EvoMuse Presents: Slintensity (writeup)

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  1. EvoMuse Presents: Slintensity (writeup)


    EvoMuse Presents: Slintensity (writeup)

    As you may or may not know, I designed the original Slin Sane product, which pioneered the use of Arginase Inhibitors in a Glucose Disposal product to enhance peripheral blood flow, improving nutrient delivery.

    Drawing on my original concept, I'm proud to introduce Slintensity. You will notice several new angles on a fantastic product category, that is also a perfect fit to combine with Defuse, my Fat Gain Inibitor. Grow muscles, not Fat.

    Slintensity Redux Write-Up
    Intro
    Designed to help drive more nutrients into the muscle cells and away from fat, the idea behind Slintensity Redux is to make every meal more anabolic. Whether you are on a low, medium or high carbohydrate nutrition plan, Slintensity Redux has a place in the arsenal. Here are some thoughts on each:

    Low Carb Eater
    Typically low carb eaters lean towards a higher fat intake, hence the term “LCHF” for low carb/high fat. The higher fat intake can lead to a degree of insulin resistance and elevated fasting blood glucose in some people (but certainly not all). This is typically not a problem if carbs are continuously kept low, as insulin is less of a player on a LCHF diet, and insulin resistance doesn’t really matter if you’re not using much endogenous insulin.

    However, many LCHF eaters still like to have a higher carbohydrate post workout meal to replenish muscle glycogen, and this would be the perfect time to use Slintensity Redux to allow improved insulin sensitivity and insurance of the extra carbohydrate load going where it is wanted. It could also be used before a cheat meal on a ketogenic diet to reduce the time needed to get back into ketosis.

    Moderate Carb Eater
    For the moderate carb eater, Slintensity Redux is perfect to take before any carb containing meals to help maximally encourage muscle building while minimizing fat storage. You will likely find that you can get away with a higher carb intake than usual, if so desired.

    High Carb Eater
    For those on a gaining phase, or those that just eat high carbs year round, you will likely notice a much easier time building muscle and losing fat with the addition of Slintensity Redux. If you are the type that is prone to crashing/fogginess/fatigue after meals, you will also likely start to notice feeling quite a bit better once the improved nutrient partitioning takes effect. You may either be able to reduce your carb intake while still enjoying the same rate of muscle growth, or maintain/increase your high carb intake with a lower level of fat spillover and even more muscle growth.

    How does Slintensity Redux work?
    Improved GLUT4 translocation
    Improved insulin sensitivity, production and signaling
    Increased nutrient disposal into muscle
    Decreased nutrient disposal into fat cells
    And much more…see below

    Let’s take a look at each of the ingredients and how they work.
    Banaba blend (Corosolic Acid/mixed elaggitannins)
    Coming from the banaba leaf, this extract is standardized for a high concentration of corosolic acid and mixed elaggitannins. The first published study dates all the way back to 1940, and is commonly used in folk medicine for diabetes.

    Banaba has several powerful effects, the most important ones for our purposes relate to its interaction with blood sugar. It has been shown in numerous studies to decrease serum blood sugar after carbohydrate ingestion by enhancing glucose uptake at the muscle cell (1–8).

    Banaba appears to carry out its effects through favorable signaling modulation of PPARa, PPARy, MAPK, and NF-kb, while significantly increasing insulin sensitivity and translocation of GLUT4 receptors to the outside of the cell membrane, giving insulin more places to dock and let the glucose in (1–3,7,9,10). It also appears to be an insulin mimetic, albeit acting in a different way than insulin itself (11).

    Multiple studies have also elucidated banaba’s ability to either decrease or inhibit gluconeogenesis, which is the basically the conversion of protein into glucose (1,2,12). This means less protein being wasted, and more available for muscle building.

    Good news for blood lipids and other general health markers as well, take a look at these benefits:

    Antihyperlipidemic (reduces elevated blood lipids) (1,2)
    Reduces serum Triglycerides, FFA’s, and hepatic lipid content (1,2,7,10,13,14)
    Decreases blood pressure, oxidative stress, and inflammatory markers like CRP-hs (13)
    Reduces HbA1c (which is typically thought of as a window into your last three months of blood sugar levels, however it is also an indicator of the level of Advanced Glycation End Products {AGE’s} in the body) (7).
    Increases adiponectin (10).

    One group of researchers took genetically obese mice and fed them a fattening diet, and found that the addition of corosolic acid reduced fat gain by 15% over controls (10). And remember, this is in an obese model, where everything related to a functional metabolism is a disaster.

    Finally, one last cool thing about banaba; it has been shown to suppress adipocyte differentiation, preventing stem cells from becoming mature fat cells (15).
    4OH-Ile (4-hydroxyisoleucine)
    4OH-Ile is an atypical branched-chain amino acid derived from fenugreek. Unlike banaba which has insulin like effects without stimulating extra insulin production, 4OH-Ile appears to directly stimulate glucose-induced insulin release from the pancreas. This effect is seen when blood glucose starts to rise above about 118mg/dL, which would be well above a fasting glucose for a healthy person but a pretty easily achieved post-prandial level for even a moderate carbohydrate meal. Also, the more blood glucose rises, the more insulin 4OH-Ile triggers, in a biphasic fashion (16).
    Similar to banaba, 4OH-Ile has been shown to increase insulin sensitivity and glucose uptake in muscle cells, doing so by triggering translocation of GLUT4 receptors through the PI3-kinase/AKT pathway (17–21). However, even though 4OH-Ile stimulates insulin production in response to elevated blood sugar (i.e., carb intake), it also tends to lower fasting insulin levels (17,21).

    Once cells become insulin resistant, a cascade of bad things starts to happen in the body. 4OH-Ile has demonstrated the ability to reverse many of these problems. Namely, reducing total cholesterol, LDL, triglycerides, TNFa, liver enzymes AST and ALT, and HbA1c, while elevating HDL (15,18,19,21,22).

    So basically 4OH-Ile is going to crank up insulin production when it’s beneficial to get more glucose and amino acids into the muscle cells, support normal levels while fasting, and help optimize blood lipids and inflammatory cytokines.
    Momordin
    Momordin is a titerpenoid saponin extracted from the bitter melon fruit. It is the third ingredient in the Slintensity formula shown to increase GLUT4 translocation in skeletal muscle cells, thereby encouraging better insulin sensitivity and higher glucose uptake (23). Momordin works, at least in part, through PI3K/MAPK dependent PPAR signaling (24,25). It has also been shown to increase AMPK phosphorylation and reduce the expression of PEPCK. One study looking at overfed mice showed that the addition of momordin caused less visceral fat gain and reduced glucose levels, triglycerides and fatty acid synthase (FAS) (26).

    Momordin has also been shown to have a three-pronged attack on preventing fat gain in human fat cells by inhibiting its storage, increasing lipolysis, and inhibiting adipocyte differentiation (27). Finally, it also appears to slow gastric emptying which improves glucose metabolism and insulin signaling (28).
    FMOC-L-Leu
    FMOC-L-Leu is a derivative of the Amino Acid Leucine, with some highly unique effects. It acts as a ligand for PPARy, binding in a particular way that causes it to only activate the beneficial signaling pathways that we want. Specifically, it potently increases insulin sensitivity without increasing adipogenesis (often when insulin sensitivity is increased, it happens at both muscle and fat cells encouraging heightened uptake at both places, which is not ideal in a non-pathological state) (29).
    Phellodendri Cortex 20:1
    Extracted from the bark of the Phellodendron tree, Phellodendri Cortex contains two major compounds relevant to Slintensity, obacunone and berberine (30).

    Obacunone does several beneficial things, let’s take a look.

    Arginase Inhibition
    Nitric Oxide Synthase (NOS) competes with arginase for available L-arginine. Too much arginase, and the L-arginine substrate pool becomes depleted, leaving little left over for NOS to produce NO with. More NO allows us to take advantage of post meal vasodilation, encouraging enhanced delivery of nutrients to the cells. Obacunone has been demonstrated to be an arginase inhibitor, and subsequently boost NO production. It was even able to attenuate the effect of a vasoconstrictor (31).

    TRG5 agonism
    This is a protein that serves as a cell surface bile acid receptor. The activation of this receptor triggers intracellular cAMP production and MAPk signaling, demonstrating involvement in energy homeostasis. Interestingly, when this receptor is agonized it activates enzymes that convert the minimally active thyroid hormone T4 into the potent hormone T3. The ineffective conversion of T4 to T3 is quite common in people with suboptimal thyroid function, which can throw a wrench into fat loss and muscle gain, among other things.

    TRG5 agonism, which obacunone has demonstrated capability for, has been shown to prevent elevated blood sugar and obesity in mice overfed a high fat diet (32,33).

    P-gp (P-glycoprotein) inhibition
    This glycoprotein carries several things through intra and extra-cellular membranes, and it can reduce the bioavailability of many pharmaceuticals and supplements. The intestinal barrier cells use P-gp to resist absorption of berberine, which likely accounts for reports of GI distress when users consume high doses of the compound. Obacunone has demonstrated significant P-gp inhibition capabilities, allowing for better bioavailability of berberine and other ingredients (30).

    In addition to the above, obacunone also acts as an anti-aromatase, reduces inflammatory markers like NF-kB & COX2, activates the p38/MAPK pathway, and prevents glutamate induced neurotoxicity (34,35).

    As for Berberine, a ton of research has been done on this compound assessing its beneficial effect on blood sugar, insulin and diabetes management, so we will avoid going through all of that for the sake of brevity and just look at a few interesting points.

    In a recent randomized double blind placebo study, 24 subjects with metabolic syndrome participated; half were given berberine three times per day before meals. Those that received berberine compared to controls, saw reduced blood pressure, triglycerides, reduced AUC for glucose and insulin, increased insulin sensitivity, and an improvement in the Matsuda index (an index looking at the response to an oral glucose tolerance test) (36).

    Berberine has also been shown to donwregulate lipogenetic genes and upregulate energy expenditure genes in adipose and muscle cells (37). It also appears to increase insulin sensitivity in a novel way, by having a somewhat dichotomous effect on mitochondria. It activates AMPK, then inhibits mitochondrial function, then when the berberine clears the extra AMPK enhances mitochondrial function, and the end result is enhanced glucose and FFA oxidation with improved insulin sensitivity (38).

    Berberine also inhibits preadipocyte differentiation, and encourages the gut microbiota to shift towards the type that produce the extremely beneficial Short Chain Fatty Acids (SCFA’s) (39,40).
    Green Curry Leaf Extract
    GCLE is exactly what it sounds like, also known as Murraya Koenigii. GCLE has been shown in numerous studies to have a glucose lowering effect, fasting and in response to a meal. It appears to do so by the familiar mechanism of increasing GLUT4 translocation causing enhanced glucose uptake at the muscle cell, as well as being another ingredient that actually stimulates insulin synthesis and secretion (41–46).

    In addition, GLCE has also been shown to lower total cholesterol, triglycerides, reduce oxidative stress and pancreatic cell damage, inhibit glycation, and boost glutathione (41,43,46–49).

    Conclusion
    As you can see, we have combined several potent and exciting ingredients into Slintensity Redux that should have a profound effect on muscle gain and fat loss. Optimal dosing will take experimenting depending on your carbohydrate intake, so start with label directions and go from there.

    1. Miura T, Takagi S, Ishida T. Management of Diabetes and Its Complications with Banaba (Lagerstroemia speciosa L.) and Corosolic Acid. Evid Based Complement Alternat Med [Internet]. 2012 Jan [cited 2014 Jul 29];2012:871495. Available from: http://www.pubmedcentral.nih.gov/art...rtype=abstract
    2. Stohs SJ, Miller H, Kaats GR. A review of the efficacy and safety of banaba (Lagerstroemia speciosa L.) and corosolic acid. Phytother Res [Internet]. 2012 Mar [cited 2014 Jul 29];26(3):317–24. Available from: A review of the efficacy and safety of banaba (Lagerstroemia specio... - PubMed - NCBI
    3. Yang MH, Vasquez Y, Ali Z, Khan IA, Khan SI. Constituents from Terminalia species increase PPARα and PPARγ levels and stimulate glucose uptake without enhancing adipocyte differentiation. J Ethnopharmacol [Internet]. 2013 Sep 16 [cited 2014 Jul 29];149(2):490–8. Available from: Constituents from Terminalia species increase PPAR
    4. Shi L, Zhang W, Zhou Y-Y, Zhang Y-N, Li J-Y, Hu L-H, et al. Corosolic acid stimulates glucose uptake via enhancing insulin receptor phosphorylation. Eur J Pharmacol [Internet]. 2008 Apr 14 [cited 2014 Sep 27];584(1):21–9. Available from: Corosolic acid stimulates glucose uptake via enhancing insulin rece... - PubMed - NCBI
    5. Minamino K, Yanaga Y, Ohtsuru M. Bioactive substance from Grifola frondosa (maitake) mushroom inhibits CCAAT enhancer binding protein beta and delta expression on C3H10T1/2 B2C1 adipocyte cells. J Nutr Sci Vitaminol (Tokyo) [Internet]. 2008 Jun [cited 2013 Oct 9];54(3):250–4. Available from: Bioactive substance from Grifola frondosa (maitake) mushroom inhibi... - PubMed - NCBI
    6. Fukushima M, Matsuyama F, Ueda N, Egawa K, Takemoto J, Kajimoto Y, et al. Effect of corosolic acid on postchallenge plasma glucose levels. Diabetes Res Clin Pract [Internet]. 2006 Aug [cited 2014 Sep 27];73(2):174–7. Available from: Effect of corosolic acid on postchallenge plasma glucose levels. - PubMed - NCBI
    7. Park M-Y, Lee K-S, Sung M-K. Effects of dietary mulberry, Korean red ginseng, and banaba on glucose homeostasis in relation to PPAR-alpha, PPAR-gamma, and LPL mRNA expressions. Life Sci [Internet]. 2005 Nov 12 [cited 2014 Sep 27];77(26):3344–54. Available from: Effects of dietary mulberry, Korean red ginseng, and banaba on gluc... - PubMed - NCBI
    8. Judy W V, Hari SP, Stogsdill WW, Judy JS, Naguib YMA, Passwater R. Antidiabetic activity of a standardized extract (Glucosol) from Lagerstroemia speciosa leaves in Type II diabetics. A dose-dependence study. J Ethnopharmacol [Internet]. 2003 Jul [cited 2014 Sep 27];87(1):115–7. Available from: Antidiabetic activity of a standardized extract (Glucosol) from Lag... - PubMed - NCBI
    9. De Bock K, Eijnde BO, Ramaekers M, Hespel P. Acute Rhodiola rosea intake can improve endurance exercise performance. Int J Sport Nutr Exerc Metab [Internet]. 2004 Jun [cited 2014 Apr 7];14(3):298–307. Available from: Acute Rhodiola rosea intake can improve endurance exercise performa... - PubMed - NCBI
    10. Yamada K, Hosokawa M, Yamada C, Watanabe R, Fujimoto S, Fujiwara H, et al. Dietary corosolic acid ameliorates obesity and hepatic steatosis in KK-Ay mice. Biol Pharm Bull [Internet]. 2008 Apr [cited 2014 Sep 27];31(4):651–5. Available from: Dietary corosolic acid ameliorates obesity and hepatic steatosis in... - PubMed - NCBI
    11. Hattori K, Sukenobu N, Sasaki T, Takasuga S, Hayashi T, Kasai R, et al. Activation of insulin receptors by lagerstroemin. J Pharmacol Sci [Internet]. 2003 Sep [cited 2014 Sep 27];93(1):69–73. Available from: Activation of insulin receptors by lagerstroemin. - PubMed - NCBI
    12. Yamada K, Hosokawa M, Fujimoto S, Fujiwara H, Fujita Y, Harada N, et al. Effect of corosolic acid on gluconeogenesis in rat liver. Diabetes Res Clin Pract [Internet]. 2008 Apr [cited 2014 Sep 27];80(1):48–55. Available from: Effect of corosolic acid on gluconeogenesis in rat liver. - PubMed - NCBI
    13. Yamaguchi Y, Yamada K, Yoshikawa N, Nakamura K, Haginaka J, Kunitomo M. Corosolic acid prevents oxidative stress, inflammation and hypertension in SHR/NDmcr-cp rats, a model of metabolic syndrome. Life Sci [Internet]. 2006 Nov 25 [cited 2014 Sep 27];79(26):2474–9. Available from: Corosolic acid prevents oxidative stress, inflammation and hyperten... - PubMed - NCBI
    14. Suzuki Y, Unno T, U****ani M, Hayashi K, Kakuda T. Antiobesity activity of extracts from Lagerstroemia speciosa L. leaves on female KK-Ay mice. J Nutr Sci Vitaminol (Tokyo) [Internet]. 1999 Dec [cited 2014 Sep 27];45(6):791–5. Available from: Antiobesity activity of extracts from Lagerstroemia speciosa L. lea... - PubMed - NCBI
    15. Xue W-L, Li X-S, Zhang J, Liu Y-H, Wang Z-L, Zhang R-J. Effect of Trigonella foenum-graecum (fenugreek) extract on blood glucose, blood lipid and hemorheological properties in streptozotocin-induced diabetic rats. Asia Pac J Clin Nutr [Internet]. 2007 Jan [cited 2014 Jul 29];16 Suppl 1:422–6. Available from: Effect of Trigonella foenum-graecum (fenugreek) extract on blood gl... - PubMed - NCBI
    16. Sauvaire Y, Petit P, Broca C, Manteghetti M, Baissac Y, Fernandez-Alvarez J, et al. 4-Hydroxyisoleucine: a novel amino acid potentiator of insulin secretion. Diabetes [Internet]. 1998 Feb [cited 2014 Sep 19];47(2):206–10. Available from: 4-Hydroxyisoleucine: a novel amino acid potentiator of insulin secr... - PubMed - NCBI
    17. Broca C, Gross R, Petit P, Sauvaire Y, Manteghetti M, Tournier M, et al. 4-Hydroxyisoleucine: experimental evidence of its insulinotropic and antidiabetic properties. Am J Physiol [Internet]. 1999 Oct [cited 2014 Sep 19];277(4 Pt 1):E617–23. Available from: 4-Hydroxyisoleucine: experimental evidence of its insulinotropic an... - PubMed - NCBI
    18. Jetté L, Harvey L, Eugeni K, Levens N. 4-Hydroxyisoleucine: a plant-derived treatment for metabolic syndrome. Curr Opin Investig Drugs [Internet]. 2009 Apr [cited 2014 Sep 19];10(4):353–8. Available from: 4-Hydroxyisoleucine: a plant-derived treatment for metabolic syndrome. - PubMed - NCBI
    19. Yu H, Wu M, Lu F-R, Xie J, Zheng N, Qin Y, et al. [Effect of trigonella foenum-graecum 4-hydroxyisoleucine on high-glucose induced insulin resistance in 3T3-L1 adipocytes of mice]. Zhongguo Zhong Xi Yi Jie He Za Zhi [Internet]. 2013 Oct [cited 2014 Jul 29];33(10):1394–9. Available from: [Effect of trigonella foenum-graecum 4-hydroxyisoleucine on high-gl... - PubMed - NCBI
    20. Jaiswal N, Maurya CK, Venkateswarlu K, Sukanya P, Srivastava AK, Narender T, et al. 4-Hydroxyisoleucine stimulates glucose uptake by increasing surface GLUT4 level in skeletal muscle cells via phosphatidylinositol-3-kinase-dependent pathway. Eur J Nutr [Internet]. 2012 Oct [cited 2014 Jul 29];51(7):893–8. Available from: 4-Hydroxyisoleucine stimulates glucose uptake by increasing surface... - PubMed - NCBI
    21. Singh AB, Tamarkar AK, Narender T, Srivastava AK. Antihyperglycaemic effect of an unusual amino acid (4-hydroxyisoleucine) in C57BL/KsJ-db/db mice. Nat Prod Res [Internet]. 2010 Mar [cited 2014 Jul 29];24(3):258–65. Available from: Antihyperglycaemic effect of an unusual amino acid (4-hydroxyisoleu... - PubMed - NCBI
    22. Haeri MR, Izaddoost M, Ardekani MRS, Nobar MR, White KN. The effect of fenugreek 4-hydroxyisoleucine on liver function biomarkers and glucose in diabetic and fructose-fed rats. Phytother Res [Internet]. 2009 Jan [cited 2014 Jul 29];23(1):61–4. Available from: The effect of fenugreek 4-hydroxyisoleucine on liver function bioma... - PubMed - NCBI
    23. Wang ZQ, Zhang XH, Yu Y, Poulev A, Ribnicky D, Floyd ZE, et al. Bioactives from bitter melon enhance insulin signaling and modulate acyl carnitine content in skeletal muscle in high-fat diet-fed mice. J Nutr Biochem [Internet]. 2011 Jan [cited 2011 Feb 3]; Available from: Bioactives from bitter melon enhance insulin signaling and modulate... - PubMed - NCBI
    24. Sasa M, Inoue I, Shinoda Y, Takahashi S, Seo M, Komoda T, et al. Activating effect of momordin, extract of bitter melon (Momordica Charantia L.), on the promoter of human PPARdelta. J Atheroscler Thromb [Internet]. 2009 Jan [cited 2010 Jul 1];16(6):888–92. Available from: Activating effect of momordin, extract of bitter melon (Momordica C... - PubMed - NCBI
    25. Wang J, Yuan L, Xiao H, Wang C, Xiao C, Wang Y, et al. A novel mechanism for momordin Ic-induced HepG2 apoptosis: involvement of PI3K- and MAPK-dependent PPARγ activation. Food Funct [Internet]. 2014 May [cited 2014 Jul 29];5(5):859–68. Available from: A novel mechanism for momordin Ic-induced HepG2 apoptosis: involvem... - PubMed - NCBI
    26. Shih C-C, Shlau M-T, Lin C-H, Wu J-B. Momordica charantia ameliorates insulin resistance and dyslipidemia with altered hepatic glucose production and fatty acid synthesis and AMPK phosphorylation in high-fat-fed mice. Phytother Res [Internet]. 2014 Mar [cited 2014 Jul 29];28(3):363–71. Available from: Momordica charantia ameliorates insulin resistance and dyslipidemia... - PubMed - NCBI
    27. Nerurkar P V, Lee YK, Nerurkar VR. Momordica charantia (bitter melon) inhibits primary human adipocyte differentiation by modulating adipogenic genes. BMC Complement Altern Med [Internet]. 2010 Jun [cited 2010 Jul 1];10(1):34. Available from: Momordica charantia (bitter melon) inhibits primary human adipocyte... - PubMed - NCBI
    28. Matsuda H, Li Y, Yamahara J, Yoshikawa M. Inhibition of gastric emptying by triterpene saponin, momordin Ic, in mice: roles of blood glucose, capsaicin-sensitive sensory nerves, and central nervous system. J Pharmacol Exp Ther [Internet]. 1999 May [cited 2013 May 25];289(2):729–34. Available from: Inhibition of gastric emptying by triterpene saponin, momordin Ic, ... - PubMed - NCBI
    29. Rocchi S, Picard F, Vamecq J, Gelman L, Potier N, Zeyer D, et al. A unique PPARgamma ligand with potent insulin-sensitizing yet weak adipogenic activity. Mol Cell [Internet]. 2001 Oct [cited 2014 Jul 29];8(4):737–47. Available from: A unique PPARgamma ligand with potent insulin-sensitizing yet weak ... - PubMed - NCBI
    30. Min YD, Kwon HC, Yang MC, Lee KH, Choi SU, Lee KR. Isolation of limonoids and alkaloids from Phellodendron amurense and their multidrug resistance (MDR) reversal activity. Arch Pharm Res [Internet]. 2007 Jan [cited 2014 Sep 28];30(1):58–63. Available from: Isolation of limonoids and alkaloids from Phellodendron amurense an... - PubMed - NCBI
    31. Yoon J, Park M, Lee J hyung, Min BS, Ryoo S. Endothelial nitric oxide synthase activation through obacunone-dependent arginase inhibition restored impaired endothelial function in ApoE-null mice. Vascul Pharmacol [Internet]. 2014 Mar [cited 2014 Jul 29];60(3):102–9. Available from: Endothelial nitric oxide synthase activation through obacunone-depe... - PubMed - NCBI
    32. Ono E, Inoue J, Hashidume T, Shimizu M, Sato R. Anti-obesity and anti-hyperglycemic effects of the dietary citrus limonoid nomilin in mice fed a high-fat diet. Biochem Biophys Res Commun [Internet]. 2011 Jul 8 [cited 2014 Jul 29];410(3):677–81. Available from: Anti-obesity and anti-hyperglycemic effects of the dietary citrus l... - PubMed - NCBI
    33. Kim H-J, Kong M-K, Kim Y-C. Beneficial effects of Phellodendri Cortex extract on hyperglycemia and diabetic nephropathy in streptozotocin-induced diabetic rats. BMB Rep [Internet]. 2008 Oct 31 [cited 2014 Sep 28];41(10):710–5. Available from: Beneficial effects of Phellodendri Cortex extract on hyperglycemia ... - PubMed - NCBI
    34. Kim J, Jayaprakasha GK, Patil BS. Obacunone exhibits anti-proliferative and anti-aromatase activity in*vitro by inhibiting the p38 MAPK signaling pathway in MCF-7 human breast adenocarcinoma cells. Biochimie [Internet]. 2014 Jun 11 [cited 2014 Jul 29]; Available from: Obacunone exhibits anti-proliferative and anti-aromatase activity i... - PubMed - NCBI
    35. Yoon JS, Yang H, Kim SH, Sung SH, Kim YC. Limonoids from Dictamnus dasycarpus protect against glutamate-induced toxicity in primary cultured rat cortical cells. J Mol Neurosci [Internet]. 2010 Sep [cited 2014 Jul 16];42(1):9–16. Available from: Limonoids from Dictamnus dasycarpus protect against glutamate-induc... - PubMed - NCBI
    36. Pérez-Rubio KG, González-Ortiz M, Martínez-Abundis E, Robles-Cervantes JA, Espinel-Bermúdez MC. Effect of berberine administration on metabolic syndrome, insulin sensitivity, and insulin secretion. Metab Syndr Relat Disord [Internet]. 2013 Oct [cited 2014 Sep 28];11(5):366–9. Available from: Effect of berberine administration on metabolic syndrome, insulin s... - PubMed - NCBI
    37. Lee YS, Kim WS, Kim KH, Yoon MJ, Cho HJ, Shen Y, et al. Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes [Internet]. 2006 Aug [cited 2014 Sep 15];55(8):2256–64. Available from: Berberine, a natural plant product, activates AMP-activated protein... - PubMed - NCBI
    38. Zhang Y, Ye J. Mitochondrial inhibitor as a new class of insulin sensitizer. Acta Pharm Sin B [Internet]. 2012 Aug [cited 2014 Sep 28];2(4):341–9. Available from: http://www.pubmedcentral.nih.gov/art...rtype=abstract
    39. Yang J, Yin J, Gao H, Xu L, Wang Y, Xu L, et al. Berberine improves insulin sensitivity by inhibiting fat store and adjusting adipokines profile in human preadipocytes and metabolic syndrome patients. Evid Based Complement Alternat Med [Internet]. 2012 Jan [cited 2014 Sep 28];2012:363845. Available from: http://www.pubmedcentral.nih.gov/art...rtype=abstract
    40. Zhang X, Zhao Y, Zhang M, Pang X, Xu J, Kang C, et al. Structural changes of gut microbiota during berberine-mediated prevention of obesity and insulin resistance in high-fat diet-fed rats. PLoS One [Internet]. 2012 Jan [cited 2014 Sep 28];7(8):e42529. Available from: http://www.pubmedcentral.nih.gov/art...rtype=abstract
    41. Xie J-T, Chang W-T, Wang C-Z, Mehendale SR, Li J, Ambihaipahar R, et al. Curry leaf (Murraya koenigii Spreng.) reduces blood cholesterol and glucose levels in ob/ob mice. Am J Chin Med [Internet]. 2006 Jan [cited 2014 Jul 29];34(2):279–84. Available from: Curry leaf (Murraya koenigii Spreng.) reduces blood cholesterol and... - PubMed - NCBI
    42. Lawal HA, Atiku MK, Khelpai DG, Wannang NN. Hypoglycaemic and hypolipidaemic effect of aqueous leaf extract of Murraya koenigii in normal and alloxan-diabetic rats. Niger J Physiol Sci [Internet]. [cited 2014 Sep 24];23(1-2):37–40. Available from: Hypoglycaemic and hypolipidaemic effect of aqueous leaf extract of ... - PubMed - NCBI
    43. Kesari AN, Kesari S, Singh SK, Gupta RK, Watal G. Studies on the glycemic and lipidemic effect of Murraya koenigii in experimental animals. J Ethnopharmacol [Internet]. 2007 Jun 13 [cited 2014 Sep 24];112(2):305–11. Available from: Studies on the glycemic and lipidemic effect of Murraya koenigii in... - PubMed - NCBI
    44. Vinuthan MK, Girish Kumar V, Ravindra JP, Jayaprakash, Narayana K. Effect of extracts of Murraya koenigii leaves on the levels of blood glucose and plasma insulin in alloxan-induced diabetic rats. Indian J Physiol Pharmacol [Internet]. 2004 Jul [cited 2014 Sep 24];48(3):348–52. Available from: Effect of extracts of Murraya koenigii leaves on the levels of bloo... - PubMed - NCBI
    45. Pandey J, Maurya R, Raykhera R, Srivastava MN, Yadav PP, Tamrakar AK. Murraya koenigii (L.) Spreng. ameliorates insulin resistance in dexamethasone-treated mice by enhancing peripheral insulin sensitivity. J Sci Food Agric [Internet]. 2014 Aug [cited 2014 Sep 24];94(11):2282–8. Available from: Murraya koenigii (L.) Spreng. ameliorates insulin resistance in dex... - PubMed - NCBI
    46. El-Amin M, Virk P, Elobeid MAR, Almarhoon ZM, Hassan ZK, Omer SA, et al. Anti-diabetic effect of Murraya koenigii (L) and Olea europaea (L) leaf extracts on streptozotocin induced diabetic rats. Pak J Pharm Sci [Internet]. 2013 Mar [cited 2014 Sep 24];26(2):359–65. Available from: Anti-diabetic effect of Murraya koenigii (L) and Olea europaea (L) ... - PubMed - NCBI
    47. Paul S, Bandyopadhyay TK, Bhattacharyya A. Immunomodulatory effect of leaf extract of Murraya koenigii in diabetic mice. Immunopharmacol Immunotoxicol [Internet]. 2011 Dec [cited 2014 Sep 24];33(4):691–9. Available from: Immunomodulatory effect of leaf extract of Murraya koenigii in diab... - PubMed - NCBI
    48. Arulselvan P, Subramanian SP. Beneficial effects of Murraya koenigii leaves on antioxidant defense system and ultra structural changes of pancreatic beta-cells in experimental diabetes in rats. Chem Biol Interact [Internet]. 2007 Jan 30 [cited 2014 Sep 24];165(2):155–64. Available from: Beneficial effects of Murraya koenigii leaves on antioxidant defens... - PubMed - NCBI
    49. Ramkissoon JS, Mahomoodally MF, Ahmed N, Subratty AH. Antioxidant and anti-glycation activities correlates with phenolic composition of tropical medicinal herbs. Asian Pac J Trop Med [Internet]. 2013 Jul [cited 2014 Sep 23];6(7):561–9. Available from: Antioxidant and anti-glycation activities correlates with phenolic ... - PubMed - NCBI
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  2. Awesome. When can we get it???
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  3. Nice!
    EvoMuse Products Rep

    PM me with any questions!

  4. Looks promising.
    DISCLAIMER: Anything that I post on this forum should not be taken as medical advice. Consult your doctor before starting new diets, supplements, training protocols, and/or if you have any concerns about your health.
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  5. So for anyone looking for the best GDA on the market this is it, got nothing invested in saying that but after about 6-7 bottles of the Slintensity V1 I was a believer, it's a big step above OG SS so with that being said it's an awesome recomp product.

    Looking forward to this Matt, is it the same % of 4-OH that was in the previous Slintensity ? That made smell like a bottle of aunt jemima at times.

  6. Subbed for release!
  7. AnabolicMinds Site Rep
    MidwestBeast's Avatar

    I've been (impatiently lol) waiting for this for a while. Stocked up on v1 as much as I could and have been itching for this for as long as Matt has talked about it. Such an awesome product.
    Psalm 34:10 - "The lions may grow weak and hungry, but those who seek the Lord lack no good thing."
    EvoMuse Representative | [email protected] | Inspire to Evolve

  8. can we get an update on this

  9. Haven't heard anything new, but I believe this is next in our pipeline.
    EvoMuse Products Rep

    PM me with any questions!

  10. Hopefully I can get a bottle to use prior to Thanksgiving and Christmas
    PEScience Representative
    http://www.pescience.com/insider
    Instagram: kylebayne23

  11. Sounds like some good stuff on keto and this could be great for carb up days

  12. Update?
    Black Lion Representative
    I'm a Brooklyn boy I may take some gettin' use to

  13. Looks like it will be the week after thanksgiving, due to some delays at Customs. This is actually going to take a giant bite out of my revenue for November, but more than that I'm going to miss out on using it for my Gluttonous Orgy....errr, smartly prepared and controlled refeed.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  14. Quote Originally Posted by dsade View Post
    Looks like it will be the week after thanksgiving, due to some delays at Customs. This is actually going to take a giant bite out of my revenue for November, but more than that I'm going to miss out on using it for my Gluttonous Orgy....errr, smartly prepared and controlled refeed.
    Damn!
    PEScience Representative
    http://www.pescience.com/insider
    Instagram: kylebayne23

  15. Waiting anxiously !

  16. How's this coming along?? Last I heard was mid-week.

  17. They have finished up capping, and will be bottling on Monday. I should hopefully have them by Thursday or Friday.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  18. Should be a nice Christmas present to myself
    PEScience Representative
    http://www.pescience.com/insider
    Instagram: kylebayne23

  19. Quote Originally Posted by kbayne View Post
    Should be a nice Christmas present to myself
    So I guess it's fair to say you will be "stocking" up.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  20. Quote Originally Posted by dsade View Post
    So I guess it's fair to say you will be "stocking" up.
    Hopefully my "stocking" will fit it all
    PEScience Representative
    http://www.pescience.com/insider
    Instagram: kylebayne23

  21. Quote Originally Posted by dsade View Post
    So I guess it's fair to say you will be "stocking" up.
    He better get in line.

  22. Any info on forskolin + berberine? In another thread it's being said to not take them together/near eachother..? @dsade
    Owner; Human Performance Science (HPS)
    HPSSupps.com
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  23. Quote Originally Posted by chedapalooza View Post
    Any info on forskolin + berberine? In another thread it's being said to not take them together/near eachother..? @dsade
    For good reason. If you google "berberine Forskolin" you'll find a few links to different studies explaining why.

    http://www.ncbi.nlm.nih.gov/m/pubmed/20969954/
    PEScience Representative
    http://www.pescience.com/insider
    Instagram: kylebayne23

  24. Quote Originally Posted by kbayne View Post
    For good reason. If you google "berberine Forskolin" you'll find a few links to different studies explaining why. http://www.ncbi.nlm.nih.gov/m/pubmed/20969954/
    IMO it's a moot point when it comes to cAMP stimulated lipolysis as the product is intended to be used pre meal in which lipolysis is blunted due to insulin

    However if used fasted, it's another story
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