• Opiod Receptor And Obesity


      From ScienceDaily

      New research demonstrates that blocking the delta opioid receptor in mice created resistance to weight gain and stimulated gene expression promoting non-shivering thermogenesis.

      Imagine eating all of the sugar and fat that you want without gaining a pound. Thanks to new research published in The FASEB Journal, the day may come when this is not too far from reality. That's because researchers from the United States and Europe have found that blocking one of three opioid receptors in your body could turn your penchant for sweets and fried treats into a weight loss strategy that actually works. By blocking the delta opioid receptor, or DOR, mice reduced their body weight despite being fed a diet high in fat and sugar. The scientists believe that the deletion of the DOR gene in mice stimulated the expression of other genes in brown adipose tissue that promoted thermogenesis.

      "Our study provided further evidence that opioid receptors can control the metabolic response to diets high in fat and sugar, and raise the possibility that these gene products (or their respective pathways) can be targeted specifically to treat excess weight and obesity," said Traci A. Czyzyk, Ph.D., a researcher involved in the work from the Department of Physiology at the Mayo Clinic in Scottsdale, Arizona.

      Scientists studied mice lacking the delta opioid receptor (DOR KO) and wild type (WT) control mice who were fed an energy dense diet (HED), high in fat and sugar, for three months. They found that DOR KO mice had a lean phenotype specifically when they were fed the HED. While WT mice gained significant weight and fat mass on this diet, DOR KO mice remained lean even though they consumed more food. Researchers then sought to determine how DOR might regulate energy balance and found that DOR KO mice were able to maintain their energy expenditure levels, in part, due to an increase in non-shivering thermogenesis. This was evidenced by an increase in thermogenesis-promoting genes in brown adipose tissue, an increase in body surface temperature near major brown adipose tissue depots, and the ability of DOR KO mice to maintain higher core body temperatures in response to being in a cold environment.

      "Don't reach for the ice cream and doughnuts just yet," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "We don't know how all this works in humans, and of course, a diet of junk food causes other health problems. This exciting research identifies genes that activate brown adipose tissue to increase our burning of calories from any source. It may lead to a safe diet pill in the future."

      Story Source:
      The above story is reprinted from materials provided by Federation of American Societies for Experimental Biology, via EurekAlert!, a service of AAAS.
      Note: Materials may be edited for content and length. For further information, please contact the source cited above.

      Journal Reference:
      T. A. Czyzyk, A. Romero-Pico, J. Pintar, J. H. McKinzie, M. H. Tschop, M. A. Statnick, R. Nogueiras. Mice lacking -opioid receptors resist the development of diet-induced obesity. The FASEB Journal, 2012; 26 (8): 3483 DOI: 10.1096/fj.12-208041

      Source: http://www.sciencedaily.com/releases...0731103054.htm
      Comments 5 Comments
      1. fightbackhxc's Avatar
        fightbackhxc -
        Whatever happened to hard work and self control?
      1. Joelslap's Avatar
        Joelslap -
        Originally Posted by fightbackhxc View Post
        Whatever happened to hard work and self control?
        Very true, I see your point, and agree 95%. To play devil advocate the same could be said for PED's as it's an edge if used correctly. Not saying you or anyone is using, well not everyone. We're all looking for an edge, from supplements to PED's (hate saying "drug"). Except for those with weight issues they cant control no matter how hard they try so this this coud be there edge. I'm not talking about the lazy kids or adults shoving bad food down all day and no excersize, only sticking up for those with bad genetics that could possibly get an edge and more confidence if this works. My genetics needed a little boost for muscle gain, my metabolism in my mid 30s is the same as it was at 17, gaining weight has not been easy with just hardwork and self control, had to get a little help, which helped self confidence. Yes this diet idea seems odd, as anabolics seem odd to the majority. Most of us know at least someone with bad genes, they try everything and no results, I feel bad for them trying to fit into societies "look". We know lots that just shove food down and dont workout, I don't feel bad for them, nor the high obesity rates on the US. This new diet could help some.
      1. MidwestBeast's Avatar
        MidwestBeast -
        No different than someone taking clen while cutting (only in terms of potential safety and effectiveness).

        edit: in relation to the hard work comment (not MOAs, etc.)
      1. fightbackhxc's Avatar
        fightbackhxc -
        Originally Posted by MidwestBeast View Post
        No different than someone taking clen while cutting (only in terms of potential safety and effectiveness).

        edit: in relation to the hard work comment (not MOAs, etc.)
        clen is to speed up the process. You still need a clean diet to really reap the benefits. Ovwrweight people literally have zero self control. This just means they will be able to eat more crap than they already do
      1. Vengeance187's Avatar
        Vengeance187 -
        New research demonstrates that blocking the delta opioid receptor
        Here I thought this is what the article would actually be about, you know, because it said it was. This has nothing to do with "blocking" the receptor, the mice were genetically altered to be born completely without it. That could have caused other genetic malformities that haven't been taken into account. Simply blocking the receptor with a drug may not have the same effect.

        Yes, ethically it would be no different than steroids or clen.

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