m not worried about that at all, and here’s why. If this is happening, it is likely because after ingesting BHB, the body now has this flood of readily available fuel for the brain and muscles cruising around in the body, and it doesn’t need to liberate glucose now since the brain is going to feast on the superior ketone fuel, so the other choice would be breaking down stored triglyceride into free fatty acids. But there’s no point in doing that, at least initially, so the body is just regulating fuel supply.
Now, one serving of KetoInduce supplies a mere 36 calories. The average person is burning 60-90 calories PER HOUR while sleeping. The current data is showing that BHB levels will fall back to baseline after about 3-4 hours of ingestion. But, in a fasted state, with low glucose and insulin, and combined with the other ingredients in KI, the body is going to need to get more calories to fuel the metabolic rate, and its not going to be looking for glucose. People are still reporting morning BHB numbers well above the NK threshold. So if the ingested BHB is cleared from the body halfway through the night, how are we still seeing elevated ketones in the morning? Because the body is breaking down fat and creating ketones in the liver.

Additionally, user reports from ingesting BHB prior to long duration endurance events are pretty much unanimous regarding improved performance. If lipolysis and/or fatty acid oxidation were impaired, performance would decrease, or people would need to be adding in extra glucose from carbohydrate supplements during activity, which is not the case. People are definitely fueling off fat during activity while taking BHB beforehand. So it may be that the HSL inhibition is minimal, or that it is transient, only having an effect for a very short period of time. Or maybe its just in cows. Whatever the case, it’s not an issue.


Q: Won’t the blood sugar lowering effect from Na-Rala cause me to go hypoglycemic while I’m sleeping and make me wake up in the middle of the night and go crush a bunch of hot pockets?

A: The way this formula is designed, your body and brain will start by using ketones as fuel, then gradually shift over to a combination of ketones and free fatty acids. So you will quickly relinquish your physiological reliance on glucose. Also, your brain will be utilizing ketones, sparing some glucose to maintain normal blood levels. If you actually have medically diagnosed hypoglycemia however, talk to your doctor before using any supplement that impacts blood sugar.

Q: How does KetoInduce upregulate ketone production without depleting glycogen?

A: To get into an actual state of around the clock nutritional ketosis (NK), this requires an adaption phase involving, among other things, a degree of glycogen depletion (this is misunderstood, however, as you’re not completely vanquishing glycogen stores, you’re just reducing them. At least with normal keto dieting…bodybuilders/fitness competitors often invoke extreme measures to glycogen deplete but that is different).

Normal individuals (metabolically speaking), will still show slight ketones in the blood and urine in the morning. Not people on keto diets, not people taking KetoInduce, just plain people. This is simply due to the long stretch without food. But we’re talking small amounts, not above the 0.5 mmol/L threshold for nutritional ketosis.

With KetoInduce, we’re just looking to push the body into a state of temporary ketosis, above that 0.5 threshold. The ingredients in the formula have been shown to do just that. No glycogen depletion needed.


Q: What happens if I’m already in nutritional ketosis, and I take KetoInduce? Will I explode, or just get X-Ray vision?

A: This is completely fine. I’ve personally been in ketosis for over four years straight, and I still use BHB salts daily, and will be starting KetoInduce shortly (I’m just the science guy, gotta save the first run of products for the customers). However, for someone who is already keto-adapted, I would change the dosing recommendations. Instead of taking it before bed, take it between meals when you need a mental boost, take it before a workout for better performance, or use it during Intermittent Fasting to crush appetite and keep your cognitive function optimized.

I recently did a 48 hour fast with nothing but BHB salts and BCAA’s, twice per day, and felt great the whole time. Also, some people tend to struggle keeping ketones at an optimal level even when their diet is dialed in. A half or even a full serving twice per day can help keep you at a higher level. And “chasing” a high ketone number is not the goal, as more ketones are not necessarily better, but experts such as Peter Attia recommend staying over 1.0 mmol/L, and I’ve had a few clients that were doing everything right and cruising at 0.6 mmol/L. And while it’s pretty clear that higher ketones don’t necessarily mean more fat loss, there may be some other physiological benefits to being “deeper” in ketosis. You can also use it to get back into that keto-adapted state faster after a carb heavy meal.


Q: I’ve heard ketostix are unreliable, do I need to check blood ketones?

A: This is a fun topic. In Volek and Phinney’s excellent keto books “The Art and Science of Low Carbohydrate Living”, and “The Art and Science of Low Carbohydrate Performance”, considered by many to be the bible(s) of all things keto, they assert that urine strips, which measure acetoacetate, are only useful during initial phases of ketosis, then they become unreliable and the preferred method is testing blood levels of BHB with a finger stick test. They give several reasons why the urine strips would read low, even though you’re actually in ketosis. And those reasons make sense.

However, some pretty smart people disagree.

“It is said after enough time on a keto diet your strips no longer work. This is not true, I've been on this diet for years and my urine ketones still change colors and within an acceptably broad margin of error predict my blood ketones.*I can understand preference for the blood ketones as they are more precise, not to mention the incentivizing competitive nature of seeing a number value to represent ketosis.”

-Jane Plain (http://itsthewooo.blogspot.com/2014/02/blood-ketone-monitoring-list-of.html)

Jane also mentions that when looking at the urine strip, you want to go by the darkest spot, not just the broad color. So if you have a small section that is dark purple, and 90% of it is more pinkish, the dark part is accurate.

Additionally, don’t just pass the test strip through your stream of urine. You gotta do the old drug test thing and pee in a cup. Then dip the business end of your strip in the cup, leave it in there for a few seconds, wait 20 seconds for your result.

The Journal of the American Dietetic Association published a study that investigated this quandary, and found that across all 13 subjects involved, “Serum BHB correlated with urinary ketones on a keto diet for 10 weeks” (20).

Personally, I love my NovaMax blood meter. Undoubtedly precise, which might be important when trying to confirm if you’ve hit that 0.5 mmol/L NK threshold with KetoInduce. The urine strips offer more of a ballpark range (trace, small, moderate, etc). But urine strips are cheap (currently about $10 for 100 strips on Amazon), blood tests are pricey (currently about $24 for 10 strips on Amazon). And, if you buy the theory that acetoacetate decreases over several weeks of being in ketosis, this shouldn’t be an issue if you’re only in ketosis 1/3 of each day.

Long story short, if you can afford blood testing, do it. If you want to keep it cheap, urine strips will probably be just fine.



References

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17. Sumithran P, Prendergast LA, Delbridge E, Purcell K, Shulkes A, Kriketos A, et al. Ketosis and appetite-mediating nutrients and hormones after weight loss. Eur J Clin Nutr. 2013 Jul;67(7):759–64.
18. Shimazu T, Hirschey MD, Newman J, He W, Shirakawa K, Le Moan N, et al. Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science. 2013 Jan;339(6116):211–4.
19. Edwards C, Canfield J, Copes N, Rehan M, Lipps D, Bradshaw PC. D-beta-hydroxybutyrate extends lifespan in C. elegans. Aging. 2014 Aug;6(8):621–44.
20. Coleman MD, Nickols-Richardson SM. Urinary ketones reflect serum ketone concentration but do not relate to weight loss in overweight premenopausal women following a low-carbohydrate/high-protein diet. J Am Diet Assoc. 2005 Apr;105(4):608–11.

 

[cubsfan815]

Subbd for reading

 

[dsade]

It's missing a small section on Taurine. I'll update when it's done.

Also, the chart didn't render but we really didn't have permission to use it anyway.

I'm grabbing a blood Keto tester tomorrow for my own experiment.

 

[cubsfan815]

It's missing a small section on Taurine. I'll update when it's done.

Also, the chart didn't render but we really didn't have permission to use it anyway.

I'm grabbing a blood Keto tester tomorrow for my own experiment.

Awesome can't wait to see your results. I saved 2 bottles of Brite, 2 bottles metabolic rebirth to run with KI. Just need Epitome and I'm set! I have a bet going with my oncologist to see who can drop more weight before my next checkup. I'm going to smash him.

 

[dsade]

Awesome can't wait to see your results. I saved 2 bottles of Brite, 2 bottles metabolic rebirth to run with KI. Just need Epitome and I'm set! I have a bet going with my oncologist to see who can drop more weight before my next checkup. I'm going to smash him.

You got this.

 

[hvactech]

Fantastic write up and very intrigued!

 

[GiftedNatty]

Bookmarked

 

[booneman77]

Subbed to read in the morning! Been waiting for this forever!

 

[cubs1987]

subbed!!!

 

[1Fast400]

Not sure there is any data that exist that showing taking any ketone technologies and having ketones elevated temporarily increases ones need for Sodium. BTW, if you're going to use any decent amount of Potassium bhb, it will clump like a bitch. Most are running straight sodium/mag/cal combo's.

 

[MidwestBeast]

sub'd to read later on (when I'm outside and can enjoy it! lol)

 

[Depasi]

Not sure there is any data that exist that showing taking any ketone technologies and having ketones elevated temporarily increases ones need for Sodium. BTW, if you're going to use any decent amount of Potassium bhb, it will clump like a bitch. Most are running straight sodium/mag/cal combo's.

I doubt that it would increase sodium requirement, did I make it sound otherwise in the write-up?

 

[dsade]

Not sure there is any data that exist that showing taking any ketone technologies and having ketones elevated temporarily increases ones need for Sodium. BTW, if you're going to use any decent amount of Potassium bhb, it will clump like a bitch. Most are running straight sodium/mag/cal combo's.

Glad I chose the sodium then.

 

[1Fast400]

I doubt that it would increase sodium requirement, did I make it sound otherwise in the write-up?

For BHB to be a viable option, it has to be ingested with a large amount of sodium and potassium (calcium BHB is also available now), so you’ll notice a significant amount of these electrolytes in the KI formula. This is actually quite beneficial however, as being in a state of ketosis (even temporarily) causes the kidneys to upregulate water and sodium excretion, and potassium tends to drop when sodium does so that your body can maintain a proper balance


I'm unaware of any temporary state ketosis study that shows this.

 

[Depasi]

For BHB to be a viable option, it has to be ingested with a large amount of sodium and potassium (calcium BHB is also available now), so you’ll notice a significant amount of these electrolytes in the KI formula. This is actually quite beneficial however, as being in a state of ketosis (even temporarily) causes the kidneys to upregulate water and sodium excretion, and potassium tends to drop when sodium does so that your body can maintain a proper balance


I'm unaware of any temporary state ketosis study that shows this.

Oh I got that info from PA's writings as far as why the BHB products already have the high amount of sodium/potassium in them, I didn't mean to suggest people would need additional sodium beyond this.

I'll have to look back at my notes and see if I found something to lead me to believe the sodium flushing effect from ketosis happens acutely.

 

[1Fast400]

It doesn't. When in ketosis for significant periods, yes, sodium intake needs to be increased.

 

[banjobounce]

I noticed that you said KI could be taken pre-performance. What do you suppose would result for someone who carb backloads(basically zero until after training), trains around 4, and takes this sometime early morning instead of at night? I'm just thinking that timing the peak blood ketone levels with a workout would lend itself really well, especially in a partly depleted state. Improving the efficiency of a mini cut (1 week or so) within a cyclical bulking type program. This is very interesting to me, as I would think that, to a point, fat stores could still be taxed while topping glycogen levels, not to mention the obvious benefits to running off ketones during the workout. Apart from that, I think this is a no-brainer for cutting.

 

[dsade]

I differ here. If you're looking for performance, you'd be much better taking the KetoCaNa with a higher amount of ketones per serving.

 

[1Fast400]

On bhb, it's roughly a 10% rule. 10g=1mm. Varies greatly by person. Only accurate way to check is blood. Ketosis is technically .05 or higher.

 

[Geoforce]

Nice write-up

 

[Depasi]

On bhb, it's roughly a 10% rule. 10g=1mm. Varies greatly by person. Only accurate way to check is blood. Ketosis is technically .05 or higher.

Still testing various doses, with and without MCTs or Keto8, but this is on par with what I've seen so far.

 

[1Fast400]

Mct can increase as much as .05 before butt blowout. 5g of bhb and 5g/ml of mct would be roughly .5-.7 for most.

 

[bigsexy]

Are there any issues with taking KI with metformin?

 

[dsade]

Are there any issues with taking KI with metformin?

You should be fine.

 

[Tank999]

please excuse the ignorance but if I'm on a strict ketogenic diet <20gm carbs - so until now if i had a cheat meal it would take me 3-4 days to get back into ketosis. So with this product I can be back in ketosis the same night?
Thanks for your help

 

[Machine Mind]

Has this already been addressed, or does this increase the risk of ketoacidosis (metabolic acidosis)? Or is that risk attenuated by something in the formula? Forgive me I'm still reading and mentally recanting my cellular physiology.

 

[dsade]

Ketoacidosis and ketosis are far different phenomena...unrelated.

 

[Tank999]

Where is this available? Every place I checked on line was sold out! Anybody?

 

[booneman77]

Where is this available? Every place I checked on line was sold out! Anybody?

its sold out... went very quickly. not sure when the next restock is

 

[Tank999]

its sold out... went very quickly. not sure when the next restock is

Thanks. Appreciated
Any ideas where to keep an eye out?

 

[dsade]

New stock as of today.

 

[booneman77]

Thanks. Appreciated
Any ideas where to keep an eye out?

evomuse shopify store... see the post between this and yours

 

[Tank999]

evomuse shopify store... see the post between this and yours

Got it. Thanks

 

[stevenGFH]

Dsade...how would this work for a Type 1 Diabetic???

 

[bosskardo]

Anyone tried this before hard workouts (not fasted)?

 

[Wimsicle]

Anyone tried this before hard workouts (not fasted)?

Better to use a performance product like KetoCaNa or MCT than this I believe.