EvoMuse Nerve Restore Writeup

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  1. EvoMuse Nerve Restore Writeup


    Nothing is more frustrating than an impinged or injured nerve. Signal reduction triggers a whole landslide of negative effects: Weakness, pain, atrophy. After time, these side effects seem like they will last forever - and sometimes do...until now. Enter Nerve Restore. Nerve Restore is a nerve signal amplifier. In people with impingement or nerve injuries it will help alleiviate discomfort, weakness, and muscular atrophy. The enhanced nerve amplitude and velocity, in healthy people as well, should result in increased strength and quicker reflexes/coordination.

    Key Terms to Know

    Nerve Growth Factor (NGF)- A signaling protein crucial for growth, upkeep, and survival of nerves.

    Brain Derived Neurotrophic Factor (BDNF)- A neurotrophin active in the brain and periphery, aiding in growth, survival and differentiation of neurons and synapses, and a key player in long term memory.

    Neurotrophins- An umbrella of NGFs including BDNF, NT-3 and NT-4/5

    Mean Nerve Conduction Velocity (MNCV)- How fast electrical signals move through a nerve.

    Neuropathy (peripheral neuropathy)- A term used to describe a condition of damage, dysfunction or disease to nerves anywhere in the peripheral nervous system.

    Myelin- A type of organic insulation surrounding nerve axons to protect them and increase MNCV, as well as prevent electrical current from escaping the axon.

    Protein Kinase C (PKC)- A family of enzymes that control the function of other proteins through the act of phosphorylation.

    Schwann Cells- Cells that provide raw materials for myelination

    Ingredients and Function

    4-Methylcatechol (4-MC)

    Where does it come from?
    Catechol is a natural compound found in various fruits and vegetables. 4-methylcatechol is a specific, bioavailable and well-researched form of catechol that provides some potent physiological effects. It's pretty much a super-nutrient for nerves, and a major player in the efficacy of Nerve Restore.

    What does it do?
    4-MC is widely recognized in research as a potent NGF stimulator. Research in this area tends to give animal models nerve disorders, then treat them with a given compound and see what happens vs. controls. Here's some highlights from the data on 4-MC.

    Thermosensitivity is basically the sensory perception of temperature changes, which is often damaged in nerve dysfunction. 4-MC has been shown to promote reinnervation and normalization of thermosensitivity in neuropathy (1).

    Diabetes often leads to neuropathy, which causes a significant reduction in MNCV, as well as the NGF content of nerves. Several studies have found a huge benefit and reversal of these symptoms with 4-MC administration. One study showed in increase in NGF of 140% over controls (2), multiple other studies have confirmed the de novo NGF synthesis capability of 4-MC while also demonstrating its ability to significantly increase myelination and nerve blood flow (3–6).

    Several studies have given animal models a nerve toxin known as acrylamide monomer (ACR), and examined the potential protective effect of 4-MC. They found similar results as the previously mentioned studies, 4-MC was able to increase MNCV, NGF, and myelination, and researchers noted that it can "accelerate the recovery process clinically, electrophysiologically, biochemically and neuropathologically" (4,7).

    Also noteworthy, 4-MC has been shown to promote regeneration of even unmyelinated nerves as well as relieve chronic pain and depression-like behavior in nerve injuries by boosting BDNF (8,9).

    Salidroside

    Where does it come from?
    Salidroside comes from the Rhodiola Rosea plant and is well known for its numerous health promoting properties.

    What does it do?
    Several studies have demonstrated salidroside's neuroprotective ability (10–13). Due to this effect, researchers wondered if salidroside might be able to help recovery from sciatic nerve injuries, so they tested it out. In rats with sciatic nerve crush injuries, they looked at several factors, including nerve conduction speed and walking tests. The results showed that salidroside was indeed able to successfully regenerate nerve function (14).

    Methylcobalamin

    Where does it come from?
    Methylcobalamin is simply the methyl form of Vitamin B12, a key vitamin involved with proper nerve function.

    What does it do?
    Another well-researched nutrient in the arena of nerve health, methylcobalamin is a no-brainer in this formula. It has been shown to do the following:

    ě Correct nerve damage done from oxidative damage and impaired neural signaling of PKC (15).
    ě Stimulate proteosynthesis in Schwann cells to facilitate neural regeneration (16,17).
    ě Enhance recovery of myelination, muscle action potentials and motor end plate innervation (17).
    ě Improve nerve regeneration and inhibit degeneration from neuronal damage such as crushed sciatic nerves (18–20).
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  2. Palmitoylethanolamide (PEA)

    Where does it come from?
    PEA (not to be confused with the other PEA, phenylethylamine) is a fatty acid amide (formed when a fatty acid combines with an amine). Most of its functions in the body involve the regulation of pain and inflammation.

    What does it do?
    By working through numerous angles to reduce pain and improve nerve signaling, PEA holds large promise. Quite a bit of published data has shown that PEA favorably modulates PPARa, PPARg, CB(1),TRPV1, TNFa, and the mast cells of the immune system to reduce pain, inflammation and discomfort in nerve injuries such as neuropathy, carpal tunnel syndrome and sciatic nerve crushes (21–25).

    Chitooligosaccharide (COS)

    Where does it come from?
    COS is a combination of two different types of glucosamine derived from crustacean shells.

    What does it do?
    Several studies have shown COS to have a positive outcome on improvement of nerve dysfunction. One recent study looking at peripheral nerve crush injuries published in the Journal of Microsurgery found that COS significantly improved muscle action potentials, number of regenerated nerve fibers and thickness of myelin sheaths, and even an increase in muscle size of the tibialis posterior (one of the calf muscles) (26).

    Other studies have shown COS to promote nerve regeneration and differentiation, functional recovery, and nerve cell adhesion (27,28).

    Achyranthes bidentata polypeptides (ABP)

    Where does it come from?
    ABP is a polypeptide derived from the achyranthes plant found in China, Japan, Nepal, and India, known for its anti-inflammatory properties.


    What does it do?
    ABP has been shown repeatedly in research to enhance nerve regeneration and function in sciatic and common peroneal nerve injuries (29–31).

    Also of interest, ABP has central as well as peripheral nerve preservation and restoration effects, shown in the Journal of Neuroscience Research to counteract the effect of overstimulated NMDA receptors in the brain by reversing intracellular ROS and mitochondrial damage to the hippocampus (32).

    Ginsenoside Rg1 (GRg1)

    Where does it come from?
    The Rg1 group of ginsenoside is a bioactive compound found primarily in the Chinese/Korean Ginesing plant, selected for its specific nerve regeneration properties. The ginsenosides are considered the active compounds in ginesing.

    What does it do?
    Recent research has shown GRg1 can successfully promote nerve regeneration after nerve injuries (33–35). After an oxidative insult from administered hydrogen peroxide, GRg1 increases SOD, CAT and GSH with a concurrent reduction in MDA (34). It has also been shown to increase expression of NGF and BDNF through the PKA pathway in Schwann cells (35).

    Pyridoxal-5-Phosphate (P5P)

    Where does it come from?
    P5P is the active form of Vitamin B6 in the body, and is a crucial factor for a laundry list of functions in the body.

    What does it do?
    The most recent research has shown that P5P improves clinical symptoms in carpal tunnel syndrome (a nerve related disorder), which means it likely has farther reaching effects on nerve dysfunction throughout the body, (36).

    Dipsaci radix (water extract)

    Where does it come from?
    In Traditional Chinese Medicine (TCM), Dipsaci radix has been used to treat dysfunctions of the liver, kidney, tendons and bones. It comes from the plant Dipsacus asperoides.

    What does it do?
    After nerve injury, muscle atrophy tends to onset fairly quickly. Dipsaci helps improve muscle size and glycogen storage in tissues surrounding a nerve injury (37).

    Radix Hedysari

    Where does it come from?
    Also from TCM, Radix Hedysari is an herbal preperation used for nerve regeneration.

    What does it do?
    Radix Hedysari has been shown to be effective at improving peripheral nerve regeneration, MNCV, nerve fiber and axon diameter, number of nerve fibers, and amplification ratio (38–40).

    Lion's Mane mushroom extract 4:1 (Hericium erinaceus)

    Where does it come from?
    Lion's Mane Mushroom extract is an edible mushroom found in North America, Europe and Asia.

    What does it do?
    Lion's Mane is considered a neurotrophic agent, as it has been shown in multiple studies to induce NGF synthesis (41,42). Two studies have also shown oral administration of Lion's Mane to regenerate injured peroneal nerves in rats (43,44). Finally, it has been shown to directly regulate myelin genesis in vitro (45).
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  3. Earthworm extract (Dilong)

    Where does it come from?
    Exactly what it sounds like, this compound widely used in TCM is an extract from earthworms.

    What does it do?
    Two recent studies have demonstrated Earthworm Extract's ability to increase nerve cell regeneration through Schwann cell activity, stimulating myelination (46,47).

    Conclusion
    Oftentimes, nerve injuries take a massive toll on us mentally and physically. We watch, helpless, as our hard-earned size and strength gains falter and fade away. After many months of research, Evolutionary Muse offers a potential solution. While your physician or therapist should guide you along the road to recovery, and your trainer can advise you how to best prevent future injuries, EvoMuse has brought to you a product that will jumpstart the processes of recovery and help restore, and optimize, nerve function.

    Nerve Restore...fire away.



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    2. Hanaoka Y, Ohi T, Furukawa S, Furukawa Y, Hayashi K, Matsukura S. Effect of 4-methylcatechol on sciatic nerve growth factor level and motor nerve conduction velocity in experimental diabetic neuropathic process in rats. Exp. Neurol. [Internet]. 1992 Mar [cited 2013 Dec 28];115(2):292–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/1735473
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    11. Yu S, Shen Y, Liu J, Ding F. Involvement of ERK1/2 pathway in neuroprotection by salidroside against hydrogen peroxide-induced apoptotic cell death. J. Mol. Neurosci. [Internet]. 2010 Mar [cited 2013 Dec 29];40(3):321–31. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19787459
    12. Chen X, Zhang Q, Cheng Q, Ding F. Protective effect of salidroside against H2O2-induced cell apoptosis in primary culture of rat hippocampal neurons. Mol. Cell. Biochem. [Internet]. 2009 Dec [cited 2013 Dec 29];332(1-2):85–93. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19554425
    13. Chen X, Liu J, Gu X, Ding F. Salidroside attenuates glutamate-induced apoptotic cell death in primary cultured hippocampal neurons of rats. Brain Res. [Internet]. 2008 Oct 31 [cited 2013 Dec 29];1238:189–98. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18680733
    14. Sheng Q-S, Wang Z-J, Zhang J, Zhang Y-G. Salidroside promotes peripheral nerve regeneration following crush injury to the sciatic nerve in rats. Neuroreport [Internet]. 2013 Mar 27 [cited 2013 Dec 28];24(5):217–23. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23358450
    15. Mizukami H, Ogasawara S, Yamagishi S-I, Takahashi K, Yagihashi S. Methylcobalamin effects on diabetic neuropathy and nerve protein kinase C in rats. Eur. J. Clin. Invest. [Internet]. 2011 Apr [cited 2013 Dec 28];41(4):442–50. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21128935
    16. Yamatsu K, Yamanishi Y, Kaneko T, Ohkawa I. [Pharmacological studies on degeneration and regeneration of the peripheral nerves. (2) Effects of methylcobalamin on mitosis of Schwann cells and incorporation of labeled amino acid into protein fractions of crushed sciatic nerve in rats]. Nihon Yakurigaku Zasshi. [Internet]. 1976 Mar [cited 2013 Dec 28];72(2):269–78. Available from: http://www.ncbi.nlm.nih.gov/pubmed/987971
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    19. Yamazaki K, Oda K, Endo C, Kikuchi T, Wakabayashi T. Methylcobalamin (methyl-B12) promotes regeneration of motor nerve terminals degenerating in anterior gracile muscle of gracile axonal dystrophy (GAD) mutant mouse. Neurosci. Lett. [Internet]. 1994 Mar 28 [cited 2013 Dec 28];170(1):195–7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/8041506
    20. Yamatsu K, Kaneko T, Kitahara A, Ohkawa I. [Pharmacological studies on degeneration and regeneration of peripheral nerves. (1) Effects of methylcobalamin and cobamide on EMG patterns and loss of muscle weight in rats with crushed sciatic nerve]. Nihon Yakurigaku Zasshi. [Internet]. 1976 Mar [cited 2013 Dec 28];72(2):259–68. Available from: http://www.ncbi.nlm.nih.gov/pubmed/987970
    21. Di Cesare Mannelli L, D’Agostino G, Pacini A, Russo R, Zanardelli M, Ghelardini C, et al. Palmitoylethanolamide is a disease-modifying agent in peripheral neuropathy: pain relief and neuroprotection share a PPAR-alpha-mediated mechanism. Mediators Inflamm. [Internet]. 2013 Jan [cited 2013 Dec 28];2013:328797. Available from: http://www.pubmedcentral.nih.gov/art...rtype=abstract
    22. Bettoni I, Comelli F, Colombo A, Bonfanti P, Costa B. Non-neuronal cell modulation relieves neuropathic pain: efficacy of the endogenous lipid palmitoylethanolamide. CNS Neurol. Disord. Drug Targets [Internet]. 2013 Mar 1 [cited 2013 Dec 28];12(1):34–44. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23394519
    23. Conigliaro R, Drago V, Foster PS, Schievano C, Di Marzo V. Use of palmitoylethanolamide in the entrapment neuropathy of the median in the wrist. Minerva Med. [Internet]. 2011 Apr [cited 2013 Dec 28];102(2):141–7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21483401
    24. Calabr˛ RS, Gervasi G, Marino S, Mondo PN, Bramanti P. Misdiagnosed chronic pelvic pain: pudendal neuralgia responding to a novel use of palmitoylethanolamide. Pain Med. [Internet]. 2010 May [cited 2013 Dec 28];11(5):781–4. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20345619
    25. Costa B, Comelli F, Bettoni I, Colleoni M, Giagnoni G. The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB(1), TRPV1 and PPARgamma receptors and neurotrophic factors. Pain [Internet]. 2008 Oct 31 [cited 2013 Dec 28];139(3):541–50. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18602217
    26. Gong Y, Gong L, Gu X, Ding F. Chitooligosaccharides promote peripheral nerve regeneration in a rabbit common peroneal nerve crush injury model. Microsurgery [Internet]. 2009 Jan [cited 2013 Dec 28];29(8):650–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19653322
    27. Jiang M, Zhuge X, Yang Y, Gu X, Ding F. The promotion of peripheral nerve regeneration by chitooligosaccharides in the rat nerve crush injury model. Neurosci. Lett. [Internet]. 2009 May 1 [cited 2013 Dec 15];454(3):239–43. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19429091
    28. Yang Y, Liu M, Gu Y, Lin S, Ding F, Gu X. Effect of chitooligosaccharide on neuronal differentiation of PC-12 cells. Cell Biol. Int. [Internet]. 2009 Mar [cited 2013 Dec 28];33(3):352–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19272331
    29. Cheng Q, Yuan Y, Sun C, Gu X, Cao Z, Ding F. Neurotrophic and neuroprotective actions of Achyranthes bidentata polypeptides on cultured dorsal root ganglia of rats and on crushed common peroneal nerve of rabbits. Neurosci. Lett. [Internet]. 2013 Dec 17 [cited 2013 Dec 28]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/24361134
    30. Wang Y, Shen W, Yang L, Zhao H, Gu W, Yuan Y. The protective effects of Achyranthes bidentata polypeptides on rat sciatic nerve crush injury causes modulation of neurotrophic factors. Neurochem. Res. [Internet]. 2013 Mar [cited 2013 Dec 28];38(3):538–46. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23242788
    31. Yuan Y, Shen H, Yao J, Hu N, Ding F, Gu X. The protective effects of Achyranthes bidentata polypeptides in an experimental model of mouse sciatic nerve crush injury. Brain Res. Bull. [Internet]. 2010 Jan 15 [cited 2013 Dec 28];81(1):25–32. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19646511
    32. Shen H, Yuan Y, Ding F, Hu N, Liu J, Gu X. Achyranthes bidentata polypeptides confer neuroprotection through inhibition of reactive oxygen species production, Bax expression, and mitochondrial dysfunction induced by overstimulation of N-methyl-D-aspartate receptors. J. Neurosci. Res. [Internet]. 2010 Mar 15 [cited 2013 Dec 28];88(3):669–76. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19774671
    33. Ma J, Li W, Tian R, Lei W. Ginsenoside Rg1 promotes peripheral nerve regeneration in rat model of nerve crush injury. Neurosci. Lett. [Internet]. 2010 Jul 5 [cited 2013 Dec 28];478(2):66–71. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20438804
    34. Ma J, Liu J, Wang Q, Yu H, Chen Y, Xiang L. The beneficial effect of ginsenoside Rg1 on Schwann cells subjected to hydrogen peroxide induced oxidative injury. Int. J. Biol. Sci. [Internet]. 2013 Jan [cited 2013 Dec 29];9(6):624–36. Available from: http://www.pubmedcentral.nih.gov/art...rtype=abstract
    35. Liang W, Ge S, Yang L, Yang M, Ye Z, Yan M, et al. Ginsenosides Rb1 and Rg1 promote proliferation and expression of neurotrophic factors in primary Schwann cell cultures. Brain Res. [Internet]. 2010 Oct 21 [cited 2013 Dec 29];1357:19–25. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20682297
    36. Talebi M, Andalib S, Bakhti S, Ayromlou H, Aghili A, Talebi A. Effect of vitamin b6 on clinical symptoms and electrodiagnostic results of patients with carpal tunnel syndrome. Adv. Pharm. Bull. [Internet]. 2013 Jan [cited 2013 Dec 28];3(2):283–8. Available from: http://www.pubmedcentral.nih.gov/art...rtype=abstract
    37. Jung H-S, Noh C-K, Ma S-H, Hong EK, Sohn N-W, Kim Y-B, et al. Effect of Dipsaci radix on hind limb muscle atrophy of sciatic nerve transected rats. Am. J. Chin. Med. [Internet]. 2009 Jan [cited 2013 Dec 29];37(6):1069–84. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19938217
    38. Wang Z, Zhang P, Kou Y, Yin X, Han N, Jiang B. Hedysari extract improves regeneration after peripheral nerve injury by enhancing the amplification effect. PLoS One [Internet]. 2013 Jan [cited 2013 Dec 29];8(7):e67921. Available from: http://www.pubmedcentral.nih.gov/art...rtype=abstract
    39. Wang ZY, Zhang PX, Han N, Kou YH, Yin XF, Jiang BG. Effect of Modified Formula Radix Hedysari on the Amplification Effect during Peripheral Nerve Regeneration. Evid. Based. Complement. Alternat. Med. [Internet]. 2013 Jan [cited 2013 Dec 29];2013:647982. Available from: http://www.pubmedcentral.nih.gov/art...rtype=abstract
    40. Wei S-Y, Zhang P-X, Han N, Dang Y, Zhang H-B, Zhang D-Y, et al. Effects of Hedysari polysaccharides on regeneration and function recovery following peripheral nerve injury in rats. Am. J. Chin. Med. [Internet]. 2009 Jan [cited 2013 Dec 29];37(1):57–67. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19222112
    41. Lai P-L, Naidu M, Sabaratnam V, Wong K-H, David RP, Kuppusamy UR, et al. Neurotrophic Properties of the Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. Int. J. Med. Mushrooms [Internet]. 2013 Jan [cited 2013 Dec 29];15(6):539–54. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24266378
    42. Mori K, Obara Y, Hirota M, Azumi Y, Kinugasa S, Inatomi S, et al. Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells. Biol. Pharm. Bull. [Internet]. 2008 Sep [cited 2013 Dec 29];31(9):1727–32. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18758067
    43. Wong K-H, Naidu M, David RP, Bakar R, Sabaratnam V. Neuroregenerative potential of lion’s mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (higher Basidiomycetes), in the treatment of peripheral nerve injury (review). Int. J. Med. Mushrooms [Internet]. 2012 Jan [cited 2013 Dec 29];14(5):427–46. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23510212
    44. Wong K-H, Naidu M, David P, Abdulla MA, Abdullah N, Kuppusamy UR, et al. Peripheral Nerve Regeneration Following Crush Injury to Rat Peroneal Nerve by Aqueous Extract of Medicinal Mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae). Evid. Based. Complement. Alternat. Med. [Internet]. 2011 Jan [cited 2013 Dec 16];2011:580752. Available from: http://www.pubmedcentral.nih.gov/art...rtype=abstract
    45. Kolotushkina E V, Moldavan MG, Voronin KY, Skibo GG. The influence of Hericium erinaceus extract on myelination process in vitro. Fiziol. Zh. [Internet]. 2003 Jan [cited 2013 Dec 29];49(1):38–45. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12675022
    46. Chang Y-M, Shih Y-T, Chen Y-S, Liu C-L, Fang W-K, Tsai C-H, et al. Schwann Cell Migration Induced by Earthworm Extract via Activation of PAs and MMP2/9 Mediated through ERK1/2 and p38. Evid. Based. Complement. Alternat. Med. [Internet]. 2011 Jan [cited 2013 Dec 29];2011:395458. Available from: http://www.pubmedcentral.nih.gov/art...rtype=abstract
    47. Chang Y-M, Chi W-Y, Lai T-Y, Chen Y-S, Tsai F-J, Tsai C-H, et al. Dilong: role in peripheral nerve regeneration. Evid. Based. Complement. Alternat. Med. [Internet]. 2011 Jan [cited 2013 Dec 29];2011:380809. Available from: http://www.pubmedcentral.nih.gov/art...rtype=abstract
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  4. Looking forward to giving this one a shot. Anything that helps keep me in the gym is worth buying in my opinion.

  5. Quote Originally Posted by Dewey99 View Post
    Looking forward to giving this one a shot. Anything that helps keep me in the gym is worth buying in my opinion.
    I'm ready for the full formula. I have gotten a pretty dramatic strength boost just from a rough beta.
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  6. Thats a work of art.

  7. Looking forward to this and all your other products coming out!

  8. Quote Originally Posted by jjobe6 View Post
    Looking forward to this and all your other products coming out!
    This one is definitely going to revolutionize, and deliver extremely pleasing results. I've been PMed so many times from customers sharing their stories/injuries with nothing but frustration for so many years.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  9. Can't wait to see some feedback, need a alternate solution to getting cortisone injections for my L5-S1 fking sciatic pain...
    Numbeness down the right leg especially numbing on the side of hamstrings and calf atrophy on the side,,,, in addition to drop foot syndrome.

    This would be a miracle pill if it helped treat my symptoms.

  10. Honestly (just being honest), based on experience with patients undergoing nerve cell regeneration, I would expect minimal physiological effect in this regard. There are drugs which share many of these mechanistic characteristics but fall short. Murine models routinely show nerve cell improvements without any carryover to humans. It's one reason we've had virtually no success in reversing neuronal injury, save for the periphery

    That said, I will be buying this product for my chronic back pain. Why? So many of the ingredients have mechanisms geared towards reducing neuropathic pain (reducing excess NMDA signaling, etc). It seems like a great analgesic for instances in which pain is present and can no longer be exacerbated (otherwise, you'd obviously want to feel the pain).

  11. Quote Originally Posted by mr.cooper69 View Post
    Honestly (just being honest), based on experience with patients undergoing nerve cell regeneration, I would expect minimal physiological effect in this regard. There are drugs which share many of these mechanistic characteristics but fall short. Murine models routinely show nerve cell improvements without any carryover to humans. It's one reason we've had virtually no success in reversing neuronal injury, save for the periphery

    That said, I will be buying this product for my chronic back pain. Why? So many of the ingredients have mechanisms geared towards reducing neuropathic pain (reducing excess NMDA signaling, etc). It seems like a great analgesic for instances in which pain is present and can no longer be exacerbated (otherwise, you'd obviously want to feel the pain).
    I was skeptical at the beginning of development, but my leg strength (and sciatic pain), numbness, and atrophy have started full reverse, and I have only been using a beta formula.

    Still, looking forward to hearing your feedback. It seems like 90% of the people I know suffer from some sort of nerve impingement.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  12. When and where can I buy it
    Athletic Xtreme Team REP
    http://www.AthleticX.net/
    AXHOLE BY NATURE

  13. Quote Originally Posted by flightposite View Post
    When and where can I buy it
    Should be done by the end of next week.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  14. I am having some nerve issues in my inguinal region related to a previous hernia surgery where i had a mesh patch implanted. The patch was later recalled by the fda due to issues with it causing people. I got it placed in 2004, currently i am out of the gym for 6-8 weeks with chronic discomfort in the area where the patch it. My surgeon after getting xrays, mri, and ct scan with dye said the patch has slightly shifted and the pain/discomfort i feel is related to a nerve in the area and my only real option is to have the nerve clipped.

    I wonder if this would be of use to me... Srs
    Hi-Tech Pharmaceuticals Representative

  15. can't wait to try it. ulnar nerve is ****ed on my right arm, hope to see improvement in any way
    "if there's one thing women love, it's a vascular man" - stewie griffin

  16. Gonna try this. I injured my lower trap where it meets the serratus and lower lat doing pull downs last year. The weight got away from me on the way up and seemed to tear the lat and shoulder out of place for a split second.

    Since then I have had nerve and muscle (it feels like) impingement. Pain is noticeable around the clock now, strength in right arm is decreased now as well and noticing my left side is growing more and always seems to have more pump when working out.

    Been to orthos and massage therapist. Done rehab type exercises all to no avail.

  17. Quote Originally Posted by tjbruno View Post
    can't wait to try it. ulnar nerve is ****ed on my right arm, hope to see improvement in any way
    Do you have difficulty abducting and adducting your digits in succession?

    Quote Originally Posted by chedapalooza View Post
    Gonna try this. I injured my lower trap where it meets the serratus and lower lat doing pull downs last year. The weight got away from me on the way up and seemed to tear the lat and shoulder out of place for a split second.

    Since then I have had nerve and muscle (it feels like) impingement. Pain is noticeable around the clock now, strength in right arm is decreased now as well and noticing my left side is growing more and always seems to have more pump when working out.

    Been to orthos and massage therapist. Done rehab type exercises all to no avail.
    Did you have an MRI done?

  18. Quote Originally Posted by mr.cooper69 View Post


    Did you have an MRI done?
    No, he just examined me and gave me a script for PT and some muscle relaxers and said it was a rotator cuff strain. I didnt have time for PT and dont like anything that depresses/subdues me. so All I did was rest a week or two and it went away for 4-5 months. Came back 2 months ago after I did some Facepulls. Definitely an impingement. The pain / stiffness goes up my neck and down to mid Back, sometimes around the the Pec/delt tie In

  19. If you've had pain this long, you should ask to get imaging done

  20. Quote Originally Posted by tjbruno View Post
    can't wait to try it. ulnar nerve is ****ed on my right arm, hope to see improvement in any way
    Had some impingement on my left arm from doing a lot of heavy pulling coming back from a short break from lifting, doing this exercise seemed to help get rid of it quickly https://www.youtube.com/watch?v=d85QKyWvrbI#t=150 . Was pretty worried when my left pinky/ring finger would stop gripping completely at random times.

    OT this looks pretty awesome. I was interested in trying some bulk Lion's Mane for the hell of it but might wait to try this out.

  21. Quote Originally Posted by mr.cooper69 View Post
    If you've had pain this long, you should ask to get imaging done
    Would def agree with that statement!
    Hi-Tech Pharmaceuticals Representative

  22. Quote Originally Posted by mr.cooper69 View Post
    Honestly (just being honest), based on experience with patients undergoing nerve cell regeneration, I would expect minimal physiological effect in this regard. There are drugs which share many of these mechanistic characteristics but fall short. Murine models routinely show nerve cell improvements without any carryover to humans. It's one reason we've had virtually no success in reversing neuronal injury, save for the periphery

    That said, I will be buying this product for my chronic back pain. Why? So many of the ingredients have mechanisms geared towards reducing neuropathic pain (reducing excess NMDA signaling, etc). It seems like a great analgesic for instances in which pain is present and can no longer be exacerbated (otherwise, you'd obviously want to feel the pain).
    I like when you spend time in the EvoMuse subforum. Please update the thread with your experience (when the product is released).

  23. Quote Originally Posted by domore View Post
    I like when you spend time in the EvoMuse subforum. Please update the thread with your experience (when the product is released).
    One of my favorite subforums because if how unique your products are. Any criticism is a sign of interest, as it don't even bother looking at 90% of the other subforums

  24. Quote Originally Posted by mr.cooper69 View Post
    One of my favorite subforums because if how unique your products are. Any criticism is a sign of interest, as it don't even bother looking at 90% of the other subforums
    We definitely appreciate the interest, and I am particularly a fan of educated conversation between Matt and you.
    EvoMuse
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