General question, methyl vs. ethyl

[eatingisfun]

Just wondering this morning why methylation is chosen over ethylation for most common PS/DS in the market today? Why use a methyl group(toxic) over an ethyl group(not as toxic to humans).

 

[crazyfool405]

i believe it has to do with the overall passing of the liver,

however methylating it on certain spots can also make it less toxic.

 

[rms80]

Just wondering this morning why methylation is chosen over ethylation for most common PS/DS in the market today? Why use a methyl group(toxic) over an ethyl group(not as toxic to humans).

methyl: CH3

ethyl: C2H5

methyl tends to allow more of parent structure of molecule to avoid breakdown in the liver (first pass)- ethyl does the same thing, but to a lesser extent

di methyl= greater potency than di ethyl= similar potency to methyl= greater potency than ethyl

an ethylated compound is weaker than a methylated, but not by that much- you can look at some of the nandrolones as a reference- one of the 19-nors is methylated (normethandrolone @ C17), and some are ethylated (genabol is di-ethyl @ 13 and 17, nilevar is ethyl @ C17)

Q's are as follows:
normethandrolone- 400:115
genabol- 350:17
nilevar- 200:55

as far as using it in other compounds- it really just amounts to time honored synthesis methods...

 

[eatingisfun]

Great thanks a lot for the info. Do you know any information on the difference between the toxicity on the liver? Since it's debatable how toxic each methylated compound is, it might not be that easy to answer. But even though ethanol/ethyl alcohol is less toxic than methanol, maybe it's not exactly comparable.

 

[rms80]

Great thanks a lot for the info. Do you know any information on the difference between the toxicity on the liver? Since it's debatable how toxic each methylated compound is, it might not be that easy to answer. But even though ethanol/ethyl alcohol is less toxic than methanol, maybe it's not exactly comparable.

not sure- I can look around- I will say methyl alcohol is a wonderful solvent for cleaning machinery, tho

both are commonly used in oral delivery systems for many pharmaceuticals

 

[LilPsychotic]

Just wondering this morning why methylation is chosen over ethylation for most common PS/DS in the market today? Why use a methyl group(toxic) over an ethyl group(not as toxic to humans).

17a alkylation makes no difference if its methl or ethyl. You are basing a theory on the effects of methanol and ethanol which is entirely different. A 17a alkylation simple inhibits the compound from degradation by the liver.

 

[rms80]

17a alkylation makes no difference if its methl or ethyl. You are basing a theory on the effects of methanol and ethanol which is entirely different. A 17a alkylation simple inhibits the compound from degradation by the liver.

pretty much.....

 

[eatingisfun]

17a alkylation makes no difference if its methl or ethyl. You are basing a theory on the effects of methanol and ethanol which is entirely different. A 17a alkylation simple inhibits the compound from degradation by the liver.

Yep you're right, I was wondering since methanol is more toxic than ethanol, what would be the difference between the two groups when used for alkylation when comparing toxicity.

But from the answers so far it seems that it wouldn't really change too much.