Your Guide To L-Carnitine - AnabolicMinds.com
    • Your Guide To L-Carnitine



      by Jim Stoppani, Ph.D. Bodybuilding . com

      L-carnitine broke onto the supplement scene back in the 1980s as a popular fat-burner. Then it fizzled out when sexier, stimulant-based fat burners became all the rage. Today, L-carnitine is back and stronger than ever. Only now, we know this well-researched supplement not only aids in fat-burning, but also has the potential to enhance exercise performance and recovery.

      Are you wondering if a non-stimulant supplement can really work to help you burn fat? Have you heard the recent negative headlines about L-carnitine, or seen it listed as an ingredient in energy drinks, and wondered if it's safe?

      Don't believe everything you read. Let's cut the sensationalism and talk about the science behind L-carnitine.

      WHAT IS L-CARNITINE?
      While it is often categorized as an amino acid, L-carnitine isn't technically an amino. It is considered a "vitamin-like" and "amino acid-like" compound that is related to the B vitamins. When it was first studied back in the 1950s, L-carnitine was referred to as vitamin BT.

      L-carnitine is formed in the liver and kidneys from the amino acids lysine and methionine. However, it is stored elsewhere in the body, primarily in muscle (including the heart), the brain, and even in sperm. In the diet, it mainly comes from meat and other animal products. You can get some from plant products like avocado and soybeans, but as a rule, meat is the best source—and the redder the better.

      Carnitine exists in two forms, D-carnitine and L-carnitine. The L-form is the one found in nature and is biologically active. On labels, you'll see it listed as L-carnitine, L-carnitine L-tartrate, or Propionyl-L-carnitine. They're all similar, and similarly effective. The D form, on the other hand, is biologically inactive and isn't sold as a supplement.

      Acetyl L-carnitine, also known as acetylcarnitine or ALCAR, is another popular supplemental form of L-carnitine. It can be found throughout the central nervous system, where it plays a role in producing energy, as well as producing the important neurotransmitter acetylcholine.

      The acetyl group attached to the carnitine molecule enhances its ability to pass across the blood-brain barrier and enter the brain, where it acts as a powerful antioxidant. For this reason, some research suggests that acetyl-L-carnitine may provide protective actions against aging processes and neurodegeneration.

      WHAT DOES IT DO?
      The most critical role that L-carnitine plays in the body is in helping to transport fat, particularly long-chain fatty acids, into the mitochondria of cells. Once there, they can be oxidized—used as fuel—to generate adenosine triphosphate, or ATP. L-carnitine does this cellular work this both when you exercise and rest, but research confirms that it is especially effective during intense exercise.

      Without adequate L-carnitine, most dietary fats can't get into the mitochondria and be burned for fuel. But for people with L-carnitine deficiency it is a serious medical condition whose implications don't stop at being unable to burn body fat. It can lead to muscle weakness, stunted growth, an enlarged liver, and a number of other problems. This is one reason why L-carnitine is considered a "conditionally essential" nutrient: Your body produces it, but if it doesn't produce enough, your health can be seriously impacted.

      A recent study out of Scotland concluded that in addition to its fat-transporting work, L-carnitine also enhances insulin's actions on muscle cells. What this means is that L-carnitine can help keep blood glucose levels low, even following a carb-rich meal, while also aiding in glycogen repletion. This is one reason why I advocate taking L-carnitine with a post-workout meal.

      "SOME OF THE MOST INTERESTING RECENT RESEARCH INTO L-CARNITINE SUPPLEMENTATION FOCUSES ON HOW IT CAN ENHANCE ATHLETIC PERFORMANCE."

      WHAT ARE THE PERFORMANCE AND PHYSIQUE APPLICATIONS?
      L-carnitine's bona fide role as a fat-burning supplement is well-established. During bulking periods, it can help limit fat gains and make a "cleaner" bulk. If you're cutting, it can help transport the fat you have into your cellular furnaces to get burned as energy.

      Some of the most interesting recent research into L-carnitine supplementation focuses on how it can enhance athletic performance. In a recent study, University of Nottingham Medical School researchers had one group of athletes consume 2 grams of L-carnitine along with 80 grams of a high-glycemic carb first thing in the morning and four hours later for 24 weeks. Another group only took the carbs.

      The researchers found that during low-intensity cycling, the subjects taking L-carnitine burned 55 percent less muscle glycogen, while increasing fat-burning by 55 percent. During high-intensity cycling, the subjects taking L-carnitine had lower levels of lactic acid and higher levels of creatine phosphate, one of the primary building blocks of ATP.

      When they measured the subjects' ability to resist fatigue during a cycling test, they found that subjects taking L-carnitine were able to go more than 25 percent longer. This was likely because they burned more fat while preserving muscle glycogen, in addition to having lower levels of lactic acid and higher levels of creatine phosphate.

      The UK researchers also found that despite having an extra 640 calories of fast-digesting carbs in their daily diet, the subjects taking L-carnitine gained no additional body fat. The group taking the carbs without L-carnitine, on the other hand, gained more than 5 pounds of body fat.

      L-carnitine's performance benefits not only stem from its ability to increase fat-burning and decrease glycogen use, but also from the way it can enhance blood flow to the muscles. Increased blood flow means more nutrients and hormones go where they're needed most during exercise. How does this work? For one, L-carnitine reduces oxidative damage in the body's nitric oxide (NO). But it also enhances the activity of a key enzyme involved in your body's NO production. The net result is higher NO blood levels, which not only enhance energy during workouts, but also muscle recovery following workouts.

      What could be better than more NO? How about more testosterone? University of Connecticut researchers found that L-carnitine increases the amount of testosterone receptors, known as androgen receptors, inside muscle cells. The more of these receptors you have in your cells, the more testosterone can bind to them and stimulate muscle growth and strength gains.

      As one final benefit, research shows that L-carnitine supplementation facilitates the action of insulin-like growth factor-I, a critical instigator of muscle growth, by boosting levels of one of its binding proteins.

      ARE THERE ANY SIDE EFFECTS?
      There are few negative side effects from L-carnitine supplementation at reasonable doses. It can cause nausea, abdominal cramps, vomiting, and diarrhea when taken in high doses. Rare side effects can include muscle weakness in uremic patients, and seizures in people with seizure disorders.

      One recent study postulated that L-carnitine supplementation may increase the risk of atherosclerosis. However, the study design has been met with plenty of criticism from the scientific community—myself included . Medical experts have also pointed to the numerous studies that actually show a reduction in the risk of cardiovascular disease with L-carnitine supplementation.

      There's another unexpected side effect you might experience with L-carnitine supplementation, but it's not one you'd notice in the gym. One study from Italian researchers reported that L-carnitine was actually more effective than testosterone therapy for treating male erectile dysfunction. This could be because it boosts NO levels, helping you get more blood flow down there. There is also research suggesting that supplementing with L-carnitine enhances male fertility by enhancing sperm mobility.


      HOW SHOULD I STACK IT?
      Quite simply, the most important thing you take with L-carnitine is carbs. Some early studies showed no benefit of L-carnitine, because they failed to adequately raise muscle L-carnitine levels. This was because the supplement wasn't taken at the right time, when insulin would be spiked and muscle uptake would be adequate.

      Newer research shows that insulin levels must be quite high for adequate amounts of L-carnitine to enter muscle cells, where it performs the majority of its work. On the flipside, taking L-carnitine enhances insulin's actions at the muscle cells, helping to deliver more glucose into the muscle cells as well as more L-carnitine.

      While as little as 1 gram of L-carnitine can be effective, your best bet is to take 2-3 grams per dose for maximum benefit, along with at least 30-40 grams of carbs and 20-40 grams of protein, preferably with a meal. This applies if you take straight-up L-carnitine, L-carnitine L-tartrate, or propionyl-L-carnitine.

      Acetyl-L-carnitine, however, is more easily taken up by the intestines and the muscle cells, not to mention the brain, in the absence of food. Therefore, this form of L-carnitine may be stacked with other ingredients that enhance fat-burning, such as caffeine and green tea, and taken between meals.

      SHOULD I CYCLE IT?
      At this time, it appears that there is no need to cycle L-carnitine. Taken regularly, it should continue to be effective long-term.

      WHEN SHOULD I TAKE IT?
      One of the best times to take L-carnitine is post-workout, but you can take it with any other high-carb, high-protein meal throughout the day. If you want to stack L-carnitine with other fat-burning ingredients between meals, consider using the acetyl-L-carnitine form.

      One strategy I found to work well for both fat loss and performance benefits is to take 2-3 doses of acetyl-L-carnitine with other fat-burning ingredients without food between meals, and to take 1 dose of L-carnitine or L-carnitine L-tartrate with a post-workout meal.

      "YOU CAN TAKE IT WITH ANY OTHER HIGH-CARB, HIGH-PROTEIN MEAL THROUGHOUT THE DAY."
      WHAT'S THE BOTTOM LINE?

      The take-home message is that when taken correctly, L-carnitine can boost both your training and your physique. In the gym, it can mean more endurance and bigger pumps. In the mirror, picture more muscle and less fat. And despite what you may have read, it's safe.

      Don't fear L-carnitine. Learn about it and how to use it, and it can be a great tool to have in your arsenal.


      REFERENCES
      Alvarez de Sotomayor M, et al. Effect of L-carnitine and propionyl-L-carnitine on endothelial function of small mesenteric arteries from SHR. J Vasc Res. 2007;44(5):354-64.
      Bacurau RF, et al. Does exercise training interfere with the effects of L-carnitine supplementation? Nutrition. 2003 Apr;19(4):337-41.
      Bernard A, et al. L-carnitine supplementation and physical exercise restore age-associated decline in some mitochondrial functions in the rat. J Gerontol A Biol Sci Med Sci. 2008 Oct;63(10):1027-33.
      Bloomer R, et al. Glycine propionyl-L-carnitine increases plasma nitrate/nitrite in resistance trained men. J Int Soc Sports Nutr. 2007 Dec 3;4:22.
      Bloomer RJ, Tschume LC, Smith WA. Glycine propionyl-L-carnitine modulates lipid peroxidation and nitric oxide in human subjects. Int J Vitam Nutr Res. 2009 May;79(3):131-41.
      Cavallini G, et al. Carnitine versus androgen administration in the treatment of sexual dysfunction, depressed mood, and fatigue associated with male aging. Urology. 2004 Apr;63(4):641-6.
      Ferrari R, et al. Therapeutic effects of L-carnitine and propionyl-L-carnitine on cardiovascular diseases: a review. Ann N Y Acad Sci. 2004 Nov;1033:79-91. Review.
      Galloway SD, Craig TP, Cleland SJ. Effects of oral L-carnitine supplementation on insulin sensitivity indices in response to glucose feeding in lean and overweight/obese males. Amino Acids. 2011 Jul;41(2):507-15.
      Garolla A, et al. Oral carnitine supplementation increases sperm motility in asthenozoospermic men with normal sperm phospholipid hydroperoxide glutathione peroxidase levels. Fertil Steril. 2005 Feb;83(2):355-61.
      Karlic H, Lohninger A. Supplementation of L-carnitine in athletes: does it make sense? Nutrition. 2004 Jul-Aug;20(7-8):709-15.
      Kraemer WJ, et al. The effects of L-carnitine L-tartrate supplementation on hormonal responses to resistance exercise and recovery. J Strength Cond Res. 2003 Aug;17(3):455-62.
      Lenzi A, et al. A placebo-controlled double-blind randomized trial of the use of combined l-carnitine and l-acetyl-carnitine treatment in men with asthenozoospermia. Fertil Steril. 2004 Jun;81(6):1578-84.
      Malaguarnera M, et al. L-Carnitine treatment reduces severity of physical and mental fatigue and increases cognitive functions in centenarians: a randomized and controlled clinical trial. Am J Clin Nutr. 2007 Dec;86(6):1738-44.
      Müller DM, et al. Effects of oral L-carnitine supplementation on in vivo long-chain fatty acid oxidation in healthy adults. Metabolism. 2002 Nov;51(11):1389-91.
      Natali A, et al. Effects of acute hypercarnitinemia during increased fatty substrate oxidation in man. Metabolism. 1993 May;42(5):594-600.
      Spiering BA, et al. Effects of L-carnitine L-tartrate supplementation on muscle oxygenation responses to resistance exercise. J Strength Cond Res. 2008 Jul;22(4):1130-5.
      Spiering BA, et al. Responses of criterion variables to different supplemental doses of L-carnitine L-tartrate. J Strength Cond Res. 2007 Feb;21(1):259-64.
      Stephens FB, Constantin-Teodosiu D, Greenhaff PL. New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle. J Physiol. 2007 Jun 1;581(Pt 2):431-44.
      Stephens FB, et al. An acute increase in skeletal muscle carnitine content alters fuel metabolism in resting human skeletal muscle. J Clin Endocrinol Metab. 2006 Dec;91(12):5013-8.
      Stephens, FB, et al. Carbohydrate ingestion augments L-carnitine retention in humans. J Appl Physiol (1985). 2007 Mar;102(3):1065-70.
      Stephens, FB, et al. Insulin stimulates L-carnitine accumulation in human skeletal muscle. FASEB J. 2006 Feb;20(2):377-9.
      Volek JS, Kraemer et al. L-Carnitine L-tartrate supplementation favorably affects markers of recovery from exercise stress. Am J Physiol Endocrinol Metab. 2002 Feb;282(2):E474-82.
      Wall BT, et al. Chronic oral ingestion of L-carnitine and carbohydrate increases muscle carnitine content and alters muscle fuel metabolism during exercise in humans. J Physiol. 2011 Feb 15;589(Pt 4):963-73.

      Source: http://www.bodybuilding.com/fun/your...carnitine.html
      Comments 7 Comments
      1. flamini's Avatar
        flamini -
        L-carnitine in multiple studies are shown to increase cardiovascular risks . From what I have been researching it was pointing toward the reason a diet high In red meat can cause heart problems was not because of the fat but because of the l-carnitine content . So which one is right ..? I'm confused
      1. mtinsideout's Avatar
        mtinsideout -
        Originally Posted by flamini View Post
        L-carnitine in multiple studies are shown to increase cardiovascular risks . From what I have been researching it was pointing toward the reason a diet high In red meat can cause heart problems was not because of the fat but because of the l-carnitine content . So which one is right ..? I'm confused
        I think it is fine as long as you take a probiotic or have a vegetable rich diet. I don't remember all the details but the issue had to do with bacteria in the gut.
      1. rodefeeh's Avatar
        rodefeeh -
        Learned something new today!
      1. mtinsideout's Avatar
        mtinsideout -
        Here is the article which explains soem of what was going on.


        "One of the study's biggest surprises, Hazen said, was how large an impact vegan and vegetarian diets had on the formation of TMAO from carnitine; people in the study who did not habitually eat red meat did not produce the plaque-forming TMAO even when they were given large doses of carnitine in the form of a steak or a supplement. "


        http://www.cleveland.com/healthfit/i...energy_dr.html
      1. JD261985's Avatar
        JD261985 -
        In reference to the infamous carnitine causes heart disease study read this http://anthonycolpo.com/bull****-stu...heart-disease/
      1. fueledpassion's Avatar
        fueledpassion -
        Best way is to inject it. Otherwise, taking 4g/day orally can get expensive.
      1. mrmello's Avatar
        mrmello -
        Originally Posted by JD261985 View Post
        In reference to the infamous carnitine causes heart disease study read this http://anthonycolpo.com/bull****-stu...heart-disease/

        The main thing is TMAO is only produced when meat eating bacteria is found in the intestins. TMAO was not produced even when cartinite was ingested in veagans or people who didn´t eat red meat.

        So skip red meat ''eat chickin'' and fish and carnitine should be fine.

        Log in
        Log in