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Vanillean is now coming under the EvoMuse umbrella. Some of you have undoubtedly used the formula in the past. The idea is simple: take advantage of thermoreceptors to trick the body into thinking it's both hotter and colder than it really is. This results in a huge waste of calories that the body expends trying to bring everything back to normal.
Transient Receptor Potential channels are what we are manipulating here: TRPV1, TRPM8, TRPA1. These receptors are activated by two things, chemicals and temperature ranges.
Vanillean is classified as a pure thermogenic, meaning it specifically uses bodyfat stores to change the body's temperature - a wasteful process.
Now, with Vanillean version 2, we are bringing some heavy hitters into the mix: Uncoupling Proteins and FTO inhibition.
FTO is relatively unknown, especially in the supplement industry., Turns out that this protein is one of THE major players in adiposity. Inhibition of the FTO protein results in...well, you can read below an excerpt from an article in Nature:
How FTO targets obesity
The fat mass and obesity-associated (FTO) gene is associated with increased body weight and obesity risk. FTO protein is a DNA/RNA demethylase, and mice lacking it are abnormally lean. Now the crystal structure of human FTO in complex with the mononucleotide 3-meT has been determined. The structure reveals a novel mechanism by which the protein can discriminate between single- and double-stranded DNA. In addition, biochemical assays show that the C-terminal domain of FTO, previously of unknown function, is required for FTO catalytic activity via interactions with the N-terminal catalytic domain. These results provide a structural basis for understanding FTO substrate specificity, and serve as a foundation for the rational design of FTO inhibitors as potential anti-obesity agents.
Letter: Crystal structure of the FTO protein reveals basis for its substrate specificity
Zhifu Han, Tianhui Niu, Junbiao Chang, Xiaoguang Lei, Mingyan Zhao, Qiang Wang, Wei Cheng, Jinjing Wang, Yi Feng & Jijie Chai
doi:10.1038/nature08921
As well, inhibition of FTO protein causes Uncoupling Proteins to rise dramatically. Now, uncoupling proteins have been a desirable target for supplementation for years now. Leave it to EvoMuse to simultaneously target the interplay between FTO and Uncoupling Proteins to push fat loss towards ludicrous speed. So, to sum up, Vanillean takes multiple transient receptor potential channel activation to cause thermogenesis, while manipulating FTO and Uncoupling proteins. The result is an incredibly badass, non-stimulant pure Thermogenic formula.
Transient Receptor Potential channels are what we are manipulating here: TRPV1, TRPM8, TRPA1. These receptors are activated by two things, chemicals and temperature ranges.
Vanillean is classified as a pure thermogenic, meaning it specifically uses bodyfat stores to change the body's temperature - a wasteful process.
Now, with Vanillean version 2, we are bringing some heavy hitters into the mix: Uncoupling Proteins and FTO inhibition.
FTO is relatively unknown, especially in the supplement industry., Turns out that this protein is one of THE major players in adiposity. Inhibition of the FTO protein results in...well, you can read below an excerpt from an article in Nature:
How FTO targets obesity
The fat mass and obesity-associated (FTO) gene is associated with increased body weight and obesity risk. FTO protein is a DNA/RNA demethylase, and mice lacking it are abnormally lean. Now the crystal structure of human FTO in complex with the mononucleotide 3-meT has been determined. The structure reveals a novel mechanism by which the protein can discriminate between single- and double-stranded DNA. In addition, biochemical assays show that the C-terminal domain of FTO, previously of unknown function, is required for FTO catalytic activity via interactions with the N-terminal catalytic domain. These results provide a structural basis for understanding FTO substrate specificity, and serve as a foundation for the rational design of FTO inhibitors as potential anti-obesity agents.
Letter: Crystal structure of the FTO protein reveals basis for its substrate specificity
Zhifu Han, Tianhui Niu, Junbiao Chang, Xiaoguang Lei, Mingyan Zhao, Qiang Wang, Wei Cheng, Jinjing Wang, Yi Feng & Jijie Chai
doi:10.1038/nature08921
As well, inhibition of FTO protein causes Uncoupling Proteins to rise dramatically. Now, uncoupling proteins have been a desirable target for supplementation for years now. Leave it to EvoMuse to simultaneously target the interplay between FTO and Uncoupling Proteins to push fat loss towards ludicrous speed. So, to sum up, Vanillean takes multiple transient receptor potential channel activation to cause thermogenesis, while manipulating FTO and Uncoupling proteins. The result is an incredibly badass, non-stimulant pure Thermogenic formula.
