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EvoMuse Virile Mane Enhanced

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  1. CF1
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    Okay, that's cool. There is the "Administration of capsaicin and isoflavone promotes hair growth by increasing insulin-like growth factor-I production in mice and in humans with alopecia" study which shows positive effects from the application of capsaicin. And unlike the RK study that study had a placebo group.

    Of course, you may be using an entirely different TRPV1 agonist, so I don't want to make assumptions here. Regardless, definitely looking forward to the launch and ultimately the ingredient release. Was very impressed Aconiti Ciliare Tuber extract will be part of the formula.

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    You sound like you have looked into this. You're going to love the final formula.
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    Hi,

    Just a couple questions:

    1) Is the Virile Mane Enhanced close to being ready for sale?

    2) Does it have a 5 ar inhibitor?
    •   
       

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    Quote Originally Posted by CF1 View Post
    Hi,

    Just a couple questions:

    1) Is the Virile Mane Enhanced close to being ready for sale?

    2) Does it have a 5 ar inhibitor?
    Yes and yes
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    Updates?
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    Bump for update
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    I know im new here so sorry but bump for updates. My hair is going way to fast at 28 and the only thing that ever worked was Virile Mane.
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    Give me 2 more weeks. The FDA seized my last ingredient, but I have replacement on the way.
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    Quote Originally Posted by dsade View Post
    Give me 2 more weeks. The FDA seized my last ingredient, but I have replacement on the way.
    I'm guessing this will make its first appearance at NutraPlanet?
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    Quote Originally Posted by gtlifter32 View Post
    I'm guessing this will make its first appearance at NutraPlanet?
    We'll probably go direct from the website first.
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    Exp Dermatol. 2011 Dec;20(12):1015-7. doi: 10.1111/j.1600-0625.2011.01353.x. Epub 2011 Sep 22.
    Effects of topical application of EGCG on testosterone-induced hair loss in a mouse model.
    Kim YY, Up No S, Kim MH, Kim HS, Kang H, Kim HO, Park YM.
    Abstract

    We investigated the effect of topical epigallocatechin-3-gallate (EGCG) on testosterone (T)-induced hair loss in mice. Marked hair loss was observed at the T-injected site, and topical EGCG significantly reduced the hair loss (P < 0.05). TUNEL staining showed apoptosis of follicular epithelial cells in the T-injected groups where topical EGCG was found to significantly diminish T-induced apoptosis (P < 0.05). Topical EGCG down-regulated the T-induced expression of androgen receptor but did not down-regulate 17β-hydroxysteroid dehydrogenase (HSD) and three β-HSD expression. Analysis using liquid chromatography tandem mass spectrometry (LC-MS/MS) on serum and tissue samples revealed no significant difference in T and dihydrotestosterone concentrations between the T-injected and T + EGCG groups. Thus, we found that T injection in a mouse model induces hair loss by apoptosis of the hair follicles rather than through the androgen metabolic pathway and also saw that T-induced apoptosis of hair follicles was reduced by topical EGCG.

    © 2011 John Wiley & Sons A/S.

    PMID:
    21951062
    [PubMed - indexed for MEDLINE]
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    Int J Mol Sci. 2012;13(5):6407-23. doi: 10.3390/ijms13056407. Epub 2012 May 23.
    Effect of Dieckol, a Component of Ecklonia cava, on the Promotion of Hair Growth.
    Kang JI, Kim SC, Kim MK, Boo HJ, Jeon YJ, Koh YS, Yoo ES, Kang SM, Kang HK.
    Author information
    Abstract

    This study was conducted to evaluate the effect of Ecklonia cava, a marine alga native to Jeju Island in Korea, on the promotion of hair growth. When vibrissa follicles were cultured in the presence of E. cava enzymatic extract (which contains more than 35% of dieckol) for 21 days, E. cava enzymatic extract increased hair-fiber length. In addition, after topical application of the 0.5% E. cava enzymatic extract onto the back of C57BL/6 mice, anagen progression of the hair-shaft was induced. The treatment with E. cava enzymatic extract resulted in the proliferation of immortalized vibrissa dermal papilla cells (DPC). Especially, dieckol, among the isolated compounds from the E. cava enzymatic extract, showed activity that increased the proliferation of DPC. When NIH3T3 fibroblasts were treated with the E. cava enzymatic extract and the isolated compounds from the E. cava enzymatic extract, the E. cava enzymatic extract increased the proliferation of NIH3T3 fibroblasts, but the isolated compounds such as eckol, dieckol, phloroglucinol and triphlorethol-A did not affect the proliferation of NIH3T3 fibroblasts. On the other hand, the E. cava enzymatic extract and dieckol significantly inhibited 5α-reductase activity. These results suggest that dieckol from E. cava can stimulate hair growth by the proliferation of DPC and/or the inhibition of 5α-reductase activity.
    KEYWORDS:

    5α-reductase activity, C57BL/6 mice, Ecklonia cava, dermal papilla cells, dieckol, hair growth, vibrissa follicle

    PMID:
    22754373
    [PubMed]
    PMCID:
    PMC3382810

    Free PMC Article
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    Big Matt, dropping science bombs.

    Will definitely be using this to see what the impact is on my somewhat thinning crown.
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    Clin Interv Aging. 2012;7:351-61. doi: 10.2147/CIA.S34034. Epub 2012 Sep 13.
    Modulating testosterone pathway: a new strategy to tackle male skin aging?
    Bernard P, Scior T, Do QT.
    Author information
    Abstract

    In men, the level of testosterone decreases with age. At the skin level, the result is observed as a decrease in density and in a lower elasticity. Identifying compounds that are able to increase the level of testosterone appears to be an attractive strategy to develop new antiaging bioactive ingredients for men. Reverse pharmacognosy was successfully applied to identify new natural compounds able to modulate testosterone levels. Among several in silico hits, honokiol was retained as a candidate as it has the greatest potential to become an active ingredient. This result was then validated in vitro on aromatase and 5-alpha-reductase type 1 and 2, which are two types of enzymes implicated in the degradation of free testosterone. Indeed, honokiol was identified as an inhibitor of aromatase, with a half-maximal inhibitory concentration (IC(50)) of about 50 μM. In addition, honokiol was shown to be an inhibitor of 5-alpha-reductase type 1, with an IC(50) of about 75 μM. Taken together, these data indicate that honokiol modulates testosterone levels, and its structure has the potential to serve as a lead for future designs of highly selective inhibitors of 5-alpha-reductase type 1.
    KEYWORDS:

    dermopharmacy, honokiol, man cosmetics, reverse pharmacognosy, testosterone

    PMID:
    23049247
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC3459575

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    J Dermatol Sci. 2002 Oct;30(1):43-9.
    The hair growth promoting effect of Sophora flavescens extract and its molecular regulation.
    Roh SS, Kim CD, Lee MH, Hwang SL, Rang MJ, Yoon YK.
    Author information
    Abstract

    In search of natural extracts for hair growth, we found that the extract of dried root of Sophora flavescens has outstanding hair growth promoting effect. After topical application of Sophora flavescens extract onto the back of C57BL/6 mice, the earlier conversion of telogen-to-anagen was induced. The growth of dermal papilla cells cultured in vitro, however, was not affected by Sophora flavescens extract treatment. RT-PCR analysis showed that Sophora flavescens extract induced mRNA levels of growth factors such as IGF-1 and KGF in dermal papilla cells, suggesting that the effects of Sophora flavescens extract on hair growth may be mediated through the regulation of growth factors in dermal papilla cells. In addition, the Sophora flavescens extract revealed to possess potent inhibitory effect on the type II 5alpha-reductase activity. Taken together, these results suggest that Sophora flavescens extract has hair growth promoting potential and can be used for hair growing products.

    PMID:
    12354419
    [PubMed - indexed for MEDLINE]
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    Phytother Res. 2013 Sep;27(9):1352-7. doi: 10.1002/ptr.4870. Epub 2012 Nov 12.
    Hair growth activity of Crataegus pinnatifida on C57BL/6 mouse model.
    Shin HS, Lee JM, Park SY, Yang JE, Kim JH, Yi TH.
    Author information
    Abstract

    Crataegus pinnatifida has a long history of use in traditional oriental herbal medicine to stimulating digestion and improving blood circulation. Based on nutrition of hair, the present study was conducted to assess the effect of C. pinnatifida extract on hair growth using mouse model and its mechanisms of action. The C. pinnatifida extract containing the contents of total polyphenol of 5.88□0.82 g gallic acid/100 g extract and proanthocyanidin of 9.15□1.58 mg cyaniding chloride/100 g extract was orally administered daily at a dosage of 50 mg/kg weight to the 7-week-old C57BL/6 mice in telogen. The C. pinnatifida extract promoted hair growth by inducing anagen phase in mice in telogen, reflected by color of skin, thickness of hair shaft, and density of hair. The ratio of anagento telogen was determined by shape of hair follicles in vertically sectioned slide and increased by oral administration of C. pinnatifida extract. The number and the size of hair follicles were also enlarged, indicating anagen phase induction. The proliferation of human dermal papilla cells (hDPC) was accelerated by addition of C. pinnatifida extract, which activated the signaling of mitogen-activated protein kinases (Erk, p-38, and JNK) and Akt. Moreover, the ratio of Bcl-2/Bax as the determinant of cell fate was also raised in skin. These results suggest that the C. pinnatifida extract promotes hair growth by inducing anagen phase, which might be mediated by the activation of cellular signalings that enhance the survival of cultured hDPC and the increase of the ratio of Bcl-2 to Bax that protects cells against cell death.

    Copyright © 2012 John Wiley & Sons, Ltd.
    KEYWORDS:

    Crataegus pinnatifida, hair growth, mitogen-activated protein kinases, procyanidin

    PMID:
    23148028
    [PubMed - in process]
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    Let's play "guess the ingredient"!

    J Dermatol. 2006 Dec;33(12):833-41.
    Dynamic changes in nerve growth factor and substance P in the murine hair cycle induced by depilation.
    Zhou Z, Kawana S, Aoki E, Katayama M, Nagano M, Suzuki H.
    Author information
    Abstract
    Increasing evidence suggests that various neurotrophins and neuropeptides play an important role in the progression of hair follicle cycling. Among them, nerve growth factor (NGF) and substance P (SP) have attracted special interest recently. However, the interaction between these factors during hair cycling has not yet been systematically studied. We therefore investigated the mutual relationships between NGF and SP and the mechanism by which the anagen stage of the hair cycle is initiated. Fluctuations in numbers of SP-positive nerve fibers and variations in amounts of SP, NGF, and another neurotrophic factor, glial cell-derived neurotrophic factor, in skin in the C57BL/6 mouse depilation-induced hair cycle model, together with the spatiotemporal expression patterns of each of these factors, were followed simultaneously by enzyme-linked immunosorbent assay and immunohistochemistry. The main finding was that a surge in NGF expression and a rapid increase in NGF content in skin is an initial event within 1 day after depilation, followed by elevation of SP content and numbers of SP-containing fibers 2 days after the increase in NGF. Our findings suggest that a rapid and abundant increase in NGF plays a key role in the induction and progression of anagen hair cycling through keratinocyte growth promotion. NGF may also induce plastic changes such as sprouting and hyperplasia in dermal nerve fibers and enhance their SP production. Elevated levels of SP in skin may additionally contribute to the progression of consecutive anagen hair cycles.

    PMID:
    17169085
    [PubMed - indexed for MEDLINE]
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    Carried over from version 1.

    1. Br J Dermatol. 2002 Jan;146(1):41-51.
    Procyanidin B-2, extracted from apples, promotes hair growth: a laboratory study.
    Kamimura A, Takahashi T.

    Tsukuba Research Laboratories, Kyowa Hakko Kogyo Co., 2, Miyukigaoka, Tsukuba, Ibaraki 305-0841, Japan. ayako.kamimura@kyowa.co.jp
    Abstract
    BACKGROUND:

    We have previously reported that several selective protein kinase C (PKC) inhibitors, including procyanidin B-2, promote hair epithelial cell growth and stimulate anagen induction.
    OBJECTIVES:

    We discuss the hypothesis that the hair-growing activity of procyanidin B-2 is related to its downregulation or inhibition of translocation of PKC isozymes in hair epithelial cells.
    METHODS:

    We examined the effect of procyanidin B-2 on the expression of PKC isozymes in cultured murine hair epithelial cells as well as PKC isozyme localization in murine dorsal skin at different stages in the hair cycle.
    RESULTS:

    We observed that procyanidin B-2 reduces the expression of PKC-alpha, -betaI, -betaII and -eta in cultured murine hair epithelial cells and also inhibits the translocation of these isozymes to the particulate fraction of hair epithelial cells. Our immunohistochemical analyses demonstrated that PKC-alpha, -betaI, -betaII and -eta are specifically expressed in the outer root sheaths of both anagen and telogen hair follicles. The hair matrix at the anagen stage showed no positive staining for these PKC isozymes. Moderate to intense staining for PKC-betaI and -betaII in the epidermis and hair follicles was observed in a telogen-specific manner; however, expression of PKC-alpha and -eta during the telogen stage was not conspicuous. Gö 6976, an inhibitor of calcium-dependent (conventional) PKC, proved to promote hair epithelial cell growth.
    CONCLUSIONS:

    These results suggest that PKC isozymes, especially PKC-betaI and -betaII, play an important role in hair cycle progression and that the hair-growing mechanisms of procyanidin B-2 are at least partially related to its downregulation of PKC isozymes or its inhibition of translocation of PKC isozymes to the particulate fraction of hair epithelial cells.
    PMID: 11841365 [PubMed - indexed for MEDLINE]
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    Quote Originally Posted by dsade View Post
    Let's play "guess the ingredient"!

    J Dermatol. 2006 Dec;33(12):833-41.
    Dynamic changes in nerve growth factor and substance P in the murine hair cycle induced by depilation.
    Zhou Z, Kawana S, Aoki E, Katayama M, Nagano M, Suzuki H.
    Author information
    Abstract
    Increasing evidence suggests that various neurotrophins and neuropeptides play an important role in the progression of hair follicle cycling. Among them, nerve growth factor (NGF) and substance P (SP) have attracted special interest recently. However, the interaction between these factors during hair cycling has not yet been systematically studied. We therefore investigated the mutual relationships between NGF and SP and the mechanism by which the anagen stage of the hair cycle is initiated. Fluctuations in numbers of SP-positive nerve fibers and variations in amounts of SP, NGF, and another neurotrophic factor, glial cell-derived neurotrophic factor, in skin in the C57BL/6 mouse depilation-induced hair cycle model, together with the spatiotemporal expression patterns of each of these factors, were followed simultaneously by enzyme-linked immunosorbent assay and immunohistochemistry. The main finding was that a surge in NGF expression and a rapid increase in NGF content in skin is an initial event within 1 day after depilation, followed by elevation of SP content and numbers of SP-containing fibers 2 days after the increase in NGF. Our findings suggest that a rapid and abundant increase in NGF plays a key role in the induction and progression of anagen hair cycling through keratinocyte growth promotion. NGF may also induce plastic changes such as sprouting and hyperplasia in dermal nerve fibers and enhance their SP production. Elevated levels of SP in skin may additionally contribute to the progression of consecutive anagen hair cycles.

    PMID:
    17169085
    [PubMed - indexed for MEDLINE]
    I guess 4-methylcatechol, since it's in Nerve Restore.
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    Quote Originally Posted by CF2 View Post
    I guess 4-methylcatechol, since it's in Nerve Restore.
    Impressive!
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    Quote Originally Posted by dsade View Post
    Impressive!
    Same goes for your ingredient list. Actually, I have to say I was very impressed! Was worried about the NGF after first Googling at first but it's pro-NGF (or a mix of both) which would be bad. Not seeing anything about 4-methylcatechol inducing pro-NGF when Googling so yeah, that's a nice looking ingredient, and a novel angle as well for a commercial hair loss product.

    I recall Aconiti Ciliare Tuber Extract being an ingredient which was planned. Is that still going to be part of the formula?
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    Quote Originally Posted by CF2 View Post
    Same goes for your ingredient list. Actually, I have to say I was very impressed! Was worried about the NGF after first Googling at first but it's pro-NGF (or a mix of both) which would be bad. Not seeing anything about 4-methylcatechol inducing pro-NGF when Googling so yeah, that's a nice looking ingredient, and a novel angle as well for a commercial hair loss product.

    I recall Aconiti Ciliare Tuber Extract being an ingredient which was planned. Is that still going to be part of the formula?
    Still in there...I was going to post that study on Monday.
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    http://www.ncbi.nlm.nih.gov/m/pubmed/19915488

    Effects of 4-methylcatechol on skin reinnervation: promotion of cutaneous nerve regeneration after crush injury.
    J. Neuropathol. Exp. Neurol. 2009 (12):1269-81
    Yu-Lin Hsieh, Whei-Min Lin, June-Horng Lue, Ming-Fong Chang, Sung-Tsang Hsieh

    We assessed the effects of treatment with 4-methylcatechol (4MC), a known inducer of nerve growth factor, on peripheral nerve regeneration by analyzing cutaneous and muscular reinnervation in mice after sciatic nerve crush injury. At 3 months postinjury, the skin innervation index was significantly higher in the 4MC group than the control group (p=0.0002); there was also increased unmyelinated fiber density (p=0.0042) and unmyelinated fibers/Remak bundle (p = 0.001) in sural nerves, indicating unmyelinated nerve fiber regeneration. These changes were accompanied by increases of transcripts for nerve growth factor (p = 0.0026) and glial cell line-derived neurotrophic factor (p=0.03) in the 4MC group. In contrast, muscle innervation indices were similar in both groups and were higher than the skin innervation index (p < 0.0001). The regeneration of myelinated nerve fibers, as assessed by fiber density, diameter and g ratio analyses in sural nerves, and amplitudes of muscle action potential in sciatic nerves, was similar in both groups. Taken together, these data suggest that 4MC specifically promoted the regeneration of unmyelinated nerve fibers and reinnervation of the skin by increasing the expression of nerve growth factor and glial cell line-derived neurotrophic factor.
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    Might as well post it now...

    Life Sci. 2012 Nov 2;91(19-20):935-43. doi: 10.1016/j.lfs.2012.09.008. Epub 2012 Sep 21.
    Hair growth-promoting effect of Aconiti Ciliare Tuber extract mediated by the activation of Wnt/β-catenin signaling.
    Park PJ, Moon BS, Lee SH, Kim SN, Kim AR, Kim HJ, Park WS, Choi KY, Cho EG, Lee TR.
    Author information
    Abstract
    AIMS:

    The activation of Wnt/β-catenin signaling pathway plays an important role in hair follicle morphogenesis by stimulating bulge stem cells. This study was to obtain the activator of Wnt/β-catenin signaling pathway from natural products and to determine whether this activator can induce anagen hair growth in mice.
    MAIN METHODS:

    To identify materials that activate Wnt/β-catenin signaling pathway, 800 natural product extracts were screened using pTOPFlash assay and neural progenitor cell (NPC) differentiation assay. A selected extract was further tested for its effects on alkaline phosphatase (ALP) activity in human immortalized dermal papilla cell (iDPC) and the proliferation in iDPC and immortalized rat vibrissa DPC (RvDP). Finally, hair growth-promoting effects were evaluated in the dorsal skin of C57BL/6 mice.
    KEY FINDINGS:

    Aconiti Ciliare Tuber (ACT) extract was one of the most active materials in both pTOPFlash and NPC differentiation assays. It promoted the differentiation of NPC cells even under proliferation-stimulating conditions (basic fibroblast growth factor: bFGF). It also increased ALP activity and proliferation of iDPC in dose-dependent manners, and it stimulated the induction of the anagen hair growth in C57BL/6 mice. These results suggest that ACT extract activates the Wnt/β-catenin signaling pathway by enhancing β-catenin transcription and has the potential to promote the induction of hair growth via activation of the stem cell activity of the dermal papilla cells.
    SIGNIFICANCE:

    This is the first report indicating benefits of ACT extract in hair loss prevention by triggering the activation of Wnt/β-catenin signaling pathway and induction of the anagen hair growth in mice.

    Copyright © 2012 Elsevier Inc. All rights reserved.

    PMID:
    23000887
    [PubMed - indexed for MEDLINE]
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    Obviously no Heparin...

    Panminerva Med. 2011 Sep;53(3 Suppl 1):51-5.
    Aescin: microcirculatory activity. Effects of accessory components on clinical and microcirculatory efficacy.
    Luzzi R, Feragalli B, Belcaro G, Cesarone MR, Cornelli U, Dugall M, Hosoi M.
    Author information
    Abstract
    AIM:

    This study was performed to test the hypothesis that the heparin and phosphatidylcholine (PDC) included in Aescin gel formulations had the main role of allowing a better penetration of Aescin without important pharmacodynamic effects. Heparin and PDC should be considered as "enhancers". They do not have - at the dosage used - a specific or independent action. An open, registry study of patients - a group with chronic venous insufficiency (CVI) and a group of patients with diabetic microangiopathy were completed.
    METHODS:

    In patients with CVI and in patients with diabetic microangiopathy, we used a commercial gel preparation containing Aescin, PDC and heparin (group A). The first group of patients used the full complex. The second group used the complex without PDC (group B) and the third (group C) used the complex without heparin.
    RESULTS:

    In both studies the different groups of patients were comparable. In CVI patients (mean age 44.5; SD 2.4; range 40-50) venous microangiopathy was present at the perimalleolar region. Aescin produced comparable microcirculatory results with and without the two other components. Transcutaneus PO2 [TcPO2] increased in all groups. Transcutaneus PCO2 (TcCO2) decreases. The increased Laser Doppler Flux (LDF) (typical of CVI) decreased towards normality. The local Plasma Free Radicals [PFR] levels decreased as the result of better skin perfusion (P<0.05). Comparable data were observed in subjects with diabetic microangiopathy (mean age 46.5; SD 3.1). In these patients the compound was applied at the dorsum of the foot. TcPO2 increased with treatment. TcPCO2, skin flux and PFR decreased towards normal levels (P<0.05).
    CONCLUSION:

    In conclusion Aescin improves the microcirculation and PFR. Heparin and PDC - included in the gel - have an ancillary role. An improved perfusion and nutrition of the skin was observed both in diabetic and venous microangiopathy. This may possibly contribute in the reduction of the incidence of ulceration associated with diabetic and venous microangiopathy. Aescin-based products may be included in a more complex management plan, including several systemic and local treatments.

    PMID:
    22108477
    [PubMed - indexed for MEDLINE]
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    http://genesdev.cshlp.org/content/20/10/1353.short

    and

    J Cancer Res Clin Oncol. 2012 May;138(5):785-97. doi: 10.1007/s00432-012-1152-z. Epub 2012 Jan 24.
    Escin augments the efficacy of gemcitabine through down-regulation of nuclear factor-κB and nuclear factor-κB-regulated gene products in pancreatic cancer both in vitro and in vivo.
    Wang YW, Wang SJ, Zhou YN, Pan SH, Sun B.
    Author information
    Abstract
    PURPOSE:

    Pancreatic cancer is an aggressive malignancy, which generally develops resistance to chemotherapy. Agents that are safe and can sensitize cancer to chemotherapy are urgently needed. Escin, a natural mixture of triterpene saponins isolated from Aesculus wilsonii Rehd, has been demonstrated to possess anti-cancer activity both in vitro and in vivo. The anti-cancer activity of escin could be, in part, due to the inactivation of nuclear factor-κB (NF-κB). In contrast, chemotherapy including gemcitabine could activate NF-κB and lead to chemoresistance. Here, for the first time, we investigated whether escin, via the inactivation of NF-κB, would potentiate the antitumor activity of gemcitabine in pancreatic cancer.
    METHODS:

    Cell viability and proliferation, apoptosis, NF-κB activity and the expression of NF-κB-linked genes were all examined in vitro. The antitumor effect of escin with or without gemcitabine in pancreatic cancer was also assessed using BxPC-3 xenografts subcutaneously established in BALB/c nude mice.
    RESULTS:

    Escin not only potentiated the proliferation-inhibiting and apoptosis-inducing effect of gemcitabine in both BxPC-3 and PANC-1 cell lines in vitro, but also dramatically enhanced its suppressive effect on tumor growth in nude mice. The mechanism is at least partially due to the inhibition of NF-κB activity and consequent inhibition of c-Myc, COX-2, Cyclin D1, Survivin, Bcl-2 and Bcl-xL, and the activation of caspase-3.
    CONCLUSION:

    These data suggest that escin, via inactivation of NF-κB, could potentiate the efficacy of gemcitabine in combating pancreatic cancer, which could be a novel and potentially important therapeutic approach for the treatment for pancreatic cancer.

    PMID:
    22270965
    [PubMed - indexed for MEDLINE]
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    Eta?
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    Quote Originally Posted by halfhuman View Post
    Eta?
    Next week, but only direct sales until we get final packaging done.
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    Quote Originally Posted by dsade View Post
    Next week, but only direct sales until we get final packaging done.
    I want in :-)
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    Where can we get this and nerve restore Dsade? I've been looking all over
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    Quote Originally Posted by BigGame84
    Is the website up?
    X2.
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    Quote Originally Posted by dsade View Post
    Next week, but only direct sales until we get final packaging done.
    I'm in,I will be waiting for payment details via direct sale.
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    Trying to get the website up...but the server is fried.

    I'll probably have to reopen the Facebook store for this.
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    Quote Originally Posted by dsade View Post
    Trying to get the website up...but the server is fried. I'll probably have to reopen the Facebook store for this.
    I don't have FB :-( can I direct buy from Paypal
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    Quote Originally Posted by dsade
    Trying to get the website up...but the server is fried.

    I'll probably have to reopen the Facebook store for this.
    Awesome Dsade
    Please keep us updated on when you do.
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    Dsade, could you tell us why using Raspberry ketones in the original viril mane was not a good choice? Sorry if it has already been explained but I can't find the answer. Thanks.
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    Definitely keen to buy some of this!
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