The AMS products are very mild and support needs are minimal. I believe the Mass Drops are 1-Andro and Decavol combined into one product. 4ad is 4-DHEA which ultimately converts into testosterone, which can obviously aromatize into estrogen, though I doubt you'd see enough (if any) estrogen turnover to cause related sides. People will run 4ad with the stack because 1-Andro can cause a good bit of lethargy and the 4ad helps to mitigate this. If you're worried about estrogen just keep some Erase on hand and use it at a low dose if you feel you're experiencing estrogen sides, but I really doubt that it will be necessary.