Nothing is more frustrating than an impinged or injured nerve. Signal reduction triggers a whole landslide of negative effects: Weakness, pain, atrophy. After time, these side effects seem like they will last forever - and sometimes do...until now. Enter Nerve Restore. Nerve Restore is a nerve signal amplifier. In people with impingement or nerve injuries it will help alleiviate discomfort, weakness, and muscular atrophy. The enhanced nerve amplitude and velocity, in healthy people as well, should result in increased strength and quicker reflexes/coordination.
[h=2]Key Terms to Know[/h]
Nerve Growth Factor (NGF)- A signaling protein crucial for growth, upkeep, and survival of nerves.
Brain Derived Neurotrophic Factor (BDNF)- A neurotrophin active in the brain and periphery, aiding in growth, survival and differentiation of neurons and synapses, and a key player in long term memory.
Neurotrophins- An umbrella of NGFs including BDNF, NT-3 and NT-4/5
Mean Nerve Conduction Velocity (MNCV)- How fast electrical signals move through a nerve.
Neuropathy (peripheral neuropathy)- A term used to describe a condition of damage, dysfunction or disease to nerves anywhere in the peripheral nervous system.
Myelin- A type of organic insulation surrounding nerve axons to protect them and increase MNCV, as well as prevent electrical current from escaping the axon.
Protein Kinase C (PKC)- A family of enzymes that control the function of other proteins through the act of phosphorylation.
Schwann Cells- Cells that provide raw materials for myelination
[h=2]Ingredients and Function[/h][h=2]4-Methylcatechol (4-MC)[/h]
Where does it come from?
Catechol is a natural compound found in various fruits and vegetables. 4-methylcatechol is a specific, bioavailable and well-researched form of catechol that provides some potent physiological effects. It's pretty much a super-nutrient for nerves, and a major player in the efficacy of Nerve Restore.
What does it do?
4-MC is widely recognized in research as a potent NGF stimulator. Research in this area tends to give animal models nerve disorders, then treat them with a given compound and see what happens vs. controls. Here's some highlights from the data on 4-MC.
Thermosensitivity is basically the sensory perception of temperature changes, which is often damaged in nerve dysfunction. 4-MC has been shown to promote reinnervation and normalization of thermosensitivity in neuropathy (1).
Diabetes often leads to neuropathy, which causes a significant reduction in MNCV, as well as the NGF content of nerves. Several studies have found a huge benefit and reversal of these symptoms with 4-MC administration. One study showed in increase in NGF of 140% over controls (2), multiple other studies have confirmed the de novo NGF synthesis capability of 4-MC while also demonstrating its ability to significantly increase myelination and nerve blood flow (3–6).
Several studies have given animal models a nerve toxin known as acrylamide monomer (ACR), and examined the potential protective effect of 4-MC. They found similar results as the previously mentioned studies, 4-MC was able to increase MNCV, NGF, and myelination, and researchers noted that it can "accelerate the recovery process clinically, electrophysiologically, biochemically and neuropathologically" (4,7).
Also noteworthy, 4-MC has been shown to promote regeneration of even unmyelinated nerves as well as relieve chronic pain and depression-like behavior in nerve injuries by boosting BDNF (8,9).
[h=2]Salidroside[/h]
Where does it come from?
Salidroside comes from the Rhodiola Rosea plant and is well known for its numerous health promoting properties.
What does it do?
Several studies have demonstrated salidroside's neuroprotective ability (10–13). Due to this effect, researchers wondered if salidroside might be able to help recovery from sciatic nerve injuries, so they tested it out. In rats with sciatic nerve crush injuries, they looked at several factors, including nerve conduction speed and walking tests. The results showed that salidroside was indeed able to successfully regenerate nerve function (14).
[h=2]Methylcobalamin[/h]
Where does it come from?
Methylcobalamin is simply the methyl form of Vitamin B12, a key vitamin involved with proper nerve function.
What does it do?
Another well-researched nutrient in the arena of nerve health, methylcobalamin is a no-brainer in this formula. It has been shown to do the following:
Ø Correct nerve damage done from oxidative damage and impaired neural signaling of PKC (15).
Ø Stimulate proteosynthesis in Schwann cells to facilitate neural regeneration (16,17).
Ø Enhance recovery of myelination, muscle action potentials and motor end plate innervation (17).
Ø Improve nerve regeneration and inhibit degeneration from neuronal damage such as crushed sciatic nerves (18–20).
[h=2]Key Terms to Know[/h]
Nerve Growth Factor (NGF)- A signaling protein crucial for growth, upkeep, and survival of nerves.
Brain Derived Neurotrophic Factor (BDNF)- A neurotrophin active in the brain and periphery, aiding in growth, survival and differentiation of neurons and synapses, and a key player in long term memory.
Neurotrophins- An umbrella of NGFs including BDNF, NT-3 and NT-4/5
Mean Nerve Conduction Velocity (MNCV)- How fast electrical signals move through a nerve.
Neuropathy (peripheral neuropathy)- A term used to describe a condition of damage, dysfunction or disease to nerves anywhere in the peripheral nervous system.
Myelin- A type of organic insulation surrounding nerve axons to protect them and increase MNCV, as well as prevent electrical current from escaping the axon.
Protein Kinase C (PKC)- A family of enzymes that control the function of other proteins through the act of phosphorylation.
Schwann Cells- Cells that provide raw materials for myelination
[h=2]Ingredients and Function[/h][h=2]4-Methylcatechol (4-MC)[/h]
Where does it come from?
Catechol is a natural compound found in various fruits and vegetables. 4-methylcatechol is a specific, bioavailable and well-researched form of catechol that provides some potent physiological effects. It's pretty much a super-nutrient for nerves, and a major player in the efficacy of Nerve Restore.
What does it do?
4-MC is widely recognized in research as a potent NGF stimulator. Research in this area tends to give animal models nerve disorders, then treat them with a given compound and see what happens vs. controls. Here's some highlights from the data on 4-MC.
Thermosensitivity is basically the sensory perception of temperature changes, which is often damaged in nerve dysfunction. 4-MC has been shown to promote reinnervation and normalization of thermosensitivity in neuropathy (1).
Diabetes often leads to neuropathy, which causes a significant reduction in MNCV, as well as the NGF content of nerves. Several studies have found a huge benefit and reversal of these symptoms with 4-MC administration. One study showed in increase in NGF of 140% over controls (2), multiple other studies have confirmed the de novo NGF synthesis capability of 4-MC while also demonstrating its ability to significantly increase myelination and nerve blood flow (3–6).
Several studies have given animal models a nerve toxin known as acrylamide monomer (ACR), and examined the potential protective effect of 4-MC. They found similar results as the previously mentioned studies, 4-MC was able to increase MNCV, NGF, and myelination, and researchers noted that it can "accelerate the recovery process clinically, electrophysiologically, biochemically and neuropathologically" (4,7).
Also noteworthy, 4-MC has been shown to promote regeneration of even unmyelinated nerves as well as relieve chronic pain and depression-like behavior in nerve injuries by boosting BDNF (8,9).
[h=2]Salidroside[/h]
Where does it come from?
Salidroside comes from the Rhodiola Rosea plant and is well known for its numerous health promoting properties.
What does it do?
Several studies have demonstrated salidroside's neuroprotective ability (10–13). Due to this effect, researchers wondered if salidroside might be able to help recovery from sciatic nerve injuries, so they tested it out. In rats with sciatic nerve crush injuries, they looked at several factors, including nerve conduction speed and walking tests. The results showed that salidroside was indeed able to successfully regenerate nerve function (14).
[h=2]Methylcobalamin[/h]
Where does it come from?
Methylcobalamin is simply the methyl form of Vitamin B12, a key vitamin involved with proper nerve function.
What does it do?
Another well-researched nutrient in the arena of nerve health, methylcobalamin is a no-brainer in this formula. It has been shown to do the following:
Ø Correct nerve damage done from oxidative damage and impaired neural signaling of PKC (15).
Ø Stimulate proteosynthesis in Schwann cells to facilitate neural regeneration (16,17).
Ø Enhance recovery of myelination, muscle action potentials and motor end plate innervation (17).
Ø Improve nerve regeneration and inhibit degeneration from neuronal damage such as crushed sciatic nerves (18–20).