Unless your using something that isn't very suppressive, like for example, 40mg anavar a day or 400mg-500mg trans 4ad a day, then you really shouldn't be using your Activate on cycle.
Logically it just doesn't make any sense. Maybe for the first few days, but the longer your cycle goes on and the more suppressed your testosterone gets, the more that Activate is a waste of money on-cycle.
Hell, there's been atleast 2-3 logs on here that have shown low doses of M1T to completely shut you down, within a 3-5 days.
So if your using anything as suppressive or more suppressive than M1T, along with Activate, your completely wasting your money.
Think about it, whats the point of trying to increase free T, when Total T is shut down? You can't even do that.
Save Activate for PCT and off-cycle Test Booster, thats where it is most cost-effective.
BUT, if your cycle is really not very suppressive, then I agree with Robboe, there may be some synergy... it would have to be a very weak cycle though, since even most light compounds will shut down T within 45 days.
A better strategy would be to do very short, fast acting, non suppressive cycles, coupled with Activate.
Like 500mg trans 4ad day 1-14
20 cap activate day 1-28
1 cap RXT day 1-14
2 cap RXT day 15-28
From day 1-14 your total/free and supplemental T would be through the roof, with only very minimal suppression
Day 15-28 your getting a solid PCT for any suppression there might have been, which is probably close to Nil, then you could just repeat the whole thing again if you want.
Would be pretty expensive though, but this would be a kick ass HRT because your test would be way above average high year round, without really f'n with the HPTA at all.