EvoMuse Virile Mane Enhanced

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  1. Oh you're still accepting applicants? Ill send ya a pic.
    "No citizen has a right to be an amateur in the matter of physical training...what a disgrace it is for a man to grow old without ever seeing the beauty and strength of which his body is capable." - Socrates


  2. Not sure if it qualifies, since it's not MPB, it's an autoimmune disease, but tossing my name in the hat.



    This is usually just the beginning, I wish I still had photos of it when it was really bad. Bald spots about 4 inches in diameter.
    "No citizen has a right to be an amateur in the matter of physical training...what a disgrace it is for a man to grow old without ever seeing the beauty and strength of which his body is capable." - Socrates
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  3. Still around.....waiting....lol

  4. I would love to try this out.

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    Hope its not too late. But I wasn't sure how to attach pics in a pm.

  5. I'll be mixing these up this week.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless
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  6. I shave my head so would that keep me out of the trial?
    Attached Images Attached Images  

  7. i know i just joined but ive been trying to find a solution to my hair problem & would love to try it out. Im 20, healthy, ive began to recede and thin in my temples & would like to give this a try & am willing to stick to it and do a complete log of everything. let me know and ill send you a pic of my head.

  8. Any news on this?
    Black Lion Representative
    I'm a Brooklyn boy I may take some gettin' use to

  9. Quote Originally Posted by halfhuman View Post
    Any news on this?
    Betas will be available on Tuesday. They will be $20.
    EvoMuse

  10. Quote Originally Posted by domore View Post
    Betas will be available on Tuesday. They will be $20.
    Awesome! Remind us lol.
    Black Lion Representative
    I'm a Brooklyn boy I may take some gettin' use to

  11. Thanks to the shutdown, the last ingredient I was waiting for is stuck in customs.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  12. Quote Originally Posted by dsade View Post
    Thanks to the shutdown, the last ingredient I was waiting for is stuck in customs.
    Damn that sucks
    Black Lion Representative
    I'm a Brooklyn boy I may take some gettin' use to

  13. Quote Originally Posted by halfhuman View Post
    Damn that sucks
    It's an important one, too....this is the ONLY study you are getting for now.

    Life Sci. 2012 Nov 2;91(19-20):935-43. doi: 10.1016/j.lfs.2012.09.008. Epub 2012 Sep 21.
    Hair growth-promoting effect of Aconiti Ciliare Tuber extract mediated by the activation of Wnt/β-catenin signaling.
    Park PJ, Moon BS, Lee SH, Kim SN, Kim AR, Kim HJ, Park WS, Choi KY, Cho EG, Lee TR.
    Source

    Bioscience Research Institute, AmorePacific Corporation R&D Center, 314-1, Bora-dong, Giheung-gu, Yongin 446-729, Republic of Korea.
    Abstract
    AIMS:

    The activation of Wnt/β-catenin signaling pathway plays an important role in hair follicle morphogenesis by stimulating bulge stem cells. This study was to obtain the activator of Wnt/β-catenin signaling pathway from natural products and to determine whether this activator can induce anagen hair growth in mice.
    MAIN METHODS:

    To identify materials that activate Wnt/β-catenin signaling pathway, 800 natural product extracts were screened using pTOPFlash assay and neural progenitor cell (NPC) differentiation assay. A selected extract was further tested for its effects on alkaline phosphatase (ALP) activity in human immortalized dermal papilla cell (iDPC) and the proliferation in iDPC and immortalized rat vibrissa DPC (RvDP). Finally, hair growth-promoting effects were evaluated in the dorsal skin of C57BL/6 mice.
    KEY FINDINGS:

    Aconiti Ciliare Tuber (ACT) extract was one of the most active materials in both pTOPFlash and NPC differentiation assays. It promoted the differentiation of NPC cells even under proliferation-stimulating conditions (basic fibroblast growth factor: bFGF). It also increased ALP activity and proliferation of iDPC in dose-dependent manners, and it stimulated the induction of the anagen hair growth in C57BL/6 mice. These results suggest that ACT extract activates the Wnt/β-catenin signaling pathway by enhancing β-catenin transcription and has the potential to promote the induction of hair growth via activation of the stem cell activity of the dermal papilla cells.
    SIGNIFICANCE:

    This is the first report indicating benefits of ACT extract in hair loss prevention by triggering the activation of Wnt/β-catenin signaling pathway and induction of the anagen hair growth in mice.

    Copyright © 2012 Elsevier Inc. All rights reserved.

    PMID:
    23000887
    [PubMed - indexed for MEDLINE]
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  14. ^^ hopefully you will see what "stem cell activation" means for this product, especially as compared to version 1.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  15. Nice study and very promising. Can't wait for the release.
    Black Lion Representative
    I'm a Brooklyn boy I may take some gettin' use to

  16. Quote Originally Posted by halfhuman View Post
    Nice study and very promising. Can't wait for the release.
    The rest of the formula only gets better.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  17. Quote Originally Posted by dsade View Post
    The rest of the formula only gets better.
    I believe you. I love your products. Looking forward to it
    Black Lion Representative
    I'm a Brooklyn boy I may take some gettin' use to

  18. Quote Originally Posted by dsade View Post
    Thanks to the shutdown, the last ingredient I was waiting for is stuck in customs.
    Damn. That's no bueno.

  19. Quote Originally Posted by dsade View Post
    I have been watching the research VERY closely since the original. The original ended up being more effective at slowing/preventing loss in most users, though quite a few reports of excellent growth.

    I used the wrong TRPV1 agonist, IMO, and found a better one for the new version, as well as quite a few new angles.
    A Hot New Twist to Hair Biology
    Involvement of Vanilloid Receptor-1 (VR1/TRPV1) Signaling in Human Hair Growth Control

    Enikő Bodó, Tamás Bíró, [...], and Ralf Paus

    The vanilloid receptor-1 (VR1, or transient receptor potential vanilloid-1 receptor, TRPV1) is activated by capsaicin, the key ingredient of hot peppers. TRPV1 was originally described on sensory neurons as a central integrator of various nociceptive stimuli. However, several human skin cell populations are also now recognized to express TRPV1, but with unknown function. Exploiting the human hair follicle (HF) as a prototypic epithelial-mesenchymal interaction system, we have characterized the HF expression of TRPV1 in situ and have examined TRPV1 signaling in organ-cultured human scalp HF and outer root sheath (ORS) keratinocytes in vitro. TRPV1 immunoreactivity was confined to distinct epithelial compartments of the human HF, mainly to the ORS and hair matrix. In organ culture, TRPV1 activation by capsaicin resulted in a dose-dependent and TRPV1-specific inhibition of hair shaft elongation, suppression of proliferation, induction of apoptosis, premature HF regression (catagen), and up-regulation of intrafollicular transforming growth factor-β2. Cultured human ORS keratinocytes also expressed functional TRPV1, whose stimulation inhibited proliferation, induced apoptosis, elevated intracellular calcium concentration, up-regulated known endogenous hair growth inhibitors (interleukin-1β, transforming growth factor-β2), and down-regulated known hair growth promoters (hepatocyte growth factor, insulin-like growth factor-I, stem cell factor). These findings strongly support TRPV1 as a significant novel player in human hair growth control, underscore the physiological importance of TRPV1 in human skin beyond nociception, and identify TRPV1 as a promising, novel target for pharmacological manipulations of epithelial growth disorders.

    ----------------------------------------------------------------------------------------------------------------------------------------------------------

    TRPV1 antagonist, PAC-14028, can accelerate hair growth in vivo

    JA Seo, I-H Bae, MY Park, K-W Lee, Y-H Park and K-M Lim Medical Beauty Research Institute, AmorePacific Corporation R&D Center, Yongin, Republic of Korea

    Transient receptor potential vanilloid type 1 (TRPV1) is a cation channel activated by diverse noxious stimuli like capsaicin, low pH, or heat. TRPV1 is expressed not only in peripheral sensory nerve fibers (C and Aδ) but also in the skin epidermal cells, including hair follicle. Recently, it was revealed that TRPV1 might be associated with hair growth control. Here we aimed to investigate if the blockade of TRPV1 might affect hair growth, by employing a new TRPV1 antagonist, PAC-14028. The effect of PAC-14028 on hair growth was evaluated in vivo using an anagen induction and a catagen induction model in C57BL/6 mice. In macroscopic evaluation, PAC-14028 accelerated the onset of anagen hair cycle (14 days after treatment) compared to vehicle (27–28 days after treatment). Mice treated with 1% PAC-14028 showed significantly increased hair weight in a dose-dependent manner (101.25±16.51 and 56.81±10.58 mg for PAC-14028 1% and vehicle control, respectively). In the catagen induction model, the 1% PAC-14028-treated group showed darker skin as determined by a skin chromameter, which was comparable to 2% minoxidil. In addition, 1% PAC-14028 increased the skin thickness, confirming the delay of catagen induction. These results demonstrate that TRPV1 antagonist could be useful for hair growth based on anagen elongation and induction in vivo.

  20. I already covered TRPV1 activation in the original formula. The problem is that you can over or under activate it.

    in the new version we hit that perfect balance.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  21. Okay, that's cool. There is the "Administration of capsaicin and isoflavone promotes hair growth by increasing insulin-like growth factor-I production in mice and in humans with alopecia" study which shows positive effects from the application of capsaicin. And unlike the RK study that study had a placebo group.

    Of course, you may be using an entirely different TRPV1 agonist, so I don't want to make assumptions here. Regardless, definitely looking forward to the launch and ultimately the ingredient release. Was very impressed Aconiti Ciliare Tuber extract will be part of the formula.

  22. You sound like you have looked into this. You're going to love the final formula.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  23. Hi,

    Just a couple questions:

    1) Is the Virile Mane Enhanced close to being ready for sale?

    2) Does it have a 5 ar inhibitor?

  24. Quote Originally Posted by CF1 View Post
    Hi,

    Just a couple questions:

    1) Is the Virile Mane Enhanced close to being ready for sale?

    2) Does it have a 5 ar inhibitor?
    Yes and yes
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  25. Updates?

  26. Bump for update
    Black Lion Representative
    I'm a Brooklyn boy I may take some gettin' use to

  27. I know im new here so sorry but bump for updates. My hair is going way to fast at 28 and the only thing that ever worked was Virile Mane.

  28. Give me 2 more weeks. The FDA seized my last ingredient, but I have replacement on the way.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  29. Quote Originally Posted by dsade View Post
    Give me 2 more weeks. The FDA seized my last ingredient, but I have replacement on the way.
    I'm guessing this will make its first appearance at NutraPlanet?

  30. Quote Originally Posted by gtlifter32 View Post
    I'm guessing this will make its first appearance at NutraPlanet?
    We'll probably go direct from the website first.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless
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