EvoMuse Testruction™ Writeup

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Testruction Write-Up


Instructions
Take two capsules, twice per day. One dose whenever, the other right before bed. If stacking with MyoSynergy Elite, take these products at different times of the day.


Supplement Facts
E. Ulmoides 500mg
Butea Superba 200mg
Long jack 100:1 100mg
Naringenin/cyclodextrin complex 50mg
Maca 20:1 100mg
Morinda officinalis F. C. 300mg
Astragalus Membranaceous 300mg

Overview
Testruction has been formulated to optimize testosterone levels and androgen receptor responsiveness for maximum muscle gain, as well as libido and sexual performance. This unique formula, based on the most current research, is designed to make you perform better in the gym and the bedroom with a multi-angled approach to help optimize a few of your favorite things in life.


Ingredients and function
E. Ulmoides
EU comes from the bark of a small tree native to China, and has been well studied for a variety of effects on the brain and body.

While research has shown numerous beneficial characteristics attributed to EU, let’s start with the most important one for our purposes here, then we’ll take a quick look at the other bonuses.

EU acts as a mild androgen, exhibiting “phytoandrogen” properties. It also acts as an androgen booster/helper, by augmenting endogenous and/or exogenous testosterone signaling at the androgen receptor (1). So this means that any outside sources of androgens getting into your body (including EU itself, and other ingredients in the Testruction formula), as well as your own natural circulating testosterone, will now have an even stronger effect with the help of EU.

Other noteworthy benefits

Potent inducer of Growth Hormone (2)
Increases IGF-1 expression (3)
Selectively increases GLUT-4 expression in muscle cells (2)
Elevates adiponectin levels and lowers bad adipokines (2)
Supports optimal fasting insulin & blood pressure (4)
Increases fat oxidation and use of ketone bodies on a high fat diet (4,5)
Inhibits pre-adipocytes from becoming fat cells (6)
Supports healthy triglyceride levels (5)
May improve memory and cognitive function by boosting acetylcholine levels (7)
Markedly increases BMP-2 (bone growth/muscle hypertrophy signaling) (3,6,8–10)

Butea Superba
Bueta Superba is an interesting Thai herb, widely considered to have aphrodisiac qualities. Along the lines of the aphrodisiac aspect, it has been shown to increase penile erections in diabetic rats (diabetes frequently interferes with normal erectile function) (11).

This benefit has also been demonstrated in humans. Thai males aged 30-70 with erectile dysfunction were given BS in a randomized, double-blind study for 3 months, and 82% of them saw noticeable improvements in sexual function (12).

When a compound has libido boosting effects, chances are pretty good that we’ll see some positive interaction with testosterone and/or DHT, which is exactly what we see with BS. If one were to look solely at the 2008 rat study from Cherdshewasart, et al., it would appear that BSE could actually lower testosterone when taken at high doses, and even elevate liver enzymes (13). However, there’s a couple of things to keep in mind here. One, when taking prohormones or steroids, the body drops production of its own testosterone to compensate, which is likely what is happening here. And two, the rest of the published data tells a different story, in fact, another rat study using an even higher dose of BSE resulted in increased testis weight and sperm count, and found it to be safe with no adverse side effects at 100x the Thai recommended dose for humans (14).

BS has also been shown to be anti-estrogenic and androgenic in several other studies, as well as being deemed to work in conjunction, and synergistically with the body’s own testosterone levels similar to E. Ulmoides (14–17).

In a 2012 case study, a patient came in “complaining” of an increased sex drive. Lab testing revealed elevated levels of Free Testosterone, DHT, and DHEA-sulfate, and was thus diagnosed as having hyperandrogenemia (aka elevated androgens, sounds like a good problem to have). After assessing current supplement intake, the patient was advised to stop taking BS. One week after cessation, the patient’s sex drive had returned to normal and lab testing showed DHT had dropped back to normal (18).

BSE also appears to have some positive effects on the brain. Research shows it can increase neurogenesis in the hippocampus, relieve depression-like symptoms induced by chronic stress, ameliorate cognitive dysfunction, and inhibit acetylcholinesterase thereby elevating acetylcholine levels (19,20).

In summary, we should see a nice jump in muscle building anabolic hormones, more help with making circulating androgens work better, anti-estrogen activity, and a bit of a brain boost.

Long Jack 100:1
Long Jack is an aphrodisiac herb also commonly referred to as Tongkat Ali and Eurycoma Longifolia. LJ earned a spot in Testruction due to it’s ability to boost libido, enhance sexual performance, and increase testosterone. This stuff is a triple threat.

Ever wonder how researchers determine sexual performance in human subjects? Well, to the dismay of many readers, no, they typically don’t pull up a chair and kick back with a beer and a notepad while couples go at it.

 

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This questionnaire, called the IIEF, is often used to determine intervention outcomes on erectile function (21):

NOTE: THIS GRAPHIC DOESN'T LOAD INTO THE POST. CHECK THE FACEBOOK PAGE TO LOOK AT THE SURVEY.


Then there is the Male Sexual Health Questionnaire (MSHQ), which is a broader, 25 question survey (22).

The Aging Males Symptoms Questionnaire (AMS) is the most general, asking questions about well-being, joint pain, anxiety, etc., as well as sexual function (23).

Using before/after data from these surveys gives researchers quite a bit of reliable info to work with, particularly when combined with objective data like lab testing.

Armed with that information, let’s take a look at some of the research.

Libido
In a 12 week, randomized, double blind placebo study with 109 men between the ages of 30-55, the group given LJ had the following benefits (24):

Higher scores on the IEFF
Increased libido
Sperm motility increased by 44%
Semen volume increased by 18% (fun!)
Overweight subjects lost significant fat mass

In another recent study, 76 of 320 patients suffering from Late Onset Hypogonadism (LOH) were given LJ for 1 month. Before receiving the LJ, only 8 of these patients didn’t show complaints on the AMS questionnaire. After LJ supplementation, 54 of them had no complaints (and most of them showed elevated testosterone levels) (25).

LJ has also repeatedly been shown to increase libido in animal models, being called a “potent stimulator of sexual arousal” (26,27).

Sexual Performance
In a 2014 review paper, LJ was found to improve sexual health to the point of being considered a natural alternative to Testosterone Replacement Therapy (TRT), as it also restored serum testosterone levels to normal ranges (28).

LJ is also thought to act as a phosphodiesterase inhibitor, which many will recognize as the mechanism of action for Viagra and Cialis (29).

In rat studies, it has been shown to reduce ejaculation latency and post-ejaculatory interval, which basically means the rats were super excited to have sex, and then do it again right away (30). Ahhh, to be 18 again.

One of the main components in LJ, (9-HC-6-one), has also been shown to directly stimulate erections in-vitro in the corpus cavernosum (one of the two main erectile tissues in the penis) (31).

Testosterone Boosting & Muscle/Strength
LJ has been shown to increase testosterone in rats (30), and this effect has been repeated in several human studies.

A study looked at the effect of LJ on 63 subjects to determine effects on hormone levels, as well as subjective stress. They found that LJ increased testosterone by 37%, while concurrently reducing cortisol by 16% (32). The subjects also noted things like reduced tension and aggression.

In another study looking at 25 active male and female seniors, the subjects were given LJ for 5 weeks. The researchers looked at hormone levels as well as muscular strength. I like this study because they measured several relevant blood markers, including the ones that doctors are constantly calling irrelevant when you ask for them. They found that LJ caused a significant increase in not only total testosterone, but also free testosterone, in both men and women. It also reduced Sex Hormone Binding Globulin (SHBG), which is known for locking up your extra testosterone and preventing you from using it to build muscle. The reduction in SHBG was likely the reason for the elevation in testosterone from the females, not a direct androgenic activity in those subjects. The LJ subjects also recorded enhanced muscle strength (33).

An in-vitro study demonstrated that LJ increased testosterone by inhibiting the aromatase enzyme from converting testosterone to estrogen, so it also acts as an anti-estrogen (29).

The “pro-androgenic” effect of LJ has also been shown to significantly increase muscle compared to a control group in a 12 week animal study (34). And in a 5 week long, 14 subject pilot study presented at a conference, the LJ group gained more strength and significantly more lean body mass (S. Hamzah, A. Yusof).

One thing to add, just in case, there is some data showing that LJ can reduce bioavailability of the drug propranolol (a beta blocker commonly used for reducing blood pressure and/or public speaking), so if you take this drug, consult your physician before using Testruction (35).

 

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Naringenin Cyclodextrin Complex
Naringenin is a flavonone found in grapefruit, which happens to do some pretty interesting things in the body. For one, Naringenin acts as an anti-estrogen to help control unwanted potential side effects from Testruction (36).

It has also been shown to be a ligand for SHBG, meaning it will bind to the receptor and leave more circulating free testosterone to do all the things we want it to do (37,38).

As it turns out, when Naringenin is complexed with a cyclodextrin, it significantly increases the bioavailability (solubility by 400-fold and gut transport by 11-fold). Naringenin Cyclodextrin, when taken prior to a meal, decreased VLDL by 42% and increased the rate of glucose clearance by 64% compared to Naringenin alone (39).

Maca 20:1
Maca, also known as Lepidium meyenii, is a plant in the broccoli family typically grown in Peru. Maca may or may not directly affect testosterone levels, studies at this point go both ways.

Unanimously, however, it does significantly boost libido and sexual function, even in the studies showing no effect on testosterone (40,40–42).

In at least two rat studies, Maca significantly increased testosterone levels (43,44), and in one mice study, Maca reduced prostate weight & hyperplasia when administered with testosterone enanthate, vs. the testosterone only group (45).

Morinda officinalis F.C.
Also known as Bajitian, MO is an herb widely used in Traditional Chinese Medicine to treat male infertility, invigorate the kidneys and resist diseases.

MO has largely been studied for its unique ability to restore normal hormonal function in those experiencing excessive stress and fatigue.

In rats exposed to microwaves 24 hours a day for 10 days, the group pre-treated with MO demonstrated significantly improved sexual performance, increased testosterone, and increased sperm number (46).

Another study found that MO enhanced sexual behavior, increased testosterone, reduced cortisol, improved sperm quality, protected sperm DNA from the damaging administration of H2O2, and concluded that MO was “androgen-like” (47). The sperm DNA protection provided by MO from H2O2 was also demonstrated in a different study (48).

Chronic stress can reduce white blood cell counts (disrupting immune function), elevate cortisol, and decrease testosterone. MO administrated has been shown to reverse all of these (49).

MO also exhibits anti-fatigue activity, which in addition to boosting testosterone should have a nice effect on workout performance (50).

Astragalus Membranaceus
AM is a fundamental herb in Traditional Chinese Medicine, largely believed to promote life extension. But what’s the point of living forever if you have low testosterone? Great question.

AM has been shown to significantly increase Leydig cell numbers (your testosterone producing factories) and testosterone production. It also upregulates SOD and glutathione peroxidase (enzymes that protect testosterone producing cells from damage) (51). On that note, AM also appears to be effective at preserving the weight of the testes and integrity of the sperm in the highly toxic environment of chemotherapy, so yeah, this stuff is pretty good for your boys (52,53).

Other noteworthy benefits
Increases IGF-1 levels (54,55)
Reduces Myostatin levels (56)
Improves glucose uptake and insulin sensitivity in muscle cells (57,58)
Improves exercise performance by inhibiting the accumulation of metabolic waste (59)

 

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Conclusion
In summary, Testruction targets an increase in testosterone, enhanced sensitivity to testosterone, elevated libido, improved sexual performance, increase in muscle and strength, as well as estrogen control.


Citations

1. Ong VYC, Tan BKH. Novel phytoandrogens and lipidic augmenters from Eucommia ulmoides. BMC Complement Altern Med. 2007;7:3.
2. Fujikawa T, Hirata T, Wada A, Kawamura N, Yamaguchi Y, Fujimura K, et al. Chronic administration of Eucommia leaf stimulates metabolic function of rats across several organs. Br J Nutr. 2010 Dec;104(12):1868–77.
3. Kim JY, Lee J-I, Song M, Lee D, Song J, Kim SY, et al. Effects of Eucommia ulmoides extract on longitudinal bone growth rate in adolescent female rats. Phytother Res PTR. 2015 Jan;29(1):148–53.
4. Jin X, Amitani K, Zamami Y, Takatori S, Hobara N, Kawamura N, et al. Ameliorative effect of Eucommia ulmoides Oliv. leaves extract (ELE) on insulin resistance and abnormal perivascular innervation in fructose-drinking rats. J Ethnopharmacol. 2010 Apr 21;128(3):672–8.
5. Kobayashi Y, Hiroi T, Araki M, Hirokawa T, Miyazawa M, Aoki N, et al. Facilitative effects of Eucommia ulmoides on fatty acid oxidation in hypertriglyceridaemic rats. J Sci Food Agric. 2012 Jan 30;92(2):358–65.
6. Tan X-L, Zhang Y-H, Cai J-P, Zhu L-H, Ge W-J, Zhang X. 5-(Hydroxymethyl)-2-furaldehyde inhibits adipogenic and enhances osteogenic differentiation of rat bone mesenchymal stem cells. Nat Prod Commun. 2014 Apr;9(4):529–32.
7. Kwon S-H, Lee H-K, Kim J-A, Hong S-I, Kim S-Y, Jo T-H, et al. Neuroprotective effects of Eucommia ulmoides Oliv. Bark on amyloid beta(25-35)-induced learning and memory impairments in mice. Neurosci Lett. 2011 Jan 3;487(1):123–7.
8. Ha H, Ho J, Shin S, Kim H, Koo S, Kim I-H, et al. Effects of Eucommiae Cortex on osteoblast-like cell proliferation and osteoclast inhibition. Arch Pharm Res. 2003 Nov;26(11):929–36.
9. Lin J, Fan Y, Mehl C, Zhu J, Chen H, Jin L, et al. Eucommia ulmoides Oliv. antagonizes H2O2-induced rat osteoblastic MC3T3-E1 apoptosis by inhibiting expressions of caspases 3, 6, 7, and 9. J Zhejiang Univ Sci B. 2011 Jan;12(1):47–54.
10. Zhang W, Fujikawa T, Mizuno K, Ishida T, Ooi K, Hirata T, et al. Eucommia leaf extract (ELE) prevents OVX-induced osteoporosis and obesity in rats. Am J Chin Med. 2012;40(4):735–52.
11. Tocharus C, Sooksaen P, Shimbhu D, Tocharus J. Butea superba (Roxb.) improves penile erection in diabetic rats. Andrologia. 2012 May;44 Suppl 1:728–33.
12. Cherdshewasart W, Nimsakul N. Clinical trial of Butea superba, an alternative herbal treatment for erectile dysfunction. Asian J Androl. 2003 Sep;5(3):243–6.
13. Cherdshewasart W, Bhuntaku P, Panriansaen R, Dahlan W, Malaivijitnond S. Androgen disruption and toxicity tests of Butea superba Roxb., a traditional herb used for treatment of erectile dysfunction, in male rats. Maturitas. 2008 Jun 20;60(2):131–7.
14. Manosroi A, Sanphet K, Saowakon S, Aritajat S, Manosroi J. Effects of Butea superba on reproductive systems of rats. Fitoterapia. 2006 Sep;77(6):435–8.
15. Cherdshewasart W, Mahapanichkul T, Boonchird C. Estrogenic and anti-estrogenic activities of the Thai traditional herb, Butea superba Roxb. Biosci Biotechnol Biochem. 2010;74(11):2176–82.
16. Malaivijitnond S, Ketsuwan A-N, Watanabe G, Taya K, Cherdshewasart W. Androgenic activity of the Thai traditional male potency herb, Butea superba Roxb., in female rats. J Ethnopharmacol. 2009 Jan 12;121(1):123–9.
17. Malaivijitnond S, Ketsuwan A, Watanabe G, Taya K, Cherdshewasart W. Luteinizing hormone reduction by the male potency herb, Butea superba Roxb. Braz J Med Biol Res Rev Bras Pesqui Médicas E Biológicas Soc Bras Biofísica Al. 2010 Sep;43(9):843–52.
18. Chaiyasit K, Wiwnaitkit V. Hyperandrogenemia due to ingestion of Butea superba. Indian J Endocrinol Metab. 2012 May;16(3):485–6.
19. Mizuki D, Qi Z, Tanaka K, Fujiwara H, Ishikawa T, Higuchi Y, et al. Butea superba-induced amelioration of cognitive and emotional deficits in olfactory bulbectomized mice and putative mechanisms underlying its actions. J Pharmacol Sci. 2014;124(4):457–67.
20. Mizuki D, Matsumoto K, Tanaka K, Thi Le X, Fujiwara H, Ishikawa T, et al. Antidepressant-like effect of Butea superba in mice exposed to chronic mild stress and its possible mechanism of action. J Ethnopharmacol. 2014 Oct 28;156:16–25.
21. Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishra A. The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology. 1997 Jun;49(6):822–30.
22. Rosen RC, Catania J, Pollack L, Althof S, O’Leary M, Seftel AD. Male Sexual Health Questionnaire (MSHQ): scale development and psychometric validation. Urology. 2004 Oct;64(4):777–82.
23. Heinemann LA, Saad F, Zimmermann T, Novak A, Myon E, Badia X, et al. The Aging Males’ Symptoms (AMS) scale: Update and compilation of international versions. Health Qual Life Outcomes. 2003 May 1;1:15.
24. Ismail SB, Wan Mohammad WMZ, George A, Nik Hussain NH, Musthapa Kamal ZM, Liske E. Randomized Clinical Trial on the Use of PHYSTA Freeze-Dried Water Extract of Eurycoma longifolia for the Improvement of Quality of Life and Sexual Well-Being in Men. Evid-Based Complement Altern Med ECAM. 2012;2012:429268.
25. Tambi MIBM, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia. 2012 May;44 Suppl 1:226–30.
26. Ang HH, Lee KL. Effect of Eurycoma longifolia Jack on libido in middle-aged male rats. J Basic Clin Physiol Pharmacol. 2002;13(3):249–54.
27. Ang HH, Sim MK. Eurycoma longifolia Jack enhances libido in sexually experienced male rats. Exp Anim Jpn Assoc Lab Anim Sci. 1997 Oct;46(4):287–90.
28. George A, Henkel R. Phytoandrogenic properties of Eurycoma longifolia as natural alternative to testosterone replacement therapy. Andrologia. 2014 Sep;46(7):708–21.
29. Low B-S, Choi S-B, Abdul Wahab H, Das PK, Chan K-L. Eurycomanone, the major quassinoid in Eurycoma longifolia root extract increases spermatogenesis by inhibiting the activity of phosphodiesterase and aromatase in steroidogenesis. J Ethnopharmacol. 2013 Aug 26;149(1):201–7.
30. Zanoli P, Zavatti M, Montanari C, Baraldi M. Influence of Eurycoma longifolia on the copulatory activity of sexually sluggish and impotent male rats. J Ethnopharmacol. 2009 Nov 12;126(2):308–13.
31. Chiou W-F, Wu T-S. 9-Hydroxycanthin-6-One Induces Penile Erection and Delays Ejaculation. J Sex Med [Internet]. 2011 May; Available from: http://www.ncbi.nlm.nih.gov/pubmed/21569213
32. Talbott SM, Talbott JA, George A, Pugh M. Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects. J Int Soc Sports Nutr. 2013;10(1):28.
33. Henkel RR, Wang R, Bassett SH, Chen T, Liu N, Zhu Y, et al. Tongkat Ali as a potential herbal supplement for physically active male and female seniors--a pilot study. Phytother Res PTR. 2014 Apr;28(4):544–50.
34. Ang HH, Cheang HS. Effects of Eurycoma longifolia jack on laevator ani muscle in both uncastrated and testosterone-stimulated castrated intact male rats. Arch Pharm Res. 2001 Oct;24(5):437–40.
35. Salman S a. B, Amrah S, Wahab MSA, Ismail Z, Ismail R, Yuen KH, et al. Modification of propranolol’s bioavailability by Eurycoma longifolia water-based extract. J Clin Pharm Ther. 2010 Dec;35(6):691–6.
36. Galluzzo P, Ascenzi P, Bulzomi P, Marino M. The nutritional flavanone naringenin triggers antiestrogenic effects by regulating estrogen receptor alpha-palmitoylation. Endocrinology. 2008 May;149(5):2567–75.
37. Déchaud H, Ravard C, Claustrat F, de la Perrière AB, Pugeat M. Xenoestrogen interaction with human sex hormone-binding globulin (hSHBG). Steroids. 1999 May;64(5):328–34.
38. Hodgert Jury H, Zacharewski TR, Hammond GL. Interactions between human plasma sex hormone-binding globulin and xenobiotic ligands. J Steroid Biochem Mol Biol. 2000 Dec 15;75(2-3):167–76.
39. Shulman M, Cohen M, Soto-Gutierrez A, Yagi H, Wang H, Goldwasser J, et al. Enhancement of Naringenin Bioavailability by Complexation with Hydroxypropoyl-β-Cyclodextrin. PloS One. 2011 Jan;6(4):e18033.
40. Gonzales GF, Córdova A, Vega K, Chung A, Villena A, Góñez C, et al. Effect of Lepidium meyenii (MACA) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men. Andrologia. 2002 Dec;34(6):367–72.
41. Dording CM, Fisher L, Papakostas G, Farabaugh A, Sonawalla S, Fava M, et al. A double-blind, randomized, pilot dose-finding study of maca root (L. meyenii) for the management of SSRI-induced sexual dysfunction. CNS Neurosci Ther. 2008;14(3):182–91.
42. Stone M, Ibarra A, Roller M, Zangara A, Stevenson E. A pilot investigation into the effect of maca supplementation on physical activity and sexual desire in sportsmen. J Ethnopharmacol. 2009 Dec 10;126(3):574–6.
43. Ohta Y, Yoshida K, Kamiya S, Kawate N, Takahashi M, Inaba T, et al. Feeding hydroalcoholic extract powder of Lepidium meyenii (maca) increases serum testosterone concentration and enhances steroidogenic ability of Leydig cells in male rats. Andrologia. 2015 Jul 14;
44. Lembè DM, Gasco M, Gonzales GF. Synergistic effect of the hydroalcoholic extract from Lepidium meyenii (Brassicaceae) and ***ara tessmannii (Rutaceae) on male sexual organs and hormone level in rats. Pharmacogn Res. 2014 Jan;6(1):80–6.
45. Gonzales GF, Gasco M, Malheiros-Pereira A, Gonzales-Castañeda C. Antagonistic effect of Lepidium meyenii (red maca) on prostatic hyperplasia in adult mice. Andrologia. 2008 Jun;40(3):179–85.
46. Song B, Wang F, Wang W. Effect of Aqueous Extract from Morinda officinalis F. C. How on Microwave-Induced Hypothalamic-Pituitary-Testis Axis Impairment in Male Sprague-Dawley Rats. Evid-Based Complement Altern Med ECAM. 2015;2015:360730.
47. Wu Z-Q, Chen D-L, Lin F-H, Lin L, Shuai O, Wang J-Y, et al. Effect of bajijiasu isolated from Morinda officinalis F. C. how on sexual function in male mice and its antioxidant protection of human sperm. J Ethnopharmacol. 2015 Apr 22;164:283–92.
48. Chang M-S, Kim W-N, Yang W-M, Kim H-Y, Oh J-H, Park S-K. Cytoprotective effects of Morinda officinalis against hydrogen peroxide-induced oxidative stress in Leydig TM3 cells. Asian J Androl. 2008 Jul;10(4):667–74.
49. Li YF, Yuan L, Xu YK, Yang M, Zhao YM, Luo ZP. Antistress effect of oligosaccharides extracted from Morinda officinalis in mice and rats. Acta Pharmacol Sin. 2001 Dec;22(12):1084–8.
50. Zhang H-L, Li J, Li G, Wang D, Zhu L, Yang D. Structural characterization and anti-fatigue activity of polysaccharides from the roots of Morinda officinalis. Int J Biol Macromol. 2009 Apr 1;44(3):257–61.
51. Jiang X, Cao X, Huang Y, Chen J, Yao X, Zhao M, et al. Effects of treatment with Astragalus Membranaceus on function of rat leydig cells. BMC Complement Altern Med. 2015;15:261.
52. Liang P, Li H, Peng X, Xiao J, Liu J, Ye Z. [Effects of astragalus membranaceus injection on sperm abnormality in Cd-induced rats]. Zhonghua Nan Ke Xue Natl J Androl. 2004 Jan;10(1):42–5, 48.
53. Kim W, Kim S-H, Park SK, Chang MS. Astragalus membranaceus ameliorates reproductive toxicity induced by cyclophosphamide in male mice. Phytother Res PTR. 2012 Sep;26(9):1418–21.
54. Wu H, Zhou H. [Astragalus membranaceus promote expression of insulin-like growth factor 1 in rat model of olivo-cerebellar degeneration]. Zhongguo Zhong Yao Za Zhi Zhongguo Zhongyao Zazhi China J Chin Mater Medica. 2007 Feb;32(3):242–5.
55. Kim M-Y, Kim JY, Lim D, Lee D, Kim Y, Chang GT, et al. Skeletal growth and IGF levels in rats after HT042 treatment. Phytother Res PTR. 2012 Dec;26(12):1771–8.
56. Liu M, Qin J, Hao Y, Luo J, Luo T, Wei L. Astragalus polysaccharide suppresses skeletal muscle myostatin expression in diabetes: involvement of ROS-ERK and NF-κB pathways. Oxid Med Cell Longev. 2013 Jan;2013:782497.
57. Zou F, Mao X, Wang N, Liu J, Ou-Yang J. Astragalus polysaccharides alleviates glucose toxicity and restores glucose homeostasis in diabetic states via activation of AMPK. Acta Pharmacol Sin. 2009 Dec;30(12):1607–15.
58. Liu M, Wu K, Mao X, Wu Y, Ouyang J. Astragalus polysaccharide improves insulin sensitivity in KKAy mice: regulation of PKB/GLUT4 signaling in skeletal muscle. J Ethnopharmacol. 2010 Jan;127(1):32–7.
59. Yeh T-S, Chuang H-L, Huang W-C, Chen Y-M, Huang C-C, Hsu M-C. Astragalus membranaceus Improves Exercise Performance and Ameliorates Exercise-Induced Fatigue in Trained Mice. Mol Basel Switz. 2014 Jan;19(3):2793–807.

 

[cubs1987]

subbed for reading pleasure

 

[Piston Honda]

Boning up on my reading for today

 

[dsade]

Boning up on my reading for today

I see what you did there, you beautiful sick bastard.

 

[VaughnTrue]

looks great!

 

[dsade]

Just get me some of the new Blueberry Muffin Protean and maybe we can talk trade.

 

[taman6886]

Very excited about this one!

 

[ThaPeoplesChamp]

Excitement level 9000

 

[MidwestBeast]

NIiiiiiice

 

[chedapalooza]

Subd

 

[ELROCK]

Been looking forward to this one!

 

[dsade]

Been looking forward to this one!

I'm really excited about this one. You could almost say it arouses me. I am overcum with enthusiasm.

 

[jgntyce]

Would you recommend an AI be taken along with it?

 

[kbayne]

In for tester

I need a good, very huge boost.

 

[ryanp81]

Boning up on my reading for today

Let's pop some *replaced with* Testruction and issue tickets with raging, mega-huge boners.

I know I'm not the only ****er on this forum who knows this quote/movie.

 

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Would you recommend an AI be taken along with it?

Yeah, I would.

Elimistane will be coming over to EvoMuse soon, with a formula update, but for now you should find another brand for that.

 

[CobbledPath]

awesome!

 

[dsade]

Let's pop some *replaced with* Testruction and issue tickets with raging, mega-huge boners.

I know I'm not the only ****er on this forum who knows this quote/movie.

Harry Potter?

 

[ramses31]

Epic

 

[Auslifter]

wicked i like the look of this. still excited to see Demolish and Rebirth

 

[criticalbench]

Hopefully this does something good for sperm.. i need to be super fertile soon lol

 

[MidwestBeast]

Let's pop some *replaced with* Testruction and issue tickets with raging, mega-huge boners.

I know I'm not the only ****er on this forum who knows this quote/movie.

Bite the soap, make him look like a dick!

 

[cubsfan815]

Finding Nemo?

 

[dsade]

I'm also going to be looking for one female tester for this. Someone that has been having major libido problems lately.

 

[kbayne]

I'm also going to be looking for one female tester for this. Someone that has been having major libido problems lately.

I can become female real quick if you would like.

 

[cubsfan815]

I can become female real quick if you would like.

Probably win an award and endorsements Caitlyn.

 

[chedapalooza]

I'm also going to be looking for one female tester for this. Someone that has been having major libido problems lately.

What if your libido is so bad u might as well be female

 

[MidwestBeast]

I can't wait to test this out and see what it does. So exciting!

 

[abformulations]

I can't wait to test this out and see what it does. So exciting!

Ditto

 

[rtmilburn]

This looks fantastic!!!! EvoMuse never fails in making quality and innovative products.

Would there be anything that you would recommend NOT taking this with? Also what kinds of things would you recommend taking it with? I was thinking this with leterone, rebirth, trib a, and trib t (i know its not a test booster but it does help with libido and is FANTASTIC for improving mood/sense of well being) would be a killer natty t-booster stack, but i was wondering if it might be to much or if some of the ingredients would cancel each other out.

 

[Avengeme]

^^^This^^^^

Also does testruction need to be cycled? If so what is the max cycle length?

 

[dsade]

No need to cycle. The tribulus will push your libido even higher, and a good Icariin supp will further increase load volume, if you really want to blow your partners mind.

Keep your zinc, vitamins d, and magnesium levels high.

I've also noticed some blood flow synergy with a good ginkgo product.

 

[Avengeme]

Welp guess it's time to order a few more bottles.

 

[MidwestBeast]

Welp guess it's time to order a few more bottles.

lol you and me both

 

[Etomic]

So BMP + Testruction + ???? = HUNG?

 

[shirt]

Would this be any good for someone adapting to Keto? I'm not thinking it would; hopefully, I'm wrong.

 

[MidwestBeast]

Would this be any good for someone adapting to Keto? I'm not thinking it would; hopefully, I'm wrong.

Regardless of diet, this should be a welcomed addition to most anyone's arsenal.

 

[dsade]

Would this be any good for someone adapting to Keto? I'm not thinking it would; hopefully, I'm wrong.

Not directly, no.

 

[BlockBuilder]

Are any of these ingredients going to make me splatter my porcelain chair with multicolored goo?

 

[dsade]

Are any of these ingredients going to make me splatter my porcelain chair with multicolored goo?

There's no reason to think that at all.

 

[fitstar]

A little late maybe but just in case you are still in search for a female beta tester: I am ready
fitstar

 

[dsade]

We're actually shipping out Monday and Tuesday, so we are already there!

I am anxious to get some female feedback, though.

 

[fitstar]

We're actually shipping out Monday and Tuesday, so we are already there!

I am anxious to get some female feedback, though.

Why?
I will not turn into a man! I already had quite good leaning,recomp results with some so called man supps like Letrone. I noticed a real improvement that actually underlined my female curves, enhanced my female appearance
But dsade, after having had so many issues in the past, and surgeries on top, I thought that testruction could be just the right thing for me now as I want to take Evomuse for health,bones (bmp), getting a top notch body with all your recomposition agents but also enjoy my new found health, just enjoy life in every aspect possible! So you are the one to blame if I experience any major libido problems after all that trouble, because with Testruction I could get a huge kick in sexual performance,too.
I am a female and gym performance is certainly not the only thing where I wanna perforn my best
But ok, then you have to live with the fault that my sexuality got ruined because you did not want me as a beta tester,hahaha!
Fitstar

 

[abformulations]

Yea I was going to ask that. Woman can take this?

 

[kbayne]

Yea I was going to ask that. Woman can take this?

Matt really wants a female tester and feedback on this. So yeah.

 

[abformulations]

Matt really wants a female tester and feedback on this. So yeah.

Interesting. Don't want wifey turning manly lol.

 

[rtmilburn]

Interesting. Don't want wifey turning manly lol.

I don't think a test booster will do that. Women have ran low dose test with anavar are don't turn manly. Women only turn mainly when they over do it. So i don't think something like a test booster, that will only increase there natural test, will cause any masculinity in a month. Now if they used it for a couple years it might but i still dont think it would.