by Alan Gaspari Nutrient Journal
Phosphatidic acid has only recently been identified as an important signaling molecule in both plants and animals. Phosphatidic acid is a key intermediate in lipid metabolism . It is a constituent of all cell membranes and also acts as an intermediate in the biosynthesis of triacylglycerols and other phospholipids . This acid is especially interesting as it has been shown to activate the mammalian target of rapamycin (mTOR) .
mTOR Pathway Stimulation by Phosphatidic Acid
The mammalian target of rapamycin (mTOR) governs all cell growth and cell reproduction. In adult skeletal muscle the mTOR signaling pathway is currently recognized as the major pathway regulating protein synthesis leading to increased rate of mRNA translation into proteins within cells . In a study by Fang et al.  phosphatidic acid has been identified as a critical component of mTOR signaling. Both nutritional and mechanical stimuli have been implicated in stimulating this pathway. It has been shown that mechanical activation of mTOR signaling via resistance training may be further enhanced with the presence of phosphatidic acid  by increased S6 kinase activity [6,7]. So, unlike resistance exercise with eccentric contractions, phosphatidic acid activates mTOR signaling through a PI3K–PKB-independent mechanism .
Effects of Phosphatidic Acid Ingestion on Lean Body Mass and Strength
Besides its ability to activate mTOR signaling pathway, phosphatidic acid is also thought to enhance the anabolic effects of resistance training. Hoffman and associates  conducted a pilot study on 16 bodybuilders who were randomly assigned to either ingest 750 mg of phosphatidic acid or a placebo. Subjects that received phosphatidic acid demonstrated greater increase in squat strength and lean body mass but didn’t reach statistical significance. In a follow-up study  in 28 bodybuilders, 750 mg of phosphatidic acid significantly improved responses in skeletal muscle hypertrophy, lean body mass, and maximal strength.
These studies were funded by Chemi Nutra, a patent holder of soy-derived phosphatidic acid also known as Mediator®.
Typical dose used in clinical studies is 750 mg per day.
Side Effects of Phosphatidic Acid
Phosphatidic acid seems to be very well tolerated and no adverse events have been reported .
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