EvoMuse AlphaBurn

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    EvoMuse AlphaBurn


    Coming in TOMORROW, a Nutraplanet exclusive!

    You've been out of stock for far too long, my old friend....let's give the customers a hell of a deal to celebrate your return.
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    Thumbs up


    Looking for n awesome deal! As you know, been waiting for months on this one.

    Quote Originally Posted by dsade View Post
    Coming in TOMORROW, a Nutraplanet exclusive!

    You've been out of stock for far too long, my old friend....let's give the customers a hell of a deal to celebrate your return.
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    Me too, brother...me too.
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    Sweet!! Stackable with VL?
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    Quote Originally Posted by howwedo107 View Post
    Sweet!! Stackable with VL?
    Stacks extremely well with Vanillean, given the central action of TRPV1 agonists and release of adrenergic catecholamines. Add some green tea, too, for a great stack.
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    Very excited the time has finally come!
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    Re: EvoMuse AlphaBurn


    Picking this up for sure!!
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    You'll like what you see...should be around $14.99!!
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    Should it be up today?

    Quote Originally Posted by dsade View Post
    You'll like what you see...should be around $14.99!!
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    Seeing as this wasn't up yesterday, will AlphaBurn be available within the next couple of days?
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    Looks like there was a 1-day delivery delay because of weather. It will be delivered today
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    Any logging chances for this puppy?
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    Quote Originally Posted by dsade View Post
    Looks like there was a 1-day delivery delay because of weather. It will be delivered today
    Stupid Flanders...I mean weather...

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    Quote Originally Posted by RickyBDragon View Post
    Seeing as this wasn't up yesterday, will AlphaBurn be available within the next couple of days?
    Should be up anytime really. If it isn't then I can't see it going past tomorrow. I believe NP has it now.
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    I am confused, is Evo Muse part of the Southland brand? I thought you were with BPS now.

    If you managed to get legitimate rauwolscine and not yohimbine hcl you can colour me impressed.
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    Quote Originally Posted by bdcc View Post
    I am confused, is Evo Muse part of the Southland brand? I thought you were with BPS now.

    If you managed to get legitimate rauwolscine and not yohimbine hcl you can colour me impressed.
    I've been using the same supplier since I introduced alpha yohimbine to the market back in 2003.

    I researched it and had it custom extracted because I have no tolerance for Yohimbine.
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    Ladies and Gentlemen....a fantastic debut exclusive Nutraplanet price of $14.25 a bottle.

    http://www.nutraplanet.com/product/e...-capsules.html
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    Quote Originally Posted by dsade View Post
    Ladies and Gentlemen....a fantastic debut exclusive Nutraplanet price of $14.25 a bottle.

    http://www.nutraplanet.com/product/e...-capsules.html
    Wow! I want to throw this in with my VL log! That'd be a sick stack! And it's all non stim dsade doing it big bro if I wasn't such a stickler about shipping I'd pick up a bottle right now but ill have to wait until I put in my next order awesome stuff by the looks of it
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    Uhlén S, Dambrova M, Näsman J, Schiöth HB, Gu Y, Wikberg-Matsson A, Wikberg JE BioMedical Centre, Department of Pharmaceutical Biosciences, Uppsala University, Sweden. staffan.uhlen@farmbio.uu.se
    European Journal of Pharmacology [1998, 343(1):93-101]


    Type: Journal Article, Research Support, Non-U.S. Gov't, Comparative Study
    DOI: 10.1016/S0014-2999(97)01521-5
    Abstract Highlight Terms Gene Ontology(2) Genes/Proteins(3) Species(5) Chemicals(7)
    The Kd values of the recently introduced radioligand [3H]RS79948-197 ((8a R,12aS,13a-S)-5,8,8a,9,10,11,12,12a,13,13a-decahydro-3-metho xy-12-(ethylsulphonyl)-6H-isoquino[2,1-g][1,6]naphthyridine) were determined for the recombinant human and rat alpha2A-, alpha2B- and alpha2C- as well as guinea pig alpha2B- and alpha2c-adrenoceptors expressed in COS (CV-1 Origin, SV40) cells. In addition, the Kd values were also determined for [3H]RS79948-197 for the guinea pig spleen alpha2A-adrenoceptor and for pig alpha2A-, alpha2B- and alpha2C-adrenoceptors in membranes obtained from kidney and striatum. Available radioligands for alpha2-adrenoceptors, besides [3H]RS79948-197 are the tritiated forms of MK912 ((2S,12bS)1',3'-dimethylspiro(1,3,4,5',6,6',7, 12b-octa hydro-2H-benzo[b]furo[2,3-a]quinazoline)-2,4'-pyrimidin-2'-one), RX821002 (2-methoxy-idazoxan), rauwolscine and yohimbine. In the present article the binding constants of all these substances for the alpha2A-, alpha2B- and alpha2C-adrenoceptor subtypes in human, pig, rat and guinea pig are reviewed. In all species tested MK912 was alpha2C-selective, RX821002 showed a minor alpha2A-selectivity, whereas [3H]RS79948-197 was non-selective among the alpha2-adrenoceptor subtypes, showing high affinity for all three subtypes. Rauwolscine and yohimbine showed relatively low affinities for nmost of the alpha2-adrenoceptor subtypes investigated, the exception being rauwolscine having high affinity for the human and porcine alpha2C-adrenoceptors
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    Re: EvoMuse AlphaBurn


    Great deal as always bro!!
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    http://ajpregu.physiology.org/content/283/2/R287.long

    Long read, but goes into the functionality of the Alpha 2 subtypes, their physiological functions and locational prevalence, and their function, while blockaded by Alpha-Yohimbine, on both acute (fight or flight) and basal epinephrine and norepinephrine levels.
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    Neuroscience. 2002;109(4):819-26.
    Two alpha(2)-adrenergic receptor subtypes, alpha(2A) and alpha(2C), inhibit transmitter release in the brain of gene-targeted mice.

    Bücheler MM, Hadamek K, Hein L.
    Source

    Institut für Pharmakologie und Toxikologie, Universität Würzburg, Versbacher Strasse 9, 97078 Würzburg, Germany.

    Abstract

    alpha(2)-Adrenergic receptors play an essential role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the CNS. However, the role of each of the three highly homologous alpha(2)-adrenergic receptor subtypes (alpha(2A), alpha(2B), alpha(2C)) in this process has not been determined unequivocally. To address this question, the regulation of norepinephrine and dopamine release was studied in mice carrying deletions in the genes encoding the three alpha(2)-adrenergic receptor subtypes. Autoradiography and radioligand binding studies showed that alpha(2)-receptor density in alpha(2A)-deficient brains was decreased to 9 +/- 1% of the respective wild-type value, whereas alpha(2)-receptor levels were reduced to 83 +/- 4% in alpha(2C)-deficient mice. These results indicate that approximately 90% of mouse brain alpha(2)-receptors belong to the alpha(2A) subtype and 10% are alpha(2C)-receptors. In isolated brain cortex slices from wild-type mice a non-subtype-selective alpha(2)-receptor agonist inhibited release of [(3)H]norepinephrine by maximally 96%. Similarly, release of [(3)H]dopamine from isolated basal ganglion slices was inhibited by 76% by an alpha(2)-receptor agonist. In alpha(2A)-receptor-deficient mice, the inhibitory effect of the alpha(2)-receptor agonist on norepinephrine and dopamine release was significantly reduced but not abolished. Only in tissues from mice lacking both alpha(2A)- and alpha(2C)-receptors was no alpha(2)-receptor agonist effect on transmitter release observed. The time course of onset of presynaptic inhibition of norepinephrine release was much faster for the alpha(2A)-receptor than for the alpha(2C)-subtype. After prolonged stimulation with norepinephrine, presynaptic alpha(2C)-adrenergic receptors were desensitized. From these data we suggest that two functionally distinct alpha(2)-adrenergic receptor subtypes, alpha(2A) and alpha(2C), operate as presynaptic inhibitory receptors regulating neurotransmitter release in the mouse CNS.


    PMID:11927164 [PubMed - indexed for MEDLINE]

    Alpha-2A and Alpha-2C blockade results in an increase in epinephrine/Norepinephrine, Basal Ganglia Dopamine, and serotonin levels. The primary perceived effect, for me, is an increase in motivation and goal-fulfillment actions.

    The difference in affinities also can explain Alpha-Yohimbine's distinct lack of anxiety effects as compared to Yohimbine.
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    the tl;dr:

    In contrast, the inhibitory presynaptic feedback loop that tightly regulates neurotransmitter release from adrenergic nerves requires two receptor subtypes, α2A and α2C, with similar but complementary effects.

    You blockade the alpha 2 receptor subtypes, and you increase, centrally and peripherally, catecholamine level (and prevent their negative feedback) resulting in a multitude of functional effects.
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    I just gotta say that I LOVE IT when you show us all sorts of cool info from studies. Having real facts and highlights of issues that are involved in different supplement ingredients and their effects is a great tool.
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    Quote Originally Posted by saludable24 View Post
    I just gotta say that I LOVE IT when you show us all sorts of cool info from studies. Having real facts and highlights of issues that are involved in different supplement ingredients and their effects is a great tool.
    You will have a simplified writeup soon. I realized when I lost all of my RPN files, I also lost the old writeup.

    Of all of the things I brought to this industry, I am most proud of Alpha-Yohimbine. AlphaBurn is something I take consistently, year round, and find it hard to function without - especially in the morning.
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    Re: EvoMuse AlphaBurn


    Quote Originally Posted by dsade View Post
    You will have a simplified writeup soon. I realized when I lost all of my RPN files, I also lost the old writeup.

    Of all of the things I brought to this industry, I am most proud of Alpha-Yohimbine. AlphaBurn is something I take consistently, year round, and find it hard to function without - especially in the morning.
    I gotta get on that type of regimen!
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    Quote Originally Posted by 3clipseGT View Post

    I gotta get on that type of regimen!
    lol me too, man.
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    Really strong sale price here (what else to expect from NP). We don't have a ton of units here guys so for those who have been waiting now is the time to stock back up. I'll be doing the same.
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    My primary motivator behind my Alpha-Yohimbine research...

    http://www.sciencedirect.com/science...24320594005567

    Abstract

    The α2 agonist clonidine has been shown to be anxiolytic in a number of preclinical anxiety models. Interestingly, intravenous infusion of the α2 antagonists idazoxan at 10 mg/kg and rauwolscine at 2.24 mg/kg significantly disinhibited lick-shock conflict responding in rats similar to the α2 agonist clonidine (0.022 mg/kg) and the benzodiazepine diazepam (0.5 mg/kg). However, the α2 antagonists yohimbine and piperoxan, the α2 agonists medetomidine, guanfacine, and guanabenz, the non-specific α antagonist phentolamine, and the α1 antagonist prazosin did not disinhibit conflict responding in the Vogel lick-shock paradigm. In fact, yohimbine has been shown to be anxiogenic in both animals and man. This may be due to yohimbine's lack of specificity and its ability to inhibit GABAergic release. In addition, all of these agents, except idazoxan, did not increase water consumption in water deprived rats. Idazoxan (10 mg/kg) significantly decreased water consumption by 45%. Therefore, idazoxan increased conflict responding for water reward at a dose (10 mg/kg) which also decreased water consumption in a non-conflict paradigm. These data suggest that agents with selective antagonism at the α2 receptor site may be anxiolytic while agents with less specificity at this site such as yohimbine, piperoxan, and phentolamine are not anxiolytic.


    Basically, Yohimbine causes massive increases in anxiety (anxiogenic)whereas Alpha-Yohimbine is actually anxiolytic.
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    Quote Originally Posted by howwedo107 View Post
    Wow! I want to throw this in with my VL log! That'd be a sick stack! And it's all non stim dsade doing it big bro if I wasn't such a stickler about shipping I'd pick up a bottle right now but ill have to wait until I put in my next order awesome stuff by the looks of it
    When Matt brought Alpha Y to the market as Alphaburn many users started adding it in to enhance their fat burners. Stacking Alphaburn with pretty much any fat burner was a tactic many people used with many different products. The same uses for the product still exist. It's a solid product on it's own, but a fantastic addition to any cutting stack. It's also been the product since I've been working with Matt for close to a year now that I have gotten more PM's on than any other. "When's Alphaburn coming back?" Finally we can say it's back!
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    Alphaburn was the first isolated Alpha-Yohimbine product. We first released it in 2003-2004 under Avant Labs as the original HEAT Stack.

    I purposely left the pricing extremely reasonable for the customers, as I consider this staple product and staple products shouldn't bankrupt us, especially with the new taxes hitting everyone.
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    Very nice price point on the intro release.
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    Dsade do you happen to know what it will be priced around when the intro sale is over?I stocked up but you can never have to much A-yohimbe in my book.
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    Probably around $20
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    Got mine today I noticed a decrease in appetite cravings from my first dose it was nice! Excited to lift tomorrow with this
    Email me for free prodigy samples
    Ricky@pni-online.com
    www.pni-online.com
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    Quote Originally Posted by howwedo107 View Post
    Got mine today I noticed a decrease in appetite cravings from my first dose it was nice! Excited to lift tomorrow with this
    Let me know how it works, especially in the morning, with motivation.

    When I first got this compound, back in 2003, there wasn't a whole lot of information about it other than the receptor affinities and areas of the brain it effects. About 45 minutes after taking the first dose, I always notice this RUSH of motivation that i love. Gotta love activating dopamine centers of the brain!!
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    Quote Originally Posted by dsade View Post

    Let me know how it works, especially in the morning, with motivation.

    When I first got this compound, back in 2003, there wasn't a whole lot of information about it other than the receptor affinities and areas of the brain it effects. About 45 minutes after taking the first dose, I always notice this RUSH of motivation that i love. Gotta love activating dopamine centers of the brain!!
    Honestly that's funny bc I SWEAR I didn't wanna do any of my "honeydos" today but after my dose I ended up vacuuming and cleaning the litter box haha now how long can I run this? Thinking of picking up 2-3 more bottles with my next NP order
    Email me for free prodigy samples
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    www.pni-online.com
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    Quote Originally Posted by howwedo107 View Post
    Honestly that's funny bc I SWEAR I didn't wanna do any of my "honeydos" today but after my dose I ended up vacuuming and cleaning the litter box haha now how long can I run this? Thinking of picking up 2-3 more bottles with my next NP order
    You can run it indefinitely. There is no tolerance.
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    Quote Originally Posted by dsade View Post

    You can run it indefinitely. There is no tolerance.
    Challenge accepted!
    Psalm 34:10 - "The lions may grow weak and hungry, but those who seek the Lord lack no good thing."
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