Melting Point Write-Up

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    Melting Point Write-Up


    Folks, here is a slightly revised write-up that you may all want to peruse...
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    What is Mindight EST in GMT? 5AM?
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    I think so, yeah. There's 5hrs between us and NYC so i imagine that'll be right.

    Early morning for you tomorrow?
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    Bugger.

    Maybe I'll wait for the 2nd batch and get some feedback before I decide to drop the cash.
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    Quote Originally Posted by meathead1987
    What is Mindight EST in GMT? 5AM?
    Its 4 AM. 5 AM CET. Too damn early Its a HOLIDAY here and I have to put an alarm in the "middle" of the night lol
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    After reading this... I am very interested to see how this effects women. My g/f in particular who can only exercise doing cardio 3-4 times a week.
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    Quote Originally Posted by houseman
    After reading this... I am very interested to see how this effects women. My g/f in particular who can only exercise doing cardio 3-4 times a week.
    Bump on that!

    BTW, Nice job on the write up Robboe. Me likes it. Well done.
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    Does exercise increase the number of PPAR-alpha receptors?

    Or am I not understanding this correctly...when EPA binds to the PPAR-alpha receptor it releases more peroxisomes?


    **Please ignore anything under this, these are some notes I am taking and researching. Have a look if you like**

    "PPAR alpha is activated by free fatty acids including linoleic, arachidonic, and oleic acids."
    http://www.bioreagents.com/index.cfm...CatNbr/MA1-822

    http://www.roche-applied-science.com...4566416001.pdf


    "In other words, even though increasing the amount of fish oil in the diet increased PPA-80 (and thus PPAR-alpha activity), there was no appetite suppression. This suggests that though fish oil increased PPA-80 in some tissues, it does not appear to do so in the gut. It is only local PPAR-alpha activation in the gut that directly affects appetite.
    Instead, what the researchers found was that PPA-80 was increased markedly in the liver and had minor increases in skeletal muscle and adipocytes (fat cells). In the liver, PPAR-alpha activation turned on specific gene coding for a series of enzymes involved in fat burning.

    These enzymes (specifically acyl-CoA oxidase, medium chain acyl-CoA dehydrogenase and lipoprotein lipase) were increased in the cells and their mitochondria, increasing the rate of calorie burning.

    Interestingly, uncoupling protein-2 was also increased. Uncoupling proteins decrease the efficiency of the mitochondria, increasing the number of calories burned to maintain cell function."

    "Exercise training has also been shown to double the levels of muscle PPARalpha, and may enhance skeletal muscle oxidative capacity"

    http://www.thefactsaboutfitness.com/news/fippa.htm
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    Another thing that I don't think is in th write up is how long each bottle should last at the reccomended dosage? I think the reccomendation in the other thread was to 4 caps per day and earlier in the thread it was stated that DS always strives to provide a month supply per bottle. So for the $65.00 are we getting 120 capsules (4 X 30 days)? or no?
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    Quote Originally Posted by thecrunk
    Does exercise increase the number of PPAR-alpha receptors?

    Or am I not understanding this correctly...when EPA binds to the PPAR-alpha receptor it releases more peroxisomes?
    It doesn't "release" more peroxisomes, it creates more.

    Exercise doesn't create more peroxisomes necessarily, no. But having more peroxisomes allows you to burn more fat at anyone time. Exercise promotes release of fat from the cells and promotes the burning of said fat. MP does this without you having to move a muscle, which is where the "exercise in a bottle"-type explanation comes from.
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    Quote Originally Posted by Mr.50
    Another thing that I don't think is in th write up is how long each bottle should last at the reccomended dosage? I think the reccomendation in the other thread was to 4 caps per day and earlier in the thread it was stated that DS always strives to provide a month supply per bottle. So for the $65.00 are we getting 120 capsules (4 X 30 days)? or no?
    That's because, at the time of writing:

    a) I didn't know how much active would be in each cap, and
    b) We have a recommended dosage, but we're playing around with dosing and environmental conditions during the alpha testing.

    I'll let matt and steve tell you their current results themselves, but lets just say i think most will be impressed considering what and how much food matt and steve actually eat.

    You people do know Matt has an endorsement deal with krispy kreme, right?
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    "Exercise training has also been shown to double the levels of muscle PPARalpha, and may enhance skeletal muscle oxidative capacity"

    http://www.thefactsaboutfitness.com/news/fippa.htm

    So can we conslude that with more PPAR-alpha receptors to be bound to, the more peroxisomes can be created?
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    Quote Originally Posted by thecrunk
    "Exercise training has also been shown to double the levels of muscle PPARalpha, and may enhance skeletal muscle oxidative capacity"
    Yeah, exercise can upregulate expression of PPAR-alpha, but it won't necessarily activate it also (which is what needs to happen to promote peroxisome numbers). That is where good diet comes in.
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    Quote Originally Posted by thecrunk
    "Exercise training has also been shown to double the levels of muscle PPARalpha, and may enhance skeletal muscle oxidative capacity"

    http://www.thefactsaboutfitness.com/news/fippa.htm

    So can we conslude that with more PPAR-alpha receptors to be bound to, the more peroxisomes can be created?
    Generally speaking, yes. Which is why general health enthusiasts tell you to exercise regularly and supplement with omega-3 fatty acids.
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    Quote Originally Posted by Robboe
    I'll let matt and steve tell you their current results themselves, but lets just say i think most will be impressed considering what and how much food matt and steve actually eat.
    Actually, if i leave it to them you'll be waiting an age.

    Without changes in diet, Steve has dropped 3.5lbs this week (yes, mr non-responder himself), whereas matt has dropped 4lbs this week, also without dietary amendment.
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    So did I already miss the sale, or is there still no date yet?
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    Quote Originally Posted by Robboe
    Actually, if i leave it to them you'll be waiting an age.

    Without changes in diet, Steve has dropped 3.5lbs this week (yes, mr non-responder himself), whereas matt has dropped 4lbs this week, also without dietary amendment.
    So this lipace is in fact an omega-3...
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    Quote Originally Posted by thecrunk
    So this lipace is in fact an omega-3...
    well fish oil was part of the fatty acid complex if i remember right, so not necessarily
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    Quote Originally Posted by Robboe
    Folks, here is a slightly revised write-up that you may all want to peruse...
    Do you really mean EST, or do you mean EDT? We are in daylight savings, after all.

    I suppose if you're from Indiana you might not do the whole daylight savings time thing...

    -kwantam
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    Quote Originally Posted by jblaze22
    well fish oil was part of the fatty acid complex if i remember right, so not necessarily
    I actually kinda jumped the gun when i told DA there was fish oil in it. I was under the impression it was, but now i'm not so sure and Matt and Steve don't trust me with the complete ingredients list that comprises LipidAce lol.
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    Quote Originally Posted by thecrunk
    So this lipace is in fact an omega-3...
    No, it's a modified fatty acid complex.
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    So at 11pm CST I'm going to need to place my order on designersupps.com, right?
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    Too many buzz-words for what is essentally an EFA product. Yawn...
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    This could get really interesting before I leave for Cancun on July 8th... Just started SD @ 10mg yesterday, along with SesaThin, Fish Oil, Vitamin C, and Hawthorne Berry... I wonder what adding MP into THAT mix would do for a nice month-long cutter!
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    Quote Originally Posted by BigSwede
    Too many buzz-words for what is essentally an EFA product. Yawn...
    Cool, BigSwede doesn't want any, meaning more chance others who do will get some.

    Everybody wins.
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    Quote Originally Posted by BigSwede
    Too many buzz-words for what is essentally an EFA product. Yawn...
    If combined with a good diet and it works, what does it matter?
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    Quote Originally Posted by kwantam
    Do you really mean EST, or do you mean EDT? We are in daylight savings, after all.

    I suppose if you're from Indiana you might not do the whole daylight savings time thing...

    -kwantam
    Midnight Eastern, tonight. If you can't figure this out, no soup for you!
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    Quote Originally Posted by Robboe
    Midnight Eastern, tonight. If you can't figure this out, no soup for you!
    Are you being serious or is this one of your "moments"?

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    Quote Originally Posted by houseman
    If combined with a good diet and it works, what does it matter?
    Because I see a disturbing trend developing. These pseudo-abstracts attempting to mask what is nothing more than an EFA. To use the term, "uncoupler" in the traditional sense is absurd. That being said; I've got 6 bottles of LX here. I don't want to see DS turn into another Biotest.
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    Quote Originally Posted by BigSwede
    Because I see a disturbing trend developing. These pseudo-abstracts attempting to mask what is nothing more than an EFA. To use the term, "uncoupler" in the traditional sense is absurd. That being said; I've got 6 bottles of LX here. I don't want to see DS turn into another Biotest.
    I guess we'll find out soon enough.

    I'll admit, I just don't buy 3.5 and 4lbs fat loss in one week with no change to diet, training or cardio.

    Maybe it is. Maybe it is. Without pictures it'll be tough to prove and unfortunately, pics after a week won't show that much unless it WAS actual FAT loss. Pics over 4 weeks should show very noticable results, however.
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    Quote Originally Posted by BigSwede
    Because I see a disturbing trend developing. These pseudo-abstracts attempting to mask what is nothing more than an EFA. To use the term, "uncoupler" in the traditional sense is absurd. That being said; I've got 6 bottles of LX here. I don't want to see DS turn into another Biotest.
    Do you really think DS would just release a basic EFA product? Do you not expect something a little extra special?
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    Quote Originally Posted by Robboe
    Do you really think DS would just release a basic EFA product? Do you not expect something a little extra special?
    A coupon for a massage and a happy ending?
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    Quote Originally Posted by Robboe
    Actually, if i leave it to them you'll be waiting an age.

    Without changes in diet, Steve has dropped 3.5lbs this week (yes, mr non-responder himself), whereas matt has dropped 4lbs this week, also without dietary amendment.
    Am I the only one who realises the signifigance of those #s??

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    Quote Originally Posted by Robboe
    Do you really think DS would just release a basic EFA product? Do you not expect something a little extra special?
    Who knows what to believe in the Supplement world these days.

    I got faith in DS but it just seems things are being rushed here. I understand people are bitching, whining and moaning for this product and if it pans out like it should... then I see the urgency to bring it out.

    But without full alpha and beta testing WITH before and after pictures along with a detailed nutritional and training log is bound to throw up some road blocks for some people as I;m sure you can imagine.

    $65 isn't a ton of money but at the same time, without some real world results, yet, it is a lot of money to some people especially when two of the reported results thus far have been 3.5 and 4lbs loss with NO change in diets, training, cardio, etc.

    We all want to see this product be everything that it's being touted as but you can't blame some for being concerned, can you?
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    Quote Originally Posted by Lean One
    Am I the only one who realises the signifigance of those #s??

    No Sir... my jaw dropped and I'm going to be taking a nap during work (ok, I do that anyway) just to make sure I'm up and can order some.

    OMG OMG OMG...

    Even if these numbers are inflated and these two "subjects" are just responding very well, I'll take HALF of that...
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    Please forgive me in this, if it has been said before.. should one cut back on fish oil usage while using MP.... if so.. by how much
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    I don't believe it has been mentioned, but with some of MP's positives- it sounds like it would be good to run Post SD cycle. How bout on?
    My The 1 LOG: http://anabolicminds.com/forum/steroids/254164-my-one-log.html
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    Quote Originally Posted by motiv8er
    I don't believe it has been mentioned, but with some of MP's positives- it sounds like it would be good to run Post SD cycle. How bout on?
    Dude... no offence or anything but I much prefered your old avatar
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