[h=1]CardioTryx Write Up[/h]
We are thrilled to announce the release CardioTryx, a supplement that is truly the first of its kind. We like to call it a "Cardio Amplifier". If you are into endurance sports, MMA, are prepping for a contest or special life event and you want to maximize your cardiovascular training without spending hours on end, this is your product.
CardioTryx has been designed to do three main things:
1. Increase endurance
2. Reduce perception of work and pain
3. Shift the body's fuel substrate usage from carbohydrate to fat
These three things are accomplished by some very novel mechanisms; which are thoroughly explained in this write-up backed by 86 published studies.
We plan on this being an immediate must-have supplement for MMA fighters, Crossfitters, and really anyone that wants to squeeze dramatically more out of each minute they spend doing cardio or metabolic training.
CardioTryx is so potent, that we recommend you only use it once per day about 45 minutes before cardio or metabolic conditioning (a lot of this has to do with the significant boost to AMPk, explained below). Those of you doing two-a-day workouts might be able to get away with 1.5x the normal dose split up before each session, but this will require self-experimentation, as everyone will respond differently.
Each ingredient has been broken down for you, detailing what it is and why it was included in the formula. A ton of research went into this product, and we encourage you to spend some time reading through this so you can truly understand why we are so excited about bringing you this product.
[h=2]Platycodin d.[/h][h=3]Where does it come from?[/h]Platycodin d. is isolated from the roots of the Platycodon grandiflorum plant, found in East Asia.
[h=3]Performance or Fat Loss?[/h]Fat Loss
[h=3]Primary Effects[/h]AMPk Activation
Fat loss and fat gain are moderated by numerous complex mechanisms, and AMPk is a key player in this flux. Generally speaking, bolstering AMPk activation is great for fat loss, in the right amount. Platycodin d. has been shown in multiple studies to significantly inhibit fat gain and increase fat burning through AMPk activation. Downstream, this AMPk activation attenuates activation of SREBP-1 and fatty acid synthase (FAS), two hormones responsible for fat storage. This is done in a novel way by triggering SIRT1 and CaMMK-b (1–3).
Crank up AMPk too high for too long, and we run the risk of losing muscle. We want to get a nice warm crackling fire burning in the fireplace without setting the furniture ablaze. This is one of the reasons it is generally advised to stick to once per day dosing of CardioTryx, before exercise to get the maximum benefits without risking muscle loss from chronic AMPk activation.
PPAR-y and C/EBPa Modulation
Platycon d. has been shown to reduce abdominal and whole body fat accumulation in mice fed an obesogenic diet by targeting two important cellular fat storage proteins, PPAR-y and C/EBPa (2). Basically they gave mice Platycodon d., tried to make them fat, and couldn't do it.
Adipokine and Glucose Management
Another recent study trying to fatten up mice found that Platycodon d. was able to kick-start adiponectin (a fat burning adipokine) locally in fat cells while keeping it stable in serum compared to the placebo group. It was also able to suppress TNFa (an inflammatory cytokine) locally in fat cells. This resulted in reduced food intake and reduced fat accumulation while increasing glucose uptake in skeletal muscle (4). With regards to glucose, another study showed it was able to reduce blood sugar without stimulating insulin release, which is great for enhancing fat burning as well as long term health (5).
[h=2]Methyl Cinnamate[/h][h=3]Where does it come from?[/h]Methyl Cinnimate (MC) is an ester of cinnamic acid found in several plants and spices.
[h=3]Performance or Fat Loss?[/h]Fat Loss
[h=3]Primary Effects[/h]Like Platycodin d., MC interacts favorably with PPAR-y, SREBP-1, and C/EBPa, CaMMK2, and AMPk. However, MC targets pre-adipocytes, preventing potential fat cells from going down that pathway, thereby reducing the ability of the body to accumulate fat storage (6).
[h=2][/h][h=2]Rhodiola crenulata/rosea[/h][h=2](Standardized for 6% Salidroside content)[/h]
[h=3]Where does it come from?[/h]Rhodiola is a plant in the Crassulaceae family; various forms of it grow in cold regions all over the world.
[h=3]Performance or Fat Loss?[/h]Both
[h=3]Primary Effects[/h]The published beneficial effects of Rhodiola are nothing short of daunting in volume, the focus here will be on just the most exciting, primary reasons for inclusion in this formula.
[h=3]Performance[/h]EPO/Hematopoiesis Stimulation
Erythropoietin, or EPO, is a hormone responsible for stimulating blood cell production (a process known as hematopoiesis). Exogenous EPO has become infamous in recent years as a doping agent used in professional cycling due to its profound benefits on boosting cardiovascular performance. One of the star players in Rhodiola is a compound called Salidroside, which has been shown in multiple studies to boost EPO (7,8).
Lactate control, ROS scavenging, Muscle damage reduction, Anti-inflammation
A recent study out of Italy looked at the effect of Rhodiola supplementation in trained athletes, and found, among other things, that the supplemented group showed significantly lower levels of blood lactate and creatine kinase (a marker of muscle damage) after exhaustive exercise compared to placebo (9).
Rhodiola also cranks up superoxide dismutase (SOD), which is a crucial antioxidant in almost all cells of the body exposed to oxygen (10). The reduced damage from ROS allows the body to optimally recover from exercise and reduces muscle damage. Supporting the body's natural antioxidant system is the only way to go around exercise, as adding in most exogenous antioxidants can overload the already up-regulated system and actually delay recovery (11). Along these lines, salidroside has also been shown to be cardioprotective against oxidative stress and elevated homocysteine levels, even when subjects were given a potent cardiotoxic antitumor pharmaceutical drug (12,13).
One of the biggest obstacles to hurdle in hard training athletes is inflammation control. Some inflammation after exercise is necessary for proper adaptation, but those who tend to train hard and often will typically battle with controlling the balance between just enough inflammation, and chronic, performance crushing inflammation. Rhodiola/salidroside has been shown in multiple studies to help reduce excessive inflammation by targeting NF-kB, COX2, TNF-a, and the inflammatory interleukins (14,15).
Finally on the performance front, Salidroside potentially has another cool effect, it could turn out to be a great tool to help power through those rough cold weather workouts. A very recent study out of China showed Salidroside supplementation reduced mucus overproduction induced by cold stimulation (16).
[h=3]Fat Loss[/h]Appetite
Losing fat is tough to do when you get stressed out and fire down an entire bag of Oreos. Salidroside has been shown to modulate a stress response that can trigger binge eating. A recent study out of Italy basically mimicked what physique athletes often do, reduce calories and deprive themselves; then inevitably end up facing temptation. The Salidroside treated group was able to resist "highly palatable foods" and avoid binge eating (17).
Insulin Sensitivity, Fat Oxidation, AMPk activation, and more
Salidroside has been shown to activate AMPk, thereby enhancing glucose uptake and insulin sensitivity at the muscle cell, as well as the other previously mentioned benefits of turning up AMPk on fat loss (18).
In a 30-day study published in the Journal of Sports Medicine and Physical Fitness, researchers took 14 male athletes, made them do exhaustive cardio, and measured several blood markers with and without Rhodiola supplementation. They found that the same athletes exhibited significantly higher levels of fat oxidation after Rhodiola supplementation (9). Not only can Rhodiola help you burn more fat during exercise, it has also been shown to reduce fat accumulation when you're not exercising (10).
[h=2]Acacia Catechu[/h][h=3]Where does it come from?[/h]Found growing in various parts of China and India, Acacia Catechu is a tall thorny tree. It was selected for inclusion in CardioTryx as a source of epicatechin and EGCG.
[h=3]Performance or Fat Loss?[/h]Both.
[h=3]Primary Effects[/h][h=3]Performance[/h]Triggers building of new blood vessels and mitochondria, improves blood flow
Epicatechin does a bunch of cool things to improve performance. A 2013 study found supplementation for 30 days increased something called vascular endothelial growth factor (VEGF), which is a protein responsible for initiating the building of new blood vessels, particularly after exercise (19). The same study also demonstrated epicatechin's ability to improve skeletal muscle capillarity (simply put, improved blood flow due to less friction from the vessel walls). The authors also suggested it may stimulate mitochondrial proliferation, which is a wonderful thing for improving performance. Interestingly enough, the positive benefits were maintained a full 15 days after cessation of the supplement. Other studies have also demonstrated increased angiogenesis (at rest and during exercise, by 30% and 50% respectively) and reduced mean arterial pressure with epicatechin supplementation (20,21).
Another recent paper published in the Journal of Physiology also demonstrated the same beneficial effect on capillarity and mitochondrial volume. An interesting finding in this study was that epicatechin was able to do this in the absence of exercise, but even more so when combined with exercise, well above what exercise can do on its own (22). What did that relate to, with regards to exercise performance? Quite a bit. The supplemental group improved treadmill performance by 50%, and reduced fatigue by 30%.
The more capillaries you have per muscle fiber equates to more blood flow to the area doing work, faster clearance of metabolic byproducts, and plenty of beneficial downstream effects on performance and body composition. Cardio training (and metabolic training like Crossfit) has a profound effect on increasing the capillary:muscle (C:M) fiber ratio. Researchers at Wayne State University put 32 mice through intense exercise 5 times per week for 5 weeks, and measured the C:M ratio, which increased significantly from baseline. They then gave one group epicatechin, and another group just water. After 14 days, the epicatechin group was able to maintain the heightened C:M ratio.
Reduces inflammation, muscle damage, perception of work, and age related performance loss
Researchers know that if you want to induce muscle damage for testing purposes, one of the best ways to do that is with downhill running. Haramizu, et. al., tested this out on mice and found that the supplemented group had significantly lower muscle damage and they actually had an increased level of voluntary wheel running following the testing (23). This is highly relevant to those that train hard and want to get back at it the next day, I'm assuming these mice weren't training for any competitions, but they still wanted to go for another run after getting their butts kicked.
Another study looking at downhill running found that eight weeks of catechin ingestion "…attenuates the aging-associated loss of force production, oxidative stress, and inflammation in muscle after exercise" (24).
[h=3]Fat Loss[/h]Numerous studies have looked at the fat loss effects of epicatechin and EGCG, and it appears to be effective for this purpose by again attacking the C/EBP and PPAR-y angle, and even suppressing adipocyte differentiation (keeping preadipocytes from becoming fat cells) (25).
[h=2]Baicalin[/h][h=3]Where does it come from?[/h]Baicalin is a flavone found in the herb blue skullcap.
[h=3]Fat Loss or Performance?[/h]Both, with an emphasis on fat loss
[h=3]Primary Effects[/h][h=3]Performance[/h]Only one published paper to date has looked at the beneficial effects of Baicalin on exercise performance parameters. Researchers out of Taiwan aimed to find the root of the hypothalamic signaling melee leading to heatstroke during exercise, and suggested that baicalin might be effective at mitigating this process (26).
[h=3]Fat Loss[/h]Modulates AKt, CaMKKb, AMPk, ACC, C/EBP, FAS, KLF-2 & KLF-15
What does that alphabet soup mean for fat loss? Lots, actually. If you've been following along, several of those acronyms should already make sense. Baicalin is again going to downregulate PPAR-y and C/EBPs, which does so by suppressing Akt phosphorylation through inhibition of PDK1 (27,28). The net result of this, among other things, is going to be inhibiting fat accumulation by attenuating preadipocyte differentiation.
Baicalin is another AMPk activator, which does so through the favorable CaMMK pathway like Platycodin d. (29). Researchers in Shanghai conducted a profound study in mice fed a high fat diet (HFD) with or without baicalin supplementation (30). Keep in mind that mice don't normally eat a high fat diet, and their metabolic machinery is ill adapted to do so. After 16 weeks, the bicalin group saw the following effects:
Ø Suppression of body weight gain normally caused by the HFD
Ø Reduced visceral fat
Ø Decreased cholesterol
Ø Decreased circulating FFA's (a sign of increased fat oxidation)
Ø Decreased circulating insulin
Ø Reduced TNF-a (a potent inflammatory cytokine)
Ø Reduced liver fat gain
Ø Stimulation of AMPk and ACC
Ø Decreased SREBP-1c and FAS
This is a perfect storm for fat loss, which makes baicalin a potentially potent weapon in the fat loss game. Another study out of Korea supported the previously seen fat loss potential and concluded that baicalin upregulates anti-fat storage regulators (KLF-2) and downregulates pro-fat storing regulators (KLF-15) which results in an inhibition of cellular fat accumulation (28).
[h=2]Antrodia camphorata[/h][h=3]Where does it come from?[/h]Antrodia camphorata is a mushroom found growing in Taiwan.
[h=3]Performance or Fat Loss?[/h]Performance
[h=3]Primary Effects[/h]Little published data is available yet on the use of this compound for physical performance, but we hope to see more in the future as it appears to hold promise. In a recent university study, the researchers found some pretty impressive results (31). Here's the key bullet points:
Ø Increased exercise endurance
Ø Increased glycogen storage
Ø Decreased plasma lactate
Ø Decreased plasma ammonia
Ø Decreased creatine kinase (muscle breakdown byproduct)
Ø Increased grip strength
[h=2]Chitooligosaccharide[/h][h=3]Where does it come from?[/h]This is an oligosaccharide (a combination of several saccharides) derived from chitosan, which comes from treating crustacean shells with a special hydroxide.
[h=3]Performance or Fat Loss?[/h]Both, with an emphasis on performance
[h=3]Primary Effects[/h]Recent research has shown chitooligosaccharide can induce mitochondrial biogenesis, increase exercise endurance capacity, and act as an "exercise mimetic" (32). It appears to do these things through activation of Sirt1 and AMPk (which also make it a potentially viable fat burning compound), making it a great support nutrient to the other ingredients in CardioTryx targeting that also modulate these areas.
We are thrilled to announce the release CardioTryx, a supplement that is truly the first of its kind. We like to call it a "Cardio Amplifier". If you are into endurance sports, MMA, are prepping for a contest or special life event and you want to maximize your cardiovascular training without spending hours on end, this is your product.
CardioTryx has been designed to do three main things:
1. Increase endurance
2. Reduce perception of work and pain
3. Shift the body's fuel substrate usage from carbohydrate to fat
These three things are accomplished by some very novel mechanisms; which are thoroughly explained in this write-up backed by 86 published studies.
We plan on this being an immediate must-have supplement for MMA fighters, Crossfitters, and really anyone that wants to squeeze dramatically more out of each minute they spend doing cardio or metabolic training.
CardioTryx is so potent, that we recommend you only use it once per day about 45 minutes before cardio or metabolic conditioning (a lot of this has to do with the significant boost to AMPk, explained below). Those of you doing two-a-day workouts might be able to get away with 1.5x the normal dose split up before each session, but this will require self-experimentation, as everyone will respond differently.
Each ingredient has been broken down for you, detailing what it is and why it was included in the formula. A ton of research went into this product, and we encourage you to spend some time reading through this so you can truly understand why we are so excited about bringing you this product.
[h=2]Platycodin d.[/h][h=3]Where does it come from?[/h]Platycodin d. is isolated from the roots of the Platycodon grandiflorum plant, found in East Asia.
[h=3]Performance or Fat Loss?[/h]Fat Loss
[h=3]Primary Effects[/h]AMPk Activation
Fat loss and fat gain are moderated by numerous complex mechanisms, and AMPk is a key player in this flux. Generally speaking, bolstering AMPk activation is great for fat loss, in the right amount. Platycodin d. has been shown in multiple studies to significantly inhibit fat gain and increase fat burning through AMPk activation. Downstream, this AMPk activation attenuates activation of SREBP-1 and fatty acid synthase (FAS), two hormones responsible for fat storage. This is done in a novel way by triggering SIRT1 and CaMMK-b (1–3).
Crank up AMPk too high for too long, and we run the risk of losing muscle. We want to get a nice warm crackling fire burning in the fireplace without setting the furniture ablaze. This is one of the reasons it is generally advised to stick to once per day dosing of CardioTryx, before exercise to get the maximum benefits without risking muscle loss from chronic AMPk activation.
PPAR-y and C/EBPa Modulation
Platycon d. has been shown to reduce abdominal and whole body fat accumulation in mice fed an obesogenic diet by targeting two important cellular fat storage proteins, PPAR-y and C/EBPa (2). Basically they gave mice Platycodon d., tried to make them fat, and couldn't do it.
Adipokine and Glucose Management
Another recent study trying to fatten up mice found that Platycodon d. was able to kick-start adiponectin (a fat burning adipokine) locally in fat cells while keeping it stable in serum compared to the placebo group. It was also able to suppress TNFa (an inflammatory cytokine) locally in fat cells. This resulted in reduced food intake and reduced fat accumulation while increasing glucose uptake in skeletal muscle (4). With regards to glucose, another study showed it was able to reduce blood sugar without stimulating insulin release, which is great for enhancing fat burning as well as long term health (5).
[h=2]Methyl Cinnamate[/h][h=3]Where does it come from?[/h]Methyl Cinnimate (MC) is an ester of cinnamic acid found in several plants and spices.
[h=3]Performance or Fat Loss?[/h]Fat Loss
[h=3]Primary Effects[/h]Like Platycodin d., MC interacts favorably with PPAR-y, SREBP-1, and C/EBPa, CaMMK2, and AMPk. However, MC targets pre-adipocytes, preventing potential fat cells from going down that pathway, thereby reducing the ability of the body to accumulate fat storage (6).
[h=2][/h][h=2]Rhodiola crenulata/rosea[/h][h=2](Standardized for 6% Salidroside content)[/h]
[h=3]Where does it come from?[/h]Rhodiola is a plant in the Crassulaceae family; various forms of it grow in cold regions all over the world.
[h=3]Performance or Fat Loss?[/h]Both
[h=3]Primary Effects[/h]The published beneficial effects of Rhodiola are nothing short of daunting in volume, the focus here will be on just the most exciting, primary reasons for inclusion in this formula.
[h=3]Performance[/h]EPO/Hematopoiesis Stimulation
Erythropoietin, or EPO, is a hormone responsible for stimulating blood cell production (a process known as hematopoiesis). Exogenous EPO has become infamous in recent years as a doping agent used in professional cycling due to its profound benefits on boosting cardiovascular performance. One of the star players in Rhodiola is a compound called Salidroside, which has been shown in multiple studies to boost EPO (7,8).
Lactate control, ROS scavenging, Muscle damage reduction, Anti-inflammation
A recent study out of Italy looked at the effect of Rhodiola supplementation in trained athletes, and found, among other things, that the supplemented group showed significantly lower levels of blood lactate and creatine kinase (a marker of muscle damage) after exhaustive exercise compared to placebo (9).
Rhodiola also cranks up superoxide dismutase (SOD), which is a crucial antioxidant in almost all cells of the body exposed to oxygen (10). The reduced damage from ROS allows the body to optimally recover from exercise and reduces muscle damage. Supporting the body's natural antioxidant system is the only way to go around exercise, as adding in most exogenous antioxidants can overload the already up-regulated system and actually delay recovery (11). Along these lines, salidroside has also been shown to be cardioprotective against oxidative stress and elevated homocysteine levels, even when subjects were given a potent cardiotoxic antitumor pharmaceutical drug (12,13).
One of the biggest obstacles to hurdle in hard training athletes is inflammation control. Some inflammation after exercise is necessary for proper adaptation, but those who tend to train hard and often will typically battle with controlling the balance between just enough inflammation, and chronic, performance crushing inflammation. Rhodiola/salidroside has been shown in multiple studies to help reduce excessive inflammation by targeting NF-kB, COX2, TNF-a, and the inflammatory interleukins (14,15).
Finally on the performance front, Salidroside potentially has another cool effect, it could turn out to be a great tool to help power through those rough cold weather workouts. A very recent study out of China showed Salidroside supplementation reduced mucus overproduction induced by cold stimulation (16).
[h=3]Fat Loss[/h]Appetite
Losing fat is tough to do when you get stressed out and fire down an entire bag of Oreos. Salidroside has been shown to modulate a stress response that can trigger binge eating. A recent study out of Italy basically mimicked what physique athletes often do, reduce calories and deprive themselves; then inevitably end up facing temptation. The Salidroside treated group was able to resist "highly palatable foods" and avoid binge eating (17).
Insulin Sensitivity, Fat Oxidation, AMPk activation, and more
Salidroside has been shown to activate AMPk, thereby enhancing glucose uptake and insulin sensitivity at the muscle cell, as well as the other previously mentioned benefits of turning up AMPk on fat loss (18).
In a 30-day study published in the Journal of Sports Medicine and Physical Fitness, researchers took 14 male athletes, made them do exhaustive cardio, and measured several blood markers with and without Rhodiola supplementation. They found that the same athletes exhibited significantly higher levels of fat oxidation after Rhodiola supplementation (9). Not only can Rhodiola help you burn more fat during exercise, it has also been shown to reduce fat accumulation when you're not exercising (10).
[h=2]Acacia Catechu[/h][h=3]Where does it come from?[/h]Found growing in various parts of China and India, Acacia Catechu is a tall thorny tree. It was selected for inclusion in CardioTryx as a source of epicatechin and EGCG.
[h=3]Performance or Fat Loss?[/h]Both.
[h=3]Primary Effects[/h][h=3]Performance[/h]Triggers building of new blood vessels and mitochondria, improves blood flow
Epicatechin does a bunch of cool things to improve performance. A 2013 study found supplementation for 30 days increased something called vascular endothelial growth factor (VEGF), which is a protein responsible for initiating the building of new blood vessels, particularly after exercise (19). The same study also demonstrated epicatechin's ability to improve skeletal muscle capillarity (simply put, improved blood flow due to less friction from the vessel walls). The authors also suggested it may stimulate mitochondrial proliferation, which is a wonderful thing for improving performance. Interestingly enough, the positive benefits were maintained a full 15 days after cessation of the supplement. Other studies have also demonstrated increased angiogenesis (at rest and during exercise, by 30% and 50% respectively) and reduced mean arterial pressure with epicatechin supplementation (20,21).
Another recent paper published in the Journal of Physiology also demonstrated the same beneficial effect on capillarity and mitochondrial volume. An interesting finding in this study was that epicatechin was able to do this in the absence of exercise, but even more so when combined with exercise, well above what exercise can do on its own (22). What did that relate to, with regards to exercise performance? Quite a bit. The supplemental group improved treadmill performance by 50%, and reduced fatigue by 30%.
The more capillaries you have per muscle fiber equates to more blood flow to the area doing work, faster clearance of metabolic byproducts, and plenty of beneficial downstream effects on performance and body composition. Cardio training (and metabolic training like Crossfit) has a profound effect on increasing the capillary:muscle (C:M) fiber ratio. Researchers at Wayne State University put 32 mice through intense exercise 5 times per week for 5 weeks, and measured the C:M ratio, which increased significantly from baseline. They then gave one group epicatechin, and another group just water. After 14 days, the epicatechin group was able to maintain the heightened C:M ratio.
Reduces inflammation, muscle damage, perception of work, and age related performance loss
Researchers know that if you want to induce muscle damage for testing purposes, one of the best ways to do that is with downhill running. Haramizu, et. al., tested this out on mice and found that the supplemented group had significantly lower muscle damage and they actually had an increased level of voluntary wheel running following the testing (23). This is highly relevant to those that train hard and want to get back at it the next day, I'm assuming these mice weren't training for any competitions, but they still wanted to go for another run after getting their butts kicked.
Another study looking at downhill running found that eight weeks of catechin ingestion "…attenuates the aging-associated loss of force production, oxidative stress, and inflammation in muscle after exercise" (24).
[h=3]Fat Loss[/h]Numerous studies have looked at the fat loss effects of epicatechin and EGCG, and it appears to be effective for this purpose by again attacking the C/EBP and PPAR-y angle, and even suppressing adipocyte differentiation (keeping preadipocytes from becoming fat cells) (25).
[h=2]Baicalin[/h][h=3]Where does it come from?[/h]Baicalin is a flavone found in the herb blue skullcap.
[h=3]Fat Loss or Performance?[/h]Both, with an emphasis on fat loss
[h=3]Primary Effects[/h][h=3]Performance[/h]Only one published paper to date has looked at the beneficial effects of Baicalin on exercise performance parameters. Researchers out of Taiwan aimed to find the root of the hypothalamic signaling melee leading to heatstroke during exercise, and suggested that baicalin might be effective at mitigating this process (26).
[h=3]Fat Loss[/h]Modulates AKt, CaMKKb, AMPk, ACC, C/EBP, FAS, KLF-2 & KLF-15
What does that alphabet soup mean for fat loss? Lots, actually. If you've been following along, several of those acronyms should already make sense. Baicalin is again going to downregulate PPAR-y and C/EBPs, which does so by suppressing Akt phosphorylation through inhibition of PDK1 (27,28). The net result of this, among other things, is going to be inhibiting fat accumulation by attenuating preadipocyte differentiation.
Baicalin is another AMPk activator, which does so through the favorable CaMMK pathway like Platycodin d. (29). Researchers in Shanghai conducted a profound study in mice fed a high fat diet (HFD) with or without baicalin supplementation (30). Keep in mind that mice don't normally eat a high fat diet, and their metabolic machinery is ill adapted to do so. After 16 weeks, the bicalin group saw the following effects:
Ø Suppression of body weight gain normally caused by the HFD
Ø Reduced visceral fat
Ø Decreased cholesterol
Ø Decreased circulating FFA's (a sign of increased fat oxidation)
Ø Decreased circulating insulin
Ø Reduced TNF-a (a potent inflammatory cytokine)
Ø Reduced liver fat gain
Ø Stimulation of AMPk and ACC
Ø Decreased SREBP-1c and FAS
This is a perfect storm for fat loss, which makes baicalin a potentially potent weapon in the fat loss game. Another study out of Korea supported the previously seen fat loss potential and concluded that baicalin upregulates anti-fat storage regulators (KLF-2) and downregulates pro-fat storing regulators (KLF-15) which results in an inhibition of cellular fat accumulation (28).
[h=2]Antrodia camphorata[/h][h=3]Where does it come from?[/h]Antrodia camphorata is a mushroom found growing in Taiwan.
[h=3]Performance or Fat Loss?[/h]Performance
[h=3]Primary Effects[/h]Little published data is available yet on the use of this compound for physical performance, but we hope to see more in the future as it appears to hold promise. In a recent university study, the researchers found some pretty impressive results (31). Here's the key bullet points:
Ø Increased exercise endurance
Ø Increased glycogen storage
Ø Decreased plasma lactate
Ø Decreased plasma ammonia
Ø Decreased creatine kinase (muscle breakdown byproduct)
Ø Increased grip strength
[h=2]Chitooligosaccharide[/h][h=3]Where does it come from?[/h]This is an oligosaccharide (a combination of several saccharides) derived from chitosan, which comes from treating crustacean shells with a special hydroxide.
[h=3]Performance or Fat Loss?[/h]Both, with an emphasis on performance
[h=3]Primary Effects[/h]Recent research has shown chitooligosaccharide can induce mitochondrial biogenesis, increase exercise endurance capacity, and act as an "exercise mimetic" (32). It appears to do these things through activation of Sirt1 and AMPk (which also make it a potentially viable fat burning compound), making it a great support nutrient to the other ingredients in CardioTryx targeting that also modulate these areas.