EvoMuse Virile Mane Enhanced

Page 5 of 12 First ... 34567 ... Last

  1. Quote Originally Posted by dsade View Post
    Impressive!
    Same goes for your ingredient list. Actually, I have to say I was very impressed! Was worried about the NGF after first Googling at first but it's pro-NGF (or a mix of both) which would be bad. Not seeing anything about 4-methylcatechol inducing pro-NGF when Googling so yeah, that's a nice looking ingredient, and a novel angle as well for a commercial hair loss product.

    I recall Aconiti Ciliare Tuber Extract being an ingredient which was planned. Is that still going to be part of the formula?


  2. Quote Originally Posted by CF2 View Post
    Same goes for your ingredient list. Actually, I have to say I was very impressed! Was worried about the NGF after first Googling at first but it's pro-NGF (or a mix of both) which would be bad. Not seeing anything about 4-methylcatechol inducing pro-NGF when Googling so yeah, that's a nice looking ingredient, and a novel angle as well for a commercial hair loss product.

    I recall Aconiti Ciliare Tuber Extract being an ingredient which was planned. Is that still going to be part of the formula?
    Still in there...I was going to post that study on Monday.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless
    •   
       


  3. http://www.ncbi.nlm.nih.gov/m/pubmed/19915488

    Effects of 4-methylcatechol on skin reinnervation: promotion of cutaneous nerve regeneration after crush injury.
    J. Neuropathol. Exp. Neurol. 2009 (12):1269-81
    Yu-Lin Hsieh, Whei-Min Lin, June-Horng Lue, Ming-Fong Chang, Sung-Tsang Hsieh

    We assessed the effects of treatment with 4-methylcatechol (4MC), a known inducer of nerve growth factor, on peripheral nerve regeneration by analyzing cutaneous and muscular reinnervation in mice after sciatic nerve crush injury. At 3 months postinjury, the skin innervation index was significantly higher in the 4MC group than the control group (p=0.0002); there was also increased unmyelinated fiber density (p=0.0042) and unmyelinated fibers/Remak bundle (p = 0.001) in sural nerves, indicating unmyelinated nerve fiber regeneration. These changes were accompanied by increases of transcripts for nerve growth factor (p = 0.0026) and glial cell line-derived neurotrophic factor (p=0.03) in the 4MC group. In contrast, muscle innervation indices were similar in both groups and were higher than the skin innervation index (p < 0.0001). The regeneration of myelinated nerve fibers, as assessed by fiber density, diameter and g ratio analyses in sural nerves, and amplitudes of muscle action potential in sciatic nerves, was similar in both groups. Taken together, these data suggest that 4MC specifically promoted the regeneration of unmyelinated nerve fibers and reinnervation of the skin by increasing the expression of nerve growth factor and glial cell line-derived neurotrophic factor.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  4. Might as well post it now...

    Life Sci. 2012 Nov 2;91(19-20):935-43. doi: 10.1016/j.lfs.2012.09.008. Epub 2012 Sep 21.
    Hair growth-promoting effect of Aconiti Ciliare Tuber extract mediated by the activation of Wnt/β-catenin signaling.
    Park PJ, Moon BS, Lee SH, Kim SN, Kim AR, Kim HJ, Park WS, Choi KY, Cho EG, Lee TR.
    Author information
    Abstract
    AIMS:

    The activation of Wnt/β-catenin signaling pathway plays an important role in hair follicle morphogenesis by stimulating bulge stem cells. This study was to obtain the activator of Wnt/β-catenin signaling pathway from natural products and to determine whether this activator can induce anagen hair growth in mice.
    MAIN METHODS:

    To identify materials that activate Wnt/β-catenin signaling pathway, 800 natural product extracts were screened using pTOPFlash assay and neural progenitor cell (NPC) differentiation assay. A selected extract was further tested for its effects on alkaline phosphatase (ALP) activity in human immortalized dermal papilla cell (iDPC) and the proliferation in iDPC and immortalized rat vibrissa DPC (RvDP). Finally, hair growth-promoting effects were evaluated in the dorsal skin of C57BL/6 mice.
    KEY FINDINGS:

    Aconiti Ciliare Tuber (ACT) extract was one of the most active materials in both pTOPFlash and NPC differentiation assays. It promoted the differentiation of NPC cells even under proliferation-stimulating conditions (basic fibroblast growth factor: bFGF). It also increased ALP activity and proliferation of iDPC in dose-dependent manners, and it stimulated the induction of the anagen hair growth in C57BL/6 mice. These results suggest that ACT extract activates the Wnt/β-catenin signaling pathway by enhancing β-catenin transcription and has the potential to promote the induction of hair growth via activation of the stem cell activity of the dermal papilla cells.
    SIGNIFICANCE:

    This is the first report indicating benefits of ACT extract in hair loss prevention by triggering the activation of Wnt/β-catenin signaling pathway and induction of the anagen hair growth in mice.

    Copyright 2012 Elsevier Inc. All rights reserved.

    PMID:
    23000887
    [PubMed - indexed for MEDLINE]
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  5. Obviously no Heparin...

    Panminerva Med. 2011 Sep;53(3 Suppl 1):51-5.
    Aescin: microcirculatory activity. Effects of accessory components on clinical and microcirculatory efficacy.
    Luzzi R, Feragalli B, Belcaro G, Cesarone MR, Cornelli U, Dugall M, Hosoi M.
    Author information
    Abstract
    AIM:

    This study was performed to test the hypothesis that the heparin and phosphatidylcholine (PDC) included in Aescin gel formulations had the main role of allowing a better penetration of Aescin without important pharmacodynamic effects. Heparin and PDC should be considered as "enhancers". They do not have - at the dosage used - a specific or independent action. An open, registry study of patients - a group with chronic venous insufficiency (CVI) and a group of patients with diabetic microangiopathy were completed.
    METHODS:

    In patients with CVI and in patients with diabetic microangiopathy, we used a commercial gel preparation containing Aescin, PDC and heparin (group A). The first group of patients used the full complex. The second group used the complex without PDC (group B) and the third (group C) used the complex without heparin.
    RESULTS:

    In both studies the different groups of patients were comparable. In CVI patients (mean age 44.5; SD 2.4; range 40-50) venous microangiopathy was present at the perimalleolar region. Aescin produced comparable microcirculatory results with and without the two other components. Transcutaneus PO2 [TcPO2] increased in all groups. Transcutaneus PCO2 (TcCO2) decreases. The increased Laser Doppler Flux (LDF) (typical of CVI) decreased towards normality. The local Plasma Free Radicals [PFR] levels decreased as the result of better skin perfusion (P<0.05). Comparable data were observed in subjects with diabetic microangiopathy (mean age 46.5; SD 3.1). In these patients the compound was applied at the dorsum of the foot. TcPO2 increased with treatment. TcPCO2, skin flux and PFR decreased towards normal levels (P<0.05).
    CONCLUSION:

    In conclusion Aescin improves the microcirculation and PFR. Heparin and PDC - included in the gel - have an ancillary role. An improved perfusion and nutrition of the skin was observed both in diabetic and venous microangiopathy. This may possibly contribute in the reduction of the incidence of ulceration associated with diabetic and venous microangiopathy. Aescin-based products may be included in a more complex management plan, including several systemic and local treatments.

    PMID:
    22108477
    [PubMed - indexed for MEDLINE]
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless
    •   
       


  6. http://genesdev.cshlp.org/content/20/10/1353.short

    and

    J Cancer Res Clin Oncol. 2012 May;138(5):785-97. doi: 10.1007/s00432-012-1152-z. Epub 2012 Jan 24.
    Escin augments the efficacy of gemcitabine through down-regulation of nuclear factor-κB and nuclear factor-κB-regulated gene products in pancreatic cancer both in vitro and in vivo.
    Wang YW, Wang SJ, Zhou YN, Pan SH, Sun B.
    Author information
    Abstract
    PURPOSE:

    Pancreatic cancer is an aggressive malignancy, which generally develops resistance to chemotherapy. Agents that are safe and can sensitize cancer to chemotherapy are urgently needed. Escin, a natural mixture of triterpene saponins isolated from Aesculus wilsonii Rehd, has been demonstrated to possess anti-cancer activity both in vitro and in vivo. The anti-cancer activity of escin could be, in part, due to the inactivation of nuclear factor-κB (NF-κB). In contrast, chemotherapy including gemcitabine could activate NF-κB and lead to chemoresistance. Here, for the first time, we investigated whether escin, via the inactivation of NF-κB, would potentiate the antitumor activity of gemcitabine in pancreatic cancer.
    METHODS:

    Cell viability and proliferation, apoptosis, NF-κB activity and the expression of NF-κB-linked genes were all examined in vitro. The antitumor effect of escin with or without gemcitabine in pancreatic cancer was also assessed using BxPC-3 xenografts subcutaneously established in BALB/c nude mice.
    RESULTS:

    Escin not only potentiated the proliferation-inhibiting and apoptosis-inducing effect of gemcitabine in both BxPC-3 and PANC-1 cell lines in vitro, but also dramatically enhanced its suppressive effect on tumor growth in nude mice. The mechanism is at least partially due to the inhibition of NF-κB activity and consequent inhibition of c-Myc, COX-2, Cyclin D1, Survivin, Bcl-2 and Bcl-xL, and the activation of caspase-3.
    CONCLUSION:

    These data suggest that escin, via inactivation of NF-κB, could potentiate the efficacy of gemcitabine in combating pancreatic cancer, which could be a novel and potentially important therapeutic approach for the treatment for pancreatic cancer.

    PMID:
    22270965
    [PubMed - indexed for MEDLINE]
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  7. Eta?
    Black Lion Representative
    I'm a Brooklyn boy I may take some gettin' use to

  8. Quote Originally Posted by halfhuman View Post
    Eta?
    Next week, but only direct sales until we get final packaging done.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  9. Quote Originally Posted by dsade View Post
    Next week, but only direct sales until we get final packaging done.
    I want in :-)
    Black Lion Representative
    I'm a Brooklyn boy I may take some gettin' use to

  10. Where can we get this and nerve restore Dsade? I've been looking all over
    Athletic Xtreme Team REP
    http://www.AthleticX.net/
    AXHOLE BY NATURE

  11. Me too, take my money

  12. Is the website up?

  13. Quote Originally Posted by BigGame84
    Is the website up?
    X2.
    Athletic Xtreme Team REP
    http://www.AthleticX.net/
    AXHOLE BY NATURE

  14. Quote Originally Posted by dsade View Post
    Next week, but only direct sales until we get final packaging done.
    I'm in,I will be waiting for payment details via direct sale.

  15. Trying to get the website up...but the server is fried.

    I'll probably have to reopen the Facebook store for this.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  16. Quote Originally Posted by dsade View Post
    Trying to get the website up...but the server is fried. I'll probably have to reopen the Facebook store for this.
    I don't have FB :-( can I direct buy from Paypal
    Black Lion Representative
    I'm a Brooklyn boy I may take some gettin' use to

  17. Quote Originally Posted by dsade
    Trying to get the website up...but the server is fried.

    I'll probably have to reopen the Facebook store for this.
    Awesome Dsade
    Please keep us updated on when you do.
    Athletic Xtreme Team REP
    http://www.AthleticX.net/
    AXHOLE BY NATURE

  18. Looking forward to this one !

  19. Dsade, could you tell us why using Raspberry ketones in the original viril mane was not a good choice? Sorry if it has already been explained but I can't find the answer. Thanks.

  20. Definitely keen to buy some of this!

  21. Quote Originally Posted by Rostam View Post
    Dsade, could you tell us why using Raspberry ketones in the original viril mane was not a good choice? Sorry if it has already been explained but I can't find the answer. Thanks.
    For a dude with a pic of He-Man in his avatar,this is a lame question.

    Quote Originally Posted by dsade View Post
    I already covered TRPV1 activation in the original formula. The problem is that you can over or under activate it.

    in the new version we hit that perfect balance.
    Here's your answer from 3 pages back in this thread.

    Actually,that is a lame question for *anyone* to ask.

    Kindly do not chip away at D Sade's time with such questions.Doing so will leave him with less time to get his new products out.

    You foolish bastard.Do you want to make us all bald?

    hehe.

  22. Quote Originally Posted by Colin View Post
    For a dude with a pic of He-Man in his avatar,this is a lame question. Here's your answer from 3 pages back in this thread. Actually,that is a lame question for *anyone* to ask. Kindly do not chip away at D Sade's time with such questions.Doing so will leave him with less time to get his new products out. You foolish bastard.Do you want to make us all bald? hehe.
    Oh really? Well when he released the original version as long as I remember he was saying that he was using the exact same dosage that was used in the study he was mentioning at that time. So it was under or over activated in that study?

    And I have to say the foolish bastard is probably you if you think a topical solution (that in few years we will hear again it was under or over activating) will save any of your hair you better start shaving your hair already.

  23. By the way what does under or over activation mean? Does it mean it will not work enough or work so well you'll look like a gorilla? Hehe.. Yeah I know it's probably another lame question specially from a he-man avatar.

  24. Quote Originally Posted by Rostam View Post
    By the way what does under or over activation mean? Does it mean it will not work enough or work so well you'll look like a gorilla? Hehe.. Yeah I know it's probably another lame question specially from a he-man avatar.
    I'm far from an expert on this, but I believe I can help answer this question. There is a study* which shows capsaicin could be used to reduce unwanted hair growth, which in the context of trying to regrow hair would be an overactivation of TRPV1. Underactivation would be using so little that no effects are seen.

    My limited understanding is that a TRPV1 agonist is believed to work by increasing IGF-1, which is one of the effects of Sophora Flavescens. I see no TRPV1 agonists posted in the ingredient list so far, perhaps dsade decided to just go after the IGF-1 angle with the Sophora Flavescens?

    *Cannot post link, study name is: A Hot New Twist to Hair Biology - Involvement of Vanilloid Receptor-1 (VR1/TRPV1) Signaling in Human Hair Growth Control

  25. Just ordered a bottle
  •   

      
     

Similar Forum Threads

  1. RPN's Virile Mane... Finally!
    By Steveoph in forum Nutraplanet
    Replies: 23
    Last Post: 11-14-2008, 05:53 PM
Log in
Log in