New E-pharm product: URSOBOLIC !
- 10-06-2011, 12:41 PM
- 10-06-2011, 01:36 PM
I'd like to see how it actually works on a guy with some actual fat to lose. Not some guy/lady wanting to lose 5-10 vanity pounds.
10-06-2011, 01:47 PM
10-06-2011, 01:53 PM
10-06-2011, 01:58 PM
10-06-2011, 01:59 PM
10-06-2011, 02:14 PM
10-06-2011, 03:01 PM
Hmm on the fence to include this in my PCT or use endosurge. I know they are completely different but I'm still undecided. Guess it depends on how well people respond to Ursobolic.
Cutting all summer, cycle in September
10-06-2011, 04:44 PM
10-06-2011, 04:57 PM
10-06-2011, 06:42 PM
Yes, but then you have the problem where companies inflate their dosing requirements way above and beyond what's really needed. I'm skeptical that exact thing isn't happening with Ursobolic.
Did some research (ergo-log.com/ursolicacid.html) and turned up the following gem:
If my line of reasoning is correct, wouldn't the effects of resistance training on GH and IGF be potentiated by dosing Ursobolic pre- and post-workout? And wouldn't this be the most logical time in which to use a product that potentiates IGF?The researchers suspect that ursolic acid's prime target is the IGF-1 receptor. This becomes more sensitive and as a result the IGF-1 that is present in the body works better.
10-06-2011, 06:44 PM
Anybody have thoughts on this?
Ursolic acid causes DNA-damage, P53-mediated, mitochondria- and caspase-dependent human endothelial cell apoptosis, and accelerates atherosclerotic plaque formation in vivo
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10-06-2011, 07:01 PM
10-06-2011, 07:11 PM
10-06-2011, 07:14 PM
10-06-2011, 07:43 PM
Ursolic acid protects diabetic mice against monocyte dysfunction and accelerated atherosclerosis.
Ullevig SL, Zhao Q, Zamora D, Asmis R.
Department of Biochemistry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229-3900, United States.
Accelerated atherosclerosis is a major diabetic complication initiated by the enhanced recruitment of monocytes into the vasculature. In this study, we examined the therapeutic potential of the phytonutrients ursolic acid (UA) and resveratrol (RES) in preventing monocyte recruitment and accelerated atherosclerosis.
METHODS AND RESULTS:
Dietary supplementation with either RES or UA (0.2%) protected against accelerated atherosclerosis induced by streptozotocin in high-fat diet-fed LDL receptor-deficient mice. However, mice that received dietary UA for 11 weeks were significantly better protected and showed a 53% reduction in lesion formation while mice fed a RES-supplemented diet showed only a 31% reduction in lesion size. Importantly, UA was also significantly more effective in preventing the appearance of proinflammatory GR-1(high) monocytes induced by these diabetic conditions and reducing monocyte recruitment into MCP-1-loaded Matrigel plugs implanted into these diabetic mice. Oxidatively stressed THP-1 monocytes mimicked the behavior of blood monocytes in diabetic mice and showed enhanced responsiveness to monocyte chemoattractant protein-1 (MCP-1) without changing MCP-1 receptor (CCR2) surface expression. Pretreatment of THP-1 monocytes with RES or UA (0.3-10μM) for 15h resulted in the dose-dependent inhibition of H(2)O(2)-accelerated chemotaxis in response to MCP-1, but with an IC(50) of 0.4μM, UA was 2.7-fold more potent than RES.
Dietary UA is a potent inhibitor of monocyte dysfunction and accelerated atherosclerosis induced by diabetes. These studies identify ursolic acid as a potential therapeutic agent for the treatment of diabetic complications, including accelerated atherosclerosis, and provide a novel mechanism for the anti-atherogenic properties of ursolic acid.
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10-06-2011, 08:04 PM
I'm not really sure what to say dude. You aren't really asking anything. Are you asking if this will give you heart problems? Cause cell death? Cancer?
I don't believe in studies with mutant mice/rats. They are so effed up to begin with...
10-06-2011, 08:14 PM
10-06-2011, 08:16 PM
10-06-2011, 08:19 PM
10-06-2011, 08:50 PM
10-06-2011, 08:53 PM
10-06-2011, 08:55 PM
EndoSurge will free up some test via SHBG, as well as control prolactin and enhance sleep. Maybe increase GH levels. Some don't think that suppressing SHBG is good because SERMS increase SHBG and that in turn helps the negative feedback loop when you jump off the SERM and increases it's effectiveness in recovery. I can't comment personally though as I've only used EndoSurge in a completely non hormonal period.
Also, Usorbolic, though I'm not sure as it's effects on the HPGA, will not help you control prolactin, or increase test. IMO it's more of a body recomp agent though non HPGA pathways (Yea I dont know if those pathways even exist), but that's the way I see it. I'm going to give it a run in about 5 weeks. Still debating wether or not to make a detailed log or not yet.
10-06-2011, 08:59 PM
10-06-2011, 10:16 PM
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